Sysmex SE-9000의 Morphologic Flag 분석 및 재검토조건 설정 : Evaluation on the Morphologic flags and Determination of the Review Criteria

채석래,박장순,김대철,김성원,차영주 대한임상병리학회 2000 대한임상병리학회지 Vol.20 No.5

인공물질의 혈액적합성 평가방법중 Platelet Factor 4의 유용성에 관한 연구

채석래,조한익,이동호,전희선,차영주,박성섭,한동근,김영하 大韓血液學會 1993 大韓血液學會誌 Vol.28 No.2

Dextrin-Poly(acrylic acid) Copolymer as an Additive for Surface Sizing with Oxidized Starch

Chae Hoon Kim,Araz Rajabi Abhari,Young Bin Jeong,Hye Jung Youn,Young Seok Kim,Hak Lae Lee 한국펄프·종이공학회 2017 펄프.종이技術 Vol.49 No.2

Drying energy saving by reducing the steam consumption in the after-dryer section becomes more important for many grades of papers including linerboards because surface sizing gets more widely used for these grades. Drying energy demand in the after-dryer can be decreased by increasing the solids content of the sizing agent. This requires a new sizing agent or additive be developed that provide low in viscosity at higher solids content. A dextrin poly(acrylic acid) copolymer at a solids level of 52% was prepared and used as an additive for surface sizing with oxidized starch. The effect of the copolymer on viscosity, cooking property and retrogradation was examined using Brookfield viscometer and Brabender Viscograph. It was shown that use of the copolymer increased the solids content of sizing solutions and provided better cooking and storage properties. Starch graft copolymer could reduce the reassociation of starch molecules and hinder retrogradation after cooling and during the holding period.

혈액질환에서 세포유전학적 이상

채석래,차영주 중앙대학교 의과대학 의과학연구소 1998 中央醫大誌 Vol.23 No.3

1991년 3월부터 1998년 7월까지 중대 부속 용산병원 임상병리과에 의뢰된 혈액질환 환자 및 림프종의 골수 전이 여부를 알고자 했던 환자 218명의 골수 흡인 검체를 대상으로 고정도분염법에 의한 염색체 검사를 실시하여 다음과 같은 결과를 얻었다. 1. 급성골수성백혈병 40예 중 23예(58%)에서 염색체 이상소견을 보였으며, 중요한 염색체 이상으로는 8;21 전좌(4예), 15;17 전좌(3예), 11번 전좌(2예), 5번 결실(1예), 7번 결실(4예), 8번 획득(2예) 등이 있었으며, 3개 이상의 염색체 결함이 있는 경우가 3예 있었다. 2. 림프구성 백혈병 15예 중 7명(47%)에서 염색체 이상소견을 보였으며, 중요한 염색체 이상으로는 9;22 전좌(3예) 및 과배수성 염색체(1예)가 있었다. 3. 만성골수증식성질환 20명 중 만성골수성백혈병 7명 모두에서 9;22 전좌가 있었다. 4. 골수이형성증후군 16예 중 10예(63%)에서 염색체 이상소견을 보였으며, 특히 RA에서의 염색체 결함의 빈도가 대체로 높았다. International prognostic scoring system에 따른 염색체 예후양호군은 6예, intermediate group은 7예, 불량군은 3예이었으며, 주요 결함으로서 5번 결실(2예), 7번 결실(1예), 8번 획득(3예) 및 5;22 전좌 1예등이었다. 5. 다발성골수종, 림프종 및 기타 혈액질환 환자에서는 특이한 염색체 결함은 발견되지 않았다. 이상과 같은 결과로서 염색체 검사는 혈액질환의 진단 및 예후결정에 중요한 역할을 한다고 사료되지만 염색체 제작과정이 까다롭고 시간이 걸리며, 판독자의 실력에 따라 판독에 차이가 있을 수 있으므로 많은 경험을 쌓아야 하며, 분자생물학적 진단을 병행한다면 감도 및 특이도를 더 높일 수 있으리라 사료된다. Cytogenetic analyses of 218 patients with hematologic diseases and lymphoma were performed by MTx-treated high-resolution banding technique and the results were as follows. 1. Twenty three cases (58%) of 40 acute myelogenous leukemias revealed cytogenetic defects, and main defects were t(8;21), t(15;17), t(11q23;variable), -5, -7/del(7q), +8, and complex defects. 2. Seven cases (47%) of 15 lymphocytic leukemias revealed cytogenetic defects, and main defects were 5(9;22) and hyperdiploid chromosome. 3. In 20 cases of chronic myeloproliferative disorders, all of 7 chronic myelogenous leukemia had t(9;22). 4. Sixteen cases(63%) of 16 myelodysplastic syndromes revealed cytogenetic defects, and main defects were del(5q), -7, +8, and 5(5;12). The frequency of cytogenetic defects in the refractory anemia appeared high. According to the international prognostic scoring system(IPSS), 6 cases were classified as good, 7 cases as intermediate and 3 cases as poor karyotype group. 5. Other hematologic disease, lymphoma or multiple myeloma cases did not have disease-specific cytogenetic abnormalities. In conclusion, cytogenetic study plays an important role in the diagnosis and differential diagnosis of hematologic diseases as well as prediction of prognosis, and molecular study together with cytogenetic interpretation by skilled expert would raise sensitivity and specificity in the detection of genetic defects.

Gel Test에 의한 불규칙항체 선별검사의 유용성

채석래,방광환,장은아,차영주 大韓輸血學會 1998 大韓輸血學會誌 Vol.9 No.1

젊은 여성에 있어 과민성 장증후군과 배뇨 증상과의 관계: 인터넷 설문 조사

이석영 ( Seok Young Lee ),김병관 ( Byeong Gwan Kim ),김지원 ( Ji Won Kim ),정지봉 ( Ji Bong Jeong ),곽금연 ( Geum Yeon Kwak ),이국래 ( Kook Lae Lee ),손환철 ( Hwan Cheol Son ),정현채 ( Hyun Chae Jung ),송인성 ( In Sung Song ) 대한소화기기능성질환·운동학회 2005 Journal of Neurogastroenterology and Motility (JNM Vol.11 No.1

목적: 과민성 장증후군은 기능성 장 질환의 하나로 여성들의 유병율이 2배 이상 높고 또한, 여러 가지 다양한 장외 증상들을 보인다. 이번 연구에서는 우리나라 젊은 여성에서 과민성 장증후군과 배뇨 증상과의 관계를 알아보고자 하였다. 대상 및 방법: 2004년 7월 인터넷 전문 설문업체에 등록된 18-49세까지의 여성 50,000명에게 전자 우편을 보냈고 모든 설문에 답변한 대상자만 연구에 포함시켰으며 설문 답변 시간이 전체 대상자의 25% 미만인 경우는 Background/Aims: Patients suffering from irritable bowel syndrome (IBS) tend to have extraintestinal symptoms. The purpose of this study was to compare the nature and severity of the urinary symptoms in IBS patients in comparison to non-IBS patients. Meth

전분 공중합체를 이용한 종이 건조 에너지 저감 기술

김영석(Young-Seok Kim),장동균(Dong-Kyun Jang),이학래(Hak-Lae Lee),정영빈(Young-Bin Jeong),김채훈(Chae-Hoon Kim),Rajabi Abhari Araz 한국펄프·종이공학회 2015 한국펄프·종이공학회 학술발표논문집 Vol.2015 No.10

Dextrin-Poly(acrylic acid) Copolymer as an Additive for Surface Sizing with Oxidized Starch (Ⅱ)

Araz Rajabi,Chae Hoon Kim,Young Bin Jeong,Hye Jung Youn,Young Seok Kim,Hak Lae Lee 한국펄프·종이공학회 2017 펄프.종이技術 Vol.49 No.2

Drying energy demand in the after-dryer section for the surface sized paper is an important economic factor in papermaking. Using an efficient sizing solution with high solids content and decreasing the pickup weight can reduce the drying energy requirement in the after-dryer section. A dextrin-poly(acrylic acid) copolymer was used as an additive for surface sizing of linerboard, and its effect on the mechanical properties of linerboard, and drying energy consumption were investigated. Results showed that, addition of dextrin poly(acrylic acid) copolymer had beneficial effects on the holdout of surface sizing starch and provided higher compressive and bending strengths. It was possible to reduce pickup weight by 23% while keeping the compressive strength and bending resistance at a similar level. Consequently, the reduced pickup resulted in higher dryness after surface sizing. Even though, drying analysis of wet sized sheets at a laboratory gave a lower drying rate when the copolymer was used as an additive, the result from a mill trial revealed that steam usage decreased significantly when the copolymer was used as an additive for surface sizing, which was attributed to the reduction in the pickup weight and improvement in holdout of the surface sizing agents on linerboard surface that is more pronounced on a high speed paper machine.

자동화 매독 검사법인 Architect Syphilis TP assay와 Mediace TPLA의 일치율 및 위양성 평가

허희진,채석래 동국대학교 의학연구소 2009 東國醫學 Vol.16 No.1

자동화장비로 검사 가능한 Mediace Treponema pallidum latex agglutination (Sekisui, Japan; 이하 Mediace TPLA)와 Architect Syphilis TP assay (Abbott, Germany; 이하 Syphilis TP)의 결과치를 비교하여 일치율을 조사하였다. 트레포네마검사에서 위양성의 가능성이 높은 환자 검체를 대상으로 두 검사법의 위양성률을 구하여 두 자동화검사법의 유용성을 평가하고자 하였다. Mediace TPLA 양성이었던 161 예를 대상으로 Syphilis TP 검사를 시행하였다. 위양성률을 평가하기 위해 항핵항체 양성이거나 B형간염표면항원 양성, 항-C형간염바이러스항체 양성, rheumatoid factor 양성, CRP 양성 또는 70세 이상의 고령 환자 검체 234예를 연구 대상으로 Mediace TPLA와 Syphilis TP 검사를 시행하였다. 두 검사 결과의 차이를 보이는 예는 line-blot immunoassay (Innolia Syphilis score, Innogenetics, Belgium)로 확인하였다. Mediace TPLA 양성이었던 161예중 4예 (2.5%)는 Syphilis TP 음성이었고, 이 중 2예는 line-blot immunoassay 양성, 2에는 음성이었다. 중화후 Mediace TPLA, 중화전 Mediace TPLA와 Syphilis TP의 위양성률은 각각 0%(0/234), 1.7%(4/234), 1.7%(4/234)였다. 두 검사의 일치율은 98%(387/395) 였다. 자통화 매독검사인 Mediace TPLA와 Syphilis TP는 양성으로 나온 검체에서의 일치율이 높고 기존의 트레포네마검사 보다 낮은 위양성률을 보이므로, 수기법을 대체할 수 있는 유용한 검사로 생각된다. We compared the results of Mediace Treponema pallidum latex agglutination (TPLA) (Sekisui Chemical Co., Ltd, Japan) with Architect Syphilis TP assay (Syphilis TP) (Abbott, Germany), automated treponemal tests for the diagnosis of syphilis. To establish false positive rates, two methods were tested with patients' sera with laboratory results reported to be related with false positivity of treponemal test. One hundred sixty one patients' sera with Mediace TPLA positivity underwent Syphilis TP. Two hundred thirty four patients' sera with positivity for anti-nuclear antibody, HBs Ag, Anti-HCV, rheumatoid factor or CRP, or old age (≥70) were included in the evaluation of false positive rates. Discrepancies between Mediace TPLA and Syphilis TP results were confirmed by line-blot immunoassay (Innolia Syphilis score, Innogenetics, Belgium). Among 161 patients' sera with Mediace TPLA positivity, 4 cases (2.5%) showed discrepancy between Mediace TPLA and Syphilis TP results: Among 4 cases, 2 cases showed positive line-blot immunoassay results and 2 showed negative results. False positive rate of Mediace TPLA after neutralization, Mediace TPLA before neutralization and Syphilis TP was 0.0% (0/234), 1.7% (4/234) and 1.7% (4/234), respectively. The concordance rate of Mediace TPLA and Syphilis TP was 98% (387/395). The results of comparison data demonstrated that Mediace TPLA and Syphilis TP had high concordance. False positivity of Mediace TPLA and Syphilis TP were low compared with previously reported that of treponemal test. Therefore, automated treponemal tests would be considered to be a valid alternative to traditional treponemal test for confirmation of syphilis.

청소년 야구 선수에서 발생한 거골하 관절의 활액막 골연골종증

채종우 ( Jong Woo Chae ),조형래 ( Hyung Lae Cho ),오용승 ( Yong Seung Oh ),이완석 ( Wan Seok Lee ) 대한스포츠의학회 2018 대한스포츠의학회지 Vol.36 No.4

Synovial chondromatosis is an uncommon disorder characterized by cartilaginous proliferation within the synovial membrane of the articular joint. Smaller joints are rarely affected and it may be progressed to osteochondromatosis after ossification or calcification of metaplastic cartilage. It is commonly presented in the third to fourth decade of life, but rarely presented in adolescence. We report a unique case of synovial osteochondromatosis of the subtalar joint in 14-year-old baseball player. Arthroscopic removal of loose body and complete excision of the osteochondral mass with concomitant synovectomy resulted in satisfactory outcome without recurrence at final follow-up.