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Lee Myungsu,Chung Jin Wook,Lee Kwang-Hun,Won Jong Yun,Chun Ho Jong,Lee Han Chu,Kim Jin Hyoung,Lee In Joon,허세범,Kim Hyo-Cheol,Kim Yoon Jun,Kim Gyoung Min,Joo Seung-Moon,Oh Jung Suk 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.10
Objective: To assess the two-year treatment outcomes of chemoembolization with drug-eluting embolics (DEE) for nodular hepatocellular carcinoma (HCC). Materials and Methods: This study was a prospective, multicenter, registry-based, single-arm trial conducted at five university hospitals in Korea. Patients were recruited between May 2011 and April 2013, with a target population of 200. A DC Bead loaded with doxorubicin was used as the DEE agent. Patients were followed up for two years. Per-patient and perlesion tumor response analysis, per-patient overall survival (OS) and progression-free survival (PFS) analysis, and per-lesion tumor control analysis were performed. Results: The final study population included 152 patients, with 207 target lesions for the per-lesion analysis. At one-month, six-month, one-year, and two-year per-patient assessments, complete response (CR) rates were 40.1%, 43.0%, 33.3%, and 19.6%, respectively. The objective response (OR) rates were 91.4%, 55.4%, 35.1%, and 19.6%, respectively. The cumulative two-year OS rate was 79.7%. The cumulative two-year PFS rate was 22.4% and the median survival was 9.3 months. In multivariable analysis, the Child-Pugh score (p = 0.019) was an independent predictor of OS, and tumor multiplicity (p < 0.001), tumor size (p = 0.020), and Child-Pugh score (p = 0.006) were independent predictors of PFS. In per-lesion analysis, one-month, six-month, one-year and two-year CR rates were 57.5%, 58.5%, 45.2%, and 33.3%, respectively, and the OR rates were 84.1%, 65.2%, 46.6%, and 33.3%, respectively. The cumulative two-year per-lesion tumor control rate was 36.2%, and the median time was 14.1 months. The Child-Pugh score (p < 0.001) was the only independent predictor of tumor control. Serious adverse events were reported in 11 patients (7.2%). Conclusion: DEE chemoembolization for nodular HCCs in the Korean population showed acceptable survival, tumor response, and safety profiles after a two-year follow-up. Good liver function (Child-Pugh score A5) was a key predictor of per-patient OS, PFS, and per-lesion tumor control.
Lee, In Joon,Lee, Myungsu,Kim, Soo Jin,Kim, You Kyung,Won, Jong Yun,Chung, Jin Wook Elsevier 2018 JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY Vol.29 No.8
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>To assess feasibility and efficacy of CKD-516, a vascular disrupting agent, in transarterial chemoembolization in a liver tumor model.</P> <P><B>Materials and Methods</B></P> <P>A VX2 carcinoma strain was implanted in rabbit liver (n = 40) and incubated for 2 weeks. After confirmation of tumor growth using computed tomography, transarterial chemoembolization was performed. CKD-516 was dissolved in ethiodized oil, and animals were allocated to 4 treatment groups (n = 10 in each): group A, ethiodized oil; group B, ethiodized oil/CKD-516; group C, ethiodized oil + doxorubicin; group D, ethiodized oil/CKD-516 + doxorubicin. To assess hepatic damage, serum aspartate transaminase and alanine transaminase levels were measured on day 1, 3, and 7 after delivery. To assess tumor necrosis, animals were euthanized on day 7, and explanted tumors were stained with hematoxylin and eosin and a terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling assay. Percentage areas of viable tumors were calculated using digitalized histopathologic specimen images.</P> <P><B>Results</B></P> <P>Tumor viability rates were 47.1% ± 11.4%, 27.5% ± 13.6%, 14.4% ± 12.5%, and 0.7% ± 1.0% in groups A, B, C, and D (<I>P</I> < .001). Liver enzyme levels were elevated after drug delivery but recovered during follow-up. Significant between-group differences were observed on days 1, 3, and 7 (aspartate transaminase and alanine transaminase: <I>P</I> = .0135 and <I>P</I> = .0134, <I>P</I> = .0390 and <I>P</I> = .0084, and <I>P</I> = .8260 and <I>P</I> = .0440).</P> <P><B>Conclusions</B></P> <P>Treatment with a combination of CKD-516 and conventional transarterial chemoembolization showed therapeutic benefit in a liver tumor model.</P>
타이어공기압경고장치(TPMS)장착 자동차의 안전기준에 관한 고찰
이명수(Myungsu Lee),임재환(Jaehwan Lim) 한국자동차공학회 2010 한국자동차공학회 부문종합 학술대회 Vol.2010 No.5
Tire Pressure Monitoring System(TPMS) have a excellent effectiveness in two aspects. One is fatalities reduction of traffic accident due to tire rapid loss while driving with low tire pressure resulting from driver"s lack for tire management and the other is additional greenhouse gases exhaust. So, USA had already released FMVSS 138 in 2004 and enforced obligatory installation from 2005 to 2007 step by step. Also, Europe are preparing the motor vehicle safety standards about the TPMS and will released in 2010 at the latest. For fundamental study of rule making in Korea, the vehicle safety regulations of USA and Europe are reviewed and Full-size vehicle dynamic test was carried out according to both FMVSS 138 and ECE R64. This study will be reflected for the establishment on the Korean Motor Vehicle Safety Standard for the TPMS.