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RISS 인기검색어
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- 저자 : ( Minyoung Jung ) (검색결과 175 건)
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Evaluating Dead Time and Dilution Factors for Improving Radioactive Waste Analysis
Minyoung Jung,Kyunghun Jung,Jung Bo Yoo 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.1
The Korea Atomic Energy Research Institute (KAERI) employs a methodology for evaluating the concentration of radionuclides, dividing them into volatile and non-volatile nuclides based on their characteristics, to ensure the permanent disposal of internally generated radioactive waste. Gamma spectroscopy enables the detection and radiation concentration determination of individual nuclides in samples containing multiple gamma-emitting nuclides. Due to the stochastic nature of radioactive decay, the generated radiation signal can interact with the detector faster than the detected signal processing time, causing dead time in the gamma spectroscopy process. Radioactive waste samples typically exhibit higher radiation levels than environmental samples, leading to long dead times during the measurement process, consequently reducing the accuracy of the analysis. Therefore, dead time must be considered when analyzing radioactive waste samples. During the measurement process, dead time may vary between a few seconds to several tens of thousands of seconds. More long dead time may also result in a temporal loss in the analysis stage, requiring more time than the actual measurement time. Long dead time samples undergo re-measurement after dilution to facilitate the analysis. As the prepared solution is also utilized in the nuclide separation processes, minimizing sample loss during dilution is crucial. Hence, predicting the possibility of dead time exceeding the target sample in advance and determining the corresponding dilution factor can prevent delays in the analysis process and the loss of samples due to dilution. In this study, to improve the issues related to gamma analysis, by using data generated during the analysis process, investigated methods to predict long dead time samples in advance and determining criteria for dilution factors. As a result of comparing the dead time data of 5% or long with the dose of the solution sample, it was concluded that analysis should be performed after dilution when it is about 0.4 μSv/h or high. However, some samples required dilution even at doses below 0.4 μSv/h. Also, re-measurement after dilution, the sample with a dead time of less than 32% was measured with less than 5% when diluted 10 times, and more than 32% required more than 10 times dilution. We suppose that with additional data collection for analyzing these samples in the future, if we can establish clearer criteria, we can predict long dead time samples in advance and solve the problem of analysis delay and sample loss.
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Anti‐ageing effects of a new synthetic sphingolipid (K6EAA‐L12) on aged murine skin
Jung, Minyoung,Lee, Sanghoon,Park, Hwa‐,young,Youm, Jong‐,Kyung,Jeong, Sekyoo,Bae, Jonghwan,Kwon, Mi Jung,Park, Byeong Deog,Lee, Seung Hun,Choi, Eung Ho Blackwell Publishing Ltd 2011 Experimental dermatology Vol.20 No.4
<P><B>Abstract: </B> Recently, we reported on the anti‐ageing effects of K6PC‐5. This compound induced keratinocyte differentiation and fibroblast proliferation by increasing sphingosine‐1 phosphate synthesis. We performed this study to confirm the anti‐ageing effects of new synthetic products (the K6EAA series) derived from K6PC‐5 through an amino group induction. Cellular responses such as differentiation, proliferation and calcium mobilization were investigated using cultured human keratinocytes and fibroblasts. Also, we measured the expressions of collagen mRNA and protein using real time RT‐PCR and ELISA, respectively. The K6EAA‐L12 product, selected by <I>in vitro</I> screening, was evaluated for anti‐ageing effects on intrinsically and extrinsically (photo) aged models of hairless mice. In the intrinsically aged murine skin, K6EAA‐L12 showed anti‐ageing effects by activating collagen synthesis, eventually causing dermal thickening. Also, in the photo‐aged skin, the dermal collagen density and dermal thickness were increased. In photo‐aged murine skin, K6EAA‐L12 increased stratum corneum integrity by increasing corneodesmosome density and improved the barrier recovery rate. However, there were no changes in the expressions of epidermal differentiation maker proteins. In conclusion, topical K6EAA‐L12, a new synthetic K6PC‐5 derivative, improves intrinsically and extrinsically (photo) aged skin by increasing the collagen density and improving the skin barrier function.</P>
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Aspirin Targets SIRT1 and AMPK to Induce Senescence of Colorectal Carcinoma Cells
Jung, Yu Ri,Kim, Eun Ju,Choi, Hyeong Jwa,Park, Jung-Jin,Kim, Hak-Su,Lee, Yoon-Jin,Park, Myung-Jin,Lee, Minyoung American Society for Pharmacology and Experimental 2015 Molecular pharmacology Vol.88 No.4
<P>Cancer therapies attempt to destroy the entire tumor, but this tends to require toxic compounds and high doses of radiation. Recently, considerable attention has focused on therapy-induced senescence (TIS), which can be induced in cancer cells by low doses of therapeutic drugs or radiation and provides a barrier to tumor development. However, the molecular mechanisms governing TIS remain elusive. Special attention has been paid to the potential chemopreventive effect of aspirin against human colorectal cancer. In this study, we investigated the effects of aspirin on TIS of human colorectal carcinoma (CRC) cells and show that it occurs via sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK), two key regulators of cellular metabolism. Aspirin increased the senescence of CRC cells, increased the protein levels of SIRT1, phospho-AMPK (T172), and phospho-acetyl CoA carboxylase (S79), and reduced the cellular level of ATP. Small-interfering RNA–mediated downregulation or pharmacological inhibition of SIRT1 or AMPK significantly attenuated the aspirin-induced cellular senescence in CRC cells. In contrast, treatment with a SIRT1 agonist or an AMP analog induced cellular senescence. Remarkably, SIRT1 knockdown abrogated the aspirin-induced activation of AMPK, and vice versa. During the progression of aspirin-induced cellular senescence in CRC cells, SIRT1 showed increased deacetylase activity at a relatively early time point but was characterized by decreased activity with increased cytoplasmic localization at a later time point. Collectively, these novel findings suggest that aspirin could provide anticancer effects by inducing senescence in human CRC cells through the reciprocal regulation of SIRT1-AMPK pathways.</P>
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Estimating a Maximum Magnitude
Minyoung Kang,Eric Yee,Ekaputra Rhajendra,Changkyu Lee,Soojin Jung,Euihyun Jung 대한토목학회 2023 대한토목학회 학술대회 Vol.2023 No.10
This research discusses maximum magnitude for each seismic source in Korea, and to compare the maximum magnitude before and after the 2016 Gyeongju and 2017 Pohang earthquakes. Based on the Wells and Coppersmith(1994), the largest possible earthquake is estimated to have a magnitude of 7.9 from Tsushima faults. The application of the measured fault length as the surface rupture length introduces a potential for overestimating the values of high-magnitude.
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( Minyoung Jung ),( Chan Hee Nam ),( Byung Cheol Park ),( Myung Hwa Kim ),( Seung Phil Hong ) 한국피부장벽학회 2015 한국피부장벽학회지 Vol.17 No.2
Atopic dermatitis (AD) and psoriasis vulgaris (PSO) are most representative inflammatory skin disease. Skin barrier dysfunction is commonly seen in AD and PSO. However, their clinical features are quite different due to the pathogenetic difference. To deeply understand the clinical as well as pathogenetic differences, we have analyzed the genes involved in the epidermal lipid synthesis, epidermal development process and immune responses in the skin of AD and PSO patients. We have compared the transcriptomes of lesional skin from 6 adults AD patients (males), 4 PSO patients (1 female and 3 males) and 6 healthy young volunteers (19~24 years of age, 3 females and 3 males) by high-throughput complementary DNA sequencing (RNA-seq). For the gene expression estimation, Cufflinks v2.1.1 was used that is the gene annotation database of Ensembl release 72. 3,121 and 6,669 differentially expressed genes (DEGs) were identified in the skin of AD and PSO patients, respectively, compared with healthy skin (p<0.05). Comparing two disease groups, an overlap containing 397 genes was detected. The criterion for inclusion in the list was at least two-fold under- or over- expression in the same direction in both diseases. These transcriptomes contained AD- and PSO-associated genes for confirming diseases such as carbonic anhydrase Ⅱ (CAⅡ), neural epidermal growth factor Ⅱ (NELLⅡ), thymus and activation-regulated chemokine (TARC/CCL17), β-defensin-2 (DEFB4), psoriasin (S100A7), elafin (PI3), IL-17A, Ki67, and IL-12. The DEGs of AD and PSO groups were clustered into the GOs related to lipids metabolism, epidermal differentiation and development process, and immune response. This data help us understand the gene expressional differences in the skin barrier homeostasis pathway, cytoskeletal changes, and inflammatory response.
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Jung Bo Yoo,Kyunghun Jung,Kwang-Soon Choi,Jungweon Choi,Gi Yong Kim,Simon Oh,Hyojin An,Jihyun Kim,Minyoung Jung 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
To achieve permanent disposal of radioactive waste drums, the radionuclides analysis process is essential. A variety of waste types are generated through the operation of nuclear facilities, with dry active waste (DAW) being the most abundant. To perform radionuclides analysis, sample pretreatment technology is required to transform solid samples into solutions. In this study, we developed a dry ashing-microwave digestion method and secured the reliability of the analysis results through a validity evaluation. Additionally, we conducted a comparative analysis of the radioactivity of 94Nb nuclides with and without the chemical separation process, which reduced the minimum detectable activity (MDA) level by more than 65-fold for a certain sample.
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Jung Jinho,Park Hyun Joon,Jung Minyoung 대한의학회 2021 Journal of Korean medical science Vol.36 No.30
Background: Environmental tobacco smoke exposure due to parents is a modifiable risk factor for childhood asthma, but many studies have evaluated parental smoking using selfreported data. Therefore, we aimed to analyze the relationship between parental cotinineverified smoking status and asthma in their children. Methods: This population-based cross-sectional study used data from the Korean National Health and Nutrition Examination Survey from 2014 to 2017. Participants aged 0 to 18 years with complete self-reported physician-diagnosed childhood asthma and measurement of their parental urinary cotinine levels were included. Parental urinary cotinine-verified smoking status was defined using both urinary cotinine levels and self-report, as active, passive, and non-smoker. Sample weights were applied to all statistical analyses because of a complex, multistage and clustered survey design. Logistic regression model was used to analyze the relationship between childhood asthma and parental smoking. Results: A total of 5,264 subjects aged < 19 years were included. The prevalence of asthma was 3.4%. The proportions of paternal and maternal urinary cotinine-verified active smokers during the study period were 50.4% and 16.9%, respectively. When parental urinary cotinine level increased, the proportion of parental low household income was increased (P < 0.001). There was no significant association between the parental urinary cotinine-verified smoking group and childhood asthma group. However, the adjusted odds ratios of childhood asthma in the middle and highest tertile of paternal urinary cotinine levels compared with those in lowest tertile were 1.95 (95% confidence interval [CI], 0.98–3.89) and 2.34 (95% CI, 1.21–4.54), respectively. Conclusion: There seems to be a dose-related association between paternal urinary cotinine levels and the risk of childhood asthma. Because of the high rate of paternal smoking, further studies are needed to develop a targeted strategy to reduce parental smoking for childhood asthma.
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Minyoung Jung,Byungjoo Kim,Doo Wan Boo,소헌영 대한화학회 2007 Bulletin of the Korean Chemical Society Vol.28 No.5
An isotope dilution-liquid chromatography/tandem mass spectrometric method was developed as a candidate reference method for the accurate determination of folic acid in infant milk formula. Sample was spiked with 13C5-folic acid and then extracted with phosphate buffer (pH 6) solution. The extract was further cleaned up by deproteinization followed by a C18 solid-phase extraction cartridge. The extract was analyzed by using LC/ESI/MS/MS with selectively monitoring the collisionally induced dissociation channels of m/z 442 m/z 295 and m/z 447 m/z 295, which are the neutral glutamyl loss from the [M+H]+ ions of folic acid and 13C5-folic acid, respectively. LC/MS/MS chromatograms showed substantially reduced background from chemical noises compared to LC/MS chromatograms. Repeatability and reproducibility studies showed that the LC/MS/MS method is a reliable and reproducible method which can provide less than 1.5 relative percentage of method precision.
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