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( Ki Eun Hwang ),( Chul Park ),( Chang Hwan Seol ),( Yu Ri Hwang ),( June Seong Hwang ),( Jae Wan Jung ),( Keum Ha Choi ),( Eun Taik Jeong ),( Hak Ryul Kim ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.2
Background: This study was conducted in order to elucidate the effects of docetaxel on the growth of peroxiredoxin 1 (Prx1) knockdown A549 xenograft tumors and further tested the role of Prx1 as a predictor for how a patient would respond to docetaxel treatment. Methods: Effects of docetaxel on the growth of scrambled- and shPrx1-infected A549 xenograft tumors in nude mice were measured. Moreover, immunohistochemical expression of Prx1 was evaluated in paraffin-embedded tissues from 24 non-small cell lung cancer patients who had received docetaxel-cisplatin regimens as a first-line treatment. Results: Docetaxel treatment in Prx1 knockdown xenograft tumor resulted in reduced tumors growth compared with other groups. Prx1 knockdown increased the production of cleaved caspases-8 and -9 in the control itself compared to scramble tumors. Moreover, docetaxel treatment in Prx1 knockdown tissue led to an increased protein band. Phosphorylated Akt was found in Prx1 scramble tissues. Phosphorylated FOXO1 was detected in the docetaxel treatment group. On the other hand, Prx1 knockdown completely suppressed the Akt-FOXO1 axis. The median progression free survival (PFS) of patients with low Prx1 expression was 7 months (95% confidence interval [CI], 6.0?7.7), whereas the median progression-free survival of patients with high Prx1 expression was 4 months (95% CI, 4.0?5.0). However, high Prx1 expression was not associated with decreased PFS (p=0.114). Conclusion: Our findings suggest that elevated Prx1 provides resistance to docetaxel treatment through suppression of FOXO1-induced apoptosis in A549 xenograft tumors, but may not be related with the predictive significance for response to docetaxel treatment.
Hwang, Ki Eun,Park, Chul,Seol, Chang Hwan,Hwang, Yu Ri,Hwang, June Seong,Jung, Jae Wan,Choi, Keum Ha,Jeong, Eun Taik,Kim, Hak Ryul The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.2
Background: This study was conducted in order to elucidate the effects of docetaxel on the growth of peroxiredoxin 1 (Prx1) knockdown A549 xenograft tumors and further tested the role of Prx1 as a predictor for how a patient would respond to docetaxel treatment. Methods: Effects of docetaxel on the growth of scrambled- and shPrx1-infected A549 xenograft tumors in nude mice were measured. Moreover, immunohistochemical expression of Prx1 was evaluated in paraffin-embedded tissues from 24 non-small cell lung cancer patients who had received docetaxel-cisplatin regimens as a first-line treatment. Results: Docetaxel treatment in Prx1 knockdown xenograft tumor resulted in reduced tumors growth compared with other groups. Prx1 knockdown increased the production of cleaved caspases-8 and -9 in the control itself compared to scramble tumors. Moreover, docetaxel treatment in Prx1 knockdown tissue led to an increased protein band. Phosphorylated Akt was found in Prx1 scramble tissues. Phosphorylated FOXO1 was detected in the docetaxel treatment group. On the other hand, Prx1 knockdown completely suppressed the Akt-FOXO1 axis. The median progression-free survival (PFS) of patients with low Prx1 expression was 7 months (95% confidence interval [CI], 6.0-7.7), whereas the median progression-free survival of patients with high Prx1 expression was 4 months (95% CI, 4.0-5.0). However, high Prx1 expression was not associated with decreased PFS (p=0.114). Conclusion: Our findings suggest that elevated Prx1 provides resistance to docetaxel treatment through suppression of FOXO1-induced apoptosis in A549 xenograft tumors, but may not be related with the predictive significance for response to docetaxel treatment.
Protective Effects of Edible Insect Extracts against Acute Alcoholic Liver Damage
Bo Byeol Hwang,Min Kook Lee,Eun Hee Jo,In Seon Hwang,Seong Hwan Ahn,Yun Jin Bae,Chang Hyun Oh,Yong Seol Kim,June Su Kim,Min Chul Cho,Sam Hyun Baek,Sang Hoon Lee,Won Joon Oh,Seo Yeong Hwang,Sun Jae Kim 한국식품영양과학회 2017 한국식품영양과학회 학술대회발표집 Vol.2016 No.10
Spontaneous regression of acquired melanocytic nevus without peripheral halo
( So Young Jung ),( Hanyeong Wang ),( Wonkyung Lee ),( June Eun Seol ),( Hyojin Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Halo nevus is a pigmented nevus surrounded by depigmented patch clinically and it can be seen aroundacquired or congenital melanocytic nevus, blue nevus, Spitz nevus, dysplastic nevus or melanoma. Rarely halo nevus without halo can occur. In that case, nevus shows identical histologic features to those seen in halo nevus but without presenting a halo clinically. A 41 year-old male presented with hyperpigmented macule on the back. The lesion occurred and had been darkened since 6 months before. On physical examination, 1.5 X 1.5 cm sized hyperpigmented plaque was seen on the back, however, there was no depigmentation around the plaqueor other parts of body. Histopathologic findings of the lesion revealed dense lichenoid infiltration with nevoid cell nests in upper dermis, which was compatible with halo nevus. Halo nevus is related with spontaneous regression of the nevus that we decided to observe the lesion withoutany treatment. One year later, it disappeared without depigmentation. Herein, we report a case of histologically proven halo nevus without halo showing spontaneous regression.
In Seok Park,Jun Wook Hur,Soo Yeon Im,Dong Won Seol,Woo June Hur,Min Ouk Park,Hye Suck An,Eun Mi Kim,Seok Jung Han 한국유전학회 2008 Genes & Genomics Vol.30 No.2
Morphometric traits, percent shell weight, percent cavity volume and condition index of 4-year-old induced hybrid abalone from female Haliotis gigantea Gmelin and male Haliotis discus discus Reeve were compared to those of the parental species. Apex height/shell height of the induced hybrid abalone was in between the average height of the parental species. The induced hybrid abalone shared three traits with the paternal species and two with the maternal species. After 4 years of growth, the condition index of the induced hybrids weresignificantly higher than that of either parental species ( P< 0.05). Generally, induced hybrid abalone displayed an external morphology that was intermediate between the representative of both parental species. Haliotis gigantea and the induced hybrids had four respiratory pores, while H. discus discus had five.