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Plyometric Training과 비타민 C 투여가 남고생의 체력, 혈중 젖산, 암모니아 및 젖산탈수소효소에 미치는 영향
장준원,김세종,이현미,서혜림,조현숙,고정림,염종우,예정복,백영호 釜山大學校 附設 體育科學硏究所 2003 體育科學硏究所 論文集 Vol.19 No.-
The purpose of this was to examine the effect of plyometric training and vitamin C ingestion on physical fitness and fatigue substance....
( Hye-rim Jung ),( Ju-hee Lee ),( Yu-mi Moon ),( Tae-rim Choi ),( Soo-yeon Yang ),( Hun-suk Song ),( Jun Young Park ),( Ye Lim Park ),( Shashi Kant Bhatia ),( Ranjit Gurav ),( Byoung Joon Ko ),( Yung- 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.5
Polyhydroxybutyrate (PHB), the most well-known polyhydroxyalkanoate, is a bio-based, biodegradable polymer that has the potential to replace petroleum-based plastics. Lignocellulose hydrolysate, a non-edible resource, is a promising substrate for the sustainable, fermentative production of PHB. However, its application is limited by the generation of inhibitors during the pretreatment processes. In this study, we investigated the feasibility of PHB production in E. coli in the presence of inhibitors found in lignocellulose hydrolysates. Our results show that the introduction of PHB synthetic genes (bktB, phaB, and phaC from Ralstonia eutropha H16) improved cell growth in the presence of the inhibitors such as furfural, 4-hydroxybenzaldehyde, and vanillin, suggesting that PHB synthetic genes confer resistance to these inhibitors. In addition, increased PHB production was observed in the presence of furfural as opposed to the absence of furfural, suggesting that this compound could be used to stimulate PHB production. Our findings indicate that PHB production using lignocellulose hydrolysates in recombinant E. coli could be an innovative strategy for cost-effective PHB production, and PHB could be a good target product from lignocellulose hydrolysates, especially glucose.
Lichen striatus following Blaschko lines
( Hye Rim Ko ),( Ji Won Yun ),( Hyung Jin Hahn ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Lichen striatus is an uncommon self-limiting dermatosis that occurs mostly in children and rarely in adults. It presents as linear, erythematous, lichenoid papules distributed along Blaschko lines usually on the extremities and rarely on the trunk and face. It is important to distinguish lichen striatus from many conditions following Blaschko lines, particularly the adult “blaschkitis” initially described as a distinct entity from lichen striatus. Blaschkitis is more common in adults, consists of papules and vesicles in multiple lines usually on the trunk, is more recurrent, and histologically shows a spongiotic rather than a lichenoid pattern. However, it is still not clear whether lichen striatus and blaschkitis are two distinct diseases or variations of the same entity. A 45-year-old male presented with pruritic, linear, brownish papules on the back for 1 month. The lesions showed the pattern of a v on the spine, suggesting the distribution along Blaschko lines. Histopathological findings showed minimal spongiosis and lichenoid lymphohistiocytic infiltrates in the upper dermis and around the sweat ducts in the deep dermis. After 6 months, the lesions improved with topical steroid preparations although pigmentation persisted. The clinical features and histologic findings suggested the diagnosis of lichen striatus. Herein, we report a case of lichen striatus distributed along Blaschko lines on a trunk in an adult patient.
P148 : A clinical study of skin diseases on vulvar
( Hye Rim Ko ),( So Min Kim ),( Chae Young Won ),( Hyung Jin Hahn ),( Young Bok Lee ),( Jin Wou Kim ),( Dong Soo Yu ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Vulvar diseases are not rare in dermatology, however the clinical investigations of the vulvar lesions are insufficient. Objectives: The purpose of this study was to investigate the epidemiological aspects of the vulvar diseases, and to highlight the clinical features of dermatoses of the vulvar with the brief review of the common vulvar diseases. Methods: The retrospective clinical study was performed by reviewing charts, pathologic slide, and clinical photographs of 37 patients who had received skin biopsy for vulvar lesions at Uijeongbu St. Mary’s Hospital between February 2009 and September 2013. Results: The mean age was 47.3 years. The most frequent vulvar diseases were epidermal cyst, lichen sclerosus, lichen simplex chronicus, herpes simplex infection and condyloma accuminatum in the decreasing order of frequency. Except for the 11 asymptomatic patients, the rest of the patients complained of various symptoms such as a pain, prickling sensation, tenderness and pruritus. Of the 37 cases, 14 had patches or plaques, 11 had papules or nodules, 6 had erosions or ulcers and 6 had vulvar mass. Conclusion: We retrospectively studied 37 cases of vulvar diseases. The results of this study are similar to previousreports on the clinical features of vulvar diseases. This study suggests that various conditions can affect the vulvar. Further investigation with a larger group of patients is necessary to better understand the epidemiology of vulvar diseases.
( Hye Rim Ko ),( Sae Mi Park ),( Dae Hong Kim ),( Eun Jong Song ),( Kum Hee Jung ),( Jin Wou Kim ),( Dong Soo Yu ),( Young Bok Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: A novel injectable filler of polymethylmethacrylate and cross-linked dextran in hydroxypropyl methylcellulose was introduced in commercial filler market. Objectives: For soft tissue augmentation, the safety and biocompatibility should be evaluated and the stability at the implantation site should be assessed by histologic evaluation. Methods: Polymethylmethacrylate and cross-linked dextran in hydroxypropyl methylcellulose was subcutaneously injected into the skin of Spragu-Dawly Rats. Histologic evaluation was performed at 13 weeks and 12 months after the injection. Inflammatory cell infiltration, neovascularization, and fibrosis were scored with grading systems. Results: The mean score of histologic evaluation was 5.7 and 3.9 at 13 weeks and 12 months, respectively. Polymethylmethacrylate and cross-linked dextran in hydroxypropyl methylcellulose was kept in place through fine fibrous capsules at 12 months after injections. Conclusion: The mixture of polymethymetahcrylate and cross-linked dextran in hydroxyproly methylcellulose can be safe material for soft tissue augmentation with more than 12-month longevity.
Lyme disease presenting with erythema migrans: case report
( Hye Rim Ko ),( Sae Mi Park ),( Hyung Jin Hahn ),( Young Bok Lee ),( Dong Soo Yu ),( Jin Wou Kim ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Lyme disease is an infectious condition caused by an exposure to a tick bite containing spirochetes, most notably Borrelia burdorferi. Lyme borreliosis typically begins with an erythematous rash termed erythema migrans, but clinical manifestations include not only dermatologic findings, but also potential cardiac, neurologic findings and arthritis. Most of the cases of Lyme disease have occurred in the United States and Europe, and far fewer cases have occurred in Asia. A 55-year-old women presented with asymptomatic, solitary, 0.3 cm-sized, brownish tick with peripheral erythema on the Lt. axilla detected on the morning of visit to the clinic. There were no extracutaneous symptoms such as arthralgia, fever or malaise. Physical examination, including cardiovascular and neurologic examination, was otherwise normal. Histopathologic findings revealed focal epidermal necrosis and homogenous collagen. Perivascular Infiltration by lymphocytes and neutrophils were also seen. The erythematous patch expanded centrifugally to 15 cm in diameter over three weeks. The patient was diagnosed with lyme disease and was accordingly treated with doxycycline. Herein, we report a case of lyme disease presenting with erythema migrans in a 55-year-old female
눈꺼풀 피부 악성 종양의 모즈 미세도식 수술 후 결손부의 복원
고혜림 ( Hye Rim Ko ),민정아 ( Jung Ah Min ),이영복 ( Young Bok Lee ),한형진 ( Hyung Jin Hahn ),김진우 ( Jin Wou Kim ),유동수 ( Dong Soo Yu ) 대한피부과학회 2014 大韓皮膚科學會誌 Vol.52 No.12
Background: The reconstruction of eyelid defects is extremely complex because both functional and aesthetic aspects should be considered. Numerous techniques for reconstruction are available for repairing eyelid defects, depending on the size, location, and extent of the defect. Objective: This study was aimed at assessing the effectiveness and cosmetic consequences of various reconstruction techniques for eyelid defects after Mohs micrographic surgery. Methods: Twenty patients who received a diagnosis of skin cancer of the eyelids from November 2005 to August 2009 were analyzed. Among them, 15 patients were treated with a local flap to reconstruct the defective eyelids, and the remaining patients were treated with primary closure. The medical records and photographs were reviewed by two independent physicians, and postoperative results were evaluated. Results: Eyelid defects were reconstructed with various surgical techniques, such as primary closure, transposition flap, subcutaneous island pedicle flap, advancement flap, rotation flap, Tenzel flap, and hard palate mucous membrane graft. The cosmetic results were satisfactory, and 16 of 20 (80%) patients showed good to excellent results. However, one patient developed a sclera show and another patient showed tumor recurrence. Conclusion: Many reconstruction techniques can be used for eyelid defects. An optimal choice would be one that is based on the extent, depth, and location of the defect; skin condition and wishes of the patient; and the surgeon’s experience. Furthermore, it is important to have an understanding of the anatomy of the eyelid, the basic principles of the reconstruction techniques, and the merits and drawbacks of each technique. (Korean J Dermatol 2014; 52(12):864∼872)
CZT와 NaI 검출기 물질 기반 물리적 변화에 따른 영상의 질 분석에 관한 연구 : 몬테카를로 시뮬레이션
고혜림(Hye-Rim Ko),유유리(Yu-Ri Yoo),박찬록(Chan-Rok Park) 한국방사선학회 2021 한국방사선학회 논문지 Vol.15 No.5
본 연구의 목적은, 몬테 카를로 시뮬레이션 기반 조준기 길이와 검출기 두께 변화에 따른 Cadimium Zinc Telluride (CZT) 와 NaI 검출기 물질을 변화하면서 영상의 질을 비교 평가 해보고자 한다. CZT 와 NaI 검출기 물질 기반 감마카메라를 각각 모사하였고, 조준기 길이는 1, 2, 3, 4, 5, 6 cm, 검출기 두께는 1, 3, 5, 7 mm 로 설정하였다. 1 MBq의 점선원을 이용해 민감도, 4.45, 3.80, 3.15, 2.55 mm 의 지름을 가진 자체 제작한 팬텀을 모사하고, 가장 큰 지름인 4.45 mm 영상에 관심영역을 설정하여 signal to noise ratio (SNR)과 프로파일을 이용하여 각각 획득영상을 분석하였다. 조준기 길이에 따른 CZT 검출기 기반 민감도는 2.3 ~ 48.6 cps/MBq, NaI 검출기 기반 민감도는 1.8 ~ 43.9 cps/MBq 이고, CZT 검출기 기반 팬텀을 활용한 SNR은 3.6 ~ 9.8, NaI 검출기 기반 팬텀 SNR은 2.9~9.5다. 조준기 길이 변화에 따른 프로파일은 조준기의 길이가 증가할수록 영상의 공간 분해능이 향상함을 확인하였다. 또한, 검출기 두께에 따른 CZT 검출기 기반 민감도는 0.04 ~ 0.12 cps/MBq 이고, NaI 검출기 기반 민감도는 0.03 ~ 0.11 cps/MBq 다. CZT 검출기 기반 팬텀 SNR은 7.3~9.8 이며, NaI 검출기 기반 팬텀 SNR은 5.9~9.5다. 또한, 검출기 두께 변화에 따른 프로파일은 검출기 두께가 증가할수록 산란선이 증가함으로써 영상의 공간 분해능이 감소함을 확인하였다. 이 연구데이터를 기반으로 영상 획득 목적에 따라 검출기의 종류와 두께, 조준기의 길이를 선택하여 최고의 영상의 질을 획득할 수 있어야 한다. In this study, we evaluated image quality by changing collimator length and detector thickness using the Geant4 Application for Tomographic Emission (GATE) simulation tool. The gamma camera based on the Cadimium Zinc Telluride (CZT) and NaI detectors is modeled. In addition the images were acquired by setting 1, 2, 3, 4, 5, and 6 cm collimator length and 1, 3, 5, and 7 mm detector thickness using point source and phantom, which is designed by each diameter (4.45, 3.80, 3.15, 2.55 mm) with 447, 382, 317, and 256 Bq. The sensitivity (cps/MBq) for point source, and signal to noise ratio (SNR) and profile for phantom at the 4.45 mm by drwan the region of interests were used for quantitative analysis. Based on the results, the sensitivity according to collimator length is 2.3 ~ 48.6 cps/MBq for CZT detector, and 1.8 ~ 43.9 cps/MBq for NaI detector. The SNR using phantom is 3.6~9.8 for CZT detector, and 2.9~9.5 for NaI detector. As the collimator length is increased, the image resolution is also improved according to profile results based on the CZT and NaI detector. In addition, the senistivity for detector thickness is 0.04 ~ 0.12 cps/MBq for CZT detector, and 0.03 ~ 0.11 cps/MBq. The SNR using phnatom is 7.3~9.8 count for CZT detector, and 5.9~9.5 for NaI detector. As the detector thickness is increased, the image resolution is decreased according to profile results based on the CZT and NaI detector due to scatter ray. In conclusion, we need to set the geometric material such as detector and collimator to acuquire suitable image quality in nuclear medicine.