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김수연 ( Su Yoen Kim ),이재호 ( Jae Ho Lee ),김하늘 ( Ha Neul Kim ),김동규 ( Dong Kyu Kim ),나영 ( Young Na ),김길선 ( Guil Sun Kim ),김미경 ( Mee Kyoung Kim ),백기현 ( Ki Hyun Baek ),강무일 ( Moo IL Kang ),이광우 ( Kwang Woo Lee 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.5
연구배경: 당뇨병환자들에서 우울증의 유병률이 높고 이는 환자들이 생활 개선 요법을 적절히 수행하는데 지장을 주어 혈당 조절을 악화시키거나 합병증의 발생을 증가시킬 수 있다. 본 연구에서는 두 가지 설문 조사를 통해 우리나라 당뇨병환자들의 우울증의 빈도 및 자가 관리 정도에 관해 조사하고자 하였다. 방법: 2008년 7월에서 2008년 12월 사이에 제2형 당뇨병 치료를 위해 성모병원 외래를 방문한 환자들을 대상으로 Harvard Department of Psychiatry/National Depression Screening Day Scale (HANDS)와 Summary of Diabetes Self-Care Activities (SDSCA)를 이용하여 이들의 우울증 여부와 식사 조절, 운동, 혈당 체크, 발 관리, 금연 등의 자가 관리 수행 정도를 조사하였다. 또한 당뇨병의 유병 기간, 만성 합병증, HbA1c, 총 콜레스테롤, 중성지방, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤을 측정하였다. 위의 결과들을 토대로 당뇨병환자들의 우울증 빈도 및 우울증과 자가 관리, 우울증과 혈당 조절 정도와의 관계를 Two-tailed t tests, chi-square analysis, Pearson`s correlation coefficient 방법으로 조사하였다. 통계적 유의수준은 0.05 미만으로 정의하였다. 결과: 총 191명의 환자들이 설문 조사를 완료 하였고 이중 39명(20.4%)의 환자가 주요 우울 장애에 이환되어 있는 것으로 나타났다. 그러나 우울증이 있는 환자 39명 중 6명(15.3%)만이 이에 대해 전문가의 진단 또는 치료를 받은 기왕력이 있었다. 우울증이 없는 군과 있는 군 사이의 자가 관리 정도를 비교해 보았을 때 적절한 식사 요법과(평균점수: 18.54 vs 15.94, P=0.046) 자가 혈당 측정은(평균점수: 4.05 vs 2.69, P=0.047) 우울증이 있는 환자군에서 통계적으로 유의하게 그 수행 정도가 떨어졌다. 그러나 규칙적 운동, 매일의 발 관리, 금연 여부 등은 두 환자군 사이에 의미있는 차이를 나타내지 않았다. 당화혈색소, 총 콜레스테롤이나 중성지방, 고밀도 지단백 콜레스테롤, 저밀도 지단백 콜레스테롤 수치도 우울증이 있는 군과 없는 군 사이에 통계적으로 유의한 차이를 나타내지는 않았다. 결론: 당뇨병이 있는 환자들은 건강한 성인에 비해서 우울증이 동반되는 경우가 더 흔하며 이들 중 상당수가 적절히 진단되지 않고 있다. 우울증이 있는 당뇨병환자들은 식사 조절이나 혈당 체크와 같은 자가 관리의 수행 정도가 우울증이 없는 당뇨병환자에 비해 낮으며 따라서 당뇨병환자들의 우울증 동반 여부에 대해 적절히 진단하고 치료하는 것이 필요하다. Background: Depression is known to be a risk factor for type 2 diabetes mellitus. Conversely, diabetes is also a risk factor for depression, and patients with diabetes have nearly twice the risk of comorbid depression as the general population. Depression in patients with diabetes may cause poor clinical outcomes through lower adherence to self-care activities such as exercise, diet control, and glucose monitoring. Furthermore, diabetic patients with depression are more likely to suffer from microvascular or macrovascular complications. We explored the prevalence of major depressive disorder in Korean diabetic patients and its impact on self-care activities and glucose control. Methods: We surveyed depressive symptoms and self-care activities in 191 type 2 diabetic patients from the outpatient clinic of the St. Mary`s hospital. Two questionnaires were used for assessment, the Harvard Department of Psychiatry/National Depression Screening Day Scale (HANDS) and the Summary of Diabetes Self-Care Activities (SDSCA). Results: Of the 191 respondents who completed questionnaires, 39 (20.4%) patients were categorized as having major depressive disorder. Among the depressed patients, only six (15.3%) had been previously evaluated and managed for their psychiatric problems. The incidence of depression was significantly higher in female diabetic patients compared to patients without depression (74.4% vs. 45.4%, P<0.001). Patients with depression showed significantly poorer diet control (18.5 vs. 15.9, P=0.046) and less glucose monitoring (4.1 vs. 2.7, P=0.047). However, there were no differences in exercise, foot care, or smoking status between the two groups. Additionally, metabolic parameters such as HbA1C and lipid profile were not significantly different between the two groups. Conclusion: Many diabetic patients are suffering from depression and exhibit poorer self-care activities than patients without depression. Identifying and managing depressed diabetic patients may help improve their self-care activities. (Korean Diabetes J 33:432-438, 2009)
OPERATORS WITH THE SINGLE VALUED EXTENSION PROPERTY
Kim, Yoen-Ha,Ko, Eung-Il,Lee, Ji-Eun Korean Mathematical Society 2006 대한수학회보 Vol.43 No.3
In this Paper We Study some Operators With the single valued extension property. In particular, we investigate the Helton class of an operator and an $n{\times}n$ triangular operator matrix T.
Yoen Kyung Lee,Su Youn Yim,Seung Eun Jung,Ji Ha Kim,Ji Eun Kim,Eon Pil Lee,Hae Wook Choi,Hong Sung Kim,Jae Ho Lee,Young Jin Jung,Jung Sik Cho,Chung-Yeol Lee,Hong Joo Son,Dae Youn Hwang 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.3
Selenium (Sel) is widely distributed through the body, and performs a crucial role in the regulation of organ function. In this study, in order to determine whether Sel treatment and selenoprotein M (SelM) overexpression could affect the extracellular signal-regulated protein kinase (ERK) mitogen-activated protein kinase (MAPK) pathway, the level of ERK phosphorylation was assessed in various tissues of CMV/ EGFP-hSelM Tg rats after Sel treatment. Herein, our results demonstrated that SelM overexpression induces a slight increase in the ERK MAPK pathway in the heart, liver, and intestine, while no changes were detected in the brain, lung, and kidney. After Sel treatment, the liver and intestine evidenced higher levels of ERK activation than were induced by SelM overexpression. In particular, costimulation with SelM overexpression and Sel treatment induced a dramatic increase in the phosphorylation of ERK in the brain, heart, liver, and intestine, while a reduction in ERK phosphorylation was noted in the kidneys. The results of this study suggest that Sel and SelM may contribute to the regulation of a variety of functions via the induction of ERK phosphorylation in different organs of CMV/EGFP-hSelM Tg rats.
HIT-T15 췌장세포의 인슐린분비 촉진을 유도하는 맥문동(Liriope platyphylla) 추출물의 효능 및 독성분석
Ji Ha Kim(김지하),Ji Eun Kim(김지은),Yoen Kyung Lee(이연경),So Hee Nam(남소희),Youn Kyung Her(허윤경),Seoung Wan Jee(지승완),Sun Guen Kim(김선건),Da Jung Park(박다정),Young Whan Choi(최영환),Dae Youn Hwang(황대연) 한국생명과학회 2010 생명과학회지 Vol.20 No.7
맥문동(Liriope platyphylla)은 한국과 중국에서 전통적으로 당뇨, 비만, 뇌신경질환, 천식 등의 치료를 위해 사용해온 치료제이다. 최근에 이들 맥문동으로부터 새로운 치료제를 개발하려는 노력이 활발히 진행 중이지만 아직도 유력한 치료후보제는 확보되지 않았다. 따라서 본 연구에서는 맥문동의 새로운 추출물을 이용하여 당뇨치료 제로서의 가능성을 평가하기 위하여 새로운 방법으로 10가지 후보물질을 추출하고 이들의 독성과 효능을 평가하였다. 그 결과 10가지 추출물 중에서 LP9M80-H가 인슐린 분비를 가장 많이 촉진하였고 다음으로는 LP-H, LP-M, LP-E과 LP9M80-C 등의 순서로 촉진을 하였으나 나머지는 인슐린 분비를 촉지하지 못하였다. 그러나 이들 물질은 인슐린 분비를 촉진하는 농도에서 강한 세포 독성을 나타내었다. 따라서 이들 물질 중에서 가장 효능이 좋은 LP9M80-H의 치료용 최적농도를 설정하였으며, 대략 100-25 ㎍/㎖가 최적농도로 결정되었다. 이러한 결과는 맥문동 추출물 중에서 LP9M80-H가 췌장 β-세포의 인슐린 분비능을 유도하는 새로운 당뇨치료 후보물질로서 향후에 사용될 가능성을 시사하고 있다. Liriope platyphylla has traditionally been used in Korea and China as a therapeutic drug for the treatment of coughing, sputum, neurodegenerative disorders, obesity, and diabetes. In an effort to assess the functions of a novel extract from Liriope platyphylla in diabetes therapy, the insulin secretion abilities of 10 extracts were screened via measurements of insulin concentration in the culture supernatant using an Insulin ELISA kit. The results of this assay showed the highest levels of insulin in the LP9M80-H treated group, followed by the LP-H, LP-M, LP-E and LP9M80-C treated groups, whereas other extracts did not induce insulin secretion in the HIT-T15 cells. However, the extracts capable of stimulating insulin secretion simultaneously evidenced high apoptotic activity as compared with other extracts. Therefore, one of these extracts, LP9M80-H, was initially selected as the optimal candidate for a therapeutic drug and its optimal concentration was determined. The results of the ELISA and MTT assay demonstrated that a concentration of approximately 100-125 ㎍/㎖ of LP9M80-H was optimal with regards to cell viability and insulin secretion in the HIT-T15 cells. These results suggest that LP9M80-H could be considered as an excellent candidate for a diabetes-therapeutic drug that could induce insulin secretion in pancreatic β-cells.
( Jong Han Kim ),( Sang Young Han ),( Sung Wook Lee ),( Yang Hyun Baek ),( Ha Yoen Kim ),( Jong Han Kim ),( Jin Sook Jeong ),( Young Hoon Roh ),( Young Hoon Kim ),( Byung Ho Park ),( Hee Jin Kwon ),( 대한소화기학회 2012 Gut and Liver Vol.6 No.3
Background/Aims: This study was performed to investigate the correlation of sodium iodide symporter (NIS) expression with the functionality and loss of phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression in human cholangiocarcinoma (CCA). Methods: Immunohisto-chemistry for the expression of NIS and PTEN was performed in 60 biopsy specimens of CCA. The clinicopathological parameters were retrospectively identified from medical records. The expression pattern of NIS and loss of PTEN ex-pression were analyzed in association with the clinicopatho-logical characteristics, including survival. Results: Normal biliary trees displayed NIS expression, but hepatocytes did not. NIS expression was divided into two patterns: cytoplas-mic and membranous. Fifty-nine cases, all except for one case, displayed NIS expression in tumor cells. Twenty-two cases (33.3%) were mixed pattern, and 39 cases (65.05%) were cytoplasmic pattern; the pure membranous pattern was not noted. There was no association between the NIS expres-sion pattern and clinicopathological parameters, including age, sex, differentiation grade, T stage and tumor, node, metastasis stage (p>0.05). The survival rates were similar among various NIS expression patterns. Normal hepatocytes and biliary trees exhibited PTEN expression in the nucleus and cytoplasm. CCA cells displayed nuclear staining. Thirty-six (60.0%) of 60 cases displayed a loss of PTEN expression. The loss of PTEN expression was observed in the advanced T-stage group (p=0.0036), but there was no association be-tween the loss of PTEN expression and other clinicopatholog-ical parameters (p>0.05). No association between the loss of PTEN expression and survival was noted. Conclusions: NIS is expressed in most types of human CCA. The expression pattern suggests a role in cancer development. PTEN loss ex-pression is common in the context of human CCA, especially in the advanced T stage. (Gut Liver 2012;6:374-380)
SOME REMARKS ON THE HELTON CLASS OF AN OPERATOR
Kim, In-Sook,Kim, Yoen-Ha,Ko, Eun-Gil,Lee, Ji-Eun Korean Mathematical Society 2009 대한수학회보 Vol.46 No.3
In this paper we study some properties of the Helton class of an operator. In particular, we show that the Helton class preserves the quasinilpotent property and Dunford's boundedness condition (B). As corollaries, we get that the Helton class of some quadratically hyponormal operators or decomposable subnormal operators satisfies Dunford's boundedness condition (B).