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Surgical Obliteration in Superior Petrosal Sinus Dural Arteriovenous Fistula
Hwang, Gyo-Jun,Kang, Hyun-Seung,Oh, Chang-Wan,Kwon, O-Ki The Korean Neurosurgical Society 2011 Journal of Korean neurosurgical society Vol.49 No.4
Superior petrosal sinus (SPS) dural arteriovenous fistula (DAVF) is one of tentorial DAVFs with significant morbidity, which usually drains into the petrosal vein and its tributaries. Unless there is a connection with venous sinus, surgical obliteration is required. We present two cases of SPS DAVF which were successfully treated with the presigmold retrolabyrinthine approach.
Comparison of Different Microanastomosis Training Models : Model Accuracy and Practicality
Hwang, Gyo-Jun,Oh, Chang-Wan,Park, Sukh-Que,Sheen, Seung-Hun,Bang, Jae-Seung,Kang, Hyun-Seung The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.47 No.4
Objective : The authors evaluated the accuracies and ease of use of several commonly used microanastomosis training models (synthetic tube, chicken wing, and living rat model). Methods : A survey was conducted among neurosurgeons and neurosurgery residents at a workshop held in 2009 at the authors' institute. Questions addressed model accuracy (similarity to real vessels and actual procedures) and practicality (availability of materials and ease of application in daily practice). Answers to each question were rated using a 5-point scale. Participants were also asked what types of training methods they would chose to improve their skills and to introduce the topic to other neurosurgeons or neurosurgery residents. Results : Of the 24 participants, 20 (83.3%) responded to the survey. The living rat model was favored for model accuracy (p<0.001; synthetic tube $-0.95{\pm}0.686$, chicken wing, $0.15{\pm}0.587$, and rat, $1.75{\pm}0.444$) and the chicken wing model for practicality (p<0.001; synthetic tube $-1.55{\pm}0.605$, chicken wing, $1.80{\pm}0.523$, and rat,$1.30{\pm}0.923$). All (100%) chose the living rat model for improving their skills, and for introducing the subject to other neurosurgeons or neurosurgery residents, the chicken wing and living rat models were selected by 18 (90%) and 20 (100%), respectively. Conclusion : Of 3 methods examined, the chicken wing model was found to be the most practical, but the living rat model was found to represent reality the best. We recommend the chicken wing model to train surgeons who have mastered basic techniques, and the living rat model for experienced surgeons to maintain skill levels.
Studies on Distribution of the Zfy, Fv4<SUP>r</SUP> and AKV-type MuLV Genes in Korean Wild Mice
Sol Ha Hwang,Kyoung In Cho,Ji Hyun Park,Zae Young Ryoo,Yang-Seok Oh,Jun-Gyo Suh 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
In the Korean peninsula, there is no detailed knowledge concerning about mouse migration route during prehistoric periods. For the first step to understand this, we investigated the distribution of the Zfy, Fv4<SUP>r</SUP> and AKV-type MuLV genes for 75 wild mice that were caught from ten localities in Korea, All of 29 males Korean wild mice have two bands of 202 bp and 184 bp for Zfy as well as in M. m. musculus Y, M. m. castaneus Y and M. m. molossinus Y. But M. m. domesticus has a single band of 202 bp. There was no specific band for Fv4<SUP>r</SUP> in Korean wild mice from Kojuri, Anmyeondo, Seohae, Hwasun, Goseong, Gumi, Chungju and Hoengseong. All of Korean wild mice from Kojuri, Anmyeondo, Seohae, Hwasun, Goseong, Gumi, Chungju and Hoengseong had a specific band for AKV-type MuLV gene. Interestingly, only some of Korean wild mice from Chuncheon and Hwacheon had a specific band for AKV-type MuLV gene. These results suggested that Fv4<SUP>r</SUP> and AKV-type MuLV genes are useful for classification of Korean wild mice.
Park, Hyun,Hwang, Gyo-Jun,Jin, Sung-Chul,Bang, Jae-Seung,Oh, Chang-Wan,Kwon, O-Ki The Korean Neurosurgical Society 2012 Journal of Korean neurosurgical society Vol.51 No.2
Objective : To optimize the recanalization of acute cerebral stroke that were not effectively resolved by conventional intraarterial thrombolysis (IAT), we designed a double device technique to allow for rapid and effective reopening. In this article, we describe the feasibility and efficacy of this technique. Methods : From January 2008 to September 2009, twenty patients with acute cerebral arterial occlusion (middle cerebral artery : n=12; internal carotid artery terminus : n=5; basilar artery : n=3) were treated by the double device technique. This technique was applied when conventional thrombolytic methods using drug, microwires, microcatheters and balloons did not result in recanalization. In the double device technique, two devices are simultaneously placed at the lesion (for example, one microcatheter and one balloon or two microcatheters). Chemicomechanical or mechanicomechanical thrombolysis was performed simultaneously using various combinations of two devices. Recanalization rates, procedural time, complications, and clinical outcomes were analyzed. Results : The initial median National Institute of Health Stroke Scale (NIHSS) was 16 (range 5-26). The double device technique was applied after conventional IAT methods failed. Recanalization was achieved in 18 patients (90%). Among them, 55% (11 cases) were complete (thrombolysis in cerebral infarction 2B, 3). The median thrombolytic procedural time including the conventional technique was $135{\pm}83.7$ minutes (range 75-427). Major symptomatic hemorrhages (neurological deterioration ${\geq}4$ points in NIHSS) developed in two patients (10%). Good long term outcomes (modified Rankin Scale ${\leq}2$ at 90 days) occurred in 25% (n=5) of the cases. Mortality within 90 days developed in two cases (10%). Conclusion : The double device technique is a feasible and effective technical option for large vessel occlusion refractory to conventional thrombolysis.
Bilateral Visual Loss as a Sole Manifestation Complicating Carotid Cavernous Fistula
Yu, Jeong-Keun,Hwang, Gyo-Jun,Sheen, Seung-Hun,Cho, Yong-Jun The Korean Neurosurgical Society 2011 Journal of Korean neurosurgical society Vol.49 No.4
Visual loss is one of the ocular symptoms resulting from a carotid cavernous fistula (CCF), but has rarely been reported as the sole manifestation in CCF. Visual impairment is known to be associated with a poor outcome unless timely intervention is employed. Herein, the authors report a patient with bilateral rapid progressing visual loss as a sole manifestation in CCF. Vision was successfully restored by transarterial embolization. The authors discuss the necessity of urgent fistula obliteration in patients with visual loss.
Lim, Sung Don,Hwang, Jin-Gyu,Jung, Chang Gyo,Hwang, Sun-Goo,Moon, Jun-Cheol,Jang, Cheol Seong Oxford University Press 2013 DNA research Vol.20 No.3
<P>A large number of really interesting new gene (RING) E3 ligases contribute to the post-translational modification of target proteins during plant responses to environmental stresses. However, the physical interactome of RING E3 ligases in rice remains largely unknown. Here, we evaluated the expression patterns of 47 <I>Oryza sativa</I> RING finger protein (<I>OsRFP</I>) genes in response to abiotic stresses via semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and <I>in silico</I> analysis. Subsequently, molecular dissection of nine <I>OsRFPs</I> was performed by the examination of their E3 ubiquitin ligase activity, subcellular localization, and physical interaction with target proteins. Most of the OsRFPs examined possessed E3 ligase activity and showed diverse subcellular localization. Yeast two-hybrid analysis was then employed to construct a physical interaction map of seven OsRFPs with their 120 interacting proteins. The results indicated that these OsRFPs required dynamic translocation and partitioning for their cellular activation. Heterogeneous overexpression of each of the <I>OsRFP</I> genes in <I>Arabidopsis</I> suggested that they have functionally diverse responses to abiotic stresses, which may have been acquired during evolution. This comprehensive study provides insights into the biological functions of OsRFPs, which may be useful in understanding how rice plants adapt to unfavourable environmental conditions.</P>