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Studies on Distribution of the Zfy, Fv4<SUP>r</SUP> and AKV-type MuLV Genes in Korean Wild Mice
Sol Ha Hwang,Kyoung In Cho,Ji Hyun Park,Zae Young Ryoo,Yang-Seok Oh,Jun-Gyo Suh 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.2
In the Korean peninsula, there is no detailed knowledge concerning about mouse migration route during prehistoric periods. For the first step to understand this, we investigated the distribution of the Zfy, Fv4<SUP>r</SUP> and AKV-type MuLV genes for 75 wild mice that were caught from ten localities in Korea, All of 29 males Korean wild mice have two bands of 202 bp and 184 bp for Zfy as well as in M. m. musculus Y, M. m. castaneus Y and M. m. molossinus Y. But M. m. domesticus has a single band of 202 bp. There was no specific band for Fv4<SUP>r</SUP> in Korean wild mice from Kojuri, Anmyeondo, Seohae, Hwasun, Goseong, Gumi, Chungju and Hoengseong. All of Korean wild mice from Kojuri, Anmyeondo, Seohae, Hwasun, Goseong, Gumi, Chungju and Hoengseong had a specific band for AKV-type MuLV gene. Interestingly, only some of Korean wild mice from Chuncheon and Hwacheon had a specific band for AKV-type MuLV gene. These results suggested that Fv4<SUP>r</SUP> and AKV-type MuLV genes are useful for classification of Korean wild mice.
Hwang, Hyeon Seok,Hyoung, Bok Jin,Kim, Sol,Oh, Ha Young,Kim, Yon Su,Kim, Jung Kyung,Kim, Yeong Hoon,Kim, Yong Lim,Kim, Chan Duck,Shin, Gyu Tae,Yang, Chul Woo The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.12
<P>It is reported that a conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) relieves gastrointestinal (GI) symptom burden and improves health-related quality of life (HRQoL). However, it is unclear whether renal transplant recipients using tacrolimus receive the same benefit from the conversion. In this prospective, multi-center, open-label trial, patients were categorized into two groups by their GI symptom screening. Equimolar EC-MPS (n=175) was prescribed for patients with GI burdens; those with no complaints remained on MMF (n=83). Gastrointestinal Symptom Rating Scale (GSRS) and Gastrointestinal Quality of Life Index (GIQLI) were evaluated at baseline and after one month. Patients and physicians completed Overall Treatment Effect (OTE) at one month. EC-MPS-converted patients had worse GSRS and GIQLI scores at baseline than MMF-continued patients (all <I>P</I><0.001). Significant improvements in GSRS and GIQLI scores were observed for EC-MPS-converted patients at one month, but MMF-continued patients showed worsened GSRS scores (all <I>P</I><0.05). OTE scale indicated that EC-MPS patients improved in overall GI symptoms and HRQoL more than MMF patients did (<I>P</I><0.001). In tacrolimus-treated renal transplant recipients with GI burdens, a conversion from MMF to EC-MPS improves GI-related symptoms and HRQoL.</P>
Ha, Eun-Sol,Baek, In-hwan,Cho, Wonkyung,Hwang, Sung-Joo,Kim, Min-Soo Pharmaceutical Society of Japan 2014 Chemical & pharmaceutical bulletin Vol. No.
<P>The aim of the present study was to investigate the effect of Soluplus? on the solubility of atorvastatin calcium and to develop a solid dispersion formulation that can improve the oral bioavailability of atorvastatin calcium. We demonstrated that Soluplus? increases the aqueous solubility of atorvastatin calcium. Several solid dispersion formulations of atorvastatin calcium with Soluplus? were prepared at various drug?:?carrier ratios by spray drying. Physicochemical analysis demonstrated that atorvastatin calcium is amorphous in each solid dispersion, and the 2?:?8 drug?:?carrier ratio provided the highest degree of sustained atorvastatin supersaturation. Pharmacokinetic analysis in rats revealed that the 2?:?8 dispersion significantly improved the oral bioavailability of atorvastatin. This study demonstrates that spray-dried Soluplus? solid dispersions can be an effective method for achieving higher atorvastatin plasma levels.</P>
Hwang, Min Woo,Ahn, Tae Seok,Hong, Noo Ri,Jeong, Han-Sol,Jung, Myeong Ho,Ha, Ki-Tae,Kim, Byung Joo WJG Press 2015 WORLD JOURNAL OF GASTROENTEROLOGY Vol.21 No.4
<P>To investigate the effects of San-Huang-Xie-Xin-Tang (SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice.</P>
Tufting Enteropathy with EpCAM Mutations in Two Siblings
고재성,서정기,심정옥,Sol Ha Hwang,Heae Surng Park,강경훈 거트앤리버 소화기연관학회협의회 2010 Gut and Liver Vol.4 No.3
Tufting enteropathy is a rare autosomal recessive disorder presenting with early-onset severe intractable diarrhea. The epithelial cell adhesion molecule gene (EpCAM) has recently been identified as the gene responsible for tufting enteropathy. Based on histology,a diagnosis of tufting enteropathy was made in two Korean siblings. They developed chronic diarrhea and failure to thrive. They had a broad nasal bridge and micrognathia. Duodenal and colonic biopsies showed villous atrophy, disorganization of surface enterocytes,and focal crowding resembling tufts. Protracted diarrhea continued and so cyclic parenteral nutrition was supplied. The sister had juvenile rheumatoid arthritis. Mutation analysis of EpCAM identified two compound heterozygous mutations in these siblings: 1) a donor splicing site mutation in intron 5 (c.491+1G>A) and 2) a novel nonsense mutation in exon 3 (c.316A>T,Lys106X). Analysis of EpCAM will be useful for genetic counseling and prenatal diagnosis of tufting enteropathy.
이성(Xing Li),구남국(Namkug Ku),하솔(Sol Ha),노명일(Myung-Il Roh),황호진(Ho-jin Hwang) (사)한국CDE학회 2014 한국 CAD/CAM 학회 학술발표회 논문집 Vol.2014 No.2
This study focuses the prediction of the dynamic response of a floating offshore wind turbine (FOWT) in frequency domain. In this study, the concept of multi-body systems dynamics and numerical analysis methodology are introduced, and the nonlinear equations are solved by using the Matlab/Simulink interface. As an example, the non-linear equations of motion of double pendulum are first derived, and then the equations of motion are linearized. Dynamic response analysis of the double pendulum is carried out in time domain, and frequency domain, using the non-linear equations and linearized equations, respectively, and the applicability of this methodology are verified. The result shows that the methodology can be used to evaluate the dynamic response of floating structures such as FOWT in frequency domain.
Kim Jeong-Soo,Park Heejun,강규태,Ha Eun-Sol,김민수,Hwang Sung-Joo 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.3
Purpose In the present study, fenofibrate (a model drug with poor aqueous solubility) was micronized using the supercriticalfluid- assisted spray-drying (SA-SD) process to improve dissolution and biopharmaceutical property. Methods Solid-state characterizations including particle size analysis and dissolution test were carried out. To identify the main effects of SA-SD process parameters (such as pressure, temperature, concentration of drug solution, supercritical carbon dioxide (SC-CO2) injection rate, and drug solution injection rate) on the morphology and particle size distribution of micronized fenofibrate particles, a 27−3 IV fractional factorial screening design was employed. Moreover, the effect of improved dissolution rate via micronization using SA-SD technology on the biopharmaceutical properties of fenofibrate was evaluated in a pharmacokinetic (PK) study in Sprague–Dawley rats. Results The results of the screening design showed that the mean particle size and distribution can be controlled by manipulating the drug solution concentration and CO2 injection rate. The SA-SD process resulted in a significant decrease in mean particle size (1.8–8.33 μm), as compared with that of unprocessed fenofibrate (24.2 ± 0.8 μm). There was a significant enhancement in the dissolution rate of micronized fenofibrate particles smaller than 5 μm compared to that of unprocessed fenofibrate. Moreover, an in vivo PK study in Sprague–Dawley rats showed that the increased dissolution rate improved biopharmaceutical properties (larger area under the curve and maximum serum concentration) of micronized fenofibrate than those of unprocessed fenofibrate. Conclusion Therefore, the SA-SD process is a useful micronization technology for improving both physicochemical and biopharmaceutical properties of poorly water-soluble drugs.