Clinicopathological study on metastatic skin cancer

( Chang Il Kwon ),( Seo Mi Gon Jeong ),( Young Bin Shin ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Various primary tumors can cause metastatic skin cancer. Metastatic skin lesion should be distinguished from other skin lesion. Objectives: We studied patients with metastatic skin cancer to find out average age, gender distribution, frequency of primary tumor, time interval between manifestation and primary cancer, and their clinical appearance, location and other metastatic sites. Methods: We reviewed the medical records, clinical photographs and histopathologic records of patients who had been diagnosed with metastatic skin cancer. Results: In the comparison according to clinical records, the mean age at the time of diagnosis was 60.6 years. The ratio of men to women was 1.05:1. The most frequent primary tumors were breast cancer (22.0%), lung cancer (17.0%), head and neck cancer (17%), melanoma (17.0%), gastrointestinal cancer (11%), urologic cancer (11%), and gynecologic cancer (6%). Metastatic skin cancers usually presented as discrete, painless, hard nodules, with sudden onset (88%). Conclusion: Based on the results of this study, it is believed that it is important to recognize the metastatic lesion between various skin lesion such as infections and granulomatous changes of other cause due to drugs and reactive changes.

요추 추간판탈출증 수술 후 임상 증상의 회복

신병준,김준범,조영훈,권희,서유성,김연일,나수균,최창욱 대한척추외과학회 1997 대한척추외과학회지 Vol.4 No.2

Study Design : The authors retrospectively analysed the recovery of clinical symptoms after surgical treatment of lumbar HIVD. Objectives : To investigate the incidence of clinical symptoms, the recovery rate and time after surgical treatment and the difference between L4-5 and L5-S1 lesion. Summary of Literature Review : There are many reports concerning the clinical result of surgical treatment for the HIVD. They usually describe the result as excellent, good, fair and poor. We can't get any information about the recovery rate and recovery time of each clinical symptom from the reports. Materials and Methods : Thirty-eight patients were treated by one level open discectomy from march 1991 to december 1995. The clinical symptoms and signs including SLR, motor deficit, sensory deficit, change of DTR and severity of radiating pain were periodically followed up on the predesigned protocol, Results : In preoperative examination, SLR was positive in 82%, motor deficit in 76%, sensory deficit in 74%, DTR change in 50%, and radiating pain in 100%. The recovery rate of SLR was 96.8%, motor deficit ; 93.6%, sensory deficit ; 78.6%, DTR change ; 21 % and radiating pain ; 84.2%. The average recovery time of SLR was 3.4 months, motor deficit ; 1.9 months, sensory deficit ; 5.3 months, DTR change ; 4.1 months and radiating pain ; 3.2 months. Motor and sensory deficit was more frequent in L4-5 lesion but DTR change was usually noted in L5-S] lesion. The recovery rate and time showed no great difference between the two level. Conclusions : The recovery rate was higher in SLR, motor deficit and radiating pain rather than sensory deficit and DTR change. The recovery time was fastest in radiating pain but variable nature was noted in sensory deficit. Above results may be helpful to explain the prognosis of the lumbar HIVD.

마취중 과한기가 동맥혈과 뇌척수액의 산-염기 변화에 미치는 영향

권무일,신광일,류창한,김민구 대한마취과학회 1988 Korean Journal of Anesthesiology Vol.21 No.1

The use of controlled gyperventilation during neurosurgical procedures prevents the deleterious effects of hypercarbia on the cerbral blood flow and intracranial pressure. Hyperventilation with hypocarbia produces cerbral vasoconstriction, reduced cercbbral blood flow and a reduction in brain size in the majority of patients with increased intracranial pressure. But, since excessive cerebral vasoconstriction might induce cerebral ischemia, there has been much discussion concernin the optimal level of hypocarbia. Several studies have shown biochemical evidence of a change in cerebral glucose utilization to anaerobic metabolism during hupocarbia. In our investigation, the effect of huperventilation of 10 neurosurgical patients was evaluated by blood gas analysis and the estimation of lactate and pyruvate in arterial blood and the cerebrospinal fluid. The results were as follows: 1) PaCO_2 decreased from a prearesthetic value of 38±2.2 mmHg to 22±2.1 mmHg 1 hour postinduction and 24±2.2 mmHg at 2 hours due to hyperventilation. pH was 7.58±0.047 1 haur postionduction and 7.56±0.018 at 2 hours. PaO_2 was 251±33.0 mmHg 1 hour postinduction 1 hour and 215±20.9 mmHg at 2 hours under a 50% inspired oxygen concentration(FiO2=0.5). 2) The arterial blood lactate value increased statistically significantly from a preanesthetic value of 9.3±15 mmg% to 11.8±1.47 mg% 1 hour postinduction(p<0.01) to 12.5±1.53 mg% at 2 hours(p<0.005). However all vales were wirthin the normal range(4.7±15.1 mg%), and the lacte/pyruvate rato did not change. 3) In the cerebrospinal fluid, pH was 7.45±0.057, PCO_2 was 34±3.5 mmHg and PO_2 was 91±6.7 mmHg following hyperventilation for 1 hour. The lactate value of the cerebrospinsifluid was 19.2±3.14mg%(normal range: 11.0∼27.0mg%) and the lactate/pyruvate ratio was 14.5±2.39. 4) No evidence of an excessive increase in CSF lactate was seen in any case. The above findings suggest that maintenance of an adequate oxygen concentration and a carbon dioxide value over 20 mmHg would prevent cerebral ischemia following hypocarbia due to hyperventilation.

자동차의 타이밍벨트, 등속조인트 부트, 웨더 스트립에 관련된 고장사례 고찰

이일권(Il Kwon Lee),이정호(Jong Ho Lee),황한섭(Han sub Hwang),임하영(Ha Young Yim),유창배(Chang Bae You),김영규(Young Kyu Kim),김추하(Choo Ha Kim) 한국가스학회 2015 한국가스학회지 Vol.19 No.1

이 논문은 자동차 타이밍벨트, 등속조인트 부트, 웨더 스트립에 적용되는 고무시스템의 손상이나 내구성 약화에 대한 사례 연구를 하는 것이 목적이다. 첫 번째 사례에서는 신품의 타이밍 벨트를 교환할 때 벨트의 내구성이 떨어진 벨트를 교환하여 타이밍 벨트와 스프로킷의 마찰작용에 의해 비정상적으로 타이밍 벨트 캔버스가 마멸된 것을 확인하였다. 두 번째 사례에서는 등속 조인트에 그리스의 밀봉역할을 하는 고무 부트의 내구성이 떨어져 경화되고 갈라져 이 틈으로 그리스가 누설된 것을 확인하였다. 세 번째 사례에서는 웨더 스트립이 화학적 변화에 따른 균열로 재료 변형이 생겨 웨더 스트립 고무가 찢어졌다. 이러한 현상은 문을 닫을 때 웨더 스트립 고무를 겹쳐지게 해 운행중 외부공기가 유입되어 미세한 소음이 발생되는 것을 확인했다.따라서, 자동차에 적용되는 고무 재질의 부품들의 내구성 약화나 손상으로 인한 자동차의 고장사례가 발생하지 않도록 관리하여야 한다. This paper is to study the examples for rubber damage and weaken reliability of timing belt, constant velocity joint boot and weather strip in vehicle. The first example, when the service man replaced the new timing-belt of rubber material, he assembled the belt that was weaken its contact surface because of material transform. He knew the abnormally tearing failure by friction action between belt and sprocket. The second example, it certified the fact that the grease is leaked out boot protecting of constant velocity joint by split of rubber surface because of durability badness. The third example, the weather stripe took the minutely tearing because of damage produced the material transform by crack of chemistry change. It certified the production phenomenon of a tiny noise by coming with outside air because of overlapped the rubber of weather stripe when driving after closing the door. Therefore, the driver must always manage the rubber system part of vehicle.

Effects of <i>Ecklonia cava</i> ethanolic extracts on airway hyperresponsiveness and inflammation in a murine asthma model: Role of suppressor of cytokine signaling

Kim, Se-Kwon,Lee, Da-Young,Jung, Won-Kyo,Kim, Ji-Hye,Choi, Inhak,Park, Sae-Gwang,Seo, Su-Kil,Lee, Soo-Woong,Lee, Chang Min,Yea, Sung Su,Choi, Yung Hyun,Choi, Il-Whan Elsevier 2008 BIOMEDICINE AND PHARMACOTHERAPY Vol.62 No.5

<P><B>Abstract</B></P><P><I>Ecklonia cava</I> (EC) is a brown alga that evidences radical scavenging activity, bactericidal activity, tyrosinase inhibitory activity, and protease inhibitory activity. However, its anti-allergic effects remain poorly understood. In the current study, we attempted to determine whether pretreatment with EC induces a significant inhibition of asthmatic reactions in a mouse asthma model. Mice sensitized and challenged with ovalbumin (OVA) evidenced typical asthmatic reactions, as follows: an increase in the number of eosinophils in bronchoalveolar lavage fluid; a marked influx of inflammatory cells into the lung around blood vessels and airways, and airway luminal narrowing; the development of airway hyperresponsiveness; the detection of tumor necrosis factor-alpha (TNF-α) and Th2 cytokines, including IL-4 and IL-5 in the bronchoalveolar lavage (BAL) fluid; and the detection of allergen-specific immunoglobulin E (IgE) in the serum. However, the administration of EC extract prior to the final airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. We also demonstrated that EC extracts treatment resulted in significant reductions on matrix metalloproteinase-9 (MMP-9) and Suppressor of cytokine signaling-3 (SOCS-3) expression and a reduction in the increased eosinophil peroxidase (EPO) activity. The treatment of animals with EC extracts resulted in a significant reduction in the concentrations of the Th2 cytokine (IL-4 and IL-5) in the airways, without any concomitant increase in the concentration of Th1 cytokines. These findings indicate that EC extracts may prove useful as an adjuvant therapy for allergic airway reactions via the inhibition of the Th2 response. Accordingly, this study may provide evidence that EC extract performs a critical function in the amelioration of the pathogenetic process of asthma in mice.</P>

A survey of counseling and behavior regarding skin cancer

( Young Bin Shin ),( Chang Il Kwon ),( Jeong Won Jo ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: As the incidence of skin cancer increases, more information and education on skin cancer are needed. Although skin cancer is not rare, most patients are little known about general awareness of skin cancer. Objectives: The purpose of this study is to investigate the post-education effects on skin cancer in our hospital outpaitents and carers. Methods: We reviewed a written questionnaire and patients’ self-checked records including patients’ basic medical information and knowledge of skin cancer protective modalities. Results: In total 340 cases, 215 (63.2%) patients were female and 125 (36.8%) patients were male. 6 people in their teens, 56 people in their 20s and 30s, 156 people in their 40s and 50s, 122 people in their 60s or older. Before education, 142 people said sunlight can cause a skin cancer and 178 did not. After education, 246 people said Yes and 94 people did not. When asked how you wanted to get more information on skin cancer, 104 (30.6%) people said that they were printed handout, 142 (41.8%) were visit to dermatologists, 52 (15.3%) were photos of skin symptoms, and 42 (12.3%) were phone calls. Conclusion: This result showed that people are little known about risk factor of skin cancer such as sunlight and artificial tanning. However, we found that through education, people's perceptions could change. The education on behavior for skin cancer prevention should be continued so that the awareness of the risk of skin cancer can be changed.

A soft biomolecule actuator based on a highly functionalized bacterial cellulose nano-fiber network with carboxylic acid groups

Wang, Fan,Jeon, Jin-Han,Park, Sukho,Kee, Chang-Doo,Kim, Seong-Jun,Oh, Il-Kwon The Royal Society of Chemistry 2016 SOFT MATTER Vol.12 No.1

<P>Upcoming human-related applications such as soft wearable electronics, flexible haptic systems, and active bio-medical devices will require bio-friendly actuating materials. Here, we report a soft biomolecule actuator based on carboxylated bacterial cellulose (CBC), ionic liquid (IL), and poly (3,4-ethylenedioxythiophene)-poly(styrenesulfonate) (PEDOT:PSS) electrodes. Soft and biocompatible polymer-IL composites were prepared via doping of CBC with ILs. The highly conductive PEDOT: PSS layers were deposited on both sides of the CBC-IL membranes by a dip-coating technique to yield a sandwiched actuator system. Ionic conductivity and ionic exchange capacity of the CBC membrane can be increased up to 22.8 times and 1.5 times compared with pristine bacterial cellulose (BC), respectively, resulting in 8 times large bending deformation than the pure BC actuators with metallic electrodes in an open air environment. The developed CBC-IL actuators show significant progress in the development of biocompatible and soft actuating materials with quick response, low operating voltage and comparatively large bending deformation.</P>

열산화된 알루미늄이 첨가된 Tin black filter를 가지는 메탄센서

권오식,황숙이,심창현,임채근,방영일,김봉철,허증수,류기홍,이덕동 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

평방근 정보필터를 이용한 미지의 측정 바이어스를 갖는 시스템에 대한 적응추정기의 설계

권성숙,김경연,김창일,김경식 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

In this paper, we present an adaptive estimator for tracking of a maneuvering target containing unknown or randomly switching biased measurements using square root information filter(SRIF). The SRIF is employed instead of conventional Kalman filter since it exhibits more efficient features in handling the unknown measurements bias and improved numerical characteristics. Computer simulations for a system with unknown bias are carried out to show the adaptability and tracking performance of the proposed algorithm.

적응추정기를 이용한 강의 수질 감시 시스템 설계

김창일,권성숙,김경식,김경연 濟州大學校 情報通信硏究所 1998 情報通信硏究所論文集 Vol.1 No.-

An adaptive estimator to estimate the water quality in a river under unknown biased measurements environment is developed. In modeling the unknown measurement bias, it is assumed that the bias sequence is governed by semi-Markov process. By incorporating the semi-Markov probability concepts into the Bayesian estimation theory. an effective adaptive estimator which consists of parallel Kalman-type filters is obtained. Computer simulation results for the multiple-reach river system show that the proposed adaptive estimator have good estimation performance in spite of the unknown randomly switching measurement bias.