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Phase 2 study of 5-fluorouracil and cisplatin for inoperable hepatocellular carcinoma
( Bhum Suk Keam ),( In Sil Choi ),( Keun Wook Lee ),( Do Youn Oh ),( Se Hoon Lee ),( Jee Hyun Kim ),( Dong Wan Kim ),( Seock Ah Im ),( Tae You Kim ),( Dae Seog Heo ),( Yung Jue Bang ),( Noe Kyeong Kim 대한내과학회 2005 대한내과학회 추계학술대회 Vol.69 No.10
Genome-wide Association Study Identified TIMP2 Genetic Variant with Susceptibility to Osteoarthritis
Keam, Bhum-Suk,Hwang, Joo-Yeon,Go, Min-Jin,Heo, Jee-Yeon,Park, Mi-Sun,Lee, Ji-Young,Kim, Nam-Hee,Park, Miey,Oh, Ji-Hee,Kim, Dong-Hyun,Jeong, Jin-Young,Lee, Jong-Young,Han, Bok-Ghee,Lee, Ju-Young Korea Genome Organization 2011 Genomics & informatics Vol.9 No.3
Osteoarthritis (OA) is the most common degenerative joint disorder in the elderly population. To identify OA-associated genetic variants and candidate genes, we conducted a genome-wide association study (GWAS). A total 3,793 samples (476 cases: wrist + knee and 3317 controls) from a community-based epidemiological study were genotyped using the Affymetrix SNP 5.0. An intronic SNP (rs4789934) in the TIMP2 (tissue inhibitor of metalloproteinase-2) showed the most significance with OA (odd ratio [OR] = 2.06, 95% confidence interval [CI] = 1.52-2.81, p = $4.01{\times}10^{-6}$). Furthermore, a poly-morphism (rs1352677) in the NKAIN2 ($Na^+/K^+$ transporting ATPase interacting 2) was suggestively associated with OA (OR = 1.43, CI = 1.22-1.66, p = $7.01{\times}10^{-6}$). The present study provides new insights into the identification of genetic predisposing factors for OA.
Bhum Suk Keam,Jeong Hoon Lee,Myoung Don Oh,In Ho Kim,Sung Soo Yoon,Byoung Kook Kim,Seon Yang Park 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.1
Pneumatosis intestinalis (PI) is an uncommon disorder characterized by an accumulation of gas in the bowel wall, and has been associated with a variety of disorders and procedures. We describe a 35-year-old man who undertook hematopoietic stem cell transplantation due to myelodysplastic syndrome. An abdominal X-ray demonstrated extensive PI with pneumoperitoneum mimicking hollow organ perforation. However, the patient had no abdominal symptoms and there was no evidence of peritoneal inflammation. After two weeks of conservative management, including bowel rest and antibiotics, his pneumoperitoneum resolved spontaneously without any complications. Of the many factors that affect the gastrointestinal tract mucosal integrity, intramural pressure, and bacterial flora-produced intraluminal gas interact to produce PI. If the condition is accompanied by bowel ischemia, portomesenteric venous gas, metabolic acidosis, and abdominal sepsis, or if PI is severe in extent immediate surgical intervention is indicated. The described case supports that a mechanical rather than a bacterial etiology underlies the pathogenesis of PI.
( So Yeon Lee ),( Yoon Seok Choi ),( Bhum-suk Keam ),( Keon-uk Park ),( Ki-hyeong Lee ),( Ihn-seong Jo ),( Eun-kee Song ),( Sang-gon Park ),( Ik-chan Song ),( Hyo Jin Lee ),( Deog Yeon Jo ),( Samyong 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Introduction: Standard treatment for locally advanced (stage III-IV) head and neck squamous cell cancer (LA-HNSCC) is concurrent chemoradiation therapy (CCRT) with cisplatin 100mg/m2 every three weeks. For medically unfit patients susceptible to treatment-related adverse events, low-dose weekly cisplatin can be used as an alternative. In previous studies, weekly cisplatin-based regimen showed fair efficacy and tolerable toxicity profiles. In this study, we retrospectively compared the therapeutic outcomes of low-dose weekly cisplatin regimen and standard regimen in CCRT for LA-HNSCC.?Methods: The medical records of histologically confirmed LA-HNSCC patients were retrospectively reviewed from Jan 1, 2007 to Dec 31, 2012. 224 patients who were treated with CCRT as initial treatment were enrolled. Among them, 155 patients were treated with low-dose (30 mg/m2) weekly cisplatin and 69 patients were treated with standard-dose (100 mg/m2) three-weekly. Dose intensity of cisplatin in each group was calculated as proportion of delivered dose in full regimen dosage.?Results: Baseline characteristics of both groups did not differ significantly, except that standard-dose group contained more larynx cancer patients. Although dose intensity of standard-dose cisplatin group (84%) were lower than low-dose weekly cisplatin group (91%), difference in median progression free survival (31.2 month vs 26.3 month; p=0.469) and overall survival (36.6 month vs 31.6 month; p=0.439) was not statistically significant between standard-dose group and low-dose group.?Conclusions: In the present study, low-dose weekly cisplatin was not inferior to standard-dose cisplatin in terms of survival outcomes. Prospective comparison of standard-dose three-weekly and low-dose weekly cisplatin is warranted.
서경진 ( Koung Jin Suh ),김범석 ( Bhum Suk Keam ),임진 ( Jin Im ),김미소 ( Mi So Kim ),이대원 ( Dae Won Lee ),김동영 ( Dong Young Kim ),우홍균 ( Hong Gyun Wu ) 대한내과학회 2013 대한내과학회지 Vol.85 No.3
Solitary splenic metastases from head and neck cancer are rare. We report a 35-year-old male with nasal cavity cancer with metastasis to the cervical lymph nodes. The patient underwent three cycles of induction chemotherapy, followed by left medial maxillectomy with modified radical neck dissection and concurrent chemoradiotherapy with weekly cisplatin. After 7 months of a disease- free interval, positron-emission tomography showed a high uptake in the spleen, and a biopsy confirmed metastatic carcinoma. After four cycles of systemic chemotherapy with docetaxel and cisplatin, laparoscopic splenectomy was performed. This case highlights that solitary splenic metastasis, although rare, may occur with a locoregionally controlled head and neck cancer and could be treated with local and systemic treatment. (Korean J Med 2013;85:324-328)