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경계보존 단층영상 재구성을 위한 통계학적 최대사후 방법과 사후필터가 적용된 최대우도 방법의 성능 비교
홍효선, 이수진 배재대학교 공학연구소 2014 공학논문집 Vol.16 No.1
Maximum a posteriori (MAP) approaches have played an important role in statistical tomographic reconstruction in that they can not only accurately model the Poisson noise associated with gamma-ray projection data, but also efficiently incorporate the edge-preserving prior models. In order to reduce the computational burden in the MAP approach, it has also been a topic to apply edge-preserving post filters to the images reconstructed by the maximum-likelihood (ML) approach, which can model the statistical character of the data just like the MAP approach. In this work, we compare the quantitative performance of the two different approaches by using software phantom studies. Our experimental results indicate that, while the post-filtered ML approach can be useful in preserving the edges as well as suppressing the noise, it has unwanted effects of incurring relatively large bias errors. The MAP approach, on the other hand, yields better accuracy in terms of both the bias error and percentage error, thereby providing more accurate reconstructions.
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Clinical Implications of Circulating Tumor DNA from Ascites and Serial Plasma in Ovarian Cancer
한미령,이석형,박정윤,홍효선,호정윤,허수영,최윤진 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose The purpose of this study was to identify the clinical utility of circulating tumor DNA (ctDNA) from ascites and serial plasma samples from epithelial ovarian cancer (EOC) patients. Materials and Methods Using targeted next-generation sequencing, we analyzed a total of 55 EOC samples including ctDNA from ascites and serial plasma and gDNA from tumor tissues. Tumor tissues and ascites were collected during debulking surgeries and plasma samples were collected before and after the surgeries. Because one EOC patient underwent secondary debulking surgery, a total of 11 tumor tissues, 33 plasma samples, and 11 ascites samples were obtained from the 10 patients. Results Of the 10 patients, nine (90%) contained somatic mutations in both tumor tissues and ascites ctDNA. This mutational concordance was confirmed through correlation analysis. The mutational concordance between ascites and tumor tissues was valid in recurrent/progressive ovarian cancer. TP53was the most frequently detected gene with mutations. ctDNA from serial plasma samples identified EOC progression/recurrence at a similar time or even more rapidly than cancer antigen 125, an established serum protein tumor marker for EOC. Conclusion Our data suggest that ascites ctDNA can be used to identify the mutational landscape of ovarian cancer for therapeutic strategy planning.
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Total antioxidant status (TAS) 참고치 및 고콜레스테롤혈증, 당뇨병과의 관련성에 관한 연구
권영일 ( Young Il Kwon ),서은주 ( Eun Ju Seo ),홍효선 ( Hyo Sun Hong ),안희은 ( Hee Eun Ahn ),박찬호 ( Chan Ho Park ),노명희 ( Myung Hee Rho ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2
Introduction : The Object of this study is to investigate the reference ranges of total antioxidant status(TAS) according to age and sex in korea. The human body is constantly under attack from free radicals. Free radica1s are highly reactive molecules and once formed, attack cell structures with the body. As a resu1t, free radicals have been implicated in numerous disease. In hea1thy individua1s, the antioxidant system defends tissues against free radica1 attack. Methods and materials : We measured the tota1 antioxidant status of 90 norma1 group, 30 diabetes group and 30 hypercholesterolemia group. (The each group sex ratio : ha1f to ha1ij For each test, age and sex related variations were assessed and reference values were estimated for three different age groups.(below 20, 21-40, above 41) TAS measured by Randox Tota1 Antioxidant reagent and Hitachi 7150. Results : ’fhe reference va1ues according to age were 0.930- 1.332mmolfL in below 20 years of age, 1.007 -1.391mmolfL in 21-40 years of age and 0.995- 1.295mmolfL inabove 41 year of age and showed statistica11y significant difference.(P<0.05) The Reference ranges of tota1 age group, ma1e and fema1e group were 0.991- 1.343mmolfL, 1.038- 1.370mmolfL, and 0.977 -1.285mmolfL respectively. Between the ma1e and fema1e group were statistically signficant difference.(P<0.05) The TAS means of diabetes and hypercholesterolemia were 1.26mmoljL and 1.23mmoljL respectively. TAS values of hypercholerterolemia an normal group were no significant difference whereas diabetes and normal group were significant difference.(P<O.OOl) Conclusions : We established that reference ranges were analyzed age and sex related variations for total antioxidant status. Between experimental groups showed generally significant differences. In the future, correct diagnosis of disease induced free radicals need to measure total antioxidant level and each antioxidants.
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