소아 아토피피부염의 약물치료

지혜미,한만용 대한의사협회 2022 대한의사협회지 Vol.65 No.10

Background: Atopic dermatitis, a chronic inflammatory skin disease can significantly reduce patients’ quality of life. It is commonly observed in infants or young children but can also occur in adults. Patients with atopic dermatitis are at risk of developing food allergies, allergic rhinitis, and asthma. Current Concepts: Treatment of atopic dermatitis should commence with moisturization of epidermal skin and avoidance of environmental factors that may trigger exacerbation of atopic dermatitis. Topical corticosteroid application remains the gold standard for medical management of atopic dermatitis; however, topical corticosteroids are often avoided owing to concerns regarding the adverse effects of these drugs. Recently, several systemic immunosuppressants and biological agents have been introduced for the treatment of atopic dermatitis. These medications are associated with fewer adverse effects than those observed with previous treatments and have therefore shown positive results for successful management of atopic dermatitis. Discussion and Conclusion: It is expected that new drugs tailored to the disease level of each patient will revolutionize the treatment of atopic dermatitis more effectively in future.

Closing the chapter on twenty twenty-two

지혜미 한국운동재활학회 2022 JER Vol.18 No.6

.

Physical activity, a new norm for mythical virus

지혜미 한국운동재활학회 2020 JER Vol.16 No.4

Effects of Regularly Performed Walking on the Bilateral Limb Compositions of Post-Stroke Korean Men

지혜미 국제물리치료연구학회 2018 Journal of International Academy of Physical Ther Vol.9 No.1

The purpose of this study was to examine the effects of hemispheric damage in body composition of male adults with stroke experiences. The Fourth and Fifth Korea National Health and Nutrition Examination Surveys (KNHANES) with body composition results obtained from the DXA (dual-energy X-ray absorptiometry) assessments were used for this study. Survey data of 18 post-stroke men and 28 healthy controls were obtained. Both the lean and fat masses of the upper and lower limbs were utilized to compare for the compositions between the limbs in post-stroke subjects. In addition, the effect of exercise habit was also observed for the influence of physical activity in body composition. Mixed results in left and right limb compositions were shown between the groups. When the subjects were further divided based on walking days per week, sedentary (walk ≤2 d/wk) post-stroke group showed significantly greater fat mass and less lean mass than the physically active people (walk ≥ 3d/wk). In comparison to the healthy sedentary and physically active controls, two post-stroke groups showed greater variations. The results indicate that physical activity maintains or improve the quality of both the upper and lower limb composition in patients with post-stroke men.

Development and Application of Biological Age Prediction Models with Physical Fitness and Physiological Components in Korean Adults

지혜미,전병환,박재현,진영수 KARGER 2012 Gerontology Vol.58 No.4

알레르기비염과 위생가설

지혜미,김민지,김현희,김효빈,나영호,박 양,성명순,신윤호,염혜영,이경석,이용주,전윤홍,최봉석,최선희,박용민,대한 소아알레르기 호흡기학회 비염 연구회 대한 소아알레르기 호흡기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.1

The hygiene hypothesis, first proposed in 1989, suggested that reduced exposure to infections in early life leads to allergic diseases by the defects in the establishment of immune tolerance. Although many studies provided evidence that some exposure conditions, including family size, antibiotics, probiotics, and viral or bacterial infections, are strongly related to the prevalence of allergic diseases, thereby supporting the hygiene hypothesis, some evidence does not provide acceptable results for the hygiene hypothesis. Further, most studies have focused on patients with asthma or atopic dermatitis, not allergic rhinitis. In this review, we summarize the recent studies for and against the ‘hygiene hypothesis’ and identify causal association with the prevalence of allergic rhinitis. .

Comparisons of Quality of Life and Asymmetric Atrophy in Regularly Walking Elderly Female Stroke Survivors

지혜미 국제물리치료연구학회 2018 Journal of International Academy of Physical Ther Vol.9 No.4

Regularly participating in physical activity is known to improve quality of life and body composition in elderly with stroke. However, comparatively less physical activity is performed by the stroke survivors. The factors related to inactivity in elderly female stroke survivors have not been elucidated. Therefore, this study aims to compare the quality of life factors and limb compositions between the active and inactive elderly female stroke survivors. Forty nine subjects between the ages of 65 to 75 years were selected from the KNHANES data between the years 2009 to 2011. In addition, 186 agematched healthy peers were also selected for limb composition comparisons. The subjects were groups based on walking days per week: walkers; 3 days or more, non-walkers; less than 3 days per week. BMI and waist circumference were within the obesity ranges for both the non-walkers and walkers. As results, the trend for greater fat (±10%) and lean mass (±30%) differences were observed for non-walker and walkers, respectively. Significantly greater reasons for function limitation by stroke and hypertension were reported with significantly greater self-care difficulty was shown by the walkers. In conclusion, elderly female stroke survivals may require customized motivation and continuous support to participate in physical activity regularly.

항원특이면역요법을 위한 집먼지진드기 알레르기비염 마우스 모델의 효용성

지혜미 대한 소아알레르기 호흡기학회 2022 Allergy Asthma & Respiratory Disease Vol.10 No.4

. 알레르기비염은 아토피피부염, 천식 등과 함께 대표적인 알레르기질환 중 하나이다. 일반 인구의 10%–25%가 알레르기비염을 가지고 있는 것으로 보고되고 있으며, 콧물, 코막힘, 코가려움, 재채기 등이 주 증상이다.1 여러 알레르기질환은 유사한 발병기전, 증상 등을 보이면서 서로 연관되어 있는 특성이 있으며 알레르기비염을 가지고 있는 소아에서 천식으로 이행될 확률이 약 40% 정도로 보고되고 있다.2,3 따라서 하나의 치료가 여러 알레르기질환에 공통된 발병 기전을 억제하게 되면 동시에 여러 질환을 조절하기에 상당히 도움이 될 수 있다. 예를 들어, 천식이 동반된 알레르기비염 환자에서 류코트리엔조절제(leukotriene receptor antagonist) 복용은 두 질환에 모두 효과를 기대할 수 있어 천식과 알레르기비염 치료 가이드라인에서 모두 권장하고 있는 치료 방법이다.4

영유아 감기치료 약물의 효과와 안전성

지혜미,최선희,한만용 대한의사협회 2010 대한의사협회지 Vol.53 No.1

Common cold is a conventional term for a mild upper respiratory illness characterized by symptoms of nasal stuffiness, rhinorrhea, sneezing, sore throat, and cough. Management of the common cold is intended to provide temporary relief of symptoms until the cold completes its natural history, as well as to reduce the risk of complications. However, most studies for cold preparations focus on adults, and there are limited and conflicting evidences for children. Various preparations for cough/cold are available, which include antihistamines, decongestants,antitussives, expectorants, analgesics/antipyretics, and some combination products. Nonpharmacologic therapies are also important and it is generally agreed that such supportive cares should form the mainstay of treatment for children with common colds. Adverse effects of the specific types of cold preparations should be considered carefully for very young children. In addition, it is very important to educate parents about the natural course of common cold, along with appropriate use correct dosages and potential adverse effects of cold preparations.

Increased B cell-activating factor (BAFF) level in the sputum of children with asthma

지혜미,최봉석,김경원,손명현,한만용,김규언 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.8

Purpose: B cell-activating factor (BAFF) is a tumor-necrosis factor (TNF) superfamily member best known for its role in the survival and maturation of B cells. BAFF activity is observed in naïve cells as well as in effector/memory T cells. We aimed to explore whether BAFF in sputum is expressed at elevated levels in asthmatic airways and associated with eosinophilic inflammation, pulmonary function, and bronchial hyperresponsiveness in children. Methods: One hundred and fifty-four asthmatic children and 98healthy children were enrolled in the study. Sputum supernatants were collected and sputum BAFF and eosinophil cationic protein (ECP)levels were measured. We performed pulmonary function tests and methacholine challenge tests, while measuring total eosinophil count,total serum IgE, and serum ECP in all subjects. Results: Asthmatic children had significantly higher levels of BAFF in induced sputum [26.50 (10.50-100.27) pg/mL] compared to healthy children [18.32 (7.68-44.63) pg/mL; P=0.011]. Sputum BAFF positively correlated with sputum eosinophils (γ=0.406, P<0.001) and sputum ECP (γ=0.789, P<0.001). Significant negative correlations were found between sputum BAFF and FEV1 (γ=-0.291, P<0.001) or postbronchodilator FEV1 (γ=-0.334, P<0.001), whereas nonsignificant correlations were found between sputum BAFF and bronchial hyperresponsiveness, serum eosinophil count, and serum ECP. Conclusion: These findings suggest that BAFF may play a role in childhood asthma, and BAFF levels in sputum could be a supportive marker that represents airway inflammation, especially eosinophilic inflammation.