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The Pleiotropic Face of CREB Family Transcription Factors
정상윤,Md. Arifur Rahman Chowdhury,Jungeun An 한국분자세포생물학회 2023 Molecules and cells Vol.46 No.7
cAMP responsive element-binding protein (CREB) is one of the most intensively studied phosphorylation-dependent transcription factors that provide evolutionarily conserved mechanisms of differential gene expression in vertebrates and invertebrates. Many cellular protein kinases that function downstream of distinct cell surface receptors are responsible for the activation of CREB. Upon functional dimerization of the activated CREB to cis-acting cAMP responsive elements within the promoters of target genes, it facilitates signal-dependent gene expression. From the discovery of CREB, which is ubiquitously expressed, it has been proven to be involved in a variety of cellular processes that include cell proliferation, adaptation, survival, differentiation, and physiology, through the control of target gene expression. In this review, we highlight the essential roles of CREB proteins in the nervous system, the immune system, cancer development, hepatic physiology, and cardiovascular function and further discuss a wide range of CREB-associated diseases and molecular mechanisms underlying the pathogenesis of these diseases.
다기준의사결정 모형을 이용한 전산화된 제조관리시스템의 선정에 관한 연구
정상윤,양대용 한국컴퓨터정보학회 2001 韓國컴퓨터情報學會論文誌 Vol.6 No.1
본 연구는 전산화된 제조관리 시스템의 운영을 위한 관련 소프트웨어의 합리적 선정을 목적으로 한다. 제조관리 시스템의 운용 소프트웨어는 구입비용이 대단히 크고 또한 공장 시스템의 환경에 적용 가능하여야 하기 때문에 자동화 제조관리 시스템의 운용 소프트웨어에 대한 합리적 선정이 생산성과 제조비용의 절감에 있어서 매우 중요하다. 본 연구는 다기준 의사결정모형을 이용한 제조관리 시스템의 운용을 위한 소프트웨어의 합리적 선정에 대한 방법을 제시하고 수치예제에 의해 타당성을 분석하였다. The purpose of this study is the optimal selection for evaluating alternative computerized manufacturing control software packages. The evaluation and analysis of the alternative computerized manufacturing control software packages is based on a model for Multi-Criteria Decision Making(MCDM). The ultimate of MCDM is to take the best choice among the alternatives or to rank them and the procedure depends on the decision maker's subjective judgement. An example is given to illustrate the application of the MCDM model.
An Exploratory Study on Measuring Brand Image from a Network Perspective
정상윤,장정아,노상규 한국전자거래학회 2020 한국전자거래학회지 Vol.25 No.4
Along with the rapid advance in internet technologies, ubiquitous mobile device usage has enabled consumers to access real-time information and increased interaction with others through various social media. Consumers can now get information more easily when making purchase decisions, and these changes are affecting the brand landscape. In a digitally connected world, brand image is not communicated to the consumers one-sidedly. Rather, with consumers’ growing influence, it is a result of co-creation where consumers have an active role in building brand image. This explains a reality where people no longer purchase products just because they know the brand or because it is a famous brand. However, there has been little discussion on the matter, and many practitioners still rely on the traditional measures of brand indicators. The goal of this research is to present the limitations of traditional definition and measurement of brand and brand image, and propose a more direct and adequate measure that reflects the nature of a connected world. Inspired by the proverb, “A man is known by the company he keeps,” the proposed measurement offers insight to the position of brand (or brand image) through co-purchased product networks. This paper suggests a framework of network analysis that clusters brands of cosmetics by the frequency of other products purchased together. This is done by analyzing product networks of a brand extracted from actual purchase data on Amazon.com. This is a more direct approach, compared to past measures where consumers’ intention or cognitive aspects are examined through survey. The practical implication is that our research attempts to close the gap between brand indicators and actual purchase behavior. From a theoretical standpoint, this paper extends the traditional conceptualization of brand image to a network perspective that reflects the nature of a digitally connected society.
需要가 減少하는 減損性 製品에 대한 在庫 體系의 模型 設定에 관한 硏究
정상윤 동국대학교 대학원 1990 大學院硏究論集-東國大學校 大學院 Vol.20 No.-
In the previous studies on Inventory System for deteriorating items, it is assumed that the demand rate is constant and is independent of time during a period of each cycle. However, the assumption is unrealistic because the demand rate is influenced by the price and time. The purpose of this study is to determine optimal ordering quantity and optimal selling price which maximize profit. In this study, it is assumed that the demand rate is governed by the price and time and that replenishment orders are placed at equal intervals in a finite time horizon. A numerical example is used to illustrate the proposed model. A sensitivity analysis to v(parameter of the deterioration rate function), and α(constant representing the decreasing rate of the demand rate ) is also performed. The results of sensitivity analysis show that the optimal selling price increases gradually when v is increased with fixed α. while the optimal ordering quantity decreases with increasing α and fixed v.