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立安散이 Angiogenesis 抑制棋戰에 미치는 影響
李紀龍,崔昇勳,安圭錫 대한한방종양학회 1998 대한한방종양학회지 Vol.4 No.1
This experimental study waas carried out to evaluate the effect of Yipahnasn on angiogenic inhibition mechanism. This study investigates the effects of Yipahnsan on angiogenic inhibition mechanism evaluate cell adhesive inhibition effect, DNA fragmantation analysis, nuclear condensation assay, FACScan analysis, angiogenic lumen formation assay, immunocytochemistry analysis, RT-PCR cor mRNA expression, western blot analysis, confocal analysis for Ca^2+influx. The results were wummarized as follows: 1. The cell adhesive inhibition ability was strongly increased from 5ug/ml on ECV304 cell line and ECVPAR cell line. 2. YY water extract caused G_0/G_1 arrest peak to existed on the ECV304 cell line. 3. YY water extract caused inhibition of proliferation and inducement of apoptosis on the collagen coated plate in ECV304 cell line. 4. YY water extract inhibited the lumen formation on the matrigel coated plate in ECV304 cell line. 5. YY water extract inhibited the expressions of LFA-1 and ELAM-1 on ECV304 cell line and ECVPAR cell line. 6. YY water extract inhibited the expressions of MMP-9 and uPA on ECV304 cell line and ECVPAR cell line. 7. YY water extract inhibited the expressions of integrin α_vβ_3 on ECV304 cell line and ECVPAR cell line. 8. YY water extract dereased the change of Ca^2+ in intracellular on ECV304 cell line and ECVPAR cell line. According to the results, Yipahnsan showed to be a key antagonist of integrin α_vβ_3 and to be induction of apoptosts by p53 through flow cytometry. This report also demonstrated that expressions of MMP-9 and uPA were blocked under the angiogenesis model. Thus, we suggested that Yipahnsan blocks angiogenesis by inducing apoptosis in ECV304 and ECVPAR cell lines, and another oriental herbal medicine that treats qi-stagnation and hlood-stasis type also has angiogenic inhibition effects.
이기룡,박병춘 한국품질경영학회 2002 품질경영학회지 Vol.30 No.1
The Quality Function Deployment(QFD) is a Quality Management technique to maximize customers' satisfaction by reflecting customer requirements into all business processes, including concept definition, product planning, parts planning, process planning, production planning, and sales planning. The basic concept of the QFD is to translate customers' requirements appropriately into engineering characteristics, into parts characteristics, into process characteristics, and into specific requirements and activities in production. In this study, we reviewed and analyzed the application process of the QFD to the development of A2 FATC (Full Automatic Temperature Controller), an automotive component developed and produced by company A. It has been reported that by applying the QFD to the development of A2 FATC, company A achieved 34% improvement in control robustness quality characteristic, 27% improvement in deviation quality characteristic, and 30% improvement in overall quality characteristics.
형상 행렬을 이용한 이동로봇의 동적 경계 추종 알고리즘
이기룡,좌동경,홍석교 제어로봇시스템학회 2009 제어로봇시스템학회 국내학술대회 논문집 Vol.2009 No.9
In this paper, dynamic boundary tracking algorithm using shape matrix is proposed. Previous dynamic boundary tracking algorithm suppose that the number of mobile robots and their order does not change. If the order of mobile robots is change, this algorithm dose not work. So the proposed algorithm use the shape matrix for the dynamic boundary tracking algorithm. And generate the shape matrix at each sampling time. And mobile robots follow the position of shape matrix. Finally, it will be shown in the simulation results that mobile robots converge to a desired boundary irrespective of the order of mobile robots.