마이토마이신 병용 미용적 결막절제술 후 발생한 공막각막염 및 이차성 녹내장 1예

우제문,이승주,김상우,임진호 대한안과학회 2009 대한안과학회지 Vol.50 No.12

Purpose: To report a case of secondary glaucoma and sclerokeratitis after cosmetic eye whitening by regional conjunctivectomy with Mitomycin C application. Case summary: A 69 year-old man was referred to our clinic for a left ocular pain and ocular hypertension sustained for 3 months after cosmetic eye whitening by regional conjunctivectomy with Mitomycin C application for chronic conjunctival hyperemia. On first examination, the scleromalacia and large conjunctival epithelium defect in the nasal quadrant of the limbus area and diffuse sclerokeratitis were observed. Conjunctival and episcleral vessel deficit were seen except superior 30% portion in the left eye. The anterior chamber depth in the left eye was very shallow compared to the right eye and cell reaction in the left anterior chamber was detected. Intraocular pressure (IOP) in the left eye was 28 mmHg after CosoptⓇ and 15% mannitol 500 ml use. Glaucomatous cupping was detected. During follow-up, left IOP increased over 40 mmHg despite the maximal medical treatment and the progression of visual field defects was detected, so then left phacoemulsification, Ahmed valve implantation and amnion membrane transplantation were done. After surgery, the conjunctival epithelial defect and sclerokeratitis were improved much and IOP was regulated 20~30 mmHg without medication. Digital massage was done 2 times per day for decreasing IOP and wound remodeling after 1 month. At 3 month after surgery, the conjunctival epithelial defect recurred and scleromalacia was also progressed, so then we performed autoconjunctival flap and amnion membrane transplantation in left eye. The conjunctival epithelial defect were recovered completely, IOP was regulated 24~36 mmHg without medication, and 20~24 mmHg with Cosopt.Ⓡ The compliance of patient is very poor, further management may be needed for IOP control. Conclusions: Cosmetic eye whitening by regional conjunctivectomy with Mitomycin C application can cause serious complications such as scleromalcia and secondary glaucoma. This case shows that particular care should be taken in order to minimize these complications. 목적: 마이토마이신 병용 미용적 결막절제술 후 발생한 공막각막염 및 이차성 녹내장의 증례를 경험하였기에 이를 보고하고자 한다. 증례요약: 69세 남자가 3개월 전 좌안의 만성적인 결막충혈로 마이토마이신 병용 미용적 결막 절제술을 시행 받은 후 지속되는 좌안 통증 및 안압상승으로 전원되었다. 초진 시 비측 공막괴사와 광범위한 결막상피결손 및 염증소견이 있었고, 미만성의 점모양 각막병증 이 관찰되었으며, 위쪽 결막 부위를 제외한 광범위한 결막 및 상공막 혈관 결손이 관찰되었다. 좌안의 전방깊이는 우안에 비해 매우 얕은 상태로 세포가 관찰되었고, 좌안 안압은 CosoptⓇ과 15% mannitol 500 ml 주사 후 28 mmHg로 측정되었고, 녹내장성 시신경손상 도 관찰되었다. 경과관찰 중 좌안 안압이 상승하여 Alphagan,Ⓡ XalatanⓇ을 추가하였으나 지속적으로 안압이 40 mmHg 이상으로 측정 되고 시신경손상도 진행하여, 좌안 백내장 수술과 아메드밸브 삽입술 및 양막이식술을 시행하였다. 수술 후 결막결손과 공막괴사는 많은 호전을 보였고, 안압은 약물 사용 없이 20~30 mmHg로 조절되었다. 수술 후 1개월째 안압 조절을 위해 안구지압을 하루 2번 시행하였다. 수술 3개월 후 결막 결손부위가 다시 증가하고 공막괴사가 진행하여, 자가결막이식술 및 양막이식술을 시행하였고, 수술 후 결막결손부위는 치료가 되었다. 안압은 약물사용 없이 24~36 mmHg로 조절되었고, CosoptⓇ을 사용하고 20~24 mmHg 정도로 조절되고 있으며, 환자가 약물의 순응도가 나빠 추가적인 안압조절이 필요한 상태이다. 결론: 마이토마이신 병용 미용적 결막절제술 시 과도한 결막절제 및 마이토마이신 사용 그리고 수술 후 장기간 사용하는 스테로이드안 약사용에 주의를 요하며, 공막각막염 및 이차성 녹내장 등의 심각한 합병증이 발생할 수 있음을 보고하는 바이다.

발생액의 질과 위험요인에 대한 연구 - 한국주식시장을 중심으로

우제문,강형구,김동환,김대식 한국자료분석학회 2014 Journal of the Korean Data Analysis Society Vol.16 No.5

This paper presents that the accrual quality is significant risk factor in Korea stock market. We studied among a number of corporations, which are listed on KOSPI and KOSDAQ, operated over 7 years. We defined accrual quality factor based on Core, Guay, Verdi (2008). In addition, we constructed factor mimicking portfolio, which is result from Fama-French of 3 factor models applying equal weighted average. Our approach is used actual proof of the monthly return between 1992 and 2012. This approach is used accrual quality factor to analysis monthly return. This paper using Fama-Macbeth two stage analysis and presents accrual quality factor is not significant priced risk factor in Korea stock market. Furthermore, the result of GRS (Gibbons, Ross, Shanken) F-test is insignificant. In conclusion, the 4 factor model is not a good solution to represent excess return of Korea stock market. 본 연구에서는 발생액의 질이 국내 주식시장에서 위험요인이 될 수 있는가를 검증하였다. 1987년부터 2011년까지 KOSPI와 KOSDAQ에 상장된 7년 이상 존속기업에 대해 발생액의 질을 구성하기 위한 표본을 대상으로 진행했으며, 방법론은 Core, Guay, Verdi(2008)을 따라 진행하였다. 이를 대상으로 발생액의 질 요인을 정의하였으며, 기존의 Fama-French의 3요인 모형을 동일가중수익률로 요인복제포트폴리오를 구성하였으며 추가적으로 본 연구에서 주장하는 발생액의 질 요인을 추가하여 1992년부터 2012년까지 240개월 월간수익률 자료를 기반으로 실증분석을 진행했다. Fama-Macbeth의 2단계 회귀분석을 통해 개별기업과 포트폴리오 수준에서 진행된 실증분석의 결과 발생액의 질 요인은 국내 주식시장에서 위험요인으로서 유의미하지 않으며, GRS F-검정 결과 또한 유의하지 않은 결론을 도출함에 따라 4요인 모형으로는 국내 주식시장의 초과수익률을 완벽하게 설명하지 못한다는 결론을 도출했다.

베세트병의 임상적 고찰

우제문(Je Moon Woo),서만성(Man Seong Seo),양건진(Kun Jin Yang),박영걸(Yeong Geol Park) 대한안과학회 1997 대한안과학회지 Vol.38 No.7

전층각막이식수술후 발생한 녹내장의 임상적 고찰

우제문(Je Moon Woo),임선택(Sun Taek Lim),서만성(Man Seong Seo),양건진(Kun Jin Yang) 대한안과학회 1997 대한안과학회지 Vol.38 No.3

상안검 금조각 삽입술을 이용한 안면신경마비에 의한 불완전 안검폐쇄의 치료

우제문(Je Moon Woo),정상기(Sang Ki Jeong),박영걸(Yeoung Geol Park) 대한안과학회 1995 대한안과학회지 Vol.36 No.12

안구 안축장이 사시수술에 미치는 영향에 관한 연구

우제문(Je Moon Woo),김성주(Seong Ju Kim),정상기(Sang Ki Jeong),박영걸(Yeong Geol Park) 대한안과학회 1997 대한안과학회지 Vol.38 No.4

3회 이상 전층각막이식술을 시행 받은 환자의 장기간 임상결과와 이식실패의 위험인자

장재용,우제문,윤경철,Jae Yong Jang,Je Moon Woo,Kyung Chul Yoon 대한안과학회 2011 대한안과학회지 Vol.52 No.12

Purpose: To evaluate the primary indications, surgical outcomes, causes and risk factors for graft failure in patients with three or more penetrating keratoplasty (PKP) surgeries. Methods: We retrospectively analyzed indications for the initial corneal graft, survival periods, causes and risk factors for failure in 25 patients (26 eyes) who had undergone three or more PKP with minimum follow-up periods of nine months. Results: The most common primary indications were herpes simplex keratitis (26.9%), followed by fungal keratitis (19.2%) and bacterial keratitis (11.5%). The average survival period of graft in three or more PKP was 12.9 ± 9.1 months. As the frequency of PKP increased, the survival period became shorter; the survival period was the longest in pseudophakic bullous keratopathy and the shortest in herpes simplex keratitis. The most common cause of graft failure was allograft rejection (82.8%), and the risk factors for graft failure were short interval between penetrating keratoplasties and corneal neovascularization. Conclusions: In three or more PKP, as the frequency of PKP increases, the survival period becomes shorter. Short interval between keratoplasties and cornel neovascularization were risk factors for graft failure; this results must be considered before surgery. J Korean Ophthalmol Soc 2011;52(12):1399-1404

생체 내 분해 콜라겐기질을 이용한 섬유주절제술의 임상적 소견 및 임상 효과에 대한 분석

이승주,우제문,민정기,기창원,임진호,Sung Ju Lee,Je Moon Woo,Jung Kee Min,Chang Won Kee,Jin Ho Yim 대한안과학회 2012 대한안과학회지 Vol.53 No.2

Purpose: To observe the effects of biodegradable collagen matrix (OculusGenTM) on filtering bleb formation and maintenance and to investigate its clinical effects and usefulness in trabeculectomy. Methods: Ophthalmologic examinations were preformed 1 day, 2 weeks, 1 month, 2 months, 3 months, 6 months, and 12 months postoperatively in the case and control groups. The clinical findings of the filtering bleb were observed, and the clinical effects measured by mean intraocular pressure and complications were evaluated in both groups. Results: The success rates were 76% in the case group and 88% in the control group, and there were no significant differences between the case and control groups. In the case group, postoperative conjunctival injection persisted for more than 1 month with increasing severity, while ultrasound biomicroscopy revealed increased echogenicity of the subconjuctival and tenon tissue with no definite space-occupying effect. Conclusions: Trabeculectomy utilizing collagen matrix showed similar clinical results compared to the current traditional trabeculectomy; slit-lamp and ultrasound biomicroscopy findings did not reveal any advantageous changes to filtering bleb function. J Korean Ophthalmol Soc 2012;53(2):297-305

회사채 시장에서의 모멘텀 현상

한민연,우제문,강형구 한국재무학회 2019 한국재무학회 학술대회 Vol.2019 No.11

본 연구는 국내 회사채 시장에서 과거 수익률이 높을수록, 미래에도 높은 수익률이 지속되는 모 멘텀 현상이 존재하는지를 밝히고, 어떠한 원인으로 나타나는지를 살펴보았다. 첫 번째, 회사채의 과거 수익률이 높을수록, 향후 수익률이 높은 모멘텀 현상이 발견되는 것으로 나타났다. 그리고 회사채 모멘텀은 기존의 채권과 주식에 대한 체계적인 위험 요인들(Fama and French, 1993, Carhart 1997)로는 설명되지 않았다. 따라서 관측되는 회사채의 모멘텀 현상은 기존에 정의된 위 험에 대한 보상으로 보기는 어려웠다. 두 번째, 모멘텀 전략의 수익성은 주로 평가기간과 보유기 간이 모두 6개월 이내로 짧은 경우에 강하게 나타났다. 세 번째, 회사채 모멘텀 전략의 수익성은 금융위기를 제외한 기간과 경기확장기에서 강하게 나타났으며, 반면 금융위기와 경기 수축기에서 는 나타나지 않았다. 네 번째, 회사채 모멘텀 현상은 주로 신용등급이 낮은 그룹에서 강하게 나타 났다. 다섯 번째, 모멘텀 효과가 크게 나타나는 신용등급이 낮은 채권 그룹들은 주로 규모가 작고, 유동성이 낮았다. 이러한 결과로 볼 때, 모멘텀 효과가 신용등급이 낮은 쪽에서 발생하는 것은 정 보의 지연 반응 효과(Hong and Stein, 1999)에 의한 가능성이 있는 것으로 추측할 수 있다. 마지 막으로, 과거 연구들(Gerbhart, Hvidkjaer and Swaminathan, 2005)에서 발견되었던 주식 모멘텀과 채권 모멘텀 간의 이전효과(Spillover)는 특별하게 나타나지 않았다. The momentum effect is the phenomenon that the higher the past return of the asset, the more persistent the high return. We can find the momentum effect in not only equity, but also several other asset classes and the U.S. In addition, it is found in various regions, and various kinds of momentum strategies are appearing. In particular, among other assets, recent studies have argued that momentum effects exist in the corporate bond market (Pospisil and Zhang, 2010; Jostova et al., 2013; Israel et al. 2017; Houweling and Zundert, 2017, Ho and Wang, 2018). However, empirical studies on the momentum phenomenon in Korea are mostly limited to stocks. Among other assets, although bonds have a large portion of the domestic financial market, studies on the existence of momentum in the bond market are still difficult to find in Korea. Our results are as follows. First, the higher the past return of the bond, the higher the future past return. In other words, we can verify the momentum effect. The momentum strategy with six months formation periods and six months holding periods shows an average return of 0.27% per month (3.26% per year). And the corporate bond momentum is not explained by the existing systematic risk factors for bonds and stocks (Fama and French, 1993, Carhart 1997). Thus, we cannot conclude that the observed momentum of corporate bonds is associated with compensation for systematic risk. The profitability of the momentum strategy is robust even when we control various characteristics such as duration and the age of bond. Second, the profitability of the bond momentum strategy is strong when the formation period and holding period were short. For example, the profitability of the momentum strategy was significant and high in the short-term period of 3 ~ 6 months formation and holding periods, while the profitability of the momentum strategy deteriorated in 9 ~ 12 months formation and holding periods. As such, the corporate bond momentum is mostly sustained in the short term. Third, the bond momentum strategy is profitable during the period that excluded the financial crisis and the economic expansion, while not during the financial crisis and the contraction. Fourth, the corporate bond momentum is strong in the low credit rating group. In other words, the higher the past return, the higher the future return in the group with the lower credit rating. Fifth, Low credit rating group, which show significant momentum effects, are mostly small and have low liquidity. From these results, we suggest that the momentum effect occurs at the lower credit level due to the gradual information diffusion hypothesis from Hong and Stein (1999). For example, it is found that the momentum is high in the small market capitalization, where private information is difficult to spread. Moreover, it is hard to interpret the information from the low credit rating firm. Finally, we cannot find the spillover between stock momentum and bond momentum found in previous studies (Gerbhart, Hvidkjaer, and Swaminathan, 2005). For example, no significant relationship is observed, such as a high future bond return for companies with high stock returns in the past. This study has academic and practical implications as follows. First, this study shows that there is a momentum phenomenon in other non-stock assets, especially, the Korean corporate bond. Many studies have focused on the momentum phenomenon in stock markets. Our results suggest that we need to research on the momentum phenomenon that can occur in various asset classes in Korea. Second, portfolio managers can use our findings as a bond investment strategy. In overall asset management industry in Korea, investments in corporate bonds are increasing, especially among institutional investors such as pension funds and insurance companies. Therefore, based on the results of this study, it is possible to establish and use the momentum strategy to obtain excess returns in the Korean bond market.

마이토마이신을 사용한 섬유주절제술 후 여과포 관리에 대한 석상 봉합의 유용성

이승주,우제문,김상우,안재환,임진호,Sung Ju Lee,Je Moon Woo,Sang Woo Kim,Jae Hwan An,Jin Ho Yim 대한안과학회 2013 대한안과학회지 Vol.54 No.2

Purpose: To evaluate the usefulness of external bandage suture for bleb-related management that follows trabeculectomy with mitomycin C. Methods: External bandage sutures were performed on 10 patients having hypotony maculopathy, persistent low intraocular pressure (IOP) caused by either hyperfiltration or focal leakage, or a persisting large bleb caused by hyperfiltration and who received trabeculectomy using mitomycin C as an adjuvant treatment. The changes in IOP measured before and 4 weeks after the procedure along with complication incidences were evaluated. Results: The mean IOP 4 weeks after the procedure compared with the mean IOP prior to the procedure increased from 5.8 ± 2.0 mm Hg (3.0-9.0 mm Hg) to 14.1 ± 8.5 mm Hg (4.0-32.0 mm Hg), with statistical significance (p = 0.008). After the procedure, improvement in visual acuity was observed but without statistical significance. One patient had persistent focal leakage from an avascular bleb and conjunctival advancement with removal of the avascular conjunctiva was performed. Conclusions: An external bandage suture can be a good alternative for correction of post-trabeculectomy hypotony and severe chemosis with minimal effect on blebs while correcting focal leakage and hyperfiltration.