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쿠마린에 의한 RAW 264.7 세포주의 Nitric Oxide 생성 저해활성
노태철,최희철,김보연,김영호,안종석,김영국,이현선 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
During the screening for inhibitors on nitric oxide (NO) producfion-in LPS-activated murine macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of Ponciri Fructus. They were identified as imperatorin (10), phellopterin (11) on the basis of spectroscopic methods. The IC_50 values for NO formatiom were about 5.4μM and 35.0μM, respectively, and then eleven coumarins were tested for the inhibitory effects on NO production in activated macrophages. All the test coumarins inhibited NO production in concentration-dependent manner and furanocoumarins (6-11) showed much more potent inhibitory effect than simple coumarins. Among the compounds examined xanthotoxin (8) was the most potent inhibitors of NO production (IC_50=1.4μM). Analysis of the structure-activity relationship among these coumarins led to the conclusion that the substitution of C-5 position in furanocoumarins reduces greatly their inhibitory potency although the substitution of C-8 does not almost affect it.
호장근의 쿠마린에 의한 RAW 264.7 세포주의 nitric oxide 생성 저해활성
노태철,최희철,이승웅,김영호,노문철,김영국,이현선,Rho, Tae-Cheol,Choi, Hee-Cheol,Lee, Seung-Woong,Kim, Young-Ho,Rho, Mun-Chual,Kim, Young-Kook,Lee, Hyun-Sun 한국생약학회 2001 생약학회지 Vol.32 No.3
During the screening for inhibitors of nitric oxide production in LPS-activated macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of the root of Polygonum cuspidatum. They were identified as decursin (1) and decursinol angelate (2) on the basis of spectroscopic methods. The $IC_{50}$ values of these compounds on NO production were $0.76\;{\mu}M$ (1) and $2.6\;{\mu}M$ (2), respectively. However, the iNOS activity was not inhibited by treatment with these compounds. Their inhibitory effect on NO production seems to result from the suppression of iNOS induction through the suppression of NF-kB activity.
쿠마린에 의한 RAW 264.7 세포주의 Nitric Oxide 생성 저해활성
노태철,최희철,김보연,김영호,안종석,김영국,이현선,Rho, Tae-Cheol,Choi, Hee-Cheol,Kim, Bo-Yeon,Kim, Young-Ho,Ahn, Jong-Seog,Kim, Young-Kook,Lee, Hyun-Sun 한국생약학회 1999 생약학회지 Vol.30 No.4
During the screening for inhibitors on nitric oxide (NO) production in LPS-activated murine macrophage, RAW 264.7 cells, two coumarins were isolated from chloroform extract of Ponciri Fructus. They were identified as imperatorin (10), phellopterin (11) on the basis of spectroscopic methods. The $IC_{50}$ values for NO formatiom were about $5.4\;{\um}M$ and $35.0\;{\um}M$, respectively, and then eleven coumarins were tested for the inhibitory effects on NO production in activated macrophages. All the test coumarins inhibited NO production in concentration-dependent manner and furanocoumarins (6-11) showed much more potent inhibitory effect than simple coumarins. Among the compounds examined xanthotoxin (8) was the most potent inhibitors of NO production $(IC_{50}=1.4\;{\mu}M)$. Analysis of the structure-activity relationship among these coumarins led to the conclusion that the substitution of C-5 position in furanocoumarins reduces greatly their inhibitory potency although the substitution of C-8 does not almost affect it.
노태철(Tae-Cheol Noh) 산업기술교육훈련학회 2011 산업기술연구논문지 (JITR) Vol.16 No.4
The bending properties such as the bending rigidity and hysteresis with various twists of yarn and densities of grey fabric and finished fabric were studied for analysing the effect of finishing process. As a result, bending rigidity of finished fabric was smaller than those of yarn and grey fabric, and the effects of yarn twist and fabric weft density to the bending rigidity were not shown in the state of grey fabric but in finished fabric. The hysteresis of the finished fabrics showed less values than those of the yarn and grey fabric, and the effects of finishing processes to the bending hysteresis were larger than those of the yarn twist and the fabric density.
갯기름나물의 쿠마린에 의한 RAW 264.7 세포주의 Nitric Oxide 생성 저해활성
최희철,노태철,김보연,고학룡,오원근,성창근,민태익,안종석,이현선,Choi, Hee-Cheol,Rho, Tae-Cheol,Kim, Bo-Yeon,Ko, Hack-Ryong,Oh, Won-Keun,Seong, Chang-Keun,Mheen, Tae-Ick,Ahn, Jong-Seog,Lee, Hyun-Sun 한국생약학회 1999 생약학회지 Vol.30 No.2
During the screening for inhibitors of nitric oxide production in LPS-activated macrophage, RAW 264.7 cells. Five coumarins were isolated from chloroform extract of the root of Peucedanum japonicum. They were identified as praeruptorin A (1), xanthotoxin (2), psoralen (3), isopimpinellin (4), bergapten (5) on the basis of spectroscopic methods. The $IC_{50}$ values for nitrite production by activated macrophages were about $1.5\;{\mu}g/ml$ (1), $0.3\;{\mu}g/ml$ (2), $1.0\;{\mu}g/ml$ (3), $25\;{\mu}g/ml$ (4), $25\;{\mu}g/ml$ (5), respectively. However, the inducible nitric oxide synthase (iNOS) was not inhibited by treatment with these compounds. Their inhibitory effect on nitric oxide production was resulted from the supperssion of iNOS expression.