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Collagen으로 유발된 생쥐의 관절염에 대한 당귀사역가오수유생강탕(當歸四逆加吳茱萸生薑湯)의 효과
김민균 ( Min Kyun Kim ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2011 한방재활의학과학회지 Vol.21 No.2
Objectives: This study was carried out to know the effects of Danggwisayeokgaohsuyusaenggang-tang(hereinafter referred to DST) on arthritis induced by collagen on DBA/1 OlaHsd mice. Methods: For this purpose, DST was orally administered to mouse with arthritis induced by collagen Ⅱ. Cytotoxicity, high performance liquid chromatograph(HPLC) analysis, arthritis index, value of immunocyte in draining lymph node and paw joint, cytokine were measured in vivo. Results: 1. The cytotoxicity against human fibroblast cells(hFCs) was not measured in any concentration. 2. In HPLC analysis, There are high peak patterns at 8 minute(min), 12 min, 35 min, 45 min. 3. The arthritis index was decreased significantly. 4. The degree of arthritis induced damage of joint of DST group is slight compared with control group in histopathologic observation(Hematoxylin and eosin stain(H&E), Masson`s trichrome(M-T) staining). 5. In total cell counts of draining lymph node(DLN) and paw joint, the cells in DLN decreased significantly on DST 200 mg/kg and the cells in paw joint decreased significantly on 200 mg/kg and 50 mg/kg. 6. In DLN, CD4+/CD25+, CD3+/CD69+, major histocompatibility complex(MHC) class-II/CD11c+ cells decreased significantly on DST 200 mg/kg and 50 mg/kg, CD3+/CD8+ cells decreased significantly on DST 200 mg/kg, CD4+, CD3+/CD44+ cells decreased. 7. In paw joints, CD4+, CD11b+/Gr-1+ cells decreased significantly on DST 200 mg/kg and 50 mg/kg. 8. In joints, levels of IL-1β, IL-6, TNF-α, cyclo-oxygenase-2(COX-2), NOS-II were decreased on DST 200 mg/kg and DST 50 mg/kg. 9. In analysing of cytokine in CD3/CD28 activated spleen, IL-17 was decreased significantly, IL-4 was increased significantly and INF-γ was decreased on DST 200 mg/kg. 10. In analysing of cytokine in collagen activated spleen, IL-17 were decreased significantly, IL-4 was increased significantly. Conclusions :This results demonstrated that DST suppressed the inflammatory progression of collagen-induced arthritis(CIA) mice and supported further studies are required to survey continuously in looking for the effective substance and mechanism in the future.
김민균,오동훈,Kim, Min-Kyun,Oh, Dong-Hoon 한국벤처창업학회 2014 벤처창업연구 Vol.9 No.6
본 연구의 목적은 해외 사례 및 국내 유사 분야의 협동조합을 대상으로 활동현황을 파악하고, 국내에서 어떠한 형태의 주거와 관련되는 협동조합들을 창업할 수 있는지 이를 유형화하며, 이들을 성공적으로 조성하기 위한 필요한 요소들을 찾아 국내 주거관련 협동조합의 조성에 적합한 시사점을 도출하는 것이다. 주거관련 협동조합의 유형을 수행활동을 기준으로 주택신규공급 및 운영형, 기존주택유지관리 및 개선형, 주택설계 및 성능향상형의 세 가지로 구분하였다. 주택협동조합은 국가주택정책의 차원에서 간접적으로 접근할 수 있도록 해야 한다. 즉, 주택협동조합을 직접 조종하여 주택을 공급해야 한다는 차원보다는 자발적으로 일어나는 주택협동조합을 지원하고 간접적으로 방향을 유도하는 형태의 조치가 필요하다. 협동조합의 조직 형태가 절대적인 善이라고 할 수는 없다. 협동조합에 대한 지나친 보호나 지원정책은 오히려 민간시장영역에서 활동하는 기업체들에게 역차별이 될 수 있으며, 협동조합의 차원에서는 이러한 보호를 남용할 수도 있다. 협동조합이 기존의 경제체제를 완전히 대체할 수는 없겠지만, 보완적인 차원에서 자발적으로 노력하는 협동조합 자체의 움직임이 지역경제의 역동성을 촉진할 수 있다는 가능성에 주목할 필요가 있다. The purpose of this study is to draw the implication for building domestic housing-related co-operatives by understanding activities of housing-related co-operatives from case study and by suggesting the start-up typology for possible domestic housing-related co-operatives and requisites for building them. According to their activities housing-related co-operatives are categorized into three types which are housing supply and operation type, maintain and improve the existing housing type, and design and performance improvement type. National housing policy should be connected to housing co-operatives indirectly. That is, the policy direction ought to be not toward controlling housing co-operatives, letting them supply more houses directly, but toward supporting voluntary co-operatives, showing them the overall housing policy blueprint. Co-operatives cannot be a panacea. Too much protection or support for co-operatives could lead to a reverse discrimination against private companies, and the co-operatives might overuse this kind of prominent position. We need to focus on the possibility of the role of co-operatives as a facilitator for local economy rather than a perfect substitute for the existing economy system.
김민균,허동석,오민석,윤일지,Kim, Min-Kyun,Heo, Dong-Seok,Oh, Min-Seok,Yoon, Il-Ji 척추신경추나의학회 2007 척추신경추나의학회지 Vol.2 No.1
Objectives : To research the trend of the study related to Chuna(推拿) and to establish the direction of further studies into the Chuna(推拿). Methods : We reviewed and analyzed all theses published by Korean research institution. And these theses were classified by research institutions, published year, field of study, subject, research methods, thesis types, illness and symptoms. Results : The following results were obtained in this study. 1. Classified by the major field of study, oriental medicine accounted for 59 papers, followed by 18 in physical education and 2 in the science of nursing and medicine. 2. Upon classifying theses according to research method and thesis types, research related to clinical trial accounted for nearly half of all theses. It was followed by consideration of documents. 3. After 1998 deals with the effects of the Chuna on variable illnesses such as: ossified posterior longitudinal ligament, chronic coccyalgia, entrapment neuropathy, low birth weight infant, Bell's palsy, stress incontinence, paramenia, Parkinson disease, Bertolloti syndrom, TMJ (because of scoliosis) etc. 4. Two most widely cured illnesses using the Chuna therapy are scoliosis and HNP of L-spine. However, when considering the fact that several clinical tests and casuistics did not include research into Lumbago (including HNP of L-spine), it can be concluded that most of the Chuna therapies have been concentrated on Lumbago. Conclusion : As it can be seen in the above results, the possibility of curing illness through Chuna and the usefulness of Chuna have been shown factually and clinically through various consideration of documents, clinical trial & casuistics. Based upon such facts, it is regarded that further scientific research along with additional clinical approaches involving the Chuna should be performed.
김민균 ( Min Kyun Kim ),황재필 ( Jae Pil Hwang ),김현수 ( Hyun Soo Kim ),홍서영 ( Seo Young Hong ),허동석 ( Dong Seok Heo ),윤일지 ( Il Ji Yoon ),오민석 ( Min Seok Oh ) 한방재활의학과학회 2007 한방재활의학과학회지 Vol.17 No.4
Objectives : There are a few case reports on the treatment of fracture in patients undergoing osteoporosis by herbal medication with acupuncture and physical therapy. We got a good results on two patients with fracture undergoing osteoporosis by herbal medication with acupuncture and physical therapy. Methods : Patients were hospitalized at Dept. of Oriental Rehabilitation Medicine, College of Oriental Medicine, Dae-Jeon University, diagnosed as fracture with osteoporosis and treated mainly herbal medication ; Chungajihwang-tang(Q?nge?di?hua?ng-ta?ng), with acupuncture and physical therapy. This study was measured by radiography, BMD(Bone Mineral Density) and VAS(Visual Analog Scale) score. Results & Conclusions : Symptoms of patient such as fracture with osteoporosis were improved following the treatment. Gross synostosis on radiography, VAS score decreased and BMD value incresed in both two patient. So it is suggested that oriental medical treatment; herbal medication with acupuncture and physical therapy are effective in fracture in patients undergoing osteoporosis
봉약침으로 주관절통증과 기능부전을 치료한 Tennis Elbow 환자의 1례 증례보고
김민균 ( Min Kyun Kim ),윤일지 ( Il Ji Yoon ),오민석 ( Min Seok Oh ) 대전대학교 한의학연구소 2009 혜화의학회지 Vol.18 No.2
Objective: There is a case reports on treatment of elbow pain and dysfunction in patients diagnosed as Tennis elbow. We report the Bee venom Acupunure Theraphy about under using elbow pain and dysfunction in patients diagnosed as Tennis elbow got a good remedial value. Methods: The patients diagnosed as Tennis elbow and treated mainly with Bee venom Acupunture Therapy. Results & Conclusions: Symptoms of the patient such as elbow pain and dysfunction were improved after above treatments. So, it is suggested that oriental medical treatment(Bee venom) are effective on Tennis elbow.
김민균 ( Min Kyun Kim ),김현수 ( Hyun Soo Kim ),황재필 ( Jae Pil Hwang ),홍서영 ( Seo Young Hong ),허동석 ( Dong Seok Heo ),윤일지 ( Il Ji Yoon ) 한방재활의학과학회 2008 한방재활의학과학회지 Vol.18 No.3
Objectives : To report one case of semi-coma patient was treated by scalp acupuncture with electric stimulation. Methods : Patient (state of semi-coma) was treated by scalp acupuncture with electric stimulation, herbal medication and physical therapy. The improvement of patient was measured every other week by Glasgow Coma Scale(GCS), Modified Bathel Index(MBI), National Institutes of Health Stroke Scale(NIHSS). Results : We observed the patient decrease in NIHSS score and increase in GCS and MBI. Symptoms of patient such as semi-coma were improved following the treatment. Conclusions : It is suggested that oriental medical treatment; scalp acupuncture with electric stimulation, herbal medication and physical therapy were effective in semi-coma caused by traumatic brain injury.