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만성신부전 환자의 이차성부갑상선 기능항진증에 혈액투석이 미치는 영향
김만우,조건국,채종구 대한신장학회 1987 Kidney Research and Clinical Practice Vol.6 No.2
In the first few weeks after initiation of maintenance hemodialysis in 14 patients with chronic renal failure, there was a progressive rise in total serum calcium associated with a reciprocal and significant fall in the concentration of plasma parathyroid hormone. Studies in 16 additional patients with chronic renal failure already on hemodialysis indicated that this favorable trend did not continue: a progressive rise in parathyroid hormone concentration was associated with increasing duration of hemodialysis against the calcium concentration generally used by most concentration from 2.5 to 3. 5 mEq/l for a 2 months period failed to decrease parathyroid hormone secretion or cause a significant increase in predialysis calcium concentration in 16 uremic patients. Use of high calcium dialysis earlier in the course of the disease, alternate means of parathyroid suppression, subtotal parathyroidectomy may be necessary for the management of hyperparathyroidism in uremic patients undergoing hemodialysis. Following results were obtained 1) The protocol I patients studied prior to the initiation of hemodialysis had a mean total serum calcium of 3.91±0.4 mEq/I that rose to 4.35±0.6 mEq/1 after two dialyses and a 3 day interval. After 1 week mean total serum calcium increased to 4. 37±0.5 mEq/l. The significant rise in total serum calcium at 1 and 2 months was accompanied by a reciprocal and significant fall in PTH from a mean concentration of l. 39±0.3~0.74±0.3 ng/ml over the same period. 2) Of the patients studied by Group I, Protocol 2, after 2 months of hemodialysis during which calcium concentration in the bath was increase from 2.5 to 3.5 mEq/1, there was no significant change in the 7 patients (Group 2). 3) When mean PTH and length of time on hemodialysis were compared in the same patients, a significant correlation coefficient of 0.54 was demonstrated.
태음조위탕(太陰調胃湯)의 항산화(抗酸化) 효능(效能)에 의한 간세포(肝細胞) 보호(保護) 효과(效果)에 관한 연구(硏究)
김만우,박성식,Kim, Man-woo,Park, Seong-sik 사상체질의학회 2001 사상체질의학회지 Vol.13 No.1
Effects of Taeumjowetang on Lipid Peroxidation by Free Radicals and Oxidative Damage of Hepatocytes by tert-Butyl Hydroperoxide. 1. Purpose The present study was carried out to evaluate the antioxidant effects of Taeumjowetang in vitro. 2. Methods In this study, antioxidant effects of TJT on lipid peroxidation were determined according to the method of TBA. (Abbreviation) TJT : Taeumjowetang, TBA : 2-thiobarbituric acid. 3. Results : 1) TJT inhibited markedly peroxidation of linoleic acid during the autoxidation. 2) TJT inhibited lipid peroxidation induced by hydroxyl radical derived from H2O2-Fe2+ in rat liver homogenate. 3) TJT showed 66% scavenging effect on DPPH radical. 4) TJT exhibited a 25% inhibitory effect on superoxide generation from xanthine-xan thine oxidase system. 5) To investigate the antioxidative effects of TJT on the hepatocytes, cultured normal rat liver cells(Ac2F) were prepared and incubated with or without TJT. After 16~18hr, cells placed in DMEM medium without serum, and then incubated with 1mM t-BHP for 2hr. Viable cells were detected by MTT assay. In this test, TJT protected the cell death induced by t-BHP and significantly increased cell viability in the normal rat liver cell. (Abbreviation) DPPH : ${\alpha},{\alpha}$-diphenyl-${\beta}$-picryl hydrazyl, DMEM : Dulbecco's Modified Eagle Medium, t-BHP : terr-butyl hydroperoxide, 4. Conclusion These results suggested that TJT might play a protective role in lipid peroxidation by free radicals.
각종 암종질환에서 혈청구리 및 아연농도의 변화에 관한 연구
김만우,오금탁,장경식,채종구,홍순표,조건국 朝鮮大學校 附設 醫學硏究所 1987 The Medical Journal of Chosun University Vol.12 No.1
The copper and zinc concentrations were measured in sera of 27 cases of hepatoma, 20 cases of stomach ca., 7 cases of esophageal ca., 12 cases of colorectal ca., 9 cases of lung ca., 18 cases of ovarian ca. and 48 cases of normal control in Chosun University Hospital from Jan. 1986 to July 1986. The results are as follows; 1. The mean concentration of copper in serum of normal control group was 96.0±5.02㎍/㎗ (Mean±2SE), in hepatoma, stomach ca., esophageal ca., colorectal ca., lung ca. and ovarian ca. concentrations were significantly increased each 126.4+12.77, 125.6±11.29, 140.5±14.23, 117.3±11.91, 181.4±30.56 and 130.5±13.80㎍/㎗ (P < 0. 001) in comparison with the mean value of normal control group. 2. The mean concentration of zinc in serum of normal control group was 104.8±3.40㎍/㎗ (Mean±2SE), in hepatoma and lung ca. concentrations were significantly decreased each 65.1±7.27 and 72.7±12.86 ㎍/㎗ (P < 0. 00l). 3. The ratio of serum copper level to zinc level (Cu/Zn ratio) in serum of normal control group was 0.94±0.057 in hepatoma, stomach ca., esophageal ca., lung ca. and ovarian ca. concentration ratios were significantly increased each 2.09±0.324, 1.86±0.122, 1.50±0.114, 2.55±0.513 and 1.51±0. 243 (P < 0.001).