뇌졸중환자의 동적 균형 평가를 위한 sit-to-walk의 신뢰도 연구

김다연,최종덕,기경일,Kim, Da-Yeon,Choi, Jong-Duk,Ki, Kyong-Il 대한물리치료학회 2013 대한물리치료학회지 Vol.25 No.5

Purpose: The purposes of this study were to evaluate the correlation of clinical tools for assessment of balance and ability of gait, in order to discriminate the phases of sit-to-walk movement of patients with stroke using the motion analysis system, and to investigate the reliability of the phase of sit-to-walk movement according to functional ability of patients with stroke. Methods: Twenty -one patients participated (men 17, women 4) in this study. Sit-to-walk movement of all patients was recorded by the motion analysis system. Berg Balance Scale, Timed Up and Go test, Functional Reach Test, 10 meter Walk Timed Test, and Performance-Oriented Mobility Assessment were used as functional assessment tools. Results: The results of this study showed significant correlation between the phase I, II, IV and total phase duration of sit-to-walk movement and functional assessment tools. In addition, the intraclass correlation coefficient (ICC) showed high reliability in accordance with the functional ability of patients with stroke (Pearson's r 0.93 to 1.00). Conclusion: In conclusion, there is high reliability between measures of the phase of sit-to-walk movement of chronic stroke patients and the clinical assessment tool. Results of this study suggest that measurement of the phase of sit-to-walk movement can be used significantly as an intervention and a clinical tool for patients with stroke.

Bacillus velezensis YP2 균주의 근권 정착에 의한 케일의 생육 촉진 및 건조 스트레스 완화 효과

김다연,한지희,김정준,이상엽,Kim, Da-Yeon,Han, Ji-Hee,Kim, Jung-Jun,Lee, Sang-Yeob 한국유기농업학회 2018 韓國有機農業學會誌 Vol.26 No.2

전 세계적인 지구 온난화로 인한 가뭄은 농작물의 생산성을 저해하는 주요 원인 중 하나이며, 고온과 건조가 복합적으로 작용하여 식물 생장을 감소시킨다. 본 연구에서는 Bacillus velezensis YP2 균주의 식물 생육촉진 및 건조 스트레스 내성 증진 효과를 온실과 시설하우스 포장에서 조사하였다. 또한 B. velezensis YP2 균주의 처리 전과 후 케일 근권과 뿌리에서 배양법에 의한 상대 정량 방법으로 B. velezensis YP2 균주의 근권 및 뿌리 정착능을 분석하였다. 온실 검정 결과 YP2 균주 처리구에서는 무처리구와 비교하여 케일 유묘의 초장 26.7% 및 지상부 생체중 142.2% 증가시키는 효과가 있었다. 또한 B. velezensis YP2 처리구에서는 무처리구와 비교하여 39.4%의 건조 피해 경감 효과가 있었다. 시설하우스 포장 검정 결과에서도 B. velezensis YP2 균주 처리에 의한 케일의 생장촉진 효과와 건조 스트레스 내성 증진 효과가 있었으며, B. velezensis YP2 처리구에서 케일 잎의 상대수분함량이 무처리구와 비교하여 7, 10, 14일에 모두 높은 것으로 나타났다. B. velezensis YP2 균주의 뿌리 정착능 분석 결과, 균주 처리 21일까지 케일 근권 및 뿌리 균밀도가 무처리구와 비교하여 B. velezensis YP2 처리구에서 유의하게 높은 것으로 나타났다. 따라서 균주 처리 후 최소한 21일이 경과할 때까지 B. velezensis YP2 균주가 케일 근권과 뿌리에 정착하여 식물과 상호작용함으로서 생육을 촉진하고 식물의 물 이용률을 증가시켜 건조 스트레스 내성을 증진하는 데 관련이 있을 것으로 판단된다. 본 연구 결과를 통하여 B. velezensis YP2 균주는 가뭄으로 인한 건조한 토양 조건에서 작물 생산성을 향상시키는 가능성이 있는 유용한 미생물로 이용할 수 있을 것으로 생각된다. Drought is a major obstacle to high agricultural productivity, worldwide. In drought, it is usually presented by the simultaneous action of high temperature and drying. Also there are negative effects of plant growth under drying conditions. In this study, the effect of Bacillus velezensis YP2 on plant growth-promotion and soil drying stress tolerance of kale plants, Brassica oleracea var. alboglabra Bailey, were investigated under two different conditions; greenhouse and field environments. Root colonization ability of B. velezensis YP2 was also analysed by using plating culture method. As a result of the greenhouse test, the YP2 strain significantly promoted the growth of kale seedlings in increasement of 26.7% of plant height and 142.2% of shoot fresh weight compared to control. B. velezensis YP2 have the mitigation effect of drying injury of kale by decreasing of 39.4% compared to control. In the field test, B. velezensis YP2 strain was also found to be effective for plant growth-promotion and mitigation of drying stress injury on kale plants. Especially, relative water contents (RWC; %) were higher in B. velezensis YP2 treated kales than in control at 7, 10, 14 day after non-watering. The root colonization ability of YP2 strain was continued at least for 21 days after soil drenching treatment of B. velezensis YP2. Our result suggested that enhancement of plant growth and drying injury reduction of kale plants were involved in kale root colonization by B. velezensis YP2, which might be contributed to increasing water availability of plants. Consequentially, the use of B. velezensis YP2 might be a beneficial influence for improving productivity of kale plants under drying stress conditions.

폐도금액내 유가금속 회수를 통한 경제성 분석

김다연 ( Da Yeon Kim ),강홍윤 ( Hong Yoon Kang ),이종효 ( Jong Hyo Lee ),권택관 ( Taek Kwan Kwon ),김춘산 ( Chun San Kim ) 한국전과정평가학회 2022 한국전과정평가학회지 Vol.23 No.1

우리나라는 2018년 기준 전기전자 분야에서 은 수요는 249백만 톤으로 조사되었으며, 태양광 모듈용으로는 81백만 톤으로 조사되었다. 현재 태양광 모듈 설치의 급증으로 해당 분야의 은 사용량 또한 증가하고 있는 추세이다. 그러나 우리나라의 금속자원 및 부존량은 소비량 대비 부족한 실정이며, 금속자원 중 은광의 국내 자급률은 1.5%로 매우 낮은 상황으로 조사되어 이를 개선하기 위해 금속산업에서 발생하는 폐도금액내 함유되어 있는 유가금속 자원회수기술을 통한 재활용이 필요하다고 판단된다. 따라서, 본 연구에서는 B/C 분석을 통해 폐도금액 내 유가금속 회수공정 개선에 따른 경제성 분석하고자 하였다. 그 결과, B/C비는 1.48로 사업의 타당성이 있는 것으로 확인되었다. 따라서, 재자원화 기술의 발전이 화학물질 및 에너지의 사용 절감할 수 있으며, 이를 통해 도시광산산업에서 자원생산성을 향상시킬 수 있을 것으로 판단된다. In 2018, The silver(referred to as Ag) demand in the electrical and electronic field was 249 million tons, and for producing solar modules, 81 million tons of silver were demanded. Currently, due to the rapid increase in solar module installation, the silver demand is also increasing drastically in Korea. However, Korea's metal resources and reserves are insufficient compared to consumption, and the domestic self-sufficiency rate of silver ores among metal resources is lower than 1.5%. It implies that the recycling technology for recovering valuable metal resources contained in the waste plating solution generated in the metal industry is necessary. Therefore, in this study, through B/C analysis, the economic evaluations were compared and analyzed according to the improvement of the valuable metal recovery process in the waste plating solution. As a result, the B/C ratio was 1.48, which means feasibility. Therefore, the improvement of recycling technology has a high possibility to reduce the usage of chemicals and energy, and to improve resource productivity in the urban mining industry.

miRNA 와 mRNA 통합 분석을 위한 웹 기반 시스템 개발

김다연 ( Da-yeon Kim ),고윤희 ( Younhee Ko ) 한국정보처리학회 2022 한국정보처리학회 학술대회논문집 Vol.29 No.2

기존의 질병 관련 연구들은 대부분 유의미하게 변화되는 유전자들을 찾아내고(Differentially Expressed Genes, DEGs), 이들이 연관된 생물학적 패스웨이(biological pathway)를 찾아내는 방향으로 이루어졌다. 더불어 miRNA(microRNA)가 많은 mRNA 의 발현을 조절하며, 실제 면역, 대사 및 세포 사멸을 포함한 여러 필수 생리학적 및 질병에 매우 중요한 역할을 한다고 밝혀지며, 바이오 마커로써의 miRNA 를 찾아내고자 하는 연구가 활발히 진행되기 시작하였다. 하지만 mRNA 나 miRNA 의 독립적인 연구만으로는 명확한 질병과의 연관성이나 기능을 이해하기에는 어려움이 있다. 따라서 본 연구에서는 질병 상태에서 유의미하게 변화되는 miRNA 와 이러한 miRNA 에 의해 조절되는 mRNA 를 함께 고려하여 분석함으로써, 실제 질병의 발병 원인이 되는 생물학적 패스웨이나 메커니즘을 밝히고자 하였다. 또한, miRNA 와 mRNA 의 연관성을 찾기 위해, PPI(protein-protein interaction) 네트워크에 기반을 둔 RWR(Random Walk with Restart Algorithm)를 적용하여, 직접적 연관성뿐 아니라, 유전자 간의 숨겨진 간접적인 패스웨이를 고려하여 분석하기 위한 웹 기반 시스템을 개발하였다. 이 시스템은 mRNA-miRNA 를 함께 고려한 통합 분석을 통해 숨겨진 질병의 메커니즘을 이해하고 치료 방법을 찾아내는 데 크게 공헌할 것이다.

학습자 오개념의 양상 및 형성 요인 연구 음운 교육 내용을 중심으로

김다연 ( Kim Da-yeon ) 서울대학교 국어교육과 2019 先淸語文 Vol.46 No.-

Interpretation on the same object will differ by individual because a person’s perception on the object is assimilated differently according to the person’s preunderstanding or cognitive structure. This is also applies to a learner's understanding of grammar concepts. In spite of the fact that constructivism, which is an epistemological theory of knowledge formation, has become more specific in the field of learning, discussions on grammar education have been focused only on how to convey the concepts of grammar without paying much attention to how learners actually form grammar concepts. Here, concept formation means that learners are able to use concepts flexibly in various circumstances. Thus, whether a grammar concept functions as activated knowledge or merely exists in an ineffective state depends on how the concept is internally conceptualized by a learner. Therefore, the purpose of this study is to examine how learners, who have completed all the phoneme-related curriculum, understand the concepts they have learned, and to suggest educational contents for promoting leaners’ grammar concept formation based on the findings. Phonological education, in particular, is worth analyzing since phonology is an area for which most learners feel considerable cognitive burden even when they have already accumulated abundant voluntary concepts through experiences of pronunciation and notation before explicit learning of the scientific concepts. In chapter Ⅱ, grammar concepts are analyzed in terms of how they function as a learner’s cognitive framework for language phenomena and moreover as the learner’s tool for language operation. Here, a learner’s misconception, which is a subjective concept antithetical to scientific concept, is regarded as ‘an alternative concept for consensual concept,’ so as to emphasize that phonological education should take note of a learner’s thinking process advancing towards understanding with greater explanatory power. In addition, pointing out the fact that misconceptions has been considered merely as an object to be handled in the process of introducing them, which had been actively discussed mainly in science subject, into grammar education, this chapter demonstrates how misconceptions can be used as meaningful resources for the development of learners’ grammar concepts if they are re-conceptualized as ‘transitional concepts with potential’ based on the discussion of intermediate language. Also, after analyzing the factors of misconception formation in terms of internal and external factors of the learners, this chapter discusses the importance of understanding the learners’ current cognitive level and providing experiences to overcome it, considering the fact that a learner’s misconceptions especially stem from his/her familiar way of thinking. In Chapter Ⅲ, the patterns of misconceptions about phonological educational concepts were examined with high school learners along with the factors of forming those misconceptions. The main survey was conducted with the learners using a misconception test tool developed based on the measurements of subjective perceptions of phonology related concepts and the results from preliminary survey. Additional interview was conducted with the learners who showed distinctive responses in the survey. The patterns of misconception were analyzed along concepts as well as groups in the upper, middle, and lower level according to their correct response score. First, from the analysis of misconceptions by concepts, the learners’ misconceptions were presented in reference to phoneme, semi-vowel, diphthong, Korean Coda Rule, consonant cluster, palatalization, and ‘Saitsori’ phenomena. Second, comparing the correct response rates between the three groups by level, the concepts indicating significant difference between the groups and those showing relatively even errors from the groups were identified to present the misconceptions characteristically found in each group. Thus, the misconceptions analyzed were generalized and categorized as ‘conceptual inference based on type of notation’, ‘errors at the level of discovering concepts’, ‘lack of discerning applicable cases from non-applicable cases’ so as to determine the properties of phoneme-related misconceptions distinctive from concepts in other areas. As for the learners’ internal factors resulting in these misconceptions, their cognitive features found in this study included errors in categorizing concepts, such as assigning phoneme-related concepts not in the category of sound but in the category of notation, in addition to conceptualization relying on experience, lack of understanding for concept structure, and excessive generalization of concepts. Meanwhile, it was found that the learners’ external factors of these misconceptions involved the problems related to the internal consistency of the concepts, misconceptions of the teachers, and the problems in the presentational dimension of the textbooks, including lack of consideration for the spontaneous conceptions of learners, elimination of the context of conception formation of learners, and lack of explanation about the conditions for applying concepts. In Chapter Ⅳ, with the aim of developing learner’s phonological ability, a teaching and learning method that will improve grammar concepts was developed by using misconceptions in educational ways. After meta-checking the process of misunderstanding and the causes of cognitive conflicts based on misconceptions, grammar inquiry learning based on the learners’ misconceptions was proposed, such as a course comparing the explanatory power between concepts of school grammar, which can be seen as the tentative agreement with the learners’ conceptions. In addition, since the cognitive level of the learners’ needs to advance to a higher level for their concept development, conceptualization lessons were designed and subsequently implemented, in which prescriptions for the internal factors of misconception formation found in this study involved improving understanding in categories of concepts, differentiating experience from thinking by objectifying experiences, complementing understanding in concept structure, and restoring the context of conception formation. This study attempted to re-conceptualize from a developmental point of view misconceptions of learners, which has recently begun to be treated within the context of grammar educational, and to empirically analyse the patterns and factors of formation. This study has educational significance in that, in addition to identifying phoneme-related misconceptions of learners, it suggested concrete educational contents and method utilizing those misconceptions.

한국 특산식물 버들개회나무의 형태적 특성 비교 분석

김다연(Da Yeon Kim),신희선(Hee Sun Shin),전정일(Jeong Ill Jeon),김완순(Wan Soon Kim) 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10

버들개회나무(Syringa fauriei H.Lév.)는 물푸레나무과(Oleaceae)의 수수꽃다리속(Syringa L.), 개회나무아속(subgenus Ligustrnia 에 속하는 우리나라 특산식물이다. 본 종은 금강산 및 강원도 일대에 강과 계곡을 따라 분포한다. 버들개회나무는 특히 꽃차례의 꽃 밀도가 높기 때문에 개화기간 동안 수관 전체가 흰색 꽃으로 덮여 꽃향기가 좋고 관상 가치가 높은 식물이다. 그러나 국외 학자들의 분류학적 이견이 제기됨에 따라 본 종은 독립된 종으로 인정받지 못하고 근연 분류군인 S. reticulata subsp. amurensis의 이명으로 처리되고 있다. 본 연구에서는 같은 아종으로 이명 처리되고 있는 버들개회나무(S. fauriei)와 개회나무(S. reticulata var. mandshurica)를 대상으로 외부형태학적 형질을 재검토하였다. 2020년 5~6월 개화기간 동안 자생지에서 야외관찰하거나, 수집한 건조표본과 액침표본을 관찰 및 측정하였다. 이들에 대한 영양기관과 생식기관에서 48개의 형태학적 형질을 조사한 결과, 기존의 연구에서 제시된 주요 식별형질인 잎의 형태와 엽병 길이, 개화기 등이 본 종을 구별하는 데 유용한 형질임을 재확인하으며 꽃차례의 단위길이당 꽃수, 꽃차례의 1차 화경 길이 등 꽃차례와 꽃을 중심으로 추가한 조사형질에서 본 종은 개회나무와 구별되었다. 본 연구 결과는 버들개회나무를 독립된 종으로 보는 견해를 지지한다.

자생식물 주걱댕강나무, 섬분꽃나무의 삽목 효과

김다연(Da Yeon Kim),신영찬(Yeong Chan Shin),연제연(Je Yeon Yeon),이유리(Yuri Lee),강보경(Bo-kyeong Kang),양하람(Ha Ram Yang),이호진(Ho Jin Lee),김완순(Wan Soon Kim) 한국원예학회 2023 한국원예학회 학술발표요지 Vol.2023 No.10

허혈성 심혈관 질환의 치료제로서 혈관내피전구세포(EPC)의 가능성에 대한 고찰

김다연(Da Yeon Kim),김보민(Bo Min Kim),김소정(So Jung Kim),최진희(Jin Hee Choi),권상모(Sang-Mo Kwon) 한국생명과학회 2020 생명과학회지 Vol.30 No.7

허혈성 심혈관질환은 전 세계적으로 치사율이 높은 질병 중 하나이다. 이를 치료하기 위해 수술적 방법이 시행되고 있으나, 손상된 심근조직 회복의 어려움과 수술 후 부작용의 한계가 남아있다. 이러한 한계점을 극복하기 위해, 최근 줄기세포를 기반으로 한 심혈관질환의 세포치료제가 각광받고 있는데 그 중에서도 특히 혈관내피전구세포(EPC)는 높은 증식능과 분화능을 기반으로 손상된 혈관을 재생하고, 주변 조직의 재생을 돕는다는 장점이 있다. 또, EPC는 임상적으로 안전하며, 환자의 심근 기능을 회복시켜주기에 잠재적인 심혈관질환 치료제로서의 가능성이 대두되었다. 하지만, 환자 유래 EPC를 이용한 치료법은, 고령, 흡연 여부, 기저질환 등의 이유로 환자의 EPC 기능이 저하되어 있어, 그 치료 효능을 기대하기 어렵다. 따라서, 최근에는 세포 프라이밍 기법, 오가노이드 배양법과 같이 EPC의 생리학적 활성도를 올리는 체외 배양법의 개발과 3D 바이오프린팅 기법을 이용한 EPC의 이식 효율을 높여 치료 효능을 개선시킬 수 있는 새로운 접근법이 연구되고 있다. 본 연구에서는 EPC의 특징과 세포치료제로서의 임상적용 가능성에 대해 살펴보고자 한다. Cardiovascular disease is one of the leading causes of death across the world, and gold-standard treatments such as percutaneous coronary intervention and artery bypass grafting have various limitations including myocardial damage and subsequent maladaptive cardiac remodeling. To overcome this, stem-cell therapies are emerging as a promising strategy for cardiovascular regeneration. Endothelial progenitor cells (EPCs) have high potential to proliferate and differentiate into endothelial cells for vascularization and tissue regeneration, and several clinical trials have explored EPC function in tissue repair in relation to clinical safety and improving cardiac function. Consequently, EPC has been suggested as a feasible stem-cell therapy. However, autologous EPC transplantation in cardiovascular disease patients is restricted by risk factors such as age, smoking status, and hypertension that lead to reduced bioactivity in the EPCs. New approaches for improving EPC function and stem-cell efficacy have therefore been suggested, including cell priming, organoid culture systems, and enhancing transplantation efficiency through 3D bioprinting methods. In this review, we provide a comprehensive understanding of EPC characteristics, therapeutic approaches, and the current state of clinical research into EPCs as stem-cell therapy for cardiovascular disease.

이산화탄소기반 고리형 카보네이트 및 폴리카보네이트 제조 연구 동향

권두연(Doo Yeon Kwon),김재일(Jae Il Kim),강휘주(Hwi Ju Kang),김다연(Da Yeon Kim),김재호(Jae Ho Kim),이봉(Bong Lee),김문석(Moon Suk Kim) 한국청정기술학회 2011 청정기술 Vol.17 No.3

온실효과 유발 이산화탄소는 학문적, 산업적 관점에서 이산화탄소 기반 폴리카보네이트 제조에 대한 원료로서 적용 가능하다. 그러므로 이산화탄소 기반 폴리카보네이트는 탁월한 경제적 녹색고분자이다. 최근 이산화탄소 기반 폴리카보네이트의 빠른 개발이 산업적으로 새로운 기회를 제공하고 있다. 본 총설에서는 다양한 촉매 존재하에서 이산화탄소 및 에폭사이드계열 화합물을 이용한 고리형 카보네이트 모노마 제조 및 제조된 모노마로부터 이산화탄소 기반 폴리카보네이트 제조에 대한 연구 동향을 설명하고자 한다. The green house gas, carbon dioxide, can be utilized as raw materials to prepare carbon dioxide-based polycarbonates in research and industry. The carbon dioxide-based polycarbonates is one of the emerging low-cost green polymers. Recently, the fast development of carbon dioxide-based polycarbonates has created new chances for industry. In this review, we describe the preparation and characterization of cyclic carbonate monomer using carbon dioxide, oxiranes and oxetanes in the presence of various catalysts and preparation of polycarbonates from cyclic carbonate monomer, presenting an organized and detailed overview of the state of the art.

앉고 일어서기 동작에서 점진적 체중 이동을 이용한 시각적 되먹임 훈련이 만성 편마비 환자의 균형 및 보행능력에 미치는 영향

김경환,박성훈,김형민,박노욱,김다연,Kim, Kyung-hwan,Park, Sung-hoon,Kim, Hyung-min,Pak, Noh-wook,Kim, Da-yeon 대한고유수용성신경근촉진법학회 2017 PNF and Movement Vol.15 No.1

Purpose: This study aimed to investigate the effect of visual feedback training-for gradual weight shift in sit-to-stand training-on the balance and walking abilities of chronic hemiplegia patients. Methods: Twenty patients with chronic hemiplegia volunteered to participate in this study. The experimental group received visual feedback for gradual weight shift in the sit-to-stand training, while the contrast group followed the standard process for the sit-to-stand training. The evaluation of the balance and walking ability was conducted with the functional reach test (FRT), Berg balance scale (BBS), five time sit-to-stand (FTSTS) test, timed up and go (TUG) test, 10 m walk test (10MWT), balancia, activities-specific balance confidence (ABC) scale, and falls efficacy scale (FES). Results: In the results before and after intervention, there was a significant difference in TUG, 10MWT, ABC, and FES in the visual feedback training group (p < 0.05). In the control group, there was a significant difference in the 10MWT and ABC (p < 0.05). Also, in the evaluation of the postural fluctuations, the control group data showed a significant increase in Covar. The visual feedback group showed a significant difference in the W average. Conclusion: The visual feedback training group showed some improvement in terms balance and walking ability and on the ABC scale and FES. Therefore, if the diagonal progressive weight bearing exercise is combined with the various patterns and basic principles of PNF, it may be a more efficient intervention method.