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최용철,이창섭,왕순주 한국화재소방학회 2003 한국화재소방학회논문지 Vol.17 No.1
응급구조사는 매년 그들이 가지고 있는 지식과 기술을 유지하고 신장시키기 위해 일정시간 보수교육을 받도록 되어 있다. 보수교육과정은 급변하는 의료환경에 대응할 수 있도록 편성·운영되어야 한다. 그러나 우리나라에는 합리적인 교육과목 및 교과내용을 포함하는 표준교과과정이 없다. 따라서 본 연구는 표준교과과정을 개발하기 위해 선진국의 다양한 보수교육과정들을 분석하고 교육욕구에 대한 설문을 실시하였다. 개선방안은 다음과 같다 : (a) 교과목의 수를 늘리고 내용을 세분화시켜야 한다. (b) 과목별 합리적인 수업시간이 배정되어야 한다. (c) 현장실무에 적용가능한 교과과정이 편성되어야 한다. (d) 보수교육의 회수를 늘려서 교육기회를 확대하여야 한다. (e) 교육여건을 개선하고 교육결과에 대한 평가와 환류가 이루어져야 한다. 이러한 개선방안들을 토대로 하여, 본 연구에서는 보수교육의 표준교과과정(안)을 제시하였다. As EMTs(Emergency Medical Technician), they will be required to attend a certain number of hours of continuing education each year to maintain, update, and expand their knowledge and skills. Continuing Education courses must be designed to keep up with the rapid changes in medicine. But, there are no standard CE curricula including reasonable subject matters and contents in this country. This paper analyzed many different CE curricula in advanced countries and examined the survey for educational needs to develop a standard CE curriculum. The following alternative plans to improve was proposed : (a) The subject matters should be enlarged and the contents subdivided. (b) The reasonable school hours of each subject matter should be allocated. (c) The applicable curriculum to the field affairs should be designed. (d) The frequency of CE should increased to expand an educational chance. (e) The educational circumstances should be improved, the educational outcomes be evaluated and flowed back. On the basis of the above alternatives plans, this paper proposed a model for the standard CE curriculum.
소방 2급응급구조사의 성인 심폐소생술에 대한 숙련도 분석
최용철,이창섭,왕순주 한국화재소방학회 2004 한국화재소방학회논문지 Vol.18 No.1
Purpose: The purpose of this study is to predict a reasonable direction to design a pertinent educational program in the future by evaluating an adult CPR (Cardiopulmonary Resuscitation) skill per-formed by EMTs engaged in fire services organization and comparing the CPR success rate of Factors as like a duty place and licensed year. Methods: We studied CPR skill by the use of a CPR manikin(Skillmeter Resusci Annie, Laerdal company). The study population consisted of 320 EMTs. Every EMT performed four cycle after investigating the manikin for 2 minutes. We regarded chest compression with 100 times in a minute as the 100% success rate. We analysed the skill of chest compression, ventilation and chest Compression times- success rate by the records printed in the CPR paper. Results: The average success rate of chest compression was 59.42 f 29.26% and ventilation 49.22 129.65%. The success rate of manual CPR was different between chest compression and ventilation. Also the success rate of chest compression times was high relatively as a 87.32+9.14%(p=0.000). For the CPR skill, ventilation was lowest as 49.22%. The factors such as duty place and licensed year did not influence the CPR success rate (p>0.001). Conclusion: We could have conclusion that CPR training should be shared more time in ventilation than in chest compression. Also we could reach to a conclusion that it is important to increase the times of CPR training for improving the accuracy of CPR and that the continuing education of CPR training frequency might be more than four times in a year.
( Wang Yong Choi ),( Woo Jin Chung ),( Si Hyun Bae ),( Do Seon Song ),( Myeong Jun Song ),( Young Seok Kim ),( Hyung Joon Yim ),( Young Kul Jung ),( Sang Jun Suh ),( Jun Yong Park ),( Do Young Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The treatment responses of advanced hepatocellular carcinoma( HCC) with portal vein tumor thrombosis(PVTT) were not acceptable and treatment modalities were limited. So, we compared effects and safety of sorafenib vs. hepatic arterial infusion chemotherapy( HAIC). Methods: We prospectively collected data of 58 advanced HCC with PVTT patients whose Child-Turcotte-Pugh(CTP) score range 5 to 7 in 6 university hospitals from January 2013 to Oct 2015. Each twenty nine patients were treated with sorafenib or HAIC. Results: 1. The mean age was 60.2±8.4 years old and 89.7% of the patients were male. Causes of HCC were HBV (67.3%), HCV (8.6%), alcohol (19.0%) and others (5.2%). CTP class A was 89.7%, modified Union for International Cancer Control (mUICC) stage IVa was 63.8%, tumor diameter >10cm was 55.2%, multiple tumor was 60.3%, infiltrative type was 56.9%, main PVTT was 63.8%, median AFP value was 240.4 ng/ml. 2. 29 patients were enrolled to each groups. Baseline characteristics( sex, mean age, cause of HCC, mUICC stage, size of tumor, number of tumor, type of tumor(nodular, massive, infiltrative, diffuse), location of PVTT(main, main+branch, branch). CTP class, median value of AFP) has no significant difference between two groups. 3. The objective response rate was 38.1% in HAIC and 4.5% in sorafenib group (p=0.003). In univariate analysis, treatment modality, main portal vein invasion, objective response, massive tumor type were significant prognostic factors of overall survival (p=0.012, 0.046, 0.011, 0.041) and treatment modality, tumor number, massive tumor type were significant prognostic factors of time to progress (p=0.004, 0.043, <0.01). In multivariate analysis, objective response was a significant prognostic factor of overall survival (p=0.048) and treatment modality was a significant prognostic factor of time to progress (p=0.016). 4. Major complications were neutropenia (6.9%, more than grade 3) and catheter-related complication (3.4%) in HAIC group, hand-foot syndrome (20.7%) and diarrhea (3.4%) in sorafenib group. Conclusions: For treatment of advanced HCC with PVTT patient, HAIC can be a valuable treatment modality like as sorafenib and more large size of study is needed.
Choi, Jong Hwan,Choi, Jae Hyuk,Lee, Yoo Jin,Lee, Hyung Ki,Choi, Wang Yong,Kim, Eun Soo,Park, Kyung Sik,Cho, Kwang Bum,Jang, Byoung Kuk,Chung, Woo Jin,Hwang, Jae Seok WJG Press 2014 World journal of gastroenterology Vol.20 No.25
<P>To compare outcomes using the novel portable endoscopy with that of nasogastric (NG) aspiration in patients with gastrointestinal bleeding.</P>
Genomic structure and phylogenic analysis of the Spodoptera litura granulovirus
Yong Wang,Jae Young Choi,Jong Yul Roh,Hee Jin Shim,Soo Dong Woo,Byung Rae Jin,Yeon Ho Je 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.10
The nucleotide sequence of the Spodoptera litura granulovirus (SlGV) genome was determined and analysed. It was 124,121 bp long, with a 61.2% A+T content and contained 133 putative open reading frames (ORFs) of 150 nucleotides or larger. The 133 putative ORFs covered 86.3% of the genome. Among these, 29 ORFs were conserved in most completely sequenced baculovirus genomes, 44 were granuloviruses (GVs)-specific, 4 were nucleopolyhedroviruses (NPVs)-specific, and 56 were present in some NPVs and/or GVs. Especially, we proved that there were 9 SlGV-specific ORFs in 44 GV-specific ORFs by RT-PCR. Chitinase and cathepsin genes involved in the liquefaction of the infected hostwere not found in the SlGV genome, which explains why SlGV-infected insects do not degrade in a typical manner. When the phylogenic relationship was analyzed using the nucleotide sequence of granulin gene, SlGV was most closely related to Trichoplusia ni granulovirus (TnGV) and Xestia c-nigrum granulovirus (XcGV) which were belonged to TypeI granulovirus.
Insecticidal activity of the chitinase A from the Spodoptera lirura nucleopolyhedrovirus
Yong Wang,Jae Young Choi,Jong Yul Roh,Qin Liu,Xueying Tao,Soo Dong Woo,Byung Rae Jin,Yeon Ho Je 한국응용곤충학회 2010 한국응용곤충학회 학술대회논문집 Vol.2010 No.05
Baculovirus chitinase gene (ChiA) is a late gene and is essential for liquefying host insect at the late stage of infection for its hydrolyzing chitin function. In previous report, baculovirus ChiA can offer many interseting new opportunities for pest control. Recently, a putative chitinase gene (ChiA) was identified in the Spodopter litura nucleopolyhedorvirus (SlMNPV-K1) genome. The open reading frame (ORF) contains 1,692 nucelotides (nt) and encodes a protein of 563 amino acids (aa) with a predicted molecular weight of 62.62 kDa. To conform the insecticidal activity of ChiA from SlMNPV-K1, we constructed a baculovirus transfer vector, pBac-SlChiA, and this transfer vector was co-transfected with the bApGOZA DNA into sf9 cell to generate corresponding recombinant viru which designed Ap-SlChiA. Western blot analysis indicate that SlMNPV-K1 ChiA was successfully expressed. We found the chitinase activity of recombinant virus was enhanced 53% than wide type AcMNPV by chitinase assay, and the recombinant virus showed higher evidently insecticidal activity against 3rd instar larvae of Spodotera exigua than wide type AcMNPV (4.5 time). These results suggested that the chitinase gene from SlMNPV-K1 could be successfully applied to improve pathogenicity of bauclovirus
Sequence and Gene Organization of Spodoptera litura Granulovirus
Yong Wang,Jae Young Choi,Jong Yul Roh,Soo-Dong Woo,Byung Rae Jin,Yeon Ho Je 한국응용곤충학회 2009 한국응용곤충학회 학술대회논문집 Vol.2009 No.05
The genome of a granulovirus isolated from the tobacco cutworm, Spodoptera litura, was completely sequenced. The nucleotide sequence of the Spodoptera litura granulovirus (SlGV) genome was 124,121 bp long, with a 61.2% A+T content and contained 133 putative open reading frames (ORFs) of 150 nucleotides or larger. The 133 putative ORFs covered 86.3% of the genome. Among these, 29 ORFs were conserved in most completely sequenced baculovirus genomes, 35 were granuloviruses (GVs)-specific, and 60 were present in some NPVs and/or GVs. Especially, we proved that there were 9 SlGV-specific ORFs by RT-PCR. When the phylogenic relationship was analyzed using the nucleotide sequence of granulin gene, SlGV was most closely related to Trichoplusia ni granulovirus (TnGV) and Xestiac-nigrum granulovirus (XcGV) which were belonged to Type-I granulovirus. Comparative analysis of gene organization of the SlGV genome with those of other baculoviruses were carried out using blast matrix and gene order diagram.
Genomic structure of the Spodoptera litura multicapsid nucleopolyhedrovirus
Yong Wang,Jae Young Choi,Hee Jin Shim,Jong Yul Roh,Hong Guang,Qin Liu,Soo Dong Woo,Byung Rae Jin,Yeon Ho Je 한국응용곤충학회 2008 한국응용곤충학회 학술대회논문집 Vol.2008 No.05
The complete genomic nucleotide sequence of the Spodoptera litura multicapsid nucleopolyhedrovirus (SlMNPV) isolated in Korea, SlMNPV-K1, was determined. It was 137,435 bp long, with a 55.4 % A+T content and contained 132 putative open reading frames (ORFs) of 150 nucleotides or larger that showed minimal overlap. The 132 putative ORFs covered 87.7% of the genome. Among these, 131 ORFs were are homologous to genes identified in previously reported SlMNPV genome which consisted 139,342 bp and contained 141 putative ORFs. However, arrangement of some ORFs were somewhat different from each other. Even though the SlMNPV-K1 genome is smaller than that of previously reported SlMNPV genome and had lesser predicted ORFs, the main functional genes were all conserved. When the phylogenic relationship was analyzed using the nucleotide sequence of polyhedrin gene, SlMNPV-K1 was most closely related to Lymantria dispar multicapsid nucleopolyhedrovirus (LdMNPV) which were belonged to Group Ⅱ nucleopolyhedrovirus.