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Kwon, Hyuck Hoon,Yoon, Ji Young,Park, Seon Yong,Min, Seonguk,Kim, Yong-il,Park, Ji Yong,Lee, Yun-Sang,Thiboutot, Diane M,Suh, Dae Hun The Society for Investigative Dermatology, Inc 2015 The Journal of investigative dermatology Vol.135 No.6
Acne vulgaris is a nearly universal cutaneous disease characterized by multifactorial pathogenic processes. Because current acne medications have various side effects, investigating new pharmacologically active molecules is important for treating acne. As natural products generally provide various classes of relatively safe compounds with medicinal potentials, we performed activity-guided purification after a series of screenings from the extracts of five medicinal plants to explore alternative acne medications. Lupeol, a pentacyclic triterpene, from the hexane extract of Solanum melongena L. (SM) was identified after instrumental analysis. Lupeol targeted most of the major pathogenic features of acne with desired physicochemical traits. It strongly suppressed lipogenesis by modulating the IGF-1R/phosphatidylinositide 3 kinase (PI3K)/Akt/sterol response element–binding protein-1 (SREBP-1) signaling pathway in SEB-1 sebocytes, and reduced inflammation by suppressing the NF-κB pathway in SEB-1 sebocytes and HaCaT keratinocytes. Lupeol exhibited a marginal effect on cell viability and may have modulated dyskeratosis of the epidermis. Subsequently, histopathological analysis of human patients’ acne tissues after applying lupeol for 4 weeks demonstrated that lupeol markedly attenuated the levels of both the number of infiltrated cells and major pathogenic proteins examined in vitro around comedones or sebaceous glands, providing solid evidence for suggested therapeutic mechanisms. These results demonstrate the clinical feasibility of applying lupeol for the treatment of acne.
( Hyuck Hoon Kwon ),( Ji Young Yoon ),( Seon Yong Park ),( Dae Hun Suh ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Precise roles of P. acnes and other anaerobic bacteria in the acne pathogenesis are still unclear. Recent studies have shown that P. acnes can be further classified into several phylotypes with distinct phenotypes and virulences. Objectives: We analyzed distribution patterns of P. acnes and Peptostreptococcus phylotypes from acne patients and healthy control. Methods: A total of 370 samples from 95 acne patients and 65 samples from 65 healthy controls were investigated. Each phylotype was identified by PCR methods using type-specific primers. Results: There was no significant difference in the microflora of the skin surface from acne and healthy controls. In acne lesions, distribution patterns between surface and comedonal lesions were not different, while they were significantly different from those of both papules and pustules. In the inflammatory lesions, the proportion of type IA P. acnes was increased, while those of type IB and II were decreased. The proportion of Peptostreptococcus species was also increased in the inflammatory lesions. Parallel distribution patterns were observed as the disease severity aggravated. There was no significant difference in sebum output between patients infected with type IA and those with type IB or II. Conclusion: Our results suggest that surface microflora at the phylotype levels might not be important in triggering acne and type IA P. acnes and Peptostreptococcus species might be more closely associated with inflammatory acne lesions.
( Hyuck Hoon Kwon ),( In Ho Kwon ),( Jin Ho Chung ),( Jai Il Youn ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.3s
Although psoriasis and bullous diseases are considered to be completely different disease entities, the literature has reported a few cases of psoriasis associated with bullous diseases, most of which are bullous pemphigoid. In limited cases, pemphigus foliaceus has also been reported in association with psoriasis. In most of them, pemphigus lesions usually developed on an untreated patient with a chronic history of psoriasis. Herein, we report a case of 53-year-old male with a chronic history of psoriasis who first developed generalized erosive lesions after 26 cycles of narrow-band ultraviolet B (NBUVB) therapy. A diagnosis of pemphigus foliaceus was made based on skin biopsy and direct immunofluorescence assay. Pemphigus lesions were well controlled with combination therapy of oral steroid and azathioprine. This is the first case where pemphigus foliaceus co-occurred with psoriasis during NBUVB therapy. (Ann Dermatol 23(S3) S281~S284, 2011)
Case Reports : Intravenous Immunoglobulin Treatment in a Child with Resistant Atopic Dermatitis
( Hyuck Hoon Kwon ),( Kyu Han Kim ) 대한피부과학회 2012 Annals of Dermatology Vol.24 No.1
In a subgroup of patients suffering from atopic dermatitis (AD), treatment is quite difficult even after taking oral immunosuppressants. High-dose intravenous immunoglobulin (IVIG) treatment has been reported to be beneficial for them in a few uncontrolled trials. Herein we report a case of intractable AD in a 5-year-old girl who had significant clinical improvement after receiving 3 cycles of IVIG treatment (2 g/kg) without notable side effects. Since the first infusion of IVIG, the patient`s skin lesions improved steadily and the improvement persisted until the 8-month follow-up. The eczema area and severity index score decreased remarkably, while immunologic parameters did not correlate with clinical improvement. This case suggests that IVIG therapy can be quite effective and safe for children with resistant AD. (Ann Dermatol 24(1) 66∼69, 2012)
( Hyuck Hoon Kwon ),( Ji Young Yoon ),( Seon Yong Park ),( Seong Uk Min ),( Seok Joon Lee ),( Ho Lee ),( Dae Hun Suh ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Screening of natural compounds for the development of anti-acne treatment agents has been steadily required considering various side effects of acne medications. Objectives: To compare the clinical efficacy, safety and histopathological changes between Lactobacillus fermented Chamaecyparis obtusa (LFCO) and existing tea tree oil (TTO) for the treatment of mild to moderate acne. Methods: Total thirty four patients were instructed to apply 5 % LFCO to the involved areas of randomly allocated side and 5 % TTO extract to the other side twice a day for 8 weeks in a double blind randomized trial. Results: At the final 8 week, both LFCO and TTO sides showed significant reductions for inflammatory acne lesions. However, LFCO was superior to TTO in the degree of improvement and onset time of efficacy. LFCO side also demonstrated improvement for non-inflammatory lesions, decreased size of sebaceous glands, and sebum output reductions. Protein expressions of NF-κB decreased earlier in LFCO side, and those of IL-1α, IL-8, IGFR-1, and SREBP-1 decreased subsequently. Messenger RNA expressions showed consistent patterns. HPLC-MS analysis further demonstrated that contents of dihydrobenzoic acid, taxifolin 3-O-β -D-xylopyranosid, and quercetin 3-rhamnoside are increased in LFCO. Conclusion: LFCO was more effective and safe for treating various acne lesions compared with existing TTO. Experimental results partly elucidated related molecular mechanisms.
Hyuck Hoon Kwon,권인호,정진호,윤재일 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-
Although psoriasis and bullous diseases are considered to be completely different disease entities, the literature has reported a few cases of psoriasis associated with bullous diseases, most of which are bullous pemphigoid. In limited cases, pemphigus foliaceus has also been reported in association with psoriasis. In most of them, pemphigus lesions usually developed on an untreated patient with a chronic history of psoriasis. Herein, we report a case of 53-year-old male with a chronic history of psoriasis who first developed generalized erosive lesions after 26 cycles of narrow-band ultraviolet B (NBUVB) therapy. A diagnosis of pemphigus foliaceus was made based on skin biopsy and direct immunofluorescence assay. Pemphigus lesions were well controlled with combination therapy of oral steroid and azathioprine. This is the first case where pemphigus foliaceus co-occurred with psoriasis during NBUVB therapy. (Ann Dermatol 23(S3) S281∼S284, 2011)