방전전극을 사용한 접지시스템에 관한 연구

설동화,김명생,김창봉,우제욱 한국정보통신설비학회 2009 정보통신설비학회논문지 Vol.8 No.2

무전극 자외선램프와 광촉매를 이용한 축산분뇨 악취처리기술

이주상,노병대,이철민 한국도시환경학회 2006 한국도시환경학회지 Vol.6 No.1

접지시스템에 관한 연구

설동화,김명생,김창봉,우제욱 한국정보통신설비학회 2009 한국정보통신설비학회 학술대회 Vol.2009 No.1

Laccase-catalyzed Polymerization of Aniline with Different Soft Templates

Ya Zhang,Qiang Wang,Xuerong Fan 한국고분자학회 2018 폴리머 Vol.42 No.2

A comparison of laccase-catalyzed polymerization of aniline in the presence of two different “soft” templates - micelle forming surfactant sodium dodecylbenzenesulfonate (SDBS) and sulfonated natural polyelectrolyte calcium lignosulfonate (LGS) - was investigated to check the influences of different templates on the kinetics of the polymerization and on the characteristics of the complexes obtained. Under respective optimal conditions, pH 4.5 for SDBS and pH 3.5 for LGS, the reaction with LGS was much slower than that in SDBS emulsion. The conditions for laccase-catalyzed synthesis of emeraldine salt of polyaniline (PANI-ES) in both cases were optimized using UV-vis spectroscopy. It was found that PANI-ES obtained with LGS template had a higher degree of oxidation with a higher amount of benzene rings than PANI-ES obtained in SDBS emulsion. Since the protonation of PANI occurred on its imine sites, the doping effect of LGS-doped PANI-ES, confirmed by XPS, was thus better than that of SDBS-doped one.

팔라듐 촉매를 이용한 퀴놀론핵과 Heteroaryl Stannes의 결합 - C-7 heteroaryl 쿼놀론 유도체의 합성 -

남상훈,함원훈,김기수,임태균,양재권 대한약학회 1993 약학회지 Vol.37 No.6

The cross-coupling reaction of organo tin reagents with a variety of organic halides, catalyzed by palladium, provides a novel method for generating a carbon-carbon bond. We used this method for the antibacterial agents, and synthesis of new quinolone derivatives which have carbon-carbon bond at C-7 position of general quinolone moieties. Aryl tin, quinolone moieties, and palladium catalyst were refluxed in DMF to afford new quinolone derivatives. This palladium catalyzed coupling reactions have capacity for further synthetic elaboration.

Acid-catalyzed hydrolysis of semi-aromatic polyamide NF membrane and its application to water softening and antibiotics enrichment

Jun, Byung-Moon,Lee, Hyung Kae,Kwon, Young-Nam Elsevier 2018 CHEMICAL ENGINEERING JOURNAL -LAUSANNE- Vol.332 No.-

<P><B>Abstract</B></P> <P>The effect of post-treatment by acid-catalyzed hydrolysis of a commercial NE70 semi-aromatic polyamide (PA) membrane was systemically investigated to determine feasibility of use in water softening and antibiotic enrichment applications. The surface of a post-treated PA membrane was characterized using various analytical tools: SEM (Scanning Electron Microscopy) for surface morphology, ATR-FTIR (Attenuated Total Reflectance-Fourier Transform Infrared spectroscopy) for chemical bonds, contact angle for hydrophilicity of membrane surface, and electrophoretic light scattering spectrophotometer for surface charge of membrane surface. Conversion of amide groups to amine and carboxyl groups by post-treatment increased hydrophilicity and absolute value of surface charge as well as pore size and molecular weight cut off (MWCO) value. Post-treated membrane under optimal condition showed enhancement of water flux (∼10%) as well as ∼20% ideal selectivity (Na<SUP>+</SUP>/Mg<SUP>2+</SUP>) for water softening using a single electrolyte solution. In addition, mixture selectivity (Na<SUP>+</SUP>/Mg<SUP>2+</SUP>) using a mixture solution at pH 3 was also improved ∼2.6 times. Post-treated membranes at pH 0.25 for 7 and 14days as optimization points were also applied to enrichment of antibiotics which are erythromycin (ERY) and vancomycin (Van). Optimized post-treatment membranes showed higher water flux and lower NaCl rejection as well as competitive rejection of antibiotics when compared to virgin NE70 membrane or other commercial/fabricated membranes. The approach to post-treatment of semi-aromatic membrane by the acid-catalyzed hydrolysis method can be utilized as a multipurpose usage in the future depending on characteristics of the target compound (e.g. surface charge (positive/negative) or size diversity).</P> <P><B>Highlights</B></P> <P> <UL> <LI> We systemically investigated post-treatment on semi-aromatic polyamide membrane. </LI> <LI> Hydrolyzed amide group increased hydrophilicity, absolute value of surface charge. </LI> <LI> Post-treatment increased water flux by increasing MWCO value of membrane. </LI> <LI> In water softening, 10% water flux and 20% ideal selectivity was improved. </LI> <LI> Optimum membrane showed better performance for enrichment of antibiotics. </LI> </UL> </P>

다시마 부산물의 산 촉매 수열 가수분해 특성

박은영,김용진,정승미,이동훈 한국폐기물자원순환학회 2013 한국폐기물자원순환학회지 Vol.30 No.8

To investigate optimal condition of acid-catalyzed hydrothermal hydrolysis of Laminaria japonica, the main constituentsof Laminaria japonica such as cellulose, alginic acid and mannitol were hydrolyzed using acid-catalyzed hydrothermalreaction. Then, we proposed the re-designed experimental method including the predicted optimal conditions of the mainconstituents and performed acid-catalyzed hydrothermal hydrolysis of Laminaria japonica. The coefficients ofdetermination (R2) of Y5 (yield of reducing sugar from Laminaria japonica) were 0.877. P values of Y5 were 0.002,indicating significance, within 1% (p<0.01). The optimum reaction condition for acid-catalyzed hydrothermal hydrolysisof Laminaria japonica determined by the response surface methodology is 143.65oC of reaction temperature, 22min ofreaction time, hydrochloric acid concentration 0.108N, resulting in a production rate of 115.62mg/g-Laminaria japonica.

A microwave-assisted synthetic approach to analyzing disubstituted pyrrolo[2,3-d]pyrimidine diversity via ligand-free Cu-catalyzed N-arylation

ChangSungHong,Seung Yeong Park,Jeong Seob Byeon,EulKgunYum 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.12

Facile introduction of diverse substituents to 2- or 4-chloro-7H-pyrrolo[2,3-d]pyrimidines was examined with microwave-assisted nucleophilic substitution and Cu-catalyzed N-arylation. Microwave-assisted Cu-catalyzed N-arylation of pyrrolo[2,3-d]pyrimidines with various nucleophiles proceeded very well with diverse heteroaryl halides. Sequential microwave-assisted substitution provided good to excellent yields of 2,7- or 4,7-disubstituted pyrrolo[2,3-d]pyrimidines, with short reaction times and energy savings compared with conventional thermal heating. The diverse pyrrolo[2,3-d]pyrimidine derivatives are useful for screening drug candidates for various diseases.

Involvement of $Cu^{++}$-Catalyzed Peroxidation in Degradation of Collagen and Protective Mechanism of Sodium Salicylate on this Peroxidative Reaction

김용식,Kim, Yong-Sik The Korean Society of Pharmacology 1987 대한약리학잡지 Vol.23 No.1

$Cu^{++}$ 촉매작용에 의한 과산화현상이 관절조직손상의 한 형태인 Collagen 손상에 관여할 수 있음을 알아보고, sodium salicylate의 항 염증기전의 일부를 설명해 보고자 sodium salicylate가 이 과산화반응에 미치는 효과를 검토하였다. 쥐피부로 부터 얻은 Collagen을 이용하여 Collagen gelation에 대한 $Cu^{++}$와$H_2O_2$의 효과를 관찰한 결과 $Cu^{++}$ 또는 $H_2O_2$ 단독으로는 gelation에 영향을 미치지 못하였으나, $Cu^{++}$와 $H_2O_2$가 동시에 첨가된 경우 gelation이 억제되어 maximal turbidity가 감소되고, lag phase가 연장됨을 보였다. 그리고 같은 반응 조건에서 sodium salicylate 첨가에 의해 $Cu^{++}$와 $H_2O_2$에 의해 억제된 gelation이 회복됨을 볼 수 있었으며 회복정도는 salicylate 농도 증가에 의존적이었다. 한편 $Cu^{++}$에 의한 $H_2O_2$의 decomposition rate가 sodium salicylate에 의해 증가됨을 보였고, salicylate 농도 증가에 의해 점차 saturation되는 양상을 보였다. 이상의 결과로 부터 $Cu^{++}$ 촉매작용에 의한 과산화 현상은 collagen에 작용하여 구조적 또는 기능적인 변화를 초래함을 알 수 있었고, salicylate에 의해 이러한 과산화 현상이 억제되는 것은 $Cu^{++}$에 의한 $H_2O_2$의 decomposition rate를 증가시킨 결과임을 알 수 있었다. 그러므로 $Cu^{++}$ 촉매작용에 의한 과산화현상은 만성염증 반응 특히 rheumatoid arthritis에서 나타나는 관절조직 손상에 관여할 수 있으며, sodium salicylate는 이 과산화반응에 작용하여 항 염증효과를 나타낼 수 있으리라 믿어졌다. The present study examines firstly, the inhibition of collagen gelation to explore the possible involvement of $Cu^{++}$-catalyzed peroxidation in rheumatoid arthritis and secondly, the effect of sodium salicylate on this peroxidative reaction to provide a possible explanation for its mechanism of anti-inflammatory action. Incubation of collagen obtained from rat skin with $Cu^{++}$ and $H_2O_2$ resulted in the inhibition of gelation in terms of maximal turbidity and lag phase, but either $Cu^{++}$ or $H_2O_2$ alone essentially gave no effect in the collagen gelation. In the presence of sodium salicylate the inhibited gelation of collagen induced by $Cu^{++}$ and $H_2O_2$ was reversed with the dependency of the concentration of sodium salicylate. Moreover, the rate of $H_2O_2$ decomposition by $Cu^{++}$ was accelerated by sodium salicylate and this decomposition of $H_2O_2$ was found to be saturable in terms of concentration of this drugs. Thus it can be expected that $Cu^{++}$ -catalyzed peroxidation attacks collagen resulting in change of structural or functional integrity of collagen, and sodium salicylate may act on this peroxidative process, possibly through the enhancement of catalatic action of $Cu^{++}$. From these results $Cu^{++}$-catalyzed peroxidation can be in part responsible for degradation of joint tissue in rheumatoid arthritis and sodium salicylate may exert its anti-inflammatory action by this peroxidative reaction.

Cu⁺⁺ 촉매작용에 의한 과산화 현상이 Collagen 손상에 관여함과 Sodium Salicylate에 의한 보호 작용

김용식(Yong-Sik Kim) 대한약리학회 1987 대한약리학잡지 Vol.23 No.1

Cu⁺⁺ 촉매작용에 의한 과산화현상이 관절조직손상의 한 형태인 Collagen 손상에 관여할 수 있음을 알아보고, sodium salicylate의 항 염증기전의 일부를 설명해 보고자 sodium salicylate가 이 과산화반응에 미치는 효과를 검토하였다. 쥐피부로 부터 얻은 Collagen을 이용하여 Collagen gelation에 대한 Cu⁺⁺와H₂O₂의 효과를 관찰한 결과 Cu⁺⁺ 또는 H₂O₂ 단독으로는 gelation에 영향을 미치지 못하였으나, Cu⁺⁺와 H₂O₂가 동시에 첨가된 경우 gelation이 억제되어 maximal turbidity가 감소되고, lag phase가 연장됨을 보였다. 그리고 같은 반응 조건에서 sodium salicylate 첨가에 의해 Cu⁺⁺와 H₂O₂에 의해 억제된 gelation이 회복됨을 볼 수 있었으며 회복정도는 salicylate 농도 증가에 의존적이었다. 한편 Cu⁺⁺에 의한 H₂O₂의 decomposition rate가 sodium salicylate에 의해 증가됨을 보였고, salicylate 농도 증가에 의해 점차 saturation되는 양상을 보였다. 이상의 결과로 부터 Cu⁺⁺ 촉매작용에 의한 과산화 현상은 collagen에 작용하여 구조적 또는 기능적인 변화를 초래함을 알 수 있었고, salicylate에 의해 이러한 과산화 현상이 억제되는 것은 Cu⁺⁺에 의한 H₂O₂의 decomposition rate를 증가시킨 결과임을 알 수 있었다. 그러므로 Cu⁺⁺ 촉매작용에 의한 과산화현상은 만성염증 반응 특히 rheumatoid arthritis에서 나타나는 관절조직 손상에 관여할 수 있으며, sodium salicylate는 이 과산화반응에 작용하여 항 염증효과를 나타낼 수 있으리라 믿어졌다. The present study examines firstly, the inhibition of collagen gelation to explore the possible involvement of Cu⁺⁺-catalyzed peroxidation in rheumatoid arthritis and secondly, the effect of sodium salicylate on this peroxidative reaction to provide a possible explanation for its mechanism of anti-inflammatory action. Incubation of collagen obtained from rat skin with Cu⁺⁺ and H₂O₂ resulted in the inhibition of gelation in terms of maximal turbidity and lag phase, but either Cu⁺⁺ or H₂O₂ alone essentially gave no effect in the collagen gelation. In the presence of sodium salicylate the inhibited gelation of collagen induced by Cu⁺⁺ and H₂O₂ was reversed with the dependency of the concentration of sodium salicylate. Moreover, the rate of H₂O₂ decomposition by Cu⁺⁺ was accelerated by sodium salicylate and this decomposition of H₂O₂ was found to be saturable in terms of concentration of this drugs. Thus it can be expected that Cu⁺⁺ -catalyzed peroxidation attacks collagen resulting in change of structural or functional integrity of collagen, and sodium salicylate may act on this peroxidative process, possibly through the enhancement of catalatic action of Cu⁺⁺. From these results Cu⁺⁺-catalyzed peroxidation can be in part responsible for degradation of joint tissue in rheumatoid arthritis and sodium salicylate may exert its anti-inflammatory action by this peroxidative reaction.