중 · 장년 여성의 규칙적인 리듬운동에 따른 인지기능이 단기기억에 미치는 영향

권태원(Kwon, Tae-Won),조문식(Cho, Moon-Sik) 한국체육과학회 2016 한국체육과학회지 Vol.25 No.2

This study has been progressed with 60 minutes exercise two times per week for 12 weeks to examine whether the cognitive function has an effect on the short-time memory through the regular rhythm exercise as the method for the prevention of dementia and the maintenance and enhancement of memory, and has obtained the following conclusions for the results of tests before exercising and after exercising about short-term memory, targeting the elderly women First, as a test result of short-term memory, the meaningful syllable after exercising showed the higher value(10.83±1.29) than the meaningful syllable before exercising(9.44±1.68), and the effect of cognitive function on short-term memory showed significant difference(t= -2.335, p<.05). Second, as a test result of short-term memory, the nonsense syllable after exercising showed the lower value(13.83±3.48) than the nonsense syllable before exercising(14.27±3.48), and the effect of cognitive function on short-term memory did not show significant difference(t= -.425, p<.05). Third, as a test result of short-term memory, the digit span test after exercising showed the higher value(7.22±2.31) than the digit span test before exercising(5.83±85), and the effect of cognitive function on short-term memory showed significant difference(t= -2.335, p<.05).

규칙적인 리듬운동이 노인의 인지기능 및 단기기억에 미치는 영향

권태원(Kwon, Tae-Won),조문식(Cho, Moon-Sik) 한국체육과학회 2014 한국체육과학회지 Vol.23 No.1

The purpose of this study is to maintain and improve the old female’s recognition function and short-term memory through the rhythm exercise that does not give physical damage and has enjoyment and dance routine. Experiment consists of Dance Sports and Jive(international style), which are rhythmic exercise programs. For exercise strength, rating of perceived exertion (RPE) was used. After the exercise for 1 hour, 3 times a week for 4 weeks, recognition function and short-term memory before and after exercise were compared and analyzed and interaction effect was verified. The result revealed that the recognition function after rhythmic exercise (28.85±.587) was higher than that before rhythmic exercise (28.20±1.507) and it showed statistically significant difference(t=-2.096, p<.05). In addition, the short-term memory after rhythmic exercise (l9.35±4.392) was higher than short-term memory (19.20±3.955) but it did not show statistically significant difference(t=-187, p>.05). In the correlation between the rhythmic exercise of short-term momory and recognition function (r=.286, p>.05) did not show significant difference.

Effects of treadmill exercise-intensity on short-term memory in the rats born of the lipopolysaccharide-exposed maternal rats

Kim, Kijeong,Sung, Yun-Hee,Seo, Jin-Hee,Lee, Sang-Won,Lim, Baek-Vin,Lee, Choong-Yeol,Chung, Yong-Rak 한국운동재활학회 2015 JER Vol.11 No.6

<P>Maternal infection is an important factor causing neonatal brain injury and later developmental disability. In the present study, we investigated the effects of treadmill exercise intensity on short-term memory, hippocampal neurogenesis, and expression of brain-derived neurotrophic factor (BDNF), and tyrosine kinase receptor B (TrkB) in the rats born of lipopolysaccharide (LPS)-exposed maternal rats. The rats were divided into six groups: control group, mild-intensity exercise group, moderate-intensity exercise group, maternal LPS-exposed group, maternal LPS-exposed and mild-intensity exercise group, maternal LPS-exposed and moderate-intensity exercise group. The rats in the exercise groups were forced to run on a treadmill for 30 min 5 times a week for 4 weeks. The exercise load consisted of running at the speed of 8 m/min for the mild-intensity exercise groups and 14 m/min for moderate-intensity exercise groups. The latency in the step-down avoidance task was deter-mined for the short-term memory. Immunohistochemistry for 5-bro-mo-2′-deoxyuridine was performed to determine hippocampal cell proliferation and neurogenesis. Western blot analysis was performed for the detection of BDNF and TrkB expression. In the present study, tread-mill exercise improved short-term memory deteriorated by maternal LPS exposure. Treadmill exercise increased cell proliferation and neurogenesis in the hippocampal dentate gyrus of the rats born of the LPS-exposed maternal rats. Treadmill exercise increased BDNF and TrkB expression in the hippocampus of the rats born of the LPS-exposed maternal rats. These effects of treadmill exercise were similarly appeared at both mild-intensity and moderate-intensity.</P>

Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice

Hwang, Dong Sup,Kwak, Hyo Bum,Ko, Il Gyu,Kim, Sung Eun,Jin, Jun Jang,Ji, Eun Sang,Choi, Hyun Hee,Kwon, Oh Young Korean Continence Society 2016 International Neurourology Journal Vol.20 No.2

<P><B>Purpose</B></P><P>Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice.</P><P><B>Methods</B></P><P>The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2’-deoxyuridine immunofluorescence was used to assess neurogenesis. Western blotting was also performed to assess levels of synaptic plasticity-associated proteins, such as brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element-binding protein, early growth response protein 1, postsynaptic density protein 95, and growth-associated protein 43. The mice in the treadmill exercise at zeitgeber 1 group started exercising 1 hour after sunrise, the mice in the treadmill exercise at zeitgeber 6 group started exercising 6 hours after sunrise, and the mice in the treadmill exercise at zeitgeber 13 group started exercising 1 hour after sunset. The mice in the exercise groups were forced to run on a motorized treadmill for 30 minutes once a day for 7 weeks.</P><P><B>Results</B></P><P>Treadmill exercise improved short-term memory and spatial learning ability, and increased hippocampal neurogenesis and the expression of synaptic plasticity-associated proteins. These effects of treadmill exercise were stronger in mice that exercised during the day or in the evening than in mice that exercised at dawn.</P><P><B>Conclusions</B></P><P>Treadmill exercise improved memory function by increasing neurogenesis and the expression of synaptic plasticity-associated proteins. These results suggest that the memory-enhancing effect of treadmill exercise may depend on circadian rhythm changes.</P>

운동 강도에 따른 단기간의 유산소 운동이 면역 세포에 미치는 영향

김광래(Kim Kwang-Lai),박원화(Park Won-Hwa),조중연(Cho Joong-Yeon) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.1

The purpose of the study was to examine changes of immunocyte made at consumption of 600kcal when taking exercise at VO2max 50% and VO2max 70%, and to suggest proper exercise intensity as well as exercise quantity to promote immune function. The subjects were conducted by 16 men and measured VO2max of each person and substituted METs at exercise intensity of both VO2max 50% and VO2max 70% in accordance with energy consumption formula to set exercise time at energy consumption of 600kcal. And, the study substituted inclination and rate at exercise intensity of both VO2max 50% and VO2max 70% that was measured at preliminary test. The author took blood samples from cardinal vein of the forearms of the subjects at energy consumption of 600 kcal immediately after exercise to conduct test with interval of 2 weeks and to exclude effects of previous tests. For data analysis, mean and standard deviation scores were calculated, and repeated measure two-way ANOVA were used. The results of the analysis was as follows : First, T cell in VO2max 70% intensity was significantly decreased compared to VO2max 50% intensity. Second, B cell in VO2max intensity group was significantly decreased compared to VO2max 50% intensity. Third, NK cell was not significantly difference between two exercise intensity. The present study indicated that for set proper exercise intensity as well as exercise quantity, common people were demanded to do mid intensity exercise not exceeding 1 hour or exercise time of each individual, within approximate 30 minutes even at high exercise intensity.

Treadmill Exercise Improves Memory Function Depending on Circadian Rhythm Changes in Mice

황동섭,곽효범,고일규,김성은,진준장,지은상,최현희,권오영 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.S1

Purpose: Exercise enhances memory function by increasing neurogenesis in the hippocampus, and circadian rhythms modulate synaptic plasticity in the hippocampus. The circadian rhythm-dependent effects of treadmill exercise on memory function in relation with neurogenesis were investigated using mice. Methods: The step-down avoidance test was used to evaluate short-term memory, the 8-arm maze test was used to test spatial learning ability, and 5-bromo-2’-deoxyuridine immunofluorescence was used to assess neurogenesis. Western blotting was also performed to assess levels of synaptic plasticity-associated proteins, such as brain-derived neurotrophic factor, tyrosine kinase receptor B, phosphorylated cAMP response element-binding protein, early growth response protein 1, postsynaptic density protein 95, and growth-associated protein 43. The mice in the treadmill exercise at zeitgeber 1 group started exercising 1 hour after sunrise, the mice in the treadmill exercise at zeitgeber 6 group started exercising 6 hours after sunrise, and the mice in the treadmill exercise at zeitgeber 13 group started exercising 1 hour after sunset. The mice in the exercise groups were forced to run on a motorized treadmill for 30 minutes once a day for 7 weeks. Results: Treadmill exercise improved short-term memory and spatial learning ability, and increased hippocampal neurogenesis and the expression of synaptic plasticity-associated proteins. These effects of treadmill exercise were stronger in mice that exercised during the day or in the evening than in mice that exercised at dawn. Conclusions: Treadmill exercise improved memory function by increasing neurogenesis and the expression of synaptic plasticity- associated proteins. These results suggest that the memory-enhancing effect of treadmill exercise may depend on circadian rhythm changes.

단기간 고강도 저항운동 후 테스토스테론, IGF-1과 염증지표의 변화 연구

김재호(Kim, Jea-Ho),고영준(Ko, Young-Jun),조원제(Cho, Won-Je) 한국체육과학회 2015 한국체육과학회지 Vol.24 No.4

In this study, male adults were asked to perform a 6-weeks high intensity resistance exercise to observe the changes in testosterone, IGF-1 and blood inflammatory factors(CRP, CPK, IL-6) by exercise intensity and period. The male students in their 20’s who are currently attending the D university located in Y-si, Gyeonggi-do were participated in this study. 10 participants were assigned into a control group(CG), 10 participants were assigned into intense resistance exercise group(RTG). The participants were asked to perform the exercise for a 6-week short, 3 times a week. No exercise was given to control group. The intense exercise group was asked to perform 5 sets 70-80%RM, 3 to 8 repetitions per a set. Repeated measure ANOVA SPSS Ver. 18.0 statistics program was used to describe all data statistically. Then Repeated measure ANOVA was performed to confirm the group, period and interaction, whereas paired t-test was used to validate the difference between the groups by time. And different between CG and RTG was independent t-test after exercise treatment. As a result, the significant difference was shown on IGF-1, blood inflammatory factors in RTG pre to post. The difference in IL-6 was observed between the groups. The interaction was observed in blood inflammatory. So In correlation analysis about testosterone, IGF-1 and inflammatory factors after the short-term high-intensity resisted exercise, CPK and IL-6 showed positive correlation. Therefore, high intense resistance exercise was shown to have a positive impact on IGF-1, blood inflammatory factors, the exercise needs to be carefully prescribed considering the individual characteristics.

Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice

홍민하,김미아,김태운,박상서,김명기,박영자,성윤희,신말순 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.S1

Purpose: Thrombotic stroke is a type of ischemic stroke characterized by motor dysfunction and memory impairments. In the present study, the effect of treadmill exercise on motor function and short-term memory was evaluated in relation with synaptic plasticity in the mice with photothrombotic stroke.Methods: Photothrombotic stroke was induced by cortical photothrombotic vascular occlusion. The mice in the treadmill exercise groups performed running on a motorized treadmill for 28 days. Motor function was determined using rota-rod test and foot fault test. Step-through avoidance task was conducted to evaluate short-term memory. Immunohistochemistry for 5-bromo-2′-deoxyuridine and doublecortin was conducted to detect new cell generation. Postsynaptic density protein 95, synaptophysin, brain-derived neurotrophic factor (BDNF), and tyrosine kinase B receptor (TrkB) were determined using western blot. The number of dendritic spines was determined using Golgi stain.Results: Treadmill exercise improved motor function and short-term memory in mice with the photothrombotic stroke. The infarct size was reduced and the number of dendritic spines and expression of postsynaptic density protein 95 and synaptophysin in the peri-infarct cortex and hippocampus were increased by treadmill exercise in photothrombotic stroke mice. Treadmill exercise enhanced neurogenesis through increasing the expression of the hippocampal BDNF and TrkB in photothrombotic stroke mice.Conclusions: Treadmill exercise improved motor function and short-term memory through increasing synaptic plasticity and neurogenesis in photothrombotic stroke mice. Treadmill exercise can be used as an effective treatment strategy to improve brain function related to stroke.

Treadmill Exercise Ameliorates Short-Term Memory Disturbance in Scopolamine-Induced Amnesia Rats

허유미,신말순,이재민,김창주,백상빈,김계환,백성수 대한배뇨장애요실금학회 2014 International Neurourology Journal Vol.18 No.1

Purpose: Scopolamine is a nonselective muscarinic cholinergic receptor antagonist, which induces impairment of learning ability and memory function. Exercise is known to ameliorate brain disturbance induced by brain injuries. In the present study, we investigated the effect of treadmill exercise on short-term memory in relation to acetylcholinesterase (AChE) expression in the hippocampus, using a scopolamine-induced amnesia model in mice. Methods: To induce amnesia, 1 mg/kg scopolamine hydrobromide was administered intraperitoneally once per day for 14 days. A step-down avoidance test for short-term memory was conducted. AChE histochemistry, immunohistochemistry for collagen IV, and doublecortin were performed. Results: Short-term memory deteriorated in the mice with scopolamine-induced amnesia, concomitant with enhanced AChE expression and suppression of angiogenesis in the hippocampus. Critically, treadmill exercise ameliorated short-term memory impairment, suppressed AChE expression, and enhanced angiogenesis in the mice with scopolamine-induced amnesia. Conclusions: Overexpression of AChE is implicated in both brain and renal disease. The findings of our study indicate that treadmill exercise may be of therapeutic value in neurodegenerative and renal diseases by suppressing the effects of AChE expression.

Treadmill exercise ameliorates chemotherapy-induced memory impairment through Wnt/β-catenin signaling pathway

Sang-Seo Park,Sang-Hoon Kim,Bo-Kyun Kim,Mal-Soon Shin,Hyun-Tae Jeong,Jong-Suk Park,Tae-Woon Kim 한국운동재활학회 2023 JER Vol.19 No.6

Doxorubicin (DOX) is a widely used chemotherapy drug for various cancers and it is known to induce cognitive impairment. The aim of this study was to investigate the effect of treadmill exercise on chemother-apy-induced memory impairment. We assessed whether DOX affects inflammation, mitochondrial Ca2+ retention capacity, and Wnt/β-catenin signaling. Male Sprague-Dawley rats were divided into control group, exercise group, DOX-injection group, and DOX-injection and exercise group. To create a DOX-induced memory impairment model, animals were injected intraperitoneally with DOX (2 mg/kg) dissolved in saline solution once a week for 4 weeks. Treadmill exercise was performed once a day, 5 days a week, for 8 consecutive weeks. Short-term memo-ry was determined using the step-down avoidance test. Western blot was performed for the proinflammatory cytokines, Wnt/β-catenin sig-naling, brain-derived neurotrophic factor (BDNF), tropomyosin receptor kinase B (TrkB) in the hippocampus. Mitochondrial Ca2+ retention ca-pacity in the hippocampus was also measured. DOX-injection rats showed deterioration of short-term memory along with decreased ex-pression of BDNF and TrkB in the hippocampus. Levels of the proinflam-matory cytokines, tumor necrosis factor-α and interleukin-6, were in-creased in the DOX-injection rats. Wnt/β-catenin signaling was activat-ed and mitochondrial Ca2+ retention capacity was decreased in the DOX-injection rats. However, treadmill exercise alleviated short-term memory impairment, decreased proinflammatory cytokines, increased BDNF and TrkB expression, and enhanced mitochondrial Ca2+ retention capacity. Treadmill exercise restorated Wnt/β-catenin signaling path-way. This study demonstrated that treadmill exercise can be used for patients undergoing chemotherapy with DOX.