Paediatric Allergic Disease Quality of Life Questionnaire (PADQLQ)의 한국어판 개발과 신뢰도, 타당도에 대한 연구

박슬기,김세현,이선행,장규태,Park, Seul Ki,Kim, Sehyun,Lee, Sun Haeng,Chang, Gyu Tae The Association of Korean Oriental Pediatrics 2013 대한한방소아과학회지 Vol.27 No.3

Objectives In pediatrics of Korean Medicine, it is crucial to evaluate the overall symptoms of children, especially in the children who have serious troubles in their life. In the era when diagnosis in Korean Medicine is quite suitable to evaluate multiple allergic diseases, and when growing numbers are in needs, development of an objective measurement scale for diagnosis of allergic disease in Korean Medicine became essential. Therefore, in the study, pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ) was translated into Korean version with validations on some aspects. Methods In this study, we translated and validated the PADQLQ and established psychometric evidence on its utility in Korean children with similar problems. 71 children, age of 6 ~ 18 with allergic disease has participated. Results The internal consistency reliability of the PADQLQ by Cronbach's ${\alpha}$ was 0.94. In three domains (Practical, Physical, Emotional), the Cronbach's ${\alpha}$ was 0.77, 0.90 and 0.69. The Spearman's rank correlation coefficient between PADQLQ total score and VAS was 0.75 (p<0.001). And, Structural validity was evaluated by the ANOVA test. QoL differences of the four groups in the three domains (practical, physical, emotional) were significant. The item discriminative indices were ranged from 0.1651 to 0.8188. Conclusions Korean version PADQLQ is highly reliable and valid for children with allergic diseases. This is significant to assess the relative seriousness of the allergic diseases and to evaluate the efficacy of different treatments in Korean Medicine.

Effect of pranayama

Kuma, Amit The Association of Korean Oriental Pediatrics 2006 대한한방소아과학회지 Vol.20 No.3

Pranayama Is One Of The Part Of "Astang Yoga". It Is Controlled Breathing Exercise. The Script Basically Emphasize The Ancient Indian Yogic Science & Effect Of Pranayama On Various Human Body System. Basically This Is A Review Script Which Helps The Common People, Scientist & Other Person Related In This Field To Learn About The Effect Of Pranayama.

Anti-inflammatory Activities of GyejigaChulBuTang on Lipopolysaccharide-stimulated RAW264.7 Cells

정민정,이승연,유선애,강경화,Jeong, Min-Jeong,Lee, Seung-Yeon,Yu, Sun-Ae,Kang, Kyung-Hwa The Association of Korean Oriental Pediatrics 2014 대한한방소아과학회지 Vol.28 No.3

Objectives GyejigaChulBuTang (GCBT) is a prescription used to treat acute and chronic arthritis in Korea, China, and Japan. This study assessed the anti-inflammatory and anti-oxidant activities of GCBT on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells. Methods Raw264.7 cells were pretreated with or without GCBT for 1 hour prior to incubation with LPS. Anti-inflammatory activity of GCBT was evaluated with reference to gene expression and production levels of proinflammatory cytokines ($TNF{\alpha}$, IL-$1{\beta}$, IL-6, GM-CSF and $INF{\gamma}$) and inflammatory mediators (iNOS, COX-2, NO and $PGE_2$). In addition, intracellular ROS generation and signal transduction of MAPK family, PI3K/Akt and $I{\kappa}B{\alpha}/NF{\kappa}B$ was investigated. Results Prior treatment with GCBT inhibited elevation of $TNF{\alpha}$, IL-$1{\beta}$, IL-6, GM-CSF, $INF{\gamma}$, NO and $PGE_2$, together with their cognate mRNAs in a dose-dependent manner. Intracellular ROS contents were similarly reduced. These effects were due to inhibition of LPS-induced phosphorylation of MAPK family, PI3K/Akt and $I{\kappa}B{\alpha}$ as well as nuclear translocation of $NF{\kappa}B$. Conclusions GCBT suppresses pro-inflammatory mediators. GCBT has potential in the treatment of juvenile rheumatoid arthritis associated with inflammation.

The Efficacy and Safety of Periocular Acupoint Stimulation on Myopia Progression in Children: A Study Protocol

차호열,정아람,천진홍,최준용,김기봉,Cha, Ho yeol,Jung, A Ram,Cheon, Jin Hong,Choi, Jun Yong,Kim, Ki Bong The Association of Korean Oriental Pediatrics 2015 대한한방소아과학회지 Vol.29 No.4

Objectives Myopia has a higher prevalence rate in eastern countries, which also have a higher rate of educational fever compared to western countries. Considering this, social costs paid for myopia will increase rapidly in Korea. Although the development of myopia treatment is necessary, there has been a lack of relevant studies. Thus, this study aims to produce data to prevent unnecessary treatments and medical expenses. Methods The objective is to evaluate the effect of periocular acupressure exerted by a medical massager for myopia. This is an open-label, prospective, single-arm, and pre and post superiority study. The subjects are 7~12-year-old myopia patients with under 5 D (diopter) of spherical equivalent. A total of 56 subjects were enrolled. The selected subjects will wear the massager for 15 minutes twice a day for 24 weeks. The primary endpoint is the refraction change. The secondary endpoint is the axial length change. Statistical analysis was performed at a significant level of 0.05, using a two-tailed test. The criterion for significantly improved refraction was $-0.17{\pm}0.50$ D/6 months and that of axial length change was 0.126 mm. Results and Conclusions This study did not include a control group because children represent a vulnerable group. This objective study will bring some impact on Korean medical myopia treatment. A long-term confirmatory clinical study may be necessary in future.

The Potential Adverse Effects of Night-eating Habit on Gastrointestinal Symptom and SUI-TAI Symptom in Healthy Children

Koh, Duck-Jae,Lee, Jin-Yong,Kim, Deog-Gon The Association of Korean Oriental Pediatrics 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : Prevalence of night eating habit associated with substance use and obesity is increasing rapidly in children and adolescents. Further, staying up late and eating snacks late at night were known as leading health risk behaviors for children, suggesting the potential adverse effect of night-eating habit on children. However, only few reports had been issued on the effect of night-eating habit on gastrointestinal symptom and SUI-TAI(水滯) symptom of children. Therefore, we aimed to investigate clinical characteristics of children by night-eating symptom status. Methods : Parents were asked to give a detailed answer to a systemized medical history questionnaire concerning night-eating habit, gastrointestinal symptom and SUI-TAI symptom of their children. Medical records of 28 children treated in the Department of Pediatrics, Hospital of Oriental Medicine, were the subject of this study. Clinical characteristics of two groups of children who with no night-eating habit and frequent night-eating group(eating at night more than 3 times per week) were analysed. In addition, the correlation analysis between clinical characteristics were performed. Results : Children with frequent night-eating habit(n=7, more than 3 days of night-eating a week) were observed to have more aggravated gastrointestinal symptom and SUI-TAI symptom compared with those without night-eating habit(n=13). In parallel, the association of gastrointestinal symptom and SUI-TAI symptom was demonstrated(n=28). Conclusions : It is notable that deranged gastrointestinal function and aggravated SUI-TAI symptom were observed among children generally regarded as healthy. Therefore, endeavors to correct night-eating habit as well as to treat aggravated gastrointestinal and SUI-TAI symptoms are needed for the promotion of health of children.

Clinical Assessment of Efficacy, Safety and Usefulness of Traditional Herbal Medicine (THM) on Atopic Dermatitis

고덕재,유한정,이진용,김덕곤,Koh, Duck-Jae,You, Han-Jung,Lee, Jin-Yong,Kim, Deog-Gon The Association of Korean Oriental Pediatrics 2006 대한한방소아과학회지 Vol.20 No.2

목적 : 본 연구를 통하여 아토피 피부염 환아의 한약치료 후 임상 효능, 안전성을 평가하고, 나아가 효능과 안전성을 종합적으로 평가함으로써 아토피 피부염에 대한 한약치료의 유용성을 평가하고자 한다. 방법 : 경희대학교 한의과대학 부속한방병원 한방소아과에 내원한 아토피 피부염 환아 39명의 한약치료 전후의 의무기록을 검토하였다. 아토피피부염 치료에 대한 한약의 효능을 평가하기 위하여 치료 후 아토피 피부염의 개선정도에 대한 부모의 평가를 VAS를 사용하여 분석하였다. 아토피 피부염에 패한 한약치료 후 안정성의 평가를 위하여 치료 전후 혈중 AST, ALT, BUN, creatinine 변화를 검토하여 한약치료의 간신독성 여부에 대해 조사하였고, 보호자에 대한 설문조사를 통하여 한약치료 후 발생한 부작용 및 불편한 증상의 종류 및 정도를 평가하였다. 나아가 한약의 효능 및 안정성을 종합적으로 평가하여 아토피 피부염에 대한 한약 치료의 유용성을 분석하였다. 결과 및 결론 : 환아 39명 중 27명 (69%)의 부모가 한약치료가 아토피 피부염의 개선에 효과가 있다고 보고하였다. 안정성의 평가에 있어서, 39명의 환자에게서 한약 치료 후 간장과 신장에 미치는 독성이 발견되지 않았다. 2명의 환아가 일시적이고 경미한 복부 불쾌감을 호소하였으나, 한약투여와의 관련성은 관찰되지 않았다. 1명의 환아에서 경미한 복통이 발견되었으나, 의학적 치료 없이 증상은 소실되었으며, 치료 과정의 중단 없이 계획되었던 모든 치료 과정을 종료하였다. 치료 후 상기 환아는 아토피 피부염의 증상 개선 뿐 아니라 변비증상의 완화, 만성적 어지러움의 개선 등 제반 신체 조건의 호전을 보고 하였다. 임상적 효능과 안전성을 종합적으로 고려할 때, 환아 39명 중 27명 (69%)의 사례에서 한약치료가 아토피 피부염의 유용한 치료수단으로 평가되었다. 이를 근거로 한약치료가 아토피 피부염에 대하여 안전성을 가진 유용한 치료방법이라 사료되며, 향후 임상적 효능과 안전성을 객관적으로 평가할 수 있는 대규모의 임상연구가 필요하리라 사료된다.

Inhibitory Effects of Jojoongikgi-tang on the Secretion of PGE2 and NO and Cytokines in LPS-stimulated BV2 Microglial Cells

Lee, Jun-Moon,Lyu, Sun-Ae,Lee, Seung-Yeon,Kim, Bo-Kyung,Ko, Woo-Shin The Association of Korean Oriental Pediatrics 2007 대한한방소아과학회지 Vol.21 No.2

Objectives This experiment is about Jojoongikgi-tang(JIT) exerts anti-inflammatory effects in BV2 microglial cells, and the effect of JIT on Nitric oxide(NO) production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells were also demonstrated. Methods To investigate the anti-inflammatory effects of JIT, NO production, expression level of iNOS mRNA, PGE2 synthesis, expression COX-2 mRNA, cell viability, $TNF-{\alpha}$ mRNA expression were examined. Results The expression level of inducible nitric oxide synthase(iNOS) was decreased by JIT, and the production of Prostaglandin E2(PGE2) and the expression of Cox-2 mRNA also were inhibited by JIT. Proinflammatory mediators, such as $TNF-{\alpha}$, $IL-1{\beta}$, IL-12, were inhibited by JIT in a dose-dependent manner. Conclusions JIT have anti-inflammatory effects in BV2 microglial cells and could be used in inflammatory disease.

CASE PRESENTATION

Medrek, Robert The Association of Korean Oriental Pediatrics 1990 대한한방소아과학회지 Vol.4 No.1

Comparisons of Effects of Biman-tang according to Administration Period in Childhood Obesity

임영권,민서림,김희만,허광욱,이훈,이진수,김호철,박재우,박히준,Lim, Youngkwern,Min, Seorim,Kim, Heeman,Hur, Kwang-Wook,Lee, Hoon,Lee, Jinsoo,Kim, Hocheol,Park, Jae-Woo,Park, Hi-Joon The Association of Korean Oriental Pediatrics 2013 대한한방소아과학회지 Vol.27 No.4

Objectives The purpose of this study is to investigate the safety and effect of Biman-tang (BMT) on two different administration periods in the treatment of childhood overweight and obesity. Methods In retrospective study, 39 overweight and obese ($85^{th}$ percentile ${\leq}$ Body Mass Index (BMI)) children were treated with BMT from January 2006 to April 2013 at Korean Medical Clinic in Suwon, Korea. The primary outcomes were the changes in BMI and Obesity Index (OI) from baseline to the treatment groups. Secondary outcomes included the changes in height, weight and safety of the medicine. Comparisons of BMI, OI, height and weight between the short-period (SP) treatment group and the long-period (LP) treatment group were done by using ANCOVA. Results The change of the mean of BMI ($-0.5{\pm}0.6kg/m^2$ vs $-1.4{\pm}0.8kg/m^2$, respectively; p=0.003) and OI ($-3.6{\pm}3.9%$ vs $-9.7{\pm}4.7%$, respectively; p<0.001) showed significant reduction both in SP (n=16) and LP treatment group (n=23). The mean height showed no significant difference in both groups. The mean weight of LP treatment group showed significant reduction compared to SP treatment group ($-0.2{\pm}1.3kg$ vs $-1.6{\pm}1.6kg$, respectively; p=0.006). Most of the children were compliant to the medication and no serious adverse events were found in two groups. Conclusions These findings emphasize that BMT is effective in the treatment of childhood obesity and it requires at least 45 days of treatment for the best result.

The Study of Seunggal-tang Gamibang on the Anti-allergy Effects

Ju, Bong-Hyun,Lyu, Sun-Ae,Ko, Woo-Shin,Kim, Own-Il,Lee, Seung-Yeon The Association of Korean Oriental Pediatrics 2007 대한한방소아과학회지 Vol.21 No.2

Objectives The purpose of this study is to investigate effects of Seunggal-tang gamibang (SGT) on the PMA plus A23187-induced RBL-2H3 cells. Methods The effect of SGT on ${\beta}$ -hexosamonidase release, passive cutaneous anaphylaxis, $TNF-{\alpha}$ production and IL-4 secretion was studied. Results SGT inhibited the release of ${\beta}$ -hexosamonidase in RBL-2H3, without affecting cell viability. The passive cutaneous anaphylaxis (PCA) was inhibited by the SGT. Moreover SGT also reduced production of $TNF-{\alpha}$ and secretion of IL-4 in a dose-dependent manner. Conclusions SGT has anti-allergy effects on the RBL-2H3 cells.