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Potential molecular mechanisms underlying the effect of arsenic on angiogenesis
Juan Zhang,Yue Zhang,Weiyan Wang,Zhiyi Zhang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.11
Arsenic is a potent chemotherapeutic drug thatis applied as a treatment for cancer; it exerts its functionsthrough multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progressionof many diseases, arsenic is a feasible treatmentoption for patients with other angiogenic diseases, includingrheumatoid arthritis and psoriasis, among others. However,arsenic is also a well-known carcinogen, demonstrating apro-angiogenesis effect. This review will focus on the dualeffects of arsenic on neovascularization and the relevantmechanisms underlying these effects, aiming to provide arational understanding of arsenic treatment. In particular, weexpect to provide a comprehensive overview of the currentknowledge of the mechanisms by which arsenic influencesangiogenesis.
Juan Zhang,Shifeng Li 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.7
In the paper, we apply a structure-preserving doubling algorithm to solve the continuous coupled algebraic Riccati equation (CCARE). Using the existence and uniqueness of the CCARE, we show that the iteration solution of the CCARE are positive semi-definite, symmetric, and unique. Further, we discuss the convergent analysis of the structure-preserving doubling algorithm. Moreover, we present two modified structure-preserving doubling algorithms. Finally, we offer corresponding numerical examples to illustrate the effectiveness of the derived numerical algorithms.
RPSA Gene Mutants Associated with Risk of Colorectal Cancer among the Chinese Population
Zhang, Shan-Chun,Jin, Wen,Liu, Hui,Jin, Ming-Juan,Chen, Ze-Xin,Ding, Zhe-Yuan,Zheng, Shuang-Shuang,Wang, Li-Juan,Yu, Yun-Xian,Chen, Kun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
The primary aim of this study was to evaluate the relationship of single nucleotide polymorphisms (SNPs) in ribosomal protein SA (RPSA) gene with colorectal cancer (CRC). A case-control study including 388 controls and 387 patients with CRC was conducted in a Chinese population. Information about socio-demography and living behavior factors was collected by a structured questionnaire. Three SNPs (rs2133579, rs2269349, rs7641291) in RPSA gene were genotyped by Illumina SnapShot method. Multiple logistic regression models were used for assessing the joint effects between tea consumption and SNPs on CRC. The subjects with rs2269349 CC genotype had a decreased risk for CRC (OR=0.60; 95%CI = 0.37-0.99), compared with TT/CT genotype after adjustment for covariates. A similar association of rs2269349 with rectal cancer was observed (OR=0.49; 95%CI=0.24-1.00). Further analyses indicated that this SNP could modify the protective effect of tea drinking on CRC. Among the subjects with rs2269349 TT/CT or rs2133579 AA/GA, there was a marginal significantly lower risk of CRC (OR and 95%CI: 0.63 and 0.39-1.01 for rs2269349; 0.64 and 0.40-1.02 for rs2133579) in tea-drinking subjects in comparison to non-tea-drinking subjects. Mutants in the RPSA gene might be associated with genetic susceptibility to CRC and influence the protective effect of tea consumption in the Chinese population.
Discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins
Juan Liu,Yangrong Xu,Jingjing Yang,Wenzhi Wang,Jianqiang Zhang,Renmei Zhang,Qingguo Meng 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.3
Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax quinquefolius L., Panax japonicus, Hana mina, and Vietnamese ginseng. In recent years, the semisynthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, antimyocardial ischemia, antiinflammatory, antibacterial, and antitumor activities. Owing to their chemical structure, pharmacological actions, and the stereoselective activity on antimyocardial ischemia, ocotillol-type saponins are subjected to extensive consideration. In this review, we sum up the discovery, semisynthesis, biological activities, and metabolism of ocotillol-type saponins.
Aerosol Processing and Photocatalytic Degradation of Ag-TiO₂ Composite Nanoparticles
Juan Zhang(장쥐안),Soo Hyung Kim(김수형) 한국신재생에너지학회 2021 한국신재생에너지학회 학술대회논문집 Vol.2021 No.7
This study reports the gas-phase synthesis and characterization of Ag-TiO<sub>2</sub> composite nanoparticles (NPs), and their applications into photo-degradation of organic materials (e.g., methylene blue) under the irradiation of UV and visible light. The effects of surface plasmon resonance (SPR) and electron sink of Ag-TiO<sub>2</sub> composite NPs were made for photo-degradation of organic materials-based solution. Ag-TiO<sub>2</sub> composites NPs with different amounts of Ag(i.e., 0.5, 1. 2 and 5wt%) prepared by spray pyrolysis method using the mixture of TiO<sub>2</sub> and AgNO<sub>3</sub> as precursor solutions. All prepared photocatalysts were characterized using various technics, including crystalline phase, morphology, chemical composition, and optical property measurements. It was clearly observed that the optimized amount of Ag (i.e., 1 wt%) in the TiO<sub>2</sub> matrix confirmed that the optical excitation was successfully driven by visible light irradiation. This noteworthy enhancement was ascribed to the local SPR, which enabled Ag-TiO<sub>2</sub> composite NPs to optically absorb the visible light spectrum. Under the visible light irradiation test conditions for the various MB solutions dispersed with Ag-TiO<sub>2</sub> composite NPs, the rate constant(k) of first-order reaction that characterizes the photocatalytic reactivity values were observed to be ~ 0.232 h<sup>-1</sup> for pure TiO<sub>2</sub> and ~0.396 h<sup>-1</sup> for Ag (1 wt%)-TiO<sub>2</sub>, respectively. The Ag (1 wt%)-TiO<sub>2</sub> composite NPs under visible light irradiation showed 70% increase in photocatalytic reactivity compared with pure TiO<sub>2</sub>. In addition, the prepared Ag-TiO<sub>2</sub> composite NPs had the excellent photocatalytic activity under UV light irradiation because metallic Ag can act as an electron trap to inhibit electron-hole recombination. Similarly, under the UV light irradiation test conditions for the various MB solutions dispersed with Ag-TiO<sub>2</sub> composite NPs, the k values were observed to be ~0.260 h<sup>-1</sup> for pure TiO<sub>2</sub> and ~0.424 h<sup>-1</sup> for Ag (1 wt%)-TiO<sub>2</sub>, respectively. The Ag (1 wt%)-TiO<sub>2</sub> composite NPs under UV light irradiation showed 63% increase in photocatalytic reactivity compared with pure TiO<sub>2</sub>
Juan Zhang,Dong-Ling Xu,Xiao-Bo Liu,Shao-jie Bi,Tong Zhao,Shu-Jian Sui,Xiao-Ping Ji,Qing-Hua Lu 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.2
Purpose: Increased lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and Rho kinase activity may be associated with atherosclerosis. The principal aim of this study was to examine whether darapladib (a selective Lp-PLA2 inhibitor) could reduce the elevated Lp-PLA2 and Rho kinase activity in atherosclerosis. Materials and Methods: Studies were performed in male Sprague-Dawley rats. The atherosclerosis rats were prepared by feeding them with a high-cholesterol diet for 10 weeks. Low-dose darapladib (25 mg·kg-1·d-1) and high-dose darapladib (50 mg·kg-1·d-1) interventions were then administered over the course of 2 weeks. Results: The serum levels of triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoproteincholesterol (HDL-C), high-sensitivity C-reactive protein (hs-CRP), and Lp-PLA2, significantly increased in atherosclerosis model groups, as did Rho kinase activity and cardiomyocyte apoptosis (p<0.05 vs. sham group), whereas nitric oxide (NO) productionwas reduced. Levels of TC, LDL-C, CRP, Lp-PLA2, and Rho kinase activity were respectively reduced in darapladib groups, whereas NO production was enhanced. When compared to the low-dose darapladib group, the reduction of the levels of TC, LDL-C, CRP, and Lp-PLA2 was more prominent in the high-dose darapladib group (p<0.05), and the increase of NO productionwas more prominent (p<0.05). Cardiomyocyte apoptosis of the high-dose darapladib group was also significantly reduced compared to the low-dose darapladib group (p<0.05). However, there was no significant difference in Rho kinase activity between the low-dose darapladib group and the high-dose darapladib group (p>0.05). Conclusion: Darapladib, a Lp-PLA2 inhibitor, leads to cardiovascular protection that might be mediated by its inhibition of both Rho kinase and Lp-PLA2 in atherosclerosis.
Dissipative Analysis for Nonlinear Singular Systems with Time-delay
Juan Zhou,Qing-Ling Zhang,Yue Zhang,Bo Men 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.6
This paper is concerned with the dissipative control problem for a class of nonlinear singular systemswith time-delay. The quadratic supply rate with coefficient matrix Q > 0 and Q 0 are both discussed. Basedon the Lyapunov stability theory, sufficient conditions are given to guarantee that the system is strictly dissipativevia linear matrix inequality technique. Then congruent transformation method and Schur complement lemma arerespectively used to determine corresponding proportional and derivative feedback controller for Q > 0 andQ 0. At last, two examples involve a practical example are given to verify the effectiveness of the method proposed inthis paper.