Nonlocal-integro-vibro analysis of vertically aligned monolayered nonuniform FGM nanorods

Yuan Yuan,Ke Zhao,Yafei Zhao,Keivan Kiani 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.37 No.5

Vibration of vertically aligned-monolayered-nonuniform nanorods consist of functionally graded materials with elastic supports has not been investigated yet. To fill this gap, the problem is examined using the elasticity theories of Eringen and Gurtin-Murdoch. The geometrical and mechanical properties of the surface layer and the bulk are allowed to vary arbitrarily across the length. The nonlocal-surface energy-based governing equations are established using differential-type and integro-type formulations, and solved by employing the Galerkin method by exploiting admissible modes approach and element-free Galerkin (EFG). Through various comparison studies, the effectiveness of the EFG in capturing both nonlocal-differential/integro-based frequencies is proved. A constructive parametric study is also conducted, and the roles of nanorods’ diameter, length, stiffness of both inter-rod’s elastic layer and elastic supports, power-law index of both constituent materials and geometry, nonlocal and surface effects on the dominant frequencies are revealed.

Preliminary Report on Breeding of Coarse Size Variety CU1 x CU2 of Bombyx mori L

Yuan Zhao,Yangchun Wu,Heying Qian,Yiyuan He,Simei He 한국잠사학회 2004 International Journal of Industrial Entomology Vol.9 No.1

A number of Chinese, Japanese and European silkworm strains with coarse size filament were used for breeding the coarse size variety. Through cross breeding combined with pedigree selection within thirteen generations, a pair of coarse size silkworm variety, named CU1×CU2, was obtained after five years. Laboratory trials showed that the filament size of its F1 hybrid was over 4.3 D, and the other economic characters were also good.

Preliminary Report on the Breeding of Robust and Resistant-NPV and High Quality Silkworm Race 'Shengming No.1' for Summer-autumn Rearing

Zhao, Yuan,Chen, Kepin,Yao, Qing,Wu, Yang-Chun,Zhang, Jian,Guo, Xijie Korean Society of Sericultural Science 2006 International Journal of Industrial Entomology Vol.13 No.2

Seveval Chinese and Japanese varieties with good characters were used in the breeding. After 5 years (15 generations), a pair of robust and high quality silkworm variety with NPV resistance was bred by means of a combination of crossing and pedigree selection complemented by the selection of NPV resistance. The variety was identified jointly nationwide in 2003 and 2004, and appraised by National Mulberry and Silkworm Appraising Committee. Results are as follows: its cocooning rate is over 93%, shell rate 23-25%, filament length 1200-1300 meters, reelability 75-88%, Length of non-broken cocoon filament 900-1100 meters, raw silk rate 17-19%, neatness 95-97 points, and cocoon crop, cocoon shell weight and raw silk weight per 10000 larvae is higher than those of the control variety by 7-10%, 14-19% and 14-18%, respectively. The variety is not only robust, resistant to high temperature and NPV, easy to rear, uniform in hatching, molting and maturing, but also lays more eggs, and its fecundity is high. It is suitable to rear in the Yangtze River Basin, the Yellow River basin and the Pearl River basin of China.

Enhancing the static behavior of laminated composite plates using a porous layer

Yuan Yuan,Ke Zhao,Kuo Xu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.72 No.6

The main aim of this paper is enhancing design of traditional laminated composite plates subjected to static loads. In this regard, this paper suggests embedding a lightweight porous layer in the middle of laminated composite as the core layer of the resulted sandwich plate. The static responses of the suggested structures with uniform, symmetric and non-symmetric porosity distributions are compared to optimize their design. Using the first order shear deformation theories, the static governing equations of the suggested laminated composite plates with a porous layer (LCPPL) rested on two-parameter foundation are obtained. A finite element method is also utilized to solve the governing equations of LCPPLs. Effects of laminated composite and porosity characteristics as well as geometry dimension, edges’ boundary conditions and foundation coefficients on the static deflection and stress distribution of the suggested composite plates have been investigated. The results reveal that the use of core between the layers of laminated composites leads to a sharp reduction in the static deflections of LCPPLs. Furthermore, in compare with perfect cores, the use of porous core between the layers of laminated composite plates can offer a considerable reduction in structural weight without a significant difference in their static responses.

A Study on the Mixed Ownership Reform in Vocational Colleges in China

Yuan Zhao,Ling Lin,Tao Li 한국디지털정책학회 2022 디지털융복합연구 Vol.20 No.1

Preparation and Characterization of Sulfated TiO2/zeolite Composite Catalysts with Enhanced Photocatalytic Activity

Yuan Zhao,JingXiu Li,Ling Wang,Yanan Hao,Lin Yang,Pingting He,JianJun Xue 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.10

Sulfated TiO2 nanoparticles were successfully immobilized on zeolite through improving hydrolysis-deposition method. Microstructure, crystallization, surface state and surface area of composite catalysts were characterized by SEM, XRD, FTIR spectra, XPS and BET and the photocatalytic activity was evaluated by degradation of methyl orange under UV irradiation. We optimized these factors (SO4 -2) ions, calcination temperature and loading amount of sulfated TiO2) on photocatalytic activity and crystallization of composite photocatalysts. The results indicated that the SO4 -2 ) ions are successfully immobilized on the surface of TiO2, and sulfated TiO2/zeolite show the highest photocatalytic activity for methyl orange at the [SO4 -2]/[Ti4+] molar rate of 1:1, calcination temperature of 600 ℃ for 2 h, and sulfated TiO2 loading amount of 40%, respectively.

The role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy

Zhao Weichen,He Chunyuan,Jiang Junjie,Zhao Zongbiao,Yuan Hongzhong,Wang Facai,Shen Bingxiang 대한약리학회 2022 The Korean Journal of Physiology & Pharmacology Vol.26 No.6

Pyroptosis, a form of cell death associated with inflammation, is known to be involved in diabetic nephropathy (DN), and discoid domain receptor 1 (DDR1), an inflammatory regulatory protein, is reported to be associated with diabetes. However, the mechanism underlying DDR1 regulation and pyroptosis in DN remains unknown. We aimed to investigate the effect of DDR1 on renal tubular epithelial cell pyroptosis and the mechanism underlying DN. In this study, we used high glucose (HG)-treated HK-2 cells and rats with a single intraperitoneal injection of streptozotocin as DN models. Subsequently, the expression of pyroptosis-related proteins (cleaved caspase-1, GSDMD-N, Interleukin-1β [IL-1β], and interleukin-18 [IL-18]), DDR1, phosphorylated NF-κB (p-NF-κB), and NLR family pyrin domain-containing 3 (NLRP3) inflammasomes were determined through Western blotting. IL-1β and IL-18 levels were determined using ELISA. The rate of pyroptosis was assessed by propidium iodide (PI) staining. The results revealed upregulated expression of pyroptosisrelated proteins and increased concentration of IL-1β and IL-18, accompanied by DDR1, p-NF-κB, and NLRP3 upregulation in DN rat kidney tissues and HG-treated HK-2 cells. Moreover, DDR1 knockdown in the background of HG treatment resulted in inhibited expression of pyroptosis-related proteins and attenuation of IL-1β and IL-18 production and PI-positive cell frequency via the NF-κB/NLRP3 pathway in HK-2 cells. However, NLRP3 overexpression reversed the effect of DDR1 knockdown on pyroptosis. In conclusion, we demonstrated that DDR1 may be associated with pyroptosis, and DDR1 knockdown inhibited HG-induced renal tubular epithelial cell pyroptosis. The NF-κB/NLRP3 pathway is probably involved in the underlying mechanism of these findings.

The Loading–Unloading Model of Contact Between Fractal Rough Surfaces

Yuan Yuan,Kuo Xu,Ke Zhao 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.21 No.6

A loading–unloading elastic–plastic model of contact between three dimensional fractal rough surfaces has been presented in this paper. During loading process, the mechanical properties of a single asperity follow Hertzian theory. During unloading process, the load-area relationships of a single asperity are obtained by EK model. The truncation size distribution functions for diff erent levels of asperities are deduced. And total true contact area and total contact load are obtained during a loading–unloading process. The results show as the rough surface is in elastic deformation, the load-area relationships during loading and unloading process are identical. As the rough surface is in inelastic deformation, the total true contact area during unloading process is greater than that during loading process. An experiment is designed to verify the validity of the present model.

8q24 rs4242382 Polymorphism is a Risk Factor for Prostate Cancer among Multi-Ethnic Populations: Evidence from Clinical Detection in China and a Meta-analysis

Zhao, Cheng-Xiao,Liu, Ming,Xu, Yong,Yang, Kuo,Wei, Dong,Shi, Xiao-Hong,Yang, Fan,Zhang, Yao-Guang,Wang, Xin,Liang, Si-Ying,Zhao, Fan,Zhang, Yu-Rong,Wang, Na-Na,Chen, Xin,Sun, Liang,Zhu, Xiao-Quan,Yuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations. Materials and Methods: Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype. Results: The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, $P=7.3{\times}10^{-5}$), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, $Padj=1.1{\times}10^{-4}$). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ${\geq}65$ years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype ($P=4.6{\times}10^{-5}-3.0{\times}10^{-2}$). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, $P=1.0{\times}10^{-5}$) across Asian, Caucasian and African American populations. Conclusions: The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.

Experimental Study and Analysis of Insulator Breakdown Characteristics with Short-tail Lightning Impulse

Zhao, Yuan,Li, Yu,Deng, Chun,Yuan, Yi-Chao,He, Jin-Liang,Wang, Xi The Korean Institute of Electrical Engineers 2014 The Journal of International Council on Electrical Vol.4 No.3

The voltage waveform on the insulator by a direct lightning stroke is a short-tail lightning impulse. Experimental study and analysis of insulator breakdown characteristics under short-tail lightning impulses are given in this paper with the contrast of standard lightning impulse. The impacts of crossarm and transmission lines are also considered. The experimental results indicate that the insulator 50% breakdown voltage under short-tail impulse is significantly higher than that of standard wave with both positive and negative polarities, about 25~30%. The 50% breakdown voltage of insulator with negative-polarity short-tail impulse is about 5% higher than with positive-polarity one. The insulator voltage-time characteristics are also given with short-tail and standard lightning impulses.