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Jung Rock Moon,Chang Kyun Lee,Sung Noh Hong,Jong Pil Im,Byong Duk Ye,Jae Myung Cha,Sung-Ae Jung,Kang-Moon Lee,Dong Il Park,Yoon Tae Jeen,Young Sook Park,Jae Hee Cheon,Hyesung Kim,BoJeong Seo,Youngdoe 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.4
Background/Aims: Limited data are available regarding psychosocial distress at the time of diagnosis of ulcerative colitis (UC). We investigated the psychosocial burden and factors related to poor health-related quality of life (HRQL) among patients newly diagnosed with moderate-to-severe UC who were affiliated with the nationwide prospective cohort study. Methods: Within the first 4 weeks of UC diagnosis, all patients were assessed using the Hospital Anxiety and Depression Scale (HADS), Work Productivity and Activity Impairment questionnaire, Inflammatory Bowel Disease Questionnaire (IBDQ), and 12-Item Short Form (SF-12) health survey. A multiple linear regression model was used to identify factors associated with HRQL. Results: Between August 2014 and February 2017, 355 patients completed questionnaires. Significant mood disorders requiring psychological interventions, defined by a HADS score ≥11, were identified in 16.7% (anxiety) and 20.6% (depression) of patients. Patients with severe disease were more likely to have presenteeism, loss of work productivity, and activity loss than those with moderate disease (all p<0.05). Significant mood disorders had the strongest negative relationship with total IBDQ score, which indicates disease-specific HRQL (β coefficient: –22.1 for depression and –40.0 for anxiety, p<0.001). The scores of all SF-12 dimensions, which indicate general HRQL, were remarkably decreased in the study population compared indirectly with previously reported scores in the general population. The Mayo score, C-reactive protein level, and white blood cell count showed significant negative associations with the IBDQ score (p<0.05). Conclusions: Psychosocial screening and timely interventions should be incorporated into the initial care of patients newly diagnosed with UC.
Lee, Jung-Hun,Lee, Tae-Hyung,Shim, Kyu-Sung,Park, Ji-Won,Kim, Hyun-Joong,Kim, Youngdo,Jung, Soyoun Butterworth-Heinemann Ltd. 2017 International journal of adhesion & adhesives Vol.74 No.-
<P><B>Abstract</B></P> <P>The use of acrylic pressure sensitive adhesives (PSAs) in flexible displays involves their attachment to each layered device. Due to the high industrial demand of flexible displays, acrylic PSAs must necessarily exhibit high flexibility. In this study, the effect of the crosslinking density of acrylic PSAs on their adhesion and flexibility properties has been investigated by incorporating a diisocyanate crosslinking agent into the PSA structure. As the content of the crosslinking agent increased, the measured peel strength and tack of the synthesized PSAs decreased, while the maximum value of the lap shear stress increased. In addition, the maximum stress and shear strain determined for the crosslinked PSA specimens decreased with an increase in the crosslinking agent concentration (although, the stress measured at low strain values was initially increasing until the crosslinking agent content reached 1 phr). The results of stress relaxation testing showed a stress increase at specified strain levels with an increase in the crosslinking agent content up to 0.5 phr, while the results of creep testing revealed that the measured strain was inversely proportional to the degree of elastic recovery. The obtained data indicate that crosslinking generally improves the PSA properties related to their use in flexible display applications; however, very high crosslinking densities produce mostly a negative effect on the PSA flexibility and adhesion characteristics.</P>
Molecular weight and crosslinking on the adhesion performance and flexibility of acrylic PSAs
Lee, Jung-Hun,Lee, Tae-Hyung,Shim, Kyu-Sung,Park, Ji-Won,Kim, Hyun-Joong,Kim, Youngdo,Jung, Soyoun VNU Science Press 2016 Journal of Adhesion Science and Technology Vol. No.
<P>Acrylic pressure sensitive adhesives (PSAs) are used in the production of flexible displays. Acrylic PSAs must have high flexibility and recovery to meet the industry demands for flexible displays. For these reasons, acrylic PSAs were designed to determine the effects of molecular weight and cross-linking on acrylic PSAs. Stress relaxation and creep tests were measured with dynamic mechanical analysis to identify the flexibility and recovery of the acrylic PSAs. The molecular weight and glass transition temperature of the PSAs were measured by gel permeation chromatography and differential scanning calorimetry. A texture analyzer was used to measure the adhesion performance of the acrylic PSAs. With increasing molecular weight, the adhesion performance increased, especially from 86 to 108 K molecular weight PSAs. This is due to the entanglement of the polymer chains. The stress and recovery of cross-linked acrylic PSAs was much higher than that of neat acrylic PSAs. This result is attributed to interactions between the polymer chains due to cross-linking.</P>