우리나라 간암 환자에서의 Cytochrome P450 2E1 유전자의 다형성에 관한 연구

백승운,윤정한,황유진,장유현,이효석,김정룡 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.30 No.4

Reading Hanja (Chinese Character) in Korean Language

( Hyo Woon Yoon ) 건국대학교 이주사회통합연구소 2019 Journal of Migration and Social Integration (JMSI) Vol.4 No.1

Despite the specification of the Korean words (Hangul), which are characterized as phonemes like other alphabetic languages, their shape resembles much more morphemes like Chinese characters (Hanja). The use of functional magnetic resonance imaging permits the collection of brain activation patterns when native Korean speakers (12 persons as subjects) read Hangul and Hanja. The Korean language uses both alphabetic Hangul and logographic Hanja in its writing system. Our experimental results show that the activation patterns obtained for reading Hanja by Korean native speakers involve neural mechanisms that are similar to Chinese native speakers; i.e. strong left-lateralized middle frontal cortex activation. For the case of Korean word reading, the activation pattern in the bilateral fusiform gyrus, left middle frontal gyrus, left superior temporal gyrus, right mid temporal gyrus, precentral gyrus, and insula was observed. It is to note that the reading of Hanja by our subjects activates more late visual areas compared to reading Hangul. The activation of reading Hangul is located more anterior in that late visual area (fusiform gyrus). This suggests that the activation pattern for Hangul reading appears to corroborate that of alphabetic words at the general level. A further noteworthy finding of our study is the strong activation of the posterior part of the right dorsolateral prefrontal cortex (BA 8). The right hemispheric BA 8 belongs to the visual higher order control area and we propose that this area should be responsible for processing of visuospatial (surface form) information of Hangul. (hyowoonyoon@dcu.ac.kr)

비정상적 변연계-대뇌피질 연결고리와 자폐스펙트럼 장애: 확산텐서영상 연구

윤효운 ( Yoon Hyo-woon ),권형진 ( Kwon Hyeoung-jin ) 대구대학교 특수교육재활과학연구소 2017 특수교육재활과학연구 Vol.56 No.3

대표적인 사회적 행동 장애 질환인 자폐아동들의 두뇌 기능 측면이 아닌 두뇌 각 부위간의 연결고리의 비정상화를 알아보기 위해 연구가 진행되었다. 이를 위해 유사한 연령 및 성별의 일반아동들을 비교군으로 하여 실험을 진행하였다. 자폐아동의 뇌기능 혹은 뇌부위의 비정상적인 발달등과 같은 특징들을 골고루 설명할 수 있는 논리는 뇌부위의 연결고리 혹은 네트워크에 대한 이해라고 할 수 있는데 이를 가장 잘 설명할 수 있는 확산텐서영상법을 사용하였다. 결과로는 자폐아동은 시상부위의 분획이방성(FA) 수치가 일반아동에 비해 낮아 시상으로 시작하여 다른 대뇌피질로 연결되는 망체계가 튼튼하지 않다고 여겨진다. 이는 외부로부터 유입되는 다수의 정보처리 기능과도 밀접한 관계가 있으며, 특히 자폐아들은 사회적 정보처리에 미숙함을 나타낸다고 할 수 있다. The present paper aims to investigate the brain abnormalities in children with autism spectrum disorder in terms of the brain area connectivity. The ASD children from 9 to 14 years were recruited and the normal children at the same age as control. In order to measure brain area connectivity in non-invasive way, the diffusion tensor imaging technique was used. This technique is regarded in addition to functional MRI other powerful tool to measure the brain function as well as the connectivity. As results, the fractional anisotropy value of ASD children in thalamus area is significantly lower to the normal children. This leads to a conclusion that the connection between thalamus and iso-cortex in ASD children is weaker than the normal, which also means the lack of information processing, especially if it includes social cue.

An fMRI study on reading Hangul and Chinese Characters by Korean Native Speakers

윤효운(Hyo-Woon Yoon),조경덕(Kyung-Duk Cho) 한국언어치료학회 2005 言語治療硏究 Vol.14 No.4

The use of functional magnetic resonance imaging permits the collection of brain activation patterns when native Korean speakers (12 persons as subjects) read Korean words and Chinese characters. We presented subjects two syllable Korean words and their correpsponding Chinese characters. Our experimental results show that the activation patterns obtained for reading Chinese characters by Korean native speakers involve neural mechanisms that are similar to Chinese native speakers; Ⅰ.e. strong left-lateralized middle frontal cortex activation. For the case of Korean word reading, the activation pattern in the bilateral fusiform gyrus, left middle frontal gyrus, left superior temporal gyrus, right mid temporal gyrus, precentral gyrus, and insula was observed. This suggests that the activation pattern for Korean word reading appears to corroborate with that of alphabetic words at the general level. A further noteworthy finding of our study is the strong activation of the posterior part of the right dorsolateral prefrontal cortex (BA 8). The right hemispheric BA 8 belongs to the visual higher order control area and we propose that this area should be responsible for processing of visuospatial (surface form) information of Korean words

뇌과학이 접근하는 인간의 마음

윤효운(Yoon Hyo Woon) 건국대학교 통일인문학연구단 2007 통일인문학 Vol.45 No.-

The branches of neuroscience are composed of three parts roughly: cellular / molecular, neuroscience of disease, and cognitive / behavior level. Among them the cognitive neuroscience might contribute mostly for explaining the human mind and its biological origins. The modern widely used functional neuroimaging tools such as fMRI or PET can help us to know the exact location of human brain related to the human behavioral function, not only low level behavior such as seeing and hearing, but also higher level complex behaviors such as emotion, and social behavior. All these approaches might help to explain how the human brain is evolved.

Reports : Caffeine inhibits adipogenesis through modulation of mitoticclonal expansion and the AKT/GSK3 pathway in 3T3-L1 adipocytes

( Hyo Jung Kim ),( Bo Kyung Yoon ),( Hyounkyoung Park ),( Jo Woon Seok ),( Hyeonjin Choi ),( Jung Hwan Yu ),( Yoonjeong Choi ),( Su Jin Song ),( Ara Kim ),( Jae-woo Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.2

Caffeine has been proposed to have several beneficial effects on obesity and its related metabolic diseases; however, how caffeine affects adipocyte differentiation has not been elucidated. In this study, we demonstrated that caffeine suppressed 3T3-L1 adipocyte differentiation and inhibited the expression of CCAAT/enhancer binding protein (C/EBP)α and peroxisome proliferator-activated receptor (PPAR)α, two main adipogenic transcription factors. Anti-adipogenic markers, such as preadipocyte secreted factor (Pref)-1 and Kruppel-like factor 2, remained to be expressed in the presence of caffeine. Furthermore, 3T3-L1 cells failed to undergo typical mitotic clonal expansion in the presence of caffeine. Investigation of hormonal signaling revealed that caffeine inhibited the activation of AKT and glycogen synthase kinase (GSK) 3 in a dose-dependent manner, but not extracellular signal-regulated kinase (ERK). Our data show that caffeine is an anti-adipogenic bioactive compound involved in the modulation of mitotic clonal expansion during adipocyte differentiation through the AKT/GSK3 pathway. [BMB Reports 2016; 49(2): 111-115]

Management of postpartum hemorrhage of Lower uterine segment atony, posterior fornix and vaginal wall hematoma by balloon tamponade of three catheters and embolization

( Hyo Jin Lee ),( Yoon Ha Kim ),( Jong Woon Kim ),( Hye Yon Cho ),( Chul Hong Kim ),( Moon Kyoung Cho ),( Tae Bok Song ) 대한산부인과학회 2011 대한산부인과학회 학술대회 Vol.97 No.-

Predictive factors for peripartum cesarean hysterectomy in women with placenta previa

( Hyo Jin Lee ),( Yeo Ha Kim ),( Jong Woon Kim ),( Tae Bok Song ),( Yoon Ha Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.98 No.-

The aim of the study was to identify predictive factors for peripartum hysterectomy in women with placenta previa. We retrospectively reviewed all pregnancies with a diagnosis of placenta previa during the period January 2005 - June 2012. Data regarding the reproductive history and peripartum outcomes were analyzed. Medical records were reviewed for demographic characteristics including age, parity, gestational age at delivery, previous cesarean section, previous previa, antepartum bleeding, placental location, and degree of previa. Statistics were analyzed by t-test and chi-square test. Logistic regression was used to assess the relationship between predictive factors and cesarean hysterectomy. Four-hundred and twelve women were selected. Peripartum cesarean hysterectomy was performed in 27 patients (6.5%). Multiparity, history of abortion, previous cesarean section, total placenta previa and presence of lacuna were more common in the cesarean hysterectomy group. We concluded that in women with placenta previa, history of abortion, previous cesarean section, multiparity, and a total previa are strong antepartum risk factors for peripartum hysterectomy. The equation was constructed by combining these variables was as follows : Probability of peripartum cesarean hysterectomy in placenta previa: = -2.826-1.268*placental location (post)-0.341*placental location (ant&post)-0.884* placenta previa partialis-1.183*placenta previa marginalis+3.894*presence of lacuna

저연령층 알콜중독 환자의 상이한 뇌영상 패턴

윤효운 대구대학교 특수교육재활과학연구소 2012 특수교육재활과학연구 Vol.51 No.1

본 논문에서는 알콜중독 혹은 알콜 의존증으로 진단된 환자들과 비슷한 연령대의 일반인을 대상으로 얼굴자극과 단어자극을 제시하고 그에 대한 부호화 기능을 테스트하였다. 일반적으로 알콜중독 환자는 일반인에 비해 인지적인 부하가 걸릴 경우 좌반구보다는 우반구의 활성화가 더욱 떨어진다는 보고를 바탕으로 뇌영상 연구를 진행하였다. 연구 결과에 따르면 얼굴자극 재인에 관한 우반구의 활성화가 알콜 의존증 환자군에 있어 일반인의 그것과 비교하여 크지 않다는 사실을 볼 수 있다. 이는 기능적 자기공명 영상기법 에서 뿐만 아니라 Diffusion Tensor Imaging이라고 하는 기법을 통하여서도 보여졌다. 본 논문의 결과는 알콜중독 환자들에 대한 진단적 의미와 더불어 재활 및 교육에 대한 정보를 제공하고 있다. The present study investigated the brain activation patterns of alcoholic patients and normal volunteers by doing memory encoding tasks of verbal as well as non-verbal stimulus material using functional MRI. 15 subjects were recruited in each group. It is to note that the left hemispheric frontal lobe activity remains intact in alcoholic patients, whereas the right hemispheric parahippocampal activity seems to be affected by alcohol misuse.

품행장애청소년의 감성에 대한 반응 연구 : 뇌영상 기법을 이용

윤효운 대구대학교 특수교육재활과학연구소 2011 특수교육재활과학연구 Vol.50 No.4

논문에서는 품행장애로 진단된 청소년들(DSM-IV에 근거하여)과 대조군인 일반청소년들이 정서적인 자극을 인지하고 반응을 할 경우 나타나는 두뇌활성화차이를 기능자기공명영상법으로 관찰하였다. 연구 결과에 따르면 품행장애를 지닌 청소년들은 K-YSR을 이용하여 측정된 여러 가지 행동의 특성에서 대조군인 일반청소년들과 차이를 보였다. 두뇌활성화 부위 중 특히 시각 부분의 낮은 활성화는 품행장애 집단이 대조군에 비해 주의 집중이 어려우며, 전전두엽 부분의 낮은 활성화는 품행장애 청소년들이 감성적 자극에 대한 사회적인지기능이나 사회적 행동이 일반청소년들보다 현저히 낮다는 것으로 해석될 수 있다. 본 논문의 결과는 품행장애 청소년들에 대한 진단적 의미와 더불어 재활 및 교육에 대한 정보를 제공하고 있다. The present study investigated the brain activation patterns of violent and normal adolescents between age of 15 to 17 during seeing emotion induced picutures using functional MRI. 15 subjects were recruited in each group. It is to note that all violent adolescents were diagnosed to have conduct disorders and they showed different behavioral patterns due to the measurement using K-YSR compared to normal. Significantly reduced activity in orbifrontal areas of violent adolescents were observed and these were regared as the lack of social interface ability.