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윤도영(Doyoung Yoon),이원철(Woncheol Lee),박진호(Jinho Park) 한국HCI학회 2019 한국HCI학회 학술대회 Vol.2019 No.2
디자이너가 제품을 디자인할 때, 구상한 스케치 도면을 그리고 그것을 바탕으로 제품 이미지를 렌더링하게 된다. 단순히 스케치 이미지만으로는 실제 제품의 느낌을 얻기 어려우므로 여러 번의 시행착오를 겪게 된다. 이러한 문제 때문에 렌더링 작업은 많은 자원을 소모하게 된다. 이러한 문제를 해결하고자 컴퓨터가 먼저 렌더링 이미지를 생성하여 제품 이미지를 보여준다면 시행착오를 줄일 수 있을 것이다. 현재 이와 관련한 기계학습 기반 제품 이미지를 생성해주는 방법들이 있으나 한 가지 스타일만 생성하거나 원하는 스타일의 이미지를 입력 이미지로 넣어줘야 하는 등의 제한점이 있다. 본 연구는 이런 기존 연구들의 제한점을 보완하고자 StarGAN 모델을 변형하여 디자이너의 스케치 이미지와 원하는 스타일 즉, 도메인을 선택하여 원하는 제품 이미지를 생성할 수 있는 기법을 제안하고자 한다.
Yoon, Sukhwan,Nissen, Silke,Park, Doyoung,Sanford, Robert A.,Loffler, Frank E. American Society for Microbiology 2016 Applied and environmental microbiology Vol.82 No.13
<P>Bacteria capable of reduction of nitrous oxide (N2O) to N-2 separate into clade I and clade II organisms on the basis of nos operon structures and nosZ sequence features. To explore the possible ecological consequences of distinct nos clusters, the growth of bacterial isolates with either clade I (Pseudomonas stutzeri strain DCP-Ps1, Shewanella loihica strain PV-4) or clade II (Dechloromonas aromatica strain RCB, Anaeromyxobacter dehalogenans strain 2CP-C) nosZ with N2O was examined. Growth curves did not reveal trends distinguishing the clade I and clade II organisms tested; however, the growth yields of clade II organisms exceeded those of clade I organisms by 1.5- to 1.8-fold. Further, whole-cell half-saturation constants (K(s)s) for N2O distinguished clade I from clade II organisms. The apparent Ks values of 0.324 +/- 0.078 mu M for D. aromatica and 1.34 +/- 0.35 mu M for A. dehalogenans were significantly lower than the values measured for P. stutzeri (35.5 +/- 9.3 mu M) and S. loihica (7.07 +/- 1.13 mu M). Genome sequencing demonstrated that Dechloromonas denitrificans possessed a clade II nosZ gene, and a measured Ks of 1.01 +/- 0.18 mu M for N2O was consistent with the values determined for the other clade II organisms tested. These observations provide a plausible mechanistic basis for why the relative activity of bacteria with clade I nos operons compared to that of bacteria with clade II nos operons may control N2O emissions and determine a soil's N2O sink capacity.</P>
Yoon, Young Mee,Lee, Jin Young,Yoo, Doyoung,Sim, Young-Suk,Kim, Young-Jeon,Oh, Yu-Kyoung,Kang, Ju Seop,Kim, Sunil,Kim, Joo Sung,Kim, Jung Mogg American Society for Microbiology 2010 Infection and immunity Vol.78 No.5
<B>ABSTRACT</B><P>Enterotoxigenic <I>Bacteroides fragilis</I> (ETBF) produces an approximately 20-kDa heat-labile enterotoxin (BFT) that plays an essential role in mucosal inflammation. Although spontaneous disappearance of ETBF infection is common, little information is available on regulated expression of antibacterial factors in response to BFT stimulation. This study investigates the role of BFT in human β-defensin 2 (hBD-2) induction from intestinal epithelial cells. Stimulation of HT-29 and Caco-2 intestinal epithelial cell lines with BFT resulted in the induction of hBD-2. Activation of a reporter gene for hBD-2 was dependent on the presence of NF-κB binding sites. In contrast, suppression of AP-1 did not affect hBD-2 expression in BFT-stimulated cells. Inhibition of p38 mitogen-activated protein kinase (MAPK) using SB203580 and small interfering RNA (siRNA) transfection resulted in a significant reduction in BFT-induced IκB kinase (IKK)/NF-κB activation and hBD-2 expression. Our results suggest that a pathway including p38 MAPK, IKK, and NF-κB activation is required for hBD-2 induction in intestinal epithelial cells exposed to BFT, and may be involved in the host defense following infection with ETBF.</P>
The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages
( Doyoung Park ),( Gyumin Lim ),( Sung-jin Yoon ),( Hyon-seung Yi ),( Dong Wook Choi ) 생화학분자생물학회 2022 BMB Reports Vol.55 No.11
Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages’ inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response. [BMB Reports 2022; 55(11): 519-527]
Yoon, Yeoheung,Lee, Keunsik,Kwon, Soongeun,Seo, Sohyeon,Yoo, Heejoun,Kim, Sungjin,Shin, Yonghun,Park, Younghun,Kim, Doyoung,Choi, Jae-Young,Lee, Hyoyoung American Chemical Society 2014 ACS NANO Vol.8 No.5
<P>Supercapacitors with porous carbon structures have high energy storage capacity. However, the porous nature of the carbon electrode, composed mainly of carbon nanotubes (CNTs) and graphene oxide (GO) derivatives, negatively impacts the volumetric electrochemical characteristics of the supercapacitors because of poor packing density (<0.5 g cm<SUP>–3</SUP>). Herein, we report a simple method to fabricate highly dense and vertically aligned reduced graphene oxide (VArGO) electrodes involving simple hand-rolling and cutting processes. Because of their vertically aligned and opened-edge graphene structure, VArGO electrodes displayed high packing density and highly efficient volumetric and areal electrochemical characteristics, very fast electrolyte ion diffusion with rectangular CV curves even at a high scan rate (20 V/s), and the highest volumetric capacitance among known rGO electrodes. Surprisingly, even when the film thickness of the VArGO electrode was increased, its volumetric and areal capacitances were maintained.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-5/nn500150j/production/images/medium/nn-2014-00150j_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn500150j'>ACS Electronic Supporting Info</A></P>