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A guide to studying human hair follicle cycling <i>in vivo</i>
Oh, Ji Won,Kloepper, Jennifer,Langan, Ewan A.,Kim, Yongsoo,Yeo, Joongyeub,Kim, Min Ji,Hsi, Tsai-Ching,Rose, Christian,Yoon, Ghil Suk,Lee, Seok-Jong,Seykora, John,Kim, Jung Chul,Sung, Young Kwan,Kim, M Nature Publishing Group 2016 The Journal of investigative dermatology Vol.136 No.1
<P>Hair follicles (HFs) undergo life-long cyclical transformations, progressing through stages of rapid growth (anagen), regression (catagen), and relative “quiescence” (telogen). Since HF cycling abnormalities underlie many human hair growth disorders, the accurate classification of individual cycle stages within skin biopsies is clinically important and essential for hair research. For preclinical human hair research purposes, human scalp skin can be xenografted onto immunocompromised mice to study human HF cycling and manipulate long-lasting anagen <I>in vivo</I>. While available for mice, a comprehensive guide on how to recognize different human hair cycle stages <I>in vivo</I> is lacking. Here, we present such a guide, which uses objective, well-defined, and reproducible criteria and integrates simple morphological indicators with advanced, (immuno)-histochemical markers. This guide also characterizes human HF cycling in xenografts and highlights the utility of this model for <I>in vivo</I> hair research. Detailed schematic drawings and representative micrographs provide examples of how best to identify human HF stages, even in sub-optimally sectioned tissue, and practical recommendations are given for designing human-on-mouse hair cycle experiments. Thus, this guide seeks to offer a benchmark for human hair cycle stage classification, for both hair research experts and newcomers to the field.</P>
Highly efficient hybrid thin-film solar cells using a solution-processed hole-blocking layer
Seo, Ji Hoon,Kim, Dong-Ho,Kwon, Se-Hun,Park, Yun Chang,Jung, Hyung Hwan,Lee, Hyung Woo,Kwon, Jung-Dae,Park, Sung-Gyu,Nam, Kee-Seok,Jeong, Yongsoo,Ryu, Seung Yoon,Kang, Jae-Wook,Kim, Chang Su The Royal Society of Chemistry 2013 Physical chemistry chemical physics Vol.15 No.6
<P>We report the origin of the improvement of the power conversion efficiency (PCE) of hybrid thin-film solar cells when a soluble C<SUB>60</SUB> derivative, [6,6]-phenyl-C<SUB>61</SUB>-butyric acid methyl ester (PCBM), is introduced as a hole-blocking layer. The PCBM layer could establish better interfacial contact by decreasing the reverse dark-saturation current density, resulting in a decrease in the probability of carrier recombination. The PCE of this optimized device reached a maximum value of 8.34% and is the highest yet reported for hybrid thin-film solar cells.</P> <P>Graphic Abstract</P><P>N-doping free hybrid thin-film solar cells exceeding 8% efficiency. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cp44468b'> </P>
Yang, Ji-Hwan,Jung, Hyung-Hwan,Seo, Jihoon,Kim, Kwang-Dae,Kim, Dong-Ho,Lim, Dong-Chan,Park, Sung-Gyu,Kang, Jae-Wook,Song, Myungkwan,Choi, Min-Seung,Kwon, Jung-Dae,Nam, Kee-Seok,Jeong, Yongsoo,Kwon, Se American Chemical Society 2013 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.117 No.45
<P>Toxic doping gases are usually used to produce hydrogenated amorphous silicon (a-Si:H) layers in thin-film solar cells (TFSCs). Hence, an alternative structure that avoids the use of toxic gases is desirable. In this work, we replaced both the <I>p</I>-type-a-Si:H and <I>n</I>-type-a-Si:H layers simultaneously in a normal TFSC to form a structure that is dopant-free. Molybdenum oxide (MoO<SUB>3</SUB>) and lithium fluoride were used as the <I>p</I>-type and <I>n</I>-type layers, respectively. The effects of the deposition method and the thickness of the MoO<SUB>3</SUB> layer on the device performance were investigated. The power-conversion efficiency of the optimized hybrid solar cell reached a maximum of 7.08%, which is remarkable considering the novel structure of the dopant-free devices. The light stability of the devices with and without MoO<SUB>3</SUB> was also compared: the light stability of the device with MoO<SUB>3</SUB> was found to be much better than that of the device without MoO<SUB>3</SUB> and with <I>p-i-n</I> Si layers. This was ascribed to the insignificant number of defect sites generated by the nondoping elements, which led to a less contaminated, more compact, and smoother oxide surface, resulting in an increase in the electron lifetime and improved light stability. This work opens up a new direction toward the development of a truly dopant-free device that does not involve the use of toxic gases during fabrication and provides the potential for further enhancement of the efficiency of future dopant-free solar cells.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2013/jpccck.2013.117.issue-45/jp4031656/production/images/medium/jp-2013-031656_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp4031656'>ACS Electronic Supporting Info</A></P>
Development of nutritional risk assessment platform in Korea
Lee, Hunjoo,Kwon, Nam ji,Kim, Yongsoo,Han, Eunyoung Elsevier 2018 Regulatory toxicology and pharmacology Vol.98 No.-
<P><B>Abstract</B></P> <P>Risk assessment has been used to prevent health problems associated with eating habits in response to increased interest in a balanced diet. For nutritional risk assessment (NRA), it is important to 1) consider personal nutrition status based on year-round dietary intake, 2) organize core datasets such as food composition, intake, and health based guidance value (HBGV) datasets with public confidence, and 3) assess and predict the effects by using the computerized NRA tool. Our research staff constructed an integrated database system by compiling and organizing core datasets produced sporadically by different organizations and with different formats and developed a nutritional exposure and risk assessment system called Nutri-Risk (NUTRItional RISK assessment platform), which contained the database. Nutri-Risk is not only capable of NRA, but also contains additional data service functions. Here, the compilations and organization of an integrated database are outlined. In addition, the overall architectures of Nutri-Risk and dietary modeling are described and predictive simulation functions to support the regulatory decisions related to nutritional fortification or reduction policy were demonstrated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An integrated database with standardized codesets and a platform were developed. </LI> <LI> A platform was implemented for risk assessment with dietary modeling and simulation. </LI> <LI> The simulation can minimize the risk for nutritional fortification and reduction. </LI> </UL> </P>
( Yun Jeong Jeong ),( Yongsoo Choi ),( Jae Moon Shin ),( Hyun Ji Cho ),( Jeong Han Kang ),( Hyeun Wook Park ),( Jung Yoon Choe ),( Young Seuk Bae ),( Sang Mi Han ),( Cheorl Ho Kim ),( Hyeun Wook Chang 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Bee venom is a natural compound produced by the honey bee (Apis mellifera), and has been reported as having the biological and pharmacological activities, including anti-bacterial, anti-viral and anti-inflammation. In the present study, the inhibitory effects of bee venom and its major peptide components on the tumor invasion were demonstrated. It was confirmed the inhibitory effects of bee venom, melittin, and apamin on the EGF-induced invasion of breast cancer cells. Transwell invasion and wound-healing assays showed that bee venom and melittin significantly inhibits the EGF-induced invasion and migration of breast cancer cells. Also, bee venom and melittin reduced the EGF-stimulated F-actin reorganization at the leading edge, but apamin did not affect. Particularly, melittin inhibited the EGF-induced MMP-9 expression via blocking the NF-κB and PI3K/Akt/mTOR pathway. In addition, melittin significantly suppressed the EGF-induced FAK phosphorylation through inhibition of mTOR/p70S6K/4E-BP1 pathway. These results suggest that inhibitory effects of melittin on breast cancer cell motility and migration may be related to the inhibition of mTOR pathway.ⓒ2014 Elsevier Ltd. All rights reserved.
Lee, Hunjoo,Han, Eunyoung,Kwon, Nam ji,Kim, Yongsoo,Kim, Sena,Kim, Haengran,Min, Sung-Gi Elsevier 2017 Journal of food composition and analysis Vol.62 No.-
<P><B>Abstract</B></P> <P>Food composition databases (FCDBs) are important to studies, industries, polices, and modeling related to diet and food. A FCDB has been provided by each country’s government organizations. In Korea, the FCDB has been produced and provided by the Rural Development Administration (RDA) and the national food analysis system (NFAS), a network between qualified laboratories by the nation. In this study, a new web based system, NutriManager, was designed to support integrated database management and collaboration between RDA and NFAS. The main goal of this system is to provide an efficient tool to support a series of workflow from sample enrollment to validation results. NutriManager has many features related to food and nutrient database management and validation; the computerized laboratory notebook, the stepwise processes of algorithms for validity assessment and determination of the representative value, and creation of a Korean National Food Composition Table (KNFCT). Therefore, NutriManager contributes to production of food composition data with high reliability and also can be used as a more efficient tool to link with other public programs using FCDB as a key database in Korea.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An overall architecture to NutriManager’s database management is described. </LI> <LI> NutriManager assesses repeatability of analytical results by sample automatically. </LI> <LI> NutriManager determines the validity of representative values of food systemically. </LI> <LI> NutriManager contributes to highly reliable and historical food composition data. </LI> </UL> </P>
PRB 지진격리장치의 성능 검증을 위한 해석 및 실험적 연구
김성조,김세윤,지용수,김봉식,한동석,Kim, Sung-Jo,Kim, Se-Yun,Ji, Yongsoo,Kim, Bongsik,Han, Tong-Seok 한국전산구조공학회 2020 한국전산구조공학회논문집 Vol.33 No.5
본 논문에서는 모듈화(Module)된 부품을 활용한 탄성받침 성능개선기법에 대하여 소개하였다. 각각의 모듈화된 장치들이 지진 강도 및 이동 변위에 따른 단계별 거동을 함으로써 받침의 성능을 개선하게 된다. 모듈화된 장치들은 초기전단저항 블럭, 완충장치, 변위수용가이드, 낙교방지블럭이 있으며, 탄성받침에 추가적으로 적용되었다. 이 장치는 지진의 규모에 따라 4단계로 거동하며, 1차로 설계변위를 수용하고, 2차, 3차에서는 대규모 지진을 수용하며, 4차로는 대규모의 지진에 대해서 낙교방지가 가능하도록 설계되어 탄성받침의 용량 제한을 증가시킨다. 본 논문에서는, 개발기술인 PRB 지진격리장치를 유한요소해석을 통해 해석하여 격리장치의 이론적인 거동이 구현되는지와, 대규모 지진에 해당하는 하중을 견딜 수 있는지 확인하였다. 그리고 이를 바탕으로 실험을 통해 성능평가를 진행하여 두 결과의 비교 분석을 통해 PRB 지진격리장치가 탄성받침의 성능을 개선할 수 있는지 검증하였다. This study introduces a technique for improving the elastomeric-isolator performance using modular devices. The modular devices are shear resistance block, polymer spring, displacement acceptance guide, and anti-falling block. They are installed on the elastomeric isolator as a supplementary device. Each modularized device improves the isolator performance by performing step-by-step actions according to the seismic intensity and displacement. The PRB isolation device works in four stages, depending on the seismic magnitude, to satisfy the target performance. It is designed to accommodate design displacement in the first stage and large magnitude of earthquakes in the second and third stages. This design prevents superstructures from falling in the fourth stage due to large-magnitude earthquakes by increasing the capacity limit of the elastomeric isolator. In this study, the PRB isolation device is analyzed using finite element analysis to verify that the PRB isolation device works as intended and it can withstand loads corresponding to large-magnitude earthquakes. The performance of the PRB isolation device is validated by the analysis, which is further corroborated by actual experiments.
균열방지 전단키의 수평성능 및 내구성에 대한 실험적 연구
박진영 ( Park Jin Young ),김태상 ( Kim Tae Sang ),지용수 ( Ji Yongsoo ),김봉식 ( Kim Bongsik ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.2
균열방지 전단키(Anti-Crack Shear key, ACS)는 기존 교량구조물의 내진성능평가 결과에 따라 그 적용성이 판단된다. 받침의 공급역량 부족시 전단키를 설치하면 공급역량을 추가할 수 있어 구조물의 안전성을 확보할 수 있다. 전단키는 강재 브라켓 전단키, 콘크리트블록 전단키 및 받침형 전단키로 구분할 수 있으며 본 제품인 균열방지 전단키(ACS)는 받침형 전단키 제품군에 해당된다. 일반강재를 적용한 몸체와 미끌림 소재로 내구성이 좋은 특수 마찰소재(Engineering Plastic, EP) 그리고 스테인리스 스틸(Stainless Steel) 판을 최적 배치 적용함으로서 기존 제품대비 내구성이 높으며 부식 등과 같은 환경영향을 최소화 하도록 성능을 개선한 전단키이다. 본 연구에서는 EN 15129, EN 1337-5, EAD 등 성능평가 절차를 선정하고 완제품의 특성평가와 마찰소재의 장기 내구성실험을 수행하였다. 수평 저항성능 및 변위수용 모듈의 작동과 마찰재의 장기 거동 내구성을 확인하였다.