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Advances in the development of hemostatic biomaterials for medical application
Yong Kiel Sung,Dae Ryeong Lee,정동준 한국생체재료학회 2021 생체재료학회지 Vol.25 No.4
Background: Medical hemostatic biological materials are necessary for the development of the process of preventing and stopping damaged intravascular bleeding. In the process, some red blood cells and white blood cells are trapped in nets. The resulting plug is called a blood clot. This is often a good step in wound healing, but separation of blood clots from blood vessel walls can cause serious health problems. Main body: The advance in the development of hemostatic biomaterials is necessary for biomedical application. Firstly, the historical background of artificial hemostasis has been included and the current research of hemostasis has been included in more detail. Secondly, the current research of hemostasis has been included on the oxidized cellulose-based hemostatic biomaterials such as starch based on composite cross-linking hemostatic networks, hemostatic materials on NHS-esters, hemostatic agent from local materials and biomaterials for hemostatic management. Thirdly, polysaccharide hemostatic materials, bio-inspired adhesive catechol-conjugated chitosan, mesoporous silica and bioactive glasses for improved hemostasis, minimally invasive hemostatic biomaterials and chitosan-base materials for hemostatic application have been included. Fourthly, the biological properties of natural hemostatic agent by plasma technology and the hemostatic agents based on gelatinmicrobial transglutaminase mixes have been also included. Conclusion: Current research on hemostasis includes hemostatic biomaterials such as cellulose-based hemostatic starch based on a complex cross-linked hemostatic network. It also includes polysaccharide hemostatic materials, biomimetic adhesive catechol-binding chitosan, mesoporous silica or physiologically active glass for hemostatic improvement, minimally invasive hemostatic chitosan-based materials, and gelatin-microbial transglutaminase-based hemostatic agents. Future studies should focus on modular combination of hemostatic imitation and reinforcement mechanisms of different materials and technologies to find the optimal system to promote and strengthen active platelet or platelet imitation aggregation in bleeding sites. The second optionally increases the production of thrombin and fiber formation at the site. Third, the formed fibrin biopolymer network has strengthened to reduce thrombosis and amplify hemostasis.
Recent advances in polymeric drug delivery systems
Yong Kiel Sung,Sung Wan Kim 한국생체재료학회 2020 생체재료학회지 Vol.24 No.2
Background: Polymeric drug delivery systems have been achieved great development in the last two decades. Polymeric drug delivery has defined as a formulation or a device that enables the introduction of a therapeutic substance into the body. Biodegradable and bio-reducible polymers make the magic possible choice for lot of new drug delivery systems. The future prospects of the research for practical applications has required for the development in the field. Main body: Natural polymers such as arginine, chitosan, dextrin, polysaccharides, poly (glycolic acid), poly (lactic acid), and hyaluronic acid have been treated for polymeric drug delivery systems. Synthetic polymers such as poly (2-hydroxyethyl methacrylate), poly(N-isopropyl acrylamide)s, poly(ethylenimine)s, dendritic polymers, biodegradable and bio-absorbable polymers have been also discussed for polymeric drug delivery. Targeting polymeric drug delivery, biomimetic and bio-related polymeric systems, and drug-free macromolecular therapeutics have also treated for polymeric drug delivery. In polymeric gene delivery systems, virial vectors and non-virial vectors for gene delivery have briefly analyzed. The systems of non-virial vectors for gene delivery are polyethylenimine derivatives, polyethylenimine copolymers, and polyethylenimine conjugated bio-reducible polymers, and the systems of virial vectors are DNA conjugates and RNA conjugates for gene delivery. Conclusion: The development of polymeric drug delivery systems that have based on natural and synthetic polymers are rapidly emerging to pharmaceutical fields. The fruitful progresses have made in the application of biocompatible and bio-related copolymers and dendrimers to cancer treatment, including their use as delivery systems for potent anticancer drugs. Combining perspectives from the synthetic and biological fields will provide a new paradigm for the design of polymeric drug and gene delivery systems.
Synthesis and Solution Properties of La(III)-N-ethylmorpholine Complex
Yong Kiel Sung,Yong Zeinab M. Anwar 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.4
The complex of the composition LaL(NO3)3 (H2O)2 is prepared by the reaction of La(NO3)3•6H2O with N-ethylmorpholine in aqueous medium. The ligand is involved in the complex as a neutral species where the chelation occurs via the oxygen of the ligand moiety and the nitrate groups as bidentate ligand. The chemical structure of the studied complex is confirmed through IR, XRD, and thermal analysis data. The complexation equilibria of La(III) with N-ethylmopholine is studied in aqueous medium at ionic strength I = 0.1 moládm3 KNO3 and at 25, 35 and 45 oC, respectively. The thermodynamic parameters G, H and S values were calculated to prove the association with the complex formation. It is clearly observed that the process is accompanied by absorption of heat, i.e. endothermic process, while the entropy does not change greatly attributed to the release of constant number of water molecules during chelate formation.
Nadia Abdel Aal,M. Bououdina,A. Hajry,A. A. Chaudhry,J. A. Darr,A. A. Al-Ghamdi,E. H. El-Mossalamy,Attieh A. Al-Ghamdi,YongKielSung,Farid El-Tantawy 한국생체재료학회 2011 생체재료학회지 Vol.15 No.2
Hydroxyapatite(HAP) nanoparticles were successfully prepared from the biowaste chicken eggshells and phosphoric acid solution by chemical precipitation methods. The structures of HAP were characterized in terms of the X-ray diffraction (XRD), scanning electron microscope (SEM), and Fourier transform-infrared (FT-IR) spectroscopy. The effect of temperature on the crystallinity and lattice parameters of prepared HAP was monitored by X-ray powder diffraction. Energy dispersive X-ray analysis revealed that the HAP had a Ca/P molar ratio of about 1.65 and 1.69for as prepared and sintered HAP at 1200oC (1 hour), respectively. The temperature dependence on the electrical conductivity of sintered HAP nanoparticle was investigated. Furthermore, dielectric properties such as dielectric constant and dielectric loss as a function of frequency for the sintered HAP were also studied.