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YongJun Cheon,Eunsoo Moon,JeMin Park,ByungDae Lee,YoungMin Lee,HeeJeong Jeong,TaeUk Kang,Jeonghyun Park,Yoonmi Choi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.3
This case report aimed to describe cyclic patterns of residual mood symptoms in partially remitted bipolar I patient. In a 24-year-old woman with bipolar I disorder, residual mood symptoms measured by self-rated daily mood chart for 18 months were analyzed using wavelet analysis. A 146-day periodicity was prominent for the first 100 days after discharge. Between 100-200 days, 146-day periodicity was progressively diminished and 21- and 8-day periodicity was prominent. Between 200-516 days, 21-day periodicity was diminished and 85-day periodicity became prominent. This case suggest that bipolar patients might have cyclic residual symptoms with specific frequencies.
Noh, Seung-hyun,Moon, Seung Ho,Shin, Tae-Hyun,Lim, Yongjun,Cheon, Jinwoo ELSEVIER SCIENCE BV AMSTERDAM 2017 Nano Today Vol. No.
<P><B>Abstract</B></P> <P>Magnetic nanoparticle (MNP)-mediated heating systems have emerged as an effective strategy for the fine control of biological systems from hyperthermia to cell signaling in a spatiotemporally controlled fashion. To achieve satisfactory performance, advanced design concepts have been developed to tailor the magnetism that directly affects the heating properties of nanoparticles. In this review, we focus on recent advances in magnetism-engineered nanoparticles. Fundamental principles of magnetic heating mechanisms and related key magnetic parameters are discussed first to provide instructive guidelines for the design of MNPs with enhanced heating efficiency. Then, we highlight recent progress in MNPs for optimized heat generation with unique design approaches to control magnetism. Finally, we discuss highly effective biomedical application studies such as dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Basic principles of heat dissipation of magnetic nanoparticles. </LI> <LI> Nanoparticle design considerations for tuning the magnetism that governs magnetic heating efficiency, such as specific loss power (<I>SLP</I>). </LI> <LI> Emerging approaches for the use of heat-generating nanoparticles for dual-mode magnetic hyperthermia, magnetothermally triggered drug delivery, and the magnetothermal control of cellular activities. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Noh, Seung-hyun,Na, Wonjun,Jang, Jung-tak,Lee, Jae-Hyun,Lee, Eun Jung,Moon, Seung Ho,Lim, Yongjun,Shin, Jeon-Soo,Cheon, Jinwoo American Chemical Society 2012 NANO LETTERS Vol.12 No.7
<P>With the aim of controlling nanoscale magnetism, we demonstrate an approach encompassing concepts of surface and exchange anisotropy while reflecting size, shape, and structural hybridization of nanoparticles. We visualize that cube has higher magnetization value than sphere with highest coercivity at 60 nm. Its hybridization into core–shell (CS) structure brings about a 14-fold increase in the coercivity with an exceptional energy conversion of magnetic field into thermal energy of 10600 W/g, the largest reported to date. Such capability of the CS-cube is highly effective for drug resistant cancer cell treatment.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-7/nl301499u/production/images/medium/nl-2012-01499u_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl301499u'>ACS Electronic Supporting Info</A></P>
Ultrathin Interface Regime of Core–Shell Magnetic Nanoparticles for Effective Magnetism Tailoring
Moon, Seung Ho,Noh, Seung-hyun,Lee, Jae-Hyun,Shin, Tae-Hyun,Lim, Yongjun,Cheon, Jinwoo American Chemical Society 2017 NANO LETTERS Vol.17 No.2
<P>The magnetic exchange coupling interaction between hard and soft magnetic phases has been important for tailoring nanoscale magnetism, but spin interactions at the core-shell interface have not been well studied. Here, we systematically investigated a new interface phenomenon termed enhanced spin canting (ESC), which is operative when the shell thickness becomes ultrathin, a few atomic layers, and exhibits a large enhancement of magnetic coercivity (H-c). We found that ESC arises not from the typical hard-soft exchange coupling but rather from the large magnetic surface anisotropy (K-s) of the ultrathin interface. Due to this large increase in magnetism, ultrathin core shell nanoparticles overreach the theoretical limit of magnetic energy product ((BH)(max)) and exhibit one of the largest values of specific loss power (SLP), which testifies to their potential capability as an effective mediator of magnetic energy conversion.</P>
Eunsoo Moon,Byeong-Moo Choe,Je-Min Park,Young In Chung,Byung Dae Lee,Jae-Hong Park,Young Min Lee,Hee Jeong Jeong,YongJun Cheon,Yoonmi Choi,Jeonghyun Park 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.9
Objective Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC) activities in frontal, striatal, hippocampus and cerebellum, but also relative PKC activity ratios among brain regions according to recovery of circadian rhythm. Methods The circadian rhythm disruption protocol was applied to eight-week-old twenty male Institute Cancer Research mice. The circadian rhythm recovery patterns were collected through motor activities measured by Mlog system. Depressive and manic proneness were examined by forced swim test and quinpirole-induced open field test respectively. Enzyme-linked immunosorbent assay was employed to measure PKC activities. Results The delayed recovery group presented greater locomotor activities than the early recovery group (p=0.033). The delayed recovery group had significantly lower frontal PKC activity than the other (p=0.041). The former showed lower frontal/cerebellar PKC activity ratio (p=0.047) but higher striatal/frontal (p=0.038) and hippocampal/frontal (p=0.007) PKC activities ratios than the latter. Conclusion These findings support potential mechanism of delayed recovery after circadian disruption in bipolar animal model could be an alteration of relative PKC activities among mood regulation related brain regions. It is required to investigate the PKC downstream signaling related to the delayed recovery pattern.