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Chao Qin,Yixin Yu,Yuan Zeng 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.4
This paper proposes a novel probabilistic load flow model for power systems integrated with large-scale wind power, which considers the multi-time scale dispatching features. The ramp limitations of the units and the steady-state security constraints of the network have been comprehensively considered for the entire duration of the study period; thus, the coupling of the system operation states at different time sections has been taken into account. For each time section, the automatic generation control (AGC) strategy is considered, and all variations associated with the wind power and loads are compensated by all AGC units. Cumulants and the Gram–Charlier expansion are used to solve the proposed model. The effectiveness of the proposed method is validated using the modified IEEE RTS 24-bus system and the modified IEEE 118-bus system.
Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway
Xiaohui Jin,Yixin Yuan,Chi Zhang,Yong Zhou,Yue Song,Zhanyong Wei,Gaiping Zhang 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.3
Background: Porcine parvovirus (PPV) is a single-stranded DNA virus that causes porcine reproductive failure. It is of critical importance to study PPV pathogenesis for the prevention and control of the disease. NS1, a PPV non-structural protein, is participated in viral DNA replication, transcriptional regulation, and cytotoxicity. Our previous research showed that PPV can activate nuclear factor kappa B (NF-κB) signaling pathway and then up-regulate the expression of interleukin (IL)-6. Objectives: Herein, the purpose of this study is to determine whether the non-structural protein NS1 of PPV also has the same function. Methods: Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR), enzyme-linked immunosorbent assay, western blot, immunofluorescence assay and small interfering RNA (siRNA) were used. Results: Our findings demonstrated that PPV NS1 protein can up-regulate the expression levels of IL-6 and tumor necrosis factor-alpha in a dose-dependent manner. Moreover, PPV NS1 protein was found to induce the phosphorylation of IκBα, then leading to the phosphorylation and nuclear translocation of NF-κB. In addition, the NS1 protein activated the upstream pathways of NF-κB. Meanwhile, TLR2-siRNA assay showed TLR2 plays an important role in the activation of NF-κB signaling pathway induced by PPV-NS1. Conclusions: These findings indicated that PPV NS1 protein induced the up-regulated of IL-6 expression through activating the TLR2 and NF-κB signaling pathways. In conclusion, these findings provide a new avenue to study the innate immune mechanism of PPV infection.
Qin, Chao,Yu, Yixin,Zeng, Yuan The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.4
This paper proposes a novel probabilistic load flow model for power systems integrated with large-scale wind power, which considers the multi-time scale dispatching features. The ramp limitations of the units and the steady-state security constraints of the network have been comprehensively considered for the entire duration of the study period; thus, the coupling of the system operation states at different time sections has been taken into account. For each time section, the automatic generation control (AGC) strategy is considered, and all variations associated with the wind power and loads are compensated by all AGC units. Cumulants and the Gram-Charlier expansion are used to solve the proposed model. The effectiveness of the proposed method is validated using the modified IEEE RTS 24-bus system and the modified IEEE 118-bus system.
Assessment of Hemagglutination Activity of Porcine Deltacoronavirus
Yunfei Zhang,Li Han,Lu Xia,Yixin Yuan,Hui Hu 대한수의학회 2020 Journal of Veterinary Science Vol.21 No.1
Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus that causes diarrhea in piglets. However, the biological characteristics of PDCoV are unclear. In this study, the hemagglutination (HA) abilities of two PDCoV strains (CH-01 and HNZK-04) were investigated. Our results showed that PDCoV has the ability to agglutinate rabbit erythrocytes after virion pretreatment with trypsin or neuraminidase. Additionally, the HA assay results showed a significant positive correlation with the infectious viral titer. Our results suggest that assessing the HA activity of PDCoV may be a useful diagnostic method for investigating and surveilling PDCoV infections.