Influence of Intravenous Contrast Medium on Dose Calculation Using CT in Treatment Planning for Oesophageal Cancer

Li, Hong-Sheng,Chen, Jin-Hu,Zhang, Wei,Shang, Dong-Ping,Li, Bao-Sheng,Sun, Tao,Lin, Xiu-Tong,Yin, Yong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: To evaluate the effect of intravenous contrast on dose calculation in radiation treatment planning for oesophageal cancer. Methods: A total of 22 intravein-contrasted patients with oesophageal cancer were included. The Hounsfield unit (HU) value of the enhanced blood stream in thoracic great vessels and heart was overridden with 45 HU to simulate the non-contrast CT image, and 145 HU, 245 HU, 345 HU, and 445 HU to model the different contrast-enhanced scenarios. 1000 HU and -1000 HU were used to evaluate two non-physiologic extreme scenarios. Variation in dose distribution of the different scenarios was calculated to quantify the effect of contrast enhancement. Results: In the contrast-enhanced scenarios, the mean variation in dose for planning target volume (PTV) was less than 1.0%, and those for the total lung and spinal cord were less than 0.5%. When the HU value of the blood stream exceeded 245 the average variation exceeded 1.0% for the heart V40. In the non-physiologic extreme scenarios, the dose variation of PTV was less than 1.0%, while the dose calculations of the organs at risk were greater than 2.0%. Conclusions: The use of contrast agent does not significantly influence dose calculation of PTV, lung and spinal cord. However, it does have influence on dose accuracy for heart.

Density Functional Theoretical Study on Intermolecular Interactions of 3,6-Dihydrazino-1,2,4,5-tetrazine Dimers

Hu, Yin,Ma, Hai-Xia,Li, Jun-Feng,Gao, Rong,Song, Ji-Rong Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.10

Seven fully optimized geometries of 3,6-dihydrazino-1,2,4,5-tetrazine (DHT) dimers have been obtained with density functional theory (DFT) method at the B3LYP/$6-311++G^{**}$ level. The intermolecular interaction energy was calculated with zero point energy (ZPE) correction and basis set superposition error (BSSE) correction. The greatest corrected intermolecular interaction energy of the dimers is $-23.69\;kJ{\cdot}mol^{-1}$. Natural bond orbital (NBO) analysis is performed to reveal the origin of the interaction. Based on the vibrational analysis, the changes of thermodynamic properties from the monomers to dimer with the temperature ranging from 200.0 K to 800.0 K have been obtained using the statistical thermodynamic method. It was found that the hydrogen bonds dominantly contribute to the dimers, while the binding energies are not only determined by hydrogen bonding. The dimerization process can not occur spontaneously at given temperatures.

Density Functional Theoretical Study on Intermolecular Interactions of 3,6-Dihydrazino-1,2,4,5-tetrazine Dimers

Yin Hu,Hai-Xia Ma,Jun-Feng Li,Rong Gao,Ji-Rong Song 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.10

Seven fully optimized geometries of 3,6-dihydrazino-1,2,4,5-tetrazine (DHT) dimers have been obtained with density functional theory (DFT) method at the B3LYP/6-311++G** level. The intermolecular interaction energy was calculated with zero point energy (ZPE) correction and basis set superposition error (BSSE) correction. The greatest corrected intermolecular interaction energy of the dimers is ‒23.69 kJ·mol‒1. Natural bond orbital (NBO) analysis is performed to reveal the origin of the interaction. Based on the vibrational analysis, the changes of thermodynamic properties from the monomers to dimer with the temperature ranging from 200.0 K to 800.0 K have been obtained using the statistical thermodynamic method. It was found that the hydrogen bonds dominantly contribute to the dimers,while the binding energies are not only determined by hydrogen bonding. The dimerization process can not occur spontaneously at given temperatures.

Study on fracture characteristics of reinforced concrete wedge splitting tests

Hu Shaowei,XU Aiqing,HU Xin,YIN Yangyang 사단법인 한국계산역학회 2016 Computers and Concrete, An International Journal Vol.18 No.3

To study the influence on fracture properties of reinforced concrete wedge splitting test specimens by the addition of reinforcement, and the restriction of steel bars on crack propagation, 7 groups reinforced concrete specimens of different reinforcement position and 1 group plain concrete specimens with the same size factors were designed and constructed for the tests. Based on the double-K fracture criterion and tests, fracture toughness calculation model which was suitable for reinforced concrete wedge splitting tensile specimens has been obtained. The results show that: the value of initial craking load Pini and unstable fracture load Pun decreases gradually with the distance of reinforcement away from specimens’s top. Compared with plain concrete specimens, addition of steel bar can reduce the value of initial fracture toughness KIini, but significantly increase the value of the critical effective crack length ac and unstable fracture toughness KIun. For tensional concrete member, the effect of anti-cracking by reinforcement was mainly acted after cracking, the best function of preventing fracture initiation was when the steel bar was placed in the middle of the crack, and when the reinforcement was across the crack and located away from crack tip, it plays the best role in inhibiting the extension of crack.

菅直人內阁的边界领土政策

Hu Yin(尹虎),Jae Hwe Ko(高在?) 한국동북아학회 2012 한국동북아논총 Vol.17 No.3

간 나오토 내각은 집권기에 한、중、러 등 국가들과 일련의 영토갈등 및 분쟁을 겪었다. 한.일간의 「방위백서」를 둘러싼 외교분쟁, 중.일간의 “조어도 선박충돌사건”, 그리고 러시아 대통령의 북방영토 시찰로 인한 러.일간 외교마찰 등 일련의 “시련”을 겪는 과정에서 간 나오토 내각의 영토정책은 그 실체를 드러내게 된다. 영토문제에 대한 간 나오토 내각의 정책은 미.일관계 개선이라는 측면에서 부분적인 성과를 이루었으나, 궁극적으로 동북아 역내 국가간 갈등의 골을 깊게 하는 결과를 초래하였다. 본 연구는 간 나오토 내각 집권기의 일본과 한、중、러 3국간 영토분쟁의 실태를 다국간 관계라는 시각에서 출발하여 그 본질을 분석하고, 간 나오토 내각의 영토정책이 동북아 국제정세에 미치는 영향을 검토하고자 한다. During its administration the Naoto Kan administration launched a series of noteworthy territorial policies and also launched diplomatic games with China South Korea and Russia concerning territorial issues. In addition the Naoto Kan administrationmade great adjustments to the territorial policies implemented by the former Hatoyama administration which paved the way for the introduction of the Noda Cabinet``s territorial policies. The Naoto Kan administration``s territorial policies led to unprecedented diplomatic conflicts in Northeast Asia. Thuscareful and deep study of the Naoto Kan cabinet`s territorial policies will have enormous academic values in predicting the trend of the Democratic administration``s foreign policies and the development of political issues in Northeast Asia.

Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, by Dalbergiae Lignum

Yin, Hu-Quan,Lee, Bang-Wool,Kim, Youn-Chul,Sohn, Dong-Hwan,Lee, Byung-Hoon The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.9

The effect of an extract of Dalbergiae Lignum and four components that were isolated from the extract on the anticarcinogenic phase II marker enzyme, quinone reductase (QR), was investi-gated. Of the solvent extracts of Dalbergiae Lignum, the CH$_2$CI$_2$ fraction was the most potent in inducing QR activity, with a CD value (the concentration required to double the QR activity) of 29.5 $\mu$/mL. The CH$_2$CI$_2$ extract was further separated into six compounds, four of which were identified as 4-methoxydalbergione, latifolin, 4',6-dihydroxy-7-methoxyflavanone, and obtusafu-ran. Obtusafuran [CD = 1.1 $\mu$M; chemopreventive index (CI) = 101.9] and latifolin (CD = 1.7 $\mu$M; CI = 154.6) displayed potent QR inducing activity and high chemopreventive indices. Lati-folin and 4-methoxydalbergione were identified as strong DPPH-scavengers with half-maximal free radical scavenging concentrations of 15.9 and 17.2 $\mu$M, respectively.

Temporal Changes in the Hepatic Fatty Liver in Mice Receiving Standard Lieber-DeCarli Diet

Yin, Hu-Quan,Lee, Byung-Hoon Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol.25 No.3

Chronic exposure to ethanol induces cumulative damage to the liver starting from fatty infiltration to cirrhosis depending on the dose and duration of exposure. The whole process leading to the development of alcoholic liver disease is very complex and the mechanisms involved are not fully understood. Among many experimental animal models, Lieber-DeCarli liquid diet provides moderate to severe pathophysiological outcome depending on the compositional changes. In the present study, we investigated the temporal changes in the early phase hepatic disease in rats fed with standard Lieber-DeCarli diet. Male Wistar rats were fed with Lieber-Decarli ethanol diet for 6 weeks and the liver samples were obtained after 2, 4 and 6 weeks. Mild fatty infiltration was observed in 2 weeks of feeding and it became evident in 4 and 6 week samples. The level of hepatic triglyceride showed a good agreement with the data obtained in the pathological analysis. Feeding mice with ethanol diet resulted in the maturation and translocation of SREBP-1 to nucleus in the liver. Western blot analysis of the pooled liver sample of control and ethanol fed animals showed a clear-cut time-dependent increase in the expression of nSREBP-1. These data provide important information for selecting proper time point in experimental intervention study in the field of drug development for alcoholic liver disease.

Effects of Tanshinone IIA on the Hepatotoxicity and Gene Expression Involved in Alcoholic Liver Disease

Yin, Hu-Quan,Kim, Youn-Su,Choi, You-Jin,Kim, Youn-Chul,Sohn, Dong-Hwan,Ryu, Shi-Yong,Lee, Byung-Hoon 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5

Tanshinone IIA is one of the most abundant constituents of the root of Salvia miltiorrhiza BUNGE which exerts antioxidant and anti-inflammatory actions in many experimental disease models. In the present study, we demonstrated that the standardized fraction of S. miltiorrhiza (Sm-SF) was able to protect RAW 264.7 cells from ethanol- and lipopolysaccharide (LPS)- induced production of superoxide radical, activation of NADPH oxidase and subsequently death of the cells. Among four main components of Sm-SF, tanshinone IIA was the most potent in protecting cells from LPS-and ethanol-induced cytotoxicity. LPS or ethanol induced the expression of CD14, iNOS, and SCD1 and decreased RXR-$\alpha$, which was completely reversed by tanshinone IIA. In H4IIEC3 cells, $10\;{\mu}M$ tanshinone IIA effectively blocked ethanolinduced fat accumulation as evidenced by Nile Red binding assay. These results indicate that tanshinone IIA may have potential to inhibit alcoholic liver disease by reducing LPS- and ethanol-induced Kupffer cell sensitization, inhibiting synthesis of reactive oxygen/nitrogen species, inhibiting fatty acid synthesis and stimulating fatty acid oxidation.

Temporal Changes in the Hepatic Fatty Liver in Mice Receiving Standard Lieber-DeCarli Diet

Hu-Quan Yin,Byung-Hoon Lee 한국독성학회 2008 Toxicological Research Vol.24 No.2

Chronic exposure to ethanol induces cumulative damage to the liver starting from fatty infiltration to cirrhosis depending on the dose and duration of exposure. The whole process leading to the development of alcoholic liver disease is very complex and the mechanisms involved are not fully understood. Among many experimental animal models, Lieber-DeCarli liquid diet provides moderate to severe pathophysiological outcome depending on the compositional changes. In the present study, we investigated the temporal changes in the early phase hepatic disease in rats fed with standard Lieber-DeCarli diet. Male Wistar rats were fed with Lieber-Decarli ethanol diet for 6 weeks and the liver samples were obtained after 2, 4 and 6 weeks. Mild fatty infiltration was observed in 2 weeks of feeding and it became evident in 4 and 6 week samples. The level of hepatic triglyceride showed a good agreement with the data obtained in the pathological analysis. Feeding mice with ethanol diet resulted in the maturation and translocation of SREBP-1 to nucleus in the liver. Western blot analysis of the pooled liver sample of control and ethanol fed animals showed a clear-cut time-dependent increase in the expression of nSREBP-1. These data provide important information for selecting proper time point in experimental intervention study in the field of drug development for alcoholic liver disease.

Carbon Nanotubes-Supported Well-Dispersed Pd Nanoparticles for the Efficiently Selective Hydrogenation of Benzoic Acid to Synthesize Cyclohexane Carboxylic Acid

Yin Hu,Wei Chen,Qi Wu,Xin Xie,Weiguo Song 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.1

Pd and carbon nanotube (CNT) composites were prepared by well-dispersed deposition of Pd nanoparticles on commercial CNT, and applied to the selective hydrogenation of benzoic acid (BA) to synthesize cyclohexane carboxylic acid (CCA). The catalysts and the hydrogenation products were analyzed by XRD, TEM, TG, FTIR, UV-Vis absorption, GC and GC-MS, respectively. Hydrogenation process was also optimized through varying the reaction parameters. The results demonstrate that Pd/CNT catalysts possess the highest hydrogenation efficiency, give the full conversion of BA and 100.0% selectivity towards CCA at the optimal hydrogenation conditions, by comparing with some commercial hydrogenation catalysts and Pd/C catalysts with commercial carbonaceous supports. The excellent hydrogenation performance of Pd/CNT is attributed to the stable crystalline CNT support and the high dispersion of Pd nanoparticles. In addition, the protic solvent is also beneficial to lower the activation energy barrier of BA hydrogenation, and further to improve the hydrogenation rate. This work implies that CNT can be potentially chosen as an effective carbonaceous support to prepare Pd/C catalyst with an outstanding performance of BA selective hydrogenation.