Effect of Heat Treatment on the Microstructure and Properties of High Strain Rate Rolled 7050 Aluminum Alloy

Yang Liao,Hongge Yan,Weijun Xia,Jihua Chen,Bin Su,Xinyu Li,Lu Zhao 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.4

High strain rate rolling (HSRR) is developed to improve the strength, plasticity and stress corrosion resistance of 7050 aluminumalloy simultaneously. The volume fraction of the small-angle grain boundary in the HSRRed alloy sheet is 89.9%. TEM shows that the presence of dislocations and sub-grains promotes the precipitation of the second phase. The alloy inthe T6 state has the highest strength (622 MPa) and the biggest elongation to rupture (20.6%), but poor corrosion resistance. The over-aged state shows the best corrosion resistance. The RRA state can achieve the tensile strength equivalent to T6 of614 MPa, the highest yield strength of 561 MPa and corrosion resistance comparable to the over-aged state. TEM observationshows the existence of sub-grains and dislocations plays an important role in the nucleation of the second phase. Thehigh strength can be attributed to the higher volume fraction of the precipitates, and the high plasticity can be attributed tothe higher work hardening rate. The better corrosion resistance can be ascribe to the wider precipitate-free zones at the grainboundary and the presence of the larger size second phase particles.

EFFECT OF CODONOPSIS PILOSULA AND ASTRAGALUS ON THE TREATMENT OF CORONARY HEART DISEASE

Liao, Jiazhen,Yang, Qinfel,Chen, Wenwei 경희대학교 동서의학연구소 1991 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1991 No.3

The theory of traditional Chinese medicine (TCM) holds that the main pathogenesis of coronary heart disease (CHD) is qi-dcficiency and blood stasis. Therefore, the drugs for replenishing qi are often used for treatment of CHD. The present study is to explore the effects of Codonopsis pilosula and Astragalus (CP-A) on CHD by means of modern scientific methods. The results showed that the principal therapeutic actions of CP-A on CHD are as follows: 1. To reduce the frequency and severity of angina pectoris, decrease the depression of the ischemic ST-T and total ischemic burden during Holter Moniting. 2. To strengthen the left ventricular function, the mechanism responsible for inotropic effect of CP-A relating to inhibit the activity of PDE and increase the cAMP levels in the myocardial cells; 3. To inhibit the activity of PDE and increase the cAMP levels in the platelets resulting in the inhibition of platelet aggregation; 4. To increase the levels of ATP, glucogen, SDH and LDH in the myocardial cells and strengthen the energy metabolism in myocardiac cells. 5. To increase the volume of nutritious blood flow in the myocardium; 6. To prolong the action potential duration of myocardial cell and the activation time of sinus node; 7. Te reduce the plasma TXB2 level and increase or don't affect 6-keto-PGF1α level. 8. To strengthen the immunofunction and increase the level of OKT4 and OKT4/OKT8 ratio.

CNC Corner Milling Parameters Optimization Based on Variable-Fidelity Metamodel and Improved MOPSO Regarding Energy Consumption

Yang Yang,Yuan Wang,Qianfeng Liao,Jiongliang Pan,Junyu Meng,Hao Huang 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.4

In the corner milling process, processing energy consumption is a very important objective, since the energy efficiency of CNC machine is barely above 14.8%. Meanwhile, the excessive processing temperature will increase the thermal deformation of the product and leads to quality decline. Improper process parameters will lead to unnecessary high temperature and energy consumption. By optimizing the process parameters, the appropriate temperature and Specific Energy Consumption can be obtained. This study investigated into modeling Specific Energy Consumption and temperature in corner milling process using variable-fidelity metamodels. The adopted variable-fidelity metamodels are constructed by Hierarchical Kriging, in which 48 sets of low-fidelity data obtained from the AdvantEdge software simulation are used to reflect the trends of the metamodels, and 16 sets of high-precision data obtained from physical experiments are used to calibrate the trends. The experimental cost is reduced and the prediction accuracy is increased by making full use of both sets of data. An improved K-means Multi-objective Particle Swarm Optimization algorithm was adopted and applied on the multi-objective corner milling parameters optimization problem to find satisfactory specific energy consumption and temperature. The obtained Pareto solutions can provide guidance for selecting process parameters according to different requirements, such as reducing energy consumption or temperature.

The Typical Symbol and Cultural Identity of Hakka NiangTofu in the Perspective of Food Anthropology

Yang Liao,Shao-di Ho 한국식생활문화학회 2017 한국식생활문화학회학술대회논문집 Vol.2017 No.11

Research on the Influence of Corporate Social Responsibility on Organizational Performance based on Structural Equation Model

Yang Liao 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.5

With the economic and social transformation, corporate social responsibility has become an important factor affecting the enterprises performance. In this paper, we make an empirical analysis of the relationship between corporate social responsibility and organizational performance by using structural equation model. The result shows that CRS has an impact on the human resource management practice and organizational performance, at the same time, the HRM system has played an intermediary role. Enterprises to fulfill corporate social responsibility will significantly enhance the efficiency of human resource management, and obtain recognition of employees. So that it is necessary for enterprises to undertake the social responsibility in the long-term, and CRS will provide potential value for enterprises’ competitive advantage.

Backbone Coplanarity Tuning of 1,4-Di(3-alkoxy-2-thienyl)-2,5-difluorophenylene-Based Wide Bandgap Polymers for Efficient Organic Solar Cells Processed from Nonhalogenated Solvent

Liao, Qiaogan,Yang, Kun,Chen, Jianhua,Koh, Chang Woo,Tang, Yumin,Su, Mengyao,Wang, Yang,Yang, Yinhua,Feng, Xiyuan,He, Zhubing,Woo, Han Young,Guo, Xugang American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.34

<P>Halogenated solvents are prevailingly used in the fabrication of nonfullerene organic solar cells (NF-OSCs) at the current stage, imposing significant restraints on their practical applications. By copolymerizing phthalimide or thieno[3,4-<I>c</I>]pyrrole-4,6-dione (TPD) with 1,4-di(3-alkoxy-2-thienyl)-2,5-difluorophenylene (DOTFP), which features intramolecular noncovalent interactions, the backbone planarity of the resulting DOTFP-based polymers can be effectively tuned, yielding distinct solubilities, aggregation characters, and chain packing properties. Polymer DOTFP-PhI with a more twisted backbone showed a lower degree of aggregation in solution but an increased film crystallinity than polymer DOTFP-TPD. An organic thin-film transistor and NF-OSC based on DOTFP-PhI, processed with a nonhalogenated solvent, exhibited a high hole mobility up to 1.20 cm<SUP>2</SUP> V<SUP>-1</SUP> s<SUP>-1</SUP> and a promising power conversion efficiency up to 10.65%, respectively. The results demonstrate that DOTFP is a promising building block for constructing wide bandgap polymers and backbone coplanarity tuning is an effective strategy to develop high-performance organic semiconductors processable with a nonhalogenated solvent.</P> [FIG OMISSION]</BR>

Synthesis and application of zirconium phosphate mesoporous coordination polymer for effective removal of Co(II) from aqueous solutions

Zeng Yang,Yuan Guoyuan,Lan Tu,Li Feize,Yang Jijun,Liao Jiali,Yang Yuanyou,Liu Ning 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.11

A kind of zirconium phosphate mesoporous coordination polymer Zr-EDTMPA was successfully synthesized and characterized using XRD, FTIR, TGA, EA, SEMeEDS, and N2 sorption-desorption measurements. The prepared Zr-EDTMPA was first employed for the removal of Co(II) from an aqueous solution, and the effects of pH, contact time, temperature, initial Co(II) concentration, reusability, and sorption mechanism were systematically investigated. The results showed that the Zr-EDTMPA is a zirconium phosphate complex formed by the coordination of EDTMPA to Zr in a molar ratio of 1:1. The sorption of Co(II) by Zr-EDTMPA was a pH-dependent, spontaneous and endothermic process, which was better fitted to the pseudo-second-order kinetic model and Langmuir isotherm model. The Zr-EDTMPA was demonstrated to have excellent reusability and presented a high sorption capacity of 73.0 mgg-1 for Co(II) at pH 8.0. The sorption mechanism was mainly attributed to the strong coordination between cobalt and the untapped hydroxyl functional groups on Zr-EDTMPA, which was confirmed by XPS spectra. Therefore, as a candidate sorbent with high sorption capacity and excellent reusability, ZrEDTMPA has a great potential for the removal of Co(II) from aqueous solutions.

Phase II trial of VEGFR2 inhibitor apatinib for metastatic sarcoma: focus on efficacy and safety

Zhichao Liao,Feng Li,Chao Zhang,Lei Zhu,Yehui Shi,Gang Zhao,Xu Bai,Shafat Hassan,Xinyue Liu,Ting Li,Peipei Xing,Jun Zhao,Jin Zhang,Ruwei Xing,Sheng Teng,Yun Yang,Kexin Chen,Jilong Yang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

Apatinib (YN968D1) is a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2 (VEGFR- 2). We conducted a single-arm, nonrandomized phase II study (NCT03121846) to assess the efficacy and safety of apatinib in patients with stage IV sarcoma. We recruited 64 patients with stage IV sarcoma who had failed chemotherapy. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were progression-free survival rate (PFR), objective response rate (ORR), and disease control rate (DCR) at week 12. Treatment-related adverse effects (AEs) were evaluated. Fifty-nine patients were assessed for efficacy and 64 patients for AEs. The median PFS was 7.93 months. At 12 weeks, the PFR was 74%, the ORR was 16.95% (10/59), and the DCR was 86.44% (51/59). The final ORR was 15.25% (9/59) and the DCR was 57.63% (34/59). Notably, 22 patients (34.38%) who developed hypertension, hand-foot-skin reaction, or proteinuria had significantly longer OS than those without these AEs (18.20 vs. 10.73 months; P = 0.002). We conclude that apatinib is effective and well tolerated in patients with advanced sarcoma. The development of hypertension, hand-foot-skin reaction, or proteinuria may indicate a favorable prognosis, representing a novel finding in sarcoma patients.

Bioinformatic and integrated analysis identifies an lncRNA–miRNA–mRNA interaction mechanism in gastric adenocarcinoma

Yong Liao,Wen Cao,Kunpeng Zhang,Yang Zhou,Xin Xu,Xiaoling Zhao,Xu Yang,Jitao Wang,Shouwen Zhao,Shiyu Zhang,Longfei Yang,Dengxiang Liu,Yanpeng Tian,Weizhong Wu 한국유전학회 2021 Genes & Genomics Vol.43 No.6

Background lncRNAs–miRNAs–mRNAs networks play an important role in Gastric adenocarcinoma (GA). Identifcation of these networks provide new insight into the role of these RNAs in gastric cancer. Objectives Biological information databases were screened to characterize and examine the regulatory networks and to further investigate the potential prognostic relationship this regulation has in GA. Methods By mining The Cancer Genome Atlas (TCGA) database, we gathered information on GA-related lncRNAs, miRNAs, and mRNAs. We identifed diferentially expressed (DE) lncRNAs, miRNAs, and mRNAs using R software. The lncRNA–miRNA–mRNA interaction network was constructed and subsequent survival examination was performed. Representative genes were selected out using The Biological Networks Gene Ontology plug-in tool on Cytoscape. Additional analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms were used to screen representative genes for functional enrichment. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) were used to identify the expression of fve candidate diferential expressed RNAs. Results Information of samples from 375 cases of gastric cancer and 32 healthy cases (normal tissues) were downloaded from the TCGA database. A total of 1632 DE-mRNAs, 1008 DE-lncRNAs and 104 DE-miRNAs were identifed and screened. Among them, 65 DE-lncRNAs, 10 DE-miRNAs, and 10 DE-mRNAs form lncRNAs–miRNAs–mRNAs regulatory network. Additionally, 10 lncRNAs and 2 mRNAs were associated with the prognosis of GA. Multivariable COX analysis revealed that AC018781.1 and VCAN-AS1 were independent risk factors for GA. GO functional enrichment analysis found DE-mRNA was signifcantly enriched TERM (P<0.05). The KEGG signal regulatory network analysis found 11 signifcantly enrichment networks, the most prevailing was for the AGE-RAGE signaling pathway associated with Diabetic complications. Results of RT-qPCR was consistent with the in silico results. Conclusions The results of the present study represent a view of GA from a analysis of lncRNA, miRNA and mRNA. The network of lncRNA–miRNA–mRNA interactions revealed here may potentially further experimental studies and may help biomarker development for GA.

Investigation on large turbo-generator stator end winding dynamic characteristics based on response surface method

Zhao, Yang,Xiao, Yang,Lu, Sheng,Sun, Hao,Huo, Wenhao,Liao, Yong The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.10

The natural frequencies corresponding to the particular mode shapes of a large turbo-generator must not be in the resonance region before delivery. Different parameters may clearly affect these dynamic characteristics. Different from other studies, this paper introduces a method for obtaining the inherent characteristics of end winding in a short period of time under multiple simultaneously changing parameters. The proposed process is based on the response surface method (RSM). In this method, the main concerned natural frequencies were taken as the critical index to describe the dynamic behaviors of the end winding, with which the mathematical relationship between the dynamic characteristics and design variables was analyzed. First, the stiffness of the rings, stiffness of the radial braces and number of pins bonded to the radial braces were used as samples for orthogonal experimental design. Then, the natural modes and frequencies of 25 different samples were acquired by conducting modal analysis with ABAQUS software. Utilizing these dynamic results, a second-order polynomial response surface model was established to describe the relationships between natural frequencies and these three different parameters. Then, the quality of this model was verified by calculating the valuating indexes for comparison with support vector regression (SVR). With the response surface model, the variation regularities of the natural frequencies and modes due to the above parameters were discussed. The method proposed in this paper can enable natural frequencies in the whole design space to be quickly determined without finite-element analysis, greatly improving the development efficiency and laying a foundation for dynamic response prediction during normal operation with different parameters and additional large turbo-generator stator end winding optimization.