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Xianpan Liu,Lei Zeng,Yunfeng Xiao,Yanhua Liu,Heng Zhang,Yun Cao 대한토목학회 2022 KSCE JOURNAL OF CIVIL ENGINEERING Vol.26 No.4
Experimental and numerical studies were conducted on the cyclic behavior of steel reinforced concrete (SRC) columns with T-shaped and L-shaped steel section. A total of 8 SRC columns were tested under axial compression and lateral cyclic loading. The design details, loading procedure and main results, including the failure modes, hysteretic characteristics and ductility were reported. Four failure modes as flexural failure, shear bond failure, shear compression failure and shear compound failure were observed. By considering various unsymmetrical confinement and plastic hinge region, the experimental study was supplemented by numerical analysis to study the influence of axial compression ratio, shear-span ratio and concrete strength. The results revealed that the FEA is in good agreement with the experimental results. The ultimate loading of specimen with confinement effect has been improved by 21.4% − 33.8%. The failure modes is dominated by the shear-span ratio and type of cross section. The specimens with smaller shear-span ratio are prone to shear failure, while the unsymmetrical steel arrangement causes shear compound failure which is combined with shear bond failure and shear compression failure. Moreover, the specimens with larger shear-span ratio and stirrup ratio present greater deformation capacity and ductility. In practical engineering, the confinement degree of SRC columns with unsymmetrical steel section can be enhanced by increasing the stirrup ratio and arranging the cross ties.
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Cuicui Chen,Xiaozhu Liu,Yinfeng Li,Huankun Liang,Kangyan Li,Jiali Li,Chengwu Cheng,Xianpan Liu,Shuhai Zhong,Laiqing Li,Yan Wang 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.4
Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. In this study, we investigated the characteristics of acupuncture treatment based on effectiveness and mechanism. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to build AD-like model. Results showed that acupuncture was an effective treatment method in inhibiting inflammatory conditions, serum IgE levels, and expression of proinflammatory cytokine Th2 (IL-4, IL-6), and Th2 (IL-1b, TNF-a) mRNA compared with DNCB treatment. Acupuncture treatment also inhibited nuclear factor-kB p65, phosphorylation of IkBa, and phosphorylation of occludin proteins expression. Furthermore, it could improve the expression of epidermal growth factor in both mRNA and protein levels. These results suggest that acupuncture, as an alternative therapy treatment for its no significant side effects, was effective in alleviating ACD by reducing proinflammatory cytokines and changing proteins’ expression.
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