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Intermolecular Structural Change for Thermoswitchable Polymeric Photosensitizer
Park, Wooram,Park, Sin-Jung,Cho, Soojeong,Shin, Heejun,Jung, Young-Seok,Lee, Byeongdu,Na, Kun,Kim, Dong-Hyun American Chemical Society 2016 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.138 No.34
<P>We developed a thermoswitchable polymeric photosensitizer (T-PPS) by conjugating PS (Pheophorbide-a, PPb-a) to a. temperature-responsive polymer backbone of biacoinpatible hydroxypropyl cellulose. Self-quenched PS molecules linked in close proximity by pi-pi stacking in T-PPS were easily transited to an active monomeric state by the temperature-induced phase transition of polymer backbones. The temperature: responsive intermolecular interaction changes of PS Molecules in T-PPS were demonstrated in synchrotron small-angle X-ray scattering and UV-vis spectrophotometer analysis. The T-PPS allowed switchable activation and synergistically enhanced cancer cell killing effect at the hyperthermia temperature (45 degrees C). Our developed T-PPS has the considerable potential not only as a new class of photomedicine in clinics but also as a biosensor based on temperature responsiveness.</P>
Park, Wooram,Park, Sin-Jung,Lee, Jun,Na, Kun Techno-Press 2015 Biomaterials and Biomechanics in Bioengineering Vol.2 No.1
Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.
손우람(Wooram Son),정민석(Minseok Jung),안주영(JooYoung An),윤경로(Kyoungro Yoon) 한국정보과학회 2006 한국정보과학회 학술발표논문집 Vol.33 No.1
저장매체의 대용량화와 인터넷을 이용한 디지털 음원의 활성화로 개인이 소유하는 음원이 급속도로 증가하고 있다. 많은 양의 음원을 보유하고 있는 상황에서 사용자의 편의를 증가시키기 위하여 다양한 검색/분류 방법들이 개발되고 사용되고 있다. 본 논문에서는 음원에 사용된 표현방식이나 디렉토리 구조, 파일이름, 텍스트 태그 등에 독립적으로 적용될 수 있도록 디지털 신호처리 이론에 기반하여 파형데이터를 분석하고, 화성학 이론에 기반한 패턴매칭 기술을 응용하여 음악의 장르와 나아가 분위기를 기반으로 분류하는 방법을 제시한다.
Park, Wooram,Park, Sin-Jung,Lee, Jun,Na, Kun Techno-Press 2015 Biomaterials and biomedical engineering Vol.2 No.1
Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.
Cho, Jung-Kyo,Park, Wooram,Na, Kun Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of applied polymer science Vol.113 No.4
<P>Water-insoluble pullulan-g-poly(L-lactide) (PUPL) was successfully synthesized via a one-pot method in the presence of triethylamine in dimethyl sulfoxide, in an effort to design a novel anticancer agent carrier. Three samples (designated as PUPL 1, 2, and 3) were obtained, which differed in the moles of lactides grafted to the pullulan. The degrees of grafted lactide per 1 glucose unit in pullulan were 0.68, 0.60, and 0.45 for PUPL 1, 2, and 3, respectively. These copolymers were dissolved in several organic solvents, including dimethyl sulfoxide, acetone, and ethanol, but were insoluble in water. The self-organized nanogels were then prepared from the polymers via dialysis. To study the organizing behavior of the polymers, their critical association concentrations were measured. Their values were 5.0, 15.9, and 52.9 mg/L for PUPL 1, 2, and 3, respectively. The results showed that lactide in the polymers could function as a hydrophobic moiety for the formation of self-organized nanogels. To estimate the potential of PUPL 1 as an anticancer drug carrier, we used doxorubicin (DOX) as a model drug. The DOX loading efficiencies of PUPL 1 were more than 52%, which differed with differing initial DOX concentrations. High loading resulted in slower DOX release as the result of increases in hydrophobic interaction. In conclusion, PUPL nanogels may prove useful as anticancer drug carriers because of their low critical association concentrations and the controlled DOX release rate © 2009 Wiley Periodicals, Inc. J Appl Polym Sci, 2009</P>
이동 단말에서 끊임없는 스트리밍 미디어를 위한 오토노믹 멀티미디어 트랜스코딩 알고리즘
한우람(Wooram Han),허난숙(Nansook Heo),박총명(Chongmyung Park),서동만(Dongmahn Seo),정인범(Inbum Jung) 한국정보과학회 2007 정보과학회 컴퓨팅의 실제 논문지 Vol.13 No.5
최근 무선통신 기술의 발전으로 PC뿐만 아니라 PDA, 휴대전화 등 다양한 이동 단말을 통하여 멀티미디어 서비스를 제공받을 수 있게 되었다. 이동 단말은 제한된 하드웨어 성능을 갖는 것 이외에 무선망에서 동작하므로 낮은 네트워크 대역폭을 사용하게 된다. 이러한 이동 단말의 특성을 고려하여 스트리밍 미디어 서비스를 받기 위해서는 동작 환경에 적합하게 미디어를 트랜스코딩 하는 기술이 필요하다. 그러나 이동 단말은 무선 네트워크를 사용하며, 유선 환경에 비하여 주변 환경이나 AP(Access Point)와의 거리 등에 따라서 불안정한 네트워크 대역폭을 가지기 때문에 안정적인 QoS를 제공하기 어렵다. 본 논문에서는 무선 네트워크를 통해 이동 단말에 안정적인 QoS의 스트리밍 미디어 서비스를 제공하기 위한 트랜스코딩의 동적 비트율 제어 기법을 제안한다. 제안한 기법은 무선 네트워크의 상황에 맞게 실시간으로 트랜스코딩의 비트율을 동적으로 조절함으로서 끊임없는 스트리밍 미디어 서비스를 제공하며, 기존의 동적 트랜스코딩 서비스 시스템에 비해 보다 적은 전송 오류를 발생함을 실험을 통해 평가한다. Owing to the improved wireless communication technologies, it is possible to provide streaming service of multimedia with PDAs and mobile phones in addition to desktop PCs. Since mobile client devices have low computing power and low network bandwidth due to wireless network, the transcoding technology to adapt media for mobile client devices considering their characteristics is necessary. However, since mobile clients use wireless network and the wireless network have less stable bandwidth according to distance from AP and environments, it is hard to support stable QoS to mobile clients. In this paper, we propose a dynamic bit rate control method for transcoding in order to supprot stable QoS of streaming media service to mobile clients via wireless network. The proposed method is shown to serve seamless streaming media service with adaptive bit rate control according to state of wireless network in real time and to reduce transmission failure from experiment.
Park, Wooram,Chen, Jeane,Cho, Soojeong,Park, Sin-jung,Larson, Andrew C.,Na, Kun,Kim, Dong-Hyun American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.20
<P>Transcatheter hepatic intra-arterial (IA) injection has been considered as an effective targeted delivery technique for hepatocellular carcinoma (HCC). Recently, drug eluting beads (DEB) were developed for transcatheter IA delivery to HCC. However, the conventional DEB has offered relatively modest survival benefits. It can be difficult to control drug loading/release from DEB and to monitor selective delivery to the targeted tumors. Embolized DEBs in hepatic arteries frequently induce hypoxic and low pH conditions, promoting cancer cell growth. In this study, an acidic pH-triggered drug-eluting nanocomposite (pH-DEN) including superparamagnetic iron oxide nanocubes and pH responsive synthetic peptides with lipid tails [octadecylamine p(API-L-Asp)(10)] was developed for magnetic resonance imaging (MRI)-monitored transcatheter delivery of sorafenib (the only FDA-approved systemic therapy for liver cancer) to HCC. The synthesized sorafenib-loaded pH-DENs exhibited distinct pH-triggered drug release behavior at acidic pH levels and highly sensitive MR contrast effects. In an orthotopic HCC rat model, successful hepatic IA delivery and distribution of sorafenib-loaded pH-DEN was confirmed with MRI. IA-delivered sorafenib-loaded pH-DENs elicited significant tumor growth inhibition in a rodent HCC model. These results indicate that the sorafenib pH-DENs platform has the potential to be used as an advanced tool for liver-directed IA treatment of unresectable HCC.</P>
Park, Jung-Hoon,Park, Wooram,Cho, Soojeong,Kim, Kun Yung,Tsauo, Jiaywei,Yoon, Sung Hwan,Son, Woo Chan,Kim, Dong-Hyun,Song, Ho-Young American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.35
<P>Current therapeutic strategies are insufficient for suppressing stent-induced restenosis. Here, branched gold nanoparticles (BGNP)-coated self-expandable metallic stents (SEMSs) were developed for a local heat-induced suppression of stent-related tissue hyperplasia. Our polydopamine (PDA) coating on SEMS allowed BGNP crystal growth on the surface of SEMSs. The prepared BGNP-coated SEMS showed effective local heating under near-infrared laser irradiation. The effectiveness of BGNP-coated SEMSs for suppressing stent-related tissue hyperplasia was demonstrated in a rat esophageal model (<I>n</I> = 52). BGNP-coated SEMS placement under fluoroscopic guidance was technically successful in all rats. The placed BGNP-coated SEMS in rat esophagus achieved three different local heat dose ranges (50, 65, and 80 °C) under fluoroscopic image-guided local irradiation. Follow-up endoscopic examination readily monitored the local heating and observed significantly decreased tissue hyperplasia at 4 weeks of local heat treatments (50 and 65 °C). Finally, Western blot, histology, immunohistochemistry (HSP70, αSMA, and TUNEL), and immunofluorescence (Ki67 and BrdU) analyses along with the statistical analysis confirmed that optimized BGNP-coated SEMS-mediated local heat treatments inducing the expression of anti-inflammatory HSP70 effectively suppresses tissue hyperplasia after stent placement in the esophagus. Our local heating with nanofunctionalized stents represents a promising new approach for suppressing stent-related tissue hyperplasia.</P> [FIG OMISSION]</BR>