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왕진충 ( Zhen Zhong Wang ) 한양대학교 동아시아문화연구소 2010 동아시아 문화연구 Vol.47 No.-
在中韓文化交流史上, 十八世紀是個重要的轉折時期。一方面,從這一時期開始, 朝鮮人逐漸調整心態, 對盛淸時代的來臨, 作了全新的認識。而在령一方面, 隨着東亞形勢的變化, 以及朝鮮燕行使者孜孜不倦的公關活動, 中國官方對燕行使團成員的限制逐漸放寬。在這一世紀, 燕行使團漸漸擺脫了朝鮮館內序班(中國胥吏)的控制, 直接與琉璃廠的書商等展開頻繁的交流。由于琉璃廠是當時北京雅俗文化的中心, 這不僅極大地豊富了書籍采買的來源, 而且, 通過持續不斷的觀察, 以及與不同階層的接觸和交流, 也使得朝鮮人對于中國社會的了解更爲全面。 In the history of the Sino-Korean cultural communication, the 18th century is an important period. On the one hand, from then on the Korean gradually got to know the high Qing had been coming. On the other hand, with the change of the political situation in East Asia and the achievements of the Korean diplomats, the Qing government also gradually decreased confines to the Korean envoys. At that time, the Korean envoys extricated themselves from the Xuban(Chinese petty officials) in the Korean embassy and got to freely communicate with the booksellers in the LiuliChang(琉璃廠). As the LiuliChang was the cultural center of Beijing, this enriched the resources of the imported books for the Korean envoys. And the lasting communication with different people also made the Korean get much more information of the Chinese society.
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Zhong-Ming Wang,Weidong Lu,Md Asraful Alam,Ying Pan,William Junior Nock,Zhen-Hong Yuan 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.9
The effects of extraction time, extraction temperature, solvent to biomass ratio and solvent composition on lipid yield from lyophilized Chlorococcum sp. biomass using a mixture of ethyl acetate and ethanol (EAE), a new proposed solvent, were studied. Subsequently, the process conditions of extraction by EAE were optimized using Box- Behnken design (BBD). The results revealed that the extraction temperature had the greatest effect on lipid extraction efficiency, followed by volume ratio of ethyl acetate to ethanol (EA/E) and extraction time. The largest lipid extraction yield of 15.74% was obtained under the following extraction conditions: 40mL solvents per gram of biomass for 270 min with gentle stirring at 80 oC by EAE with an EA/E of 1.0. Furthermore, palmitic acid, stearic acid, oleic acid, and linoleic acid were the most abundant fatty acids in the lipids extracted, indicating the great potential of the proposed lipid extraction procedure for microalgae-based biodiesel production.
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A multisource image fusion method for multimodal pig-body feature detection
( Zhen Zhong ),( Minjuan Wang ),( Andwanlin Gao ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.11
The multisource image fusion has become an active topic in the last few years owing to its higher segmentation rate. To enhance the accuracy of multimodal pig-body feature segmentation, a multisource image fusion method was employed. Nevertheless, the conventional multisource image fusion methods can not extract superior contrast and abundant details of fused image. To superior segment shape feature and detect temperature feature, a new multisource image fusion method was presented and entitled as NSST-GF-IPCNN. Firstly, the multisource images were resolved into a range of multiscale and multidirectional subbands by Nonsubsampled Shearlet Transform (NSST). Then, to superior describe fine-scale texture and edge information, even-symmetrical Gabor filter and Improved Pulse Coupled Neural Network (IPCNN) were used to fuse low and high-frequency subbands, respectively. Next, the fused coefficients were reconstructed into a fusion image using inverse NSST. Finally, the shape feature was extracted using automatic threshold algorithm and optimized using morphological operation. Nevertheless, the highest temperature of pig-body was gained in view of segmentation results. Experiments revealed that the presented fusion algorithm was able to realize 2.102-4.066% higher average accuracy rate than the traditional algorithms and also enhanced efficiency.
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Wang Wei,Zhao Zhen-Jiang,Xu Yufang,Qian Xu hong,Zhong Jian-Jiang The Korean Society for Biotechnology and Bioengine 2005 Biotechnology and Bioprocess Engineering Vol.10 No.2
A series of fluorine and hydroxyl containing jasmonate derivatives, which were chemically synthesized in our institute, were investigated for their effects on the biosynthesis and heterogeneity of ginsenosides in suspension cultures of Panax notoginseng cells. Com-pared to the control (without addition of elicitors), $100{\mu}M$ of each of the jasmonate was added on day 4 to the suspension cultures of P. notoginseng cells. It was observed that, jasmonates greatly enhanced the ginsenoside content and the ratio of Rb group to Rg group (i.e. $(Rb_1\;+\;Rd)/(Rg_1\;+\;Re)$ in the P. notoginseng cells. Some of the synthetic jasmonates, such as pentafluoropropyl jasmonate (PFPJA), 2-hydroxyethyl jasmonate (HEJA) and 2-hydroxye-thoxyethyl jasmonate (HEEJA), could promote the ginsenoside content to $2.55\;\pm\;0.11,\;3.65\;\pm\;0.13\;and\;2.94\;\pm\;0.06$mg/100 mg DW, respectively, compared to that of $0.64\;\pm\;0.06$mg/100 mg DW for the control and $2.17\;\pm\;0.04$ mg/100 mg DW by the commercially available methyl jasmonate (MJA); and they could change the respective Rb:Rg ratio to $1.60\;\pm\;0.04,\;1.87\;\pm\;0.01\;and\;1.56\;\pm\;0.05$, compared to that of $0.47\;\pm\;0.01$ for the control and $1.42\;\pm\;0.06$ by MJA. The results suggest that suitable esterification of MJA with fluorine or hydroxyl group could in-crease the elicitation activity to induce plant secondary metabolism. The information obtained from this study is useful for hyper-production of heterogeneous products by plant cell cultures.
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Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro
Wang San-Ying,Zhang Jing,Xu Xiao-Gang,Su Hui-Li,Xing Wen-Min,Zhang Zhong-Shan,Jin Wei-Hua,Dai Ji-Huan,Wang Ya-Zhen,He Xin-Yue,Sun Chuan,Yan Jing,Mao Gen-Xiang 한국미생물학회 2020 The journal of microbiology Vol.58 No.8
Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with antihCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.
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( Zhong Wen Chen ),( Yin Bing Zhang ),( Xaing Jun Chen ),( Xiao Liu ),( Zhen Wang ),( Xi Kun Zhou ),( Ji Qiu ),( Nan Nan Zhang ),( Xiu Teng ),( Yong Qiu Mao ),( Chang Yong Liu ),( Yu Quan Wei ),( Jion 대한피부과학회 2015 Annals of Dermatology Vol.27 No.2
Background: Psoriasis is an autoimmune disease that is caused by a shift in the Th1/Th2 balance toward Th1- dominant immunity. It has been established as an effective treatment to counteract psoriasis by subcutaneous injection of recombinant interleukin (IL)-4, and IL-4 gene therapy by topical transdermal penetration has shown its antipsoriatic effect in mice. Retinoic acid (RA) and dimethylsulfoxide can increase the efficiency of gene transfection in the topical transdermal delivery system. Objective: We investigated whether RA could improve anti-psoriasis efficiency using IL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermal delivery system in K14-vascular endothelial growth (K14- VEGF) factor transgenic mice. Methods: After pretreatment with RA, plasmid pIL-4 in 10% dimethylsulfoxide was applied to the ear skin by topical transdermal penetration. Hematoxylin- eosin staining and immunohistochemistry were performed with ear samples to evaluate anti-psoriasis efficiency in mice. Results: The psoriasis pathological features were relieved and psoriasis-associated factors were significantly reduced. Conclusion: Our results reveal that topical application of pIL-4 in dimethylsulfoxide by transdermal delivery with RA pretreatment can improve psoriasis significantly.(Ann Dermatol 27(2) 121∼127, 2015)
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( Zhen Zhong ),( Wanlin Gao ),( Minjuan Wang ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.1
Multimodal biometric-based recognition has been an active topic because of its higher convenience in recent years. Due to high user convenience of finger, finger-based personal identification has been widely used in practice. Hence, taking Finger-Print (FP), Finger-Vein (FV) and Finger-Knuckle-Print (FKP) as the ingredients of characteristic, their feature representation were helpful for improving the universality and reliability in identification. To usefully fuse the multimodal finger-features together, a new robust representation algorithm was proposed based on hierarchical model. Firstly, to obtain more robust features, the feature maps were obtained by Gabor magnitude feature coding and then described by Local Binary Pattern (LBP). Secondly, the LGBP-based feature maps were processed hierarchically in bottom-up mode by variable rectangle and circle granules, respectively. Finally, the intension of each granule was represented by Local-invariant Gray Features (LGFs) and called Hierarchical Local-Gabor-based Gray Invariant Features (HLGGIFs). Experiment results revealed that the proposed algorithm is capable of improving rotation variation of finger-pose, and achieving lower Equal Error Rate (EER) in our homemade database.
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( Zhong Wen Chen ),( Yin Bing Zhang ),( Xaing Jun Chen ),( Xiao Liu ),( Zhen Wang ),( Xi Kun Zhou ),( Ji Qiu ),( Nan Nan Zhang ),( Xiu Teng ),( Yong Qiu Mao ),( Chang Yong Liu ),( Yu Quan Wei ),( Jion 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: Psoriasis is an autoimmune disease that is caused by a shift in the Th1/Th2 balance toward Th1- dominant immunity. It has been established as an effective treatment to counteract psoriasis by subcutaneous injection of recombinant interleukin (IL)-4, and IL-4 gene therapy by topical transdermal penetration has shown its antipsoriatic effect in mice. Retinoic acid (RA) and dimethylsulfoxide can increase the efficiency of gene transfection in the topical transdermal delivery system. Objective: We investigated whether RA could improve anti-psoriasis efficiency using IL-4 expression plasmid pORF-mIL-4 (pIL-4) via transdermal delivery system in K14-vascular endothelial growth (K14- VEGF) factor transgenic mice. Methods: After pretreatment with RA, plasmid pIL-4 in 10% dimethylsulfoxide was applied to the ear skin by topical transdermal penetration. Hematoxylin- eosin staining and immunohistochemistry were performed with ear samples to evaluate anti-psoriasis efficiency in mice. Results: The psoriasis pathological features were relieved and psoriasis-associated factors were significantly reduced. Conclusion: Our results reveal that topical application of pIL-4 in dimethylsulfoxide by transdermal delivery with RA pretreatment can improve psoriasis significantly. (Ann Dermatol 27(2) 121∼127, 2015)
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The Outlier Detection Algorithm Based on Cumulative Holoentropy in Clustering Subspace
Zhang Zhong-ping,Sun Ying,Fang Chun-zhen,Wang Ying 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.10
Subspace outlier mining has a very important significance in big data analysis. To a large extent, subspace clustering algorithm has impact on the efficiency of mining outliers in subspaces. To solve the problem that CMI method selects best clustering subspaces unstably and complexly, formulas of chain rule of Cumulative Entropy, Cumulative Total Correlation and Cumulative Holoentropy were given. Cumulative Holoentropy was used to mine the best clustering subspaces on continuous data sets in which outliers were detected. Subspace outlier detection algorithm based on Cumulative Holoentropy was then proposed. Finally, the validity and scalability of proposed method were tested on real datasets and virtual datasets. Experiment shows that the efficiency of mining outliers in subspaces is enhanced by the proposed algorithm.
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