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Hoang, Van-Hai,Ngo, Van T. H.,Cui, Minghua,Manh, Nguyen Van,Tran, Phuong-Thao,Ann, Jihyae,Ha, Hee-Jin,Kim, Hee,Choi, Kwanghyun,Kim, Young-Ho,Chang, Hyerim,Macalino, Stephani Joy Y.,Lee, Jiyoun,Choi, S American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor <B>1</B>, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.</P> [FIG OMISSION]</BR>
Hai Van Dang,주수찬,임준혁,허진환,신성원 한국해양공학회 2024 韓國海洋工學會誌 Vol.38 No.2
Oil spills pose significant threats to marine ecosystems, human health, socioeconomic aspects, and coastal communities. Accurate real-time predictions of oil slick transport along coastlines are paramount for quick preparedness and response efforts. This study used an open-source OpenOil numerical model to simulate the fate and trajectories of oil slicks released during the 2007 Hebei Spirit accident along the Korean coasts. Six combinations of input parameters, derived from a five-day met-ocean dataset incorporating various hydrodynamic, meteorological, and wave models, were investigated to determine the input variables that lead to the most reasonable results. The predictive performance of each combination was evaluated quantitatively by comparing the dimensions and matching rates between the simulated and observed oil slicks extracted from synthetic aperture radar (SAR) data on the ocean surface. The results show that the combination incorporating the Hybrid Coordinate Ocean Model (HYCOM) for hydrodynamic parameters exhibited more substantial agreement with the observed spill areas than Copernicus Marine Environment Monitoring Service (CMEMS), yielding up to 88% and 53% similarity, respectively, during a more than four-day oil transportation near Taean coasts. This study underscores the importance of integrating high-resolution met-ocean models into oil spill modeling efforts to enhance the predictive accuracy regarding oil spill dynamics and weathering processes.
Van-Hai Bui,Nah-Oak Song,Ji-Hye Lee,Hak-Man Kim 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.7
This paper deals with the real-time scheduling of a microgrid considering uncertainties of renewable energy sources (RESs). A two-step mathematical model based on real-time scheduling and demand responses (DRs) is proposed. DR programs, time of use (TOU) and emergency demand response programs (EDRP), are used to minimize the operation cost of microgrid. The proposed real-time scheduling is based on spinning and load reserves to deal with uncertainties of RESs. In the first step, the day-ahead scheduling is run for 24 hours with forecasted RESs. The second step deals with the actual RESs and the microgrid operation is rescheduled in the real time. The effectiveness of DR programs on the electrical demand for each interval is also shown in this study. The mixed-integer linear programming (MILP) method using CPLEX optimization program is used to solve the proposed two-step mathematical model.
Intelligent Charger with Online Battery Diagnosis Function
Van-Tuan Doan,Van-Binh Vu,Hai-Nam Vu,Duc-Hung Tran,Woojin Choi 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
In the battery based applications, the performance of the system highly depends on the reliability of the battery. However, it is difficult to obtain the accurate information about the state-of-health (SOH) of battery during its operation. In this paper a 3kw battery charger with online battery diagnosis function which can estimate the SOH of the battery by using online impedance spectroscopy technique is introduced. For the charger, a phase shift full bridge converter with synchronous rectification has been adopted to implement constant current/constant voltage charge and diagnosis functions. The electrochemical impedance spectroscopy (EIS) is performed after the charge to obtain the information about the internal impedance of the battery module, hence the SOH can be estimated online by observing the impedance variation of the battery over time. All the design procedure of the proposed charger is detailed and the feasibility of the system is verified by the experimental results.
Van Hai Pham,Thi Ngoc Lan Tran,Giang Vinh Le,Mehrnoosh Movahed,Ying Jiang,Nguyen Ha Pham,Hisashi Ogawa,Ken Takahashi 한국산업안전보건공단 산업안전보건연구원 2013 Safety and health at work Vol.4 No.2
This paper describes progress on formulating a national asbestos profile for the country of Vietnam. The Center of Asbestos Resource, Vietnam, formulated a National Profile on Asbestos-related Occupational Health, with due reference to the International Labor Organization/World Health Organization National Asbestos Profile. The Center of Asbestos Resource was established by the Vietnamese Health Environment Management Agency and the National Institute of Labor Protection, with the support of the Australian Agency for International Development, as a coordinating point for asbestos-related issues in Vietnam. Under the National Profile on Asbestos-related Occupational Health framework, the Center of Asbestos Resource succeeded in compiling relevant information for 15 of the 18 designated items outlined in the International Labor Organization/World Health Organization National Asbestos Profile, some overlaps of the information items notwithstanding. Today, Vietnam continues to import and use an average of more than 60,000 metric tons of raw asbestos per year. Information on asbestos-related diseases is limited, but the country has begun to diagnose mesothelioma cases, with the technical cooperation of Japan. As it stands, the National Profile on Asbestos-related Occupational Health needs further work and updating. However, we envisage that the National Profile on Asbestos-related Occupational Health will ultimately facilitate the smooth transition to an asbestos-free Vietnam.
Hai Van Dang,신성원,이은주,박형수,박준녕 한국해양공학회 2022 韓國海洋工學會誌 Vol.36 No.6
Coastal communities have been vulnerable to extreme coastal flooding induced by hurricanes and tsunamis. Many studies solely focused on the overland flow hydrodynamic and loading mechanisms on individual inland structures or buildings. Only a few studies have investigated the effects of flooding mitigation measures to protect the coastal communities represented through a complex series of building arrays. This study numerically examined the performance of flood-mitigation measures from tsunami-like wave-induced overland flows. A computational fluid dynamic model was utilized to investigate the performance of mitigation structures such as submerged breakwaters and seawalls in reducing resultant forces on a series of building arrays. This study considered the effects of incident wave heights and four geometrically structural factors: the freeboard, crest width of submerged breakwaters, and the height and location of seawalls. The results showed that prevention structures reduced inundation flow depths, velocities, and maximum forces in the inland environment. The results also indicated that increasing the seawall height or reducing the freeboard of a submerged breakwater significantly reduces the maximum horizontal forces, especially in the first row of buildings. However, installing a low-lying seawall closer to the building rows amplifies the maximum forces compared to the original seawall at the shoreline.
Van Hai HOANG,Phuong Mai NGUYEN,Thi Minh Ngoc LUU,Thi Minh Hien VU 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.4
The purpose of this study is to examine the determinants of intention to borrow consumer credit of Vietnamese people by applying the Technology Acceptance Model (TAM) and extending it with several variables, including anxiety, perceived trust, and perceived financial costs extracted and adapted from the existing literature. A questionnaire survey was administered in the big cities of Vietnam to a total of 602 consumers. Structural equation modeling (SEM) techniques have been employed to investigate the relationship among intention determinants to borrow. Findings show that perceived usefulness mediates the impact of subjective norms on the intention to borrow consumer credit. At the same time, subjective norms also directly influence the intention to borrow. Notably, anxiety, perceived trust, perceived financial cost, perceived ease of use have no significant influence on intention to borrow. Meanwhile, education level is confirmed to have a moderate influence on intention to borrow consumer credit of Vietnamese people. However, there is not enough statistical evidence about the influence of gender and marital status on the intention to borrow consumer credit in Vietnam. Based on the findings of the Vietnamese consumer credit market, we proposed some suggestions to promote the growth of the market in the future.