Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases

( Daulat Bikram Khadka ),( Giap Huu Tran ),( Somin Shin ),( Hang Thi Minh Nguyen ),( Hue Thi Cao ),( Chao Zhao ),( Yifeng Jin ),( Hue Thi My Van ),( Minh Van Chau ),( Youngjoo Kwon ),( Thanh Nguyen Le 전남대학교 약품개발연구소 2015 약품개발연구지 Vol.24 No.-

A series of 2-arylquinazolinones with structural homology to known 3-arylisoquinolines were designed and synthesized in order to develop safe. effective, and selective cytotoxic agents targeting topoisomerases (topos). 2-Arylquinzolinones with various substitutions on the aromatic rings were obtained by thermal cyclodehydration/dehydrogenation on reacting anthranilamides and benzaldehydes. The compounds had superior topo l-inhibitory activities but were generally inactive against topo IIα, Among the 6-methyl-, 6-amino-, and 7-methylquinazolinones, 6-amino-substituted derivatives displayed potent cytotoxicity at submicromolar to nanomolar concentrations against human colorectal adenocarcinoma cells (HCT-15), human ductal breast epithelial tumor cells (T47D), and cervical cancer cells (HeLa). There was a good correlation between topo I inhibition and the cytotoxic effects of 6-aminoquinazolinones. Docking models demonstrated that topo I inhibition by these compounds is owing to intercalation and H-bond interactions with the DNA bases and amino acid residues at the enzymatic site.

SERVQUAL Model in Measuring Service Quality of Sunwheel - Da Nang City

( Cao Thi Cam Huong ),( Le Thai Phuong ),( Ho Su Minh Tai ),( Le Huu Luat ) 세계문화관광학회 2016 International Journal of Culture and tourism Resea Vol.9 No.1

The purpose of the study is to measure the quality of Sun Wheel service using SERQUAL model. Sunwheel is the world`s fourth largest ferris wheel in Danang. SERVQUAL model is used to measure the gaps between Sunwheel visitor`s expectation and perceived quality in terms of tangibility, reliability, responsiveness, assurance, and empathy. Factor and multiple regression analyses were conducted on the sample of 684 customers in 2015. Findings indicate that appearance, assurance, fast service, consistency and motivation are key factors help Sunwheel increasing service quality and visitor return rate.

Effective Elimination of Charge-associated Toxicity of Low Generation Polyamidoamine Dendrimer Eases Drug Delivery of Oxaliplatin

Vo Minh Hoang Do,Long Giang Bach,Diem-Huong Nguyen Tran,Van Du Cao,Thi Nhu Quynh Nguyen,Duc Thuan Hoang,Van Cuong Ngo,Dai Hai Nguyen,Thai Thanh Hoang Thi 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.2

Polyamidoamine (PAMAM) dendrimer is emerging as an effective nanocarrier for delivering anticancer drugs. Still, unmodified PAMAM dendrimer is hardly used in vivo because of unsatisfied drug release, high tendency of interfering with cellular membranes, and rapid clearance by reticuloendothelial system. In this study, low generation polyamidoamine (PAMAM) dendrimer G3.0 is developed and surface modified with methoxypolyethylene glycol (PAMAM G3.0-mPEG) to overcome its limitations. Specifically, PAMAM G3.0 conjugated with mPEG at different ratios are investigated to effectively eliminate its charge-associated toxicity, in which PAMAM G3.0-mPEG- 8 is chosen for oxaliplatin (OX) loading. Results reveal that OX-loaded PAMAM G3.0-mPEG-8 has desirable size, good entrapment efficiency, and sustained release with minimum drug leakage. In addition, Resazurin assay indicates that the toxicity of loaded OX is reduced as compared to free drug but still maintain substantially anticancer activity on HeLa cells, suggesting the potential application of PAMAM G3.0-mPEG-8 for OX delivery in cancer therapy.

A Statistical Data-Filtering Method Proposed for Short-Term Load Forecasting Models

Duong Minh Bui,Phuc Duy Le,Tien Minh Cao,Hung Nguyen,Trang Thi Pham,Duy Anh Pham 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.5

Reliability assessment of the SCADA-system based load data is necessary for improving accuracy of short-term load forecasting (STLF) methods in a distribution network (DN). Specifi cally, the reliability evaluation of the load data is to properly eliminate noise/outliers caused by random power consumption behaviors or the sudden change in load demand from industrial and residential customers in the DN. Thus, this paper proposes a novel statistical data-fi ltering method, working at an input data pre-processing stage, which will evaluate the reliability of input load data by analyzing all possible data confi dence levels in order to fi lter-out the noise/outliers for accuracy improvement of diff erent short-term load forecasting models. The proposed statistical data-fi ltering method is also compared to other existing data-fi ltering methods (such as Kalman Filter, Density-Based Spatial Clustering of Applications with Noise (DBSCAN), Discrete Wavelet Transform (DWT) and Singular Spectrum Analysis (SSA)). Moreover, several case studies of short-term load forecasting for a typical 22 kV distribution network in Vietnam are conducted with an Artifi cial Neural Network (ANN) model, a Long Short-Term Memory Recurrent Neural Network (LSTM-RNN) model, a combined model of Long Short-Term Memory Network and Convolutional Neural Network (LSTM-CNN), and a conventional Autoregressive Integrated Moving Average (ARIMA) model to validate the statistical data-fi ltering method proposed. The achieved results demonstrate which the STLF using ANN, LSTM-RNN, LSTMCNN, and ARIMA models with the statistical data-fi ltering method can all outperform those with the existing data-fi ltering methods. Additionally, the numerical results also indicate that in case the SCADA-based load data is normally distributed, time-series forecasting models should be more preferred than neural network models; otherwise, when the SCADA-based load data contains multiple normally distributed sub-datasets, neural network-based prediction models are highly recommended.

A Novel Approach for Shaken Image Deblurring

Quang Thi Nguyen,Yong Gang Cao,Guang Wen Liu,Nghia Pham Minh,Van Nhu Le 보안공학연구지원센터(IJSIP) 2014 International Journal of Signal Processing, Image Vol.7 No.2

Factors Affecting Intention to Purchase Green Products in Vietnam

NGUYEN, Thi Kim Chi,NGUYEN, Dat Minh,TRINH, Van Thien,TRAN, Thi Phuong Diu,CAO, Tuan Phong Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.4

The study aims to assess factors affecting intention to purchase green products in Vietnam. The study employs samples from customers who have actually experienced green consumption in Vietnam. The samples were collected by convenient sampling methods. The survey obtained 206 responses with full information. The survey was conducted from October 2019 to January 2020. The measurement scale was a 5-point scale with 1- completely disagree and 5- strongly agree. This study employs factor analysis and structural equation modelling analysis. The results showed that the social and environment sustainability awareness have positive effects on altruism of customers who are interested in green consumption. Altruism also has the same direction on green purchase intention. Besides, the attitude toward buying green and health consciousness affects green purchase intention. At the same time, the altruism and attitude towards buying green products also influence positively on green purchase intention. Besides, the health consciousness positively affects attitude towards buying green products. The results show that the health consciousness has a negative impact on intention to purchase green products. The findings suggest that it is necessary to raise customers' health consciousness, customers' altruism from disseminating knowledge about environmental protection as well as society to enhance the green consumption in Vietnam.

Does conventional freezing affect sperm DNA fragmentation?

Le, Minh Tam,Nguyen, Thai Thanh Thi,Nguyen, Tung Thanh,Nguyen, Trung Van,Nguyen, Tam An Thi,Nguyen, Quoc Huy Vu,Cao, Thanh Ngoc The Korean Society for Reproductive Medicine 2019 Clinical and Experimental Reproductive Medicine Vol.46 No.2

Objective: Sperm cryopreservation has been widely used in assisted reproductive technology, as it offers great potential for the treatment of some types of male infertility. However, cryopreservation may result in changes in membrane lipid composition and acrosome status, as well as reductions in sperm motility and viability. This study aimed to evaluate sperm DNA fragmentation damage caused by conventional freezing using the sperm chromatin dispersion test. Methods: In total, 120 fresh human semen samples were frozen by conventional methods, using SpermFreeze Solution as a cryoprotectant. Routine semen analysis and a Halosperm test (using the Halosperm kit) were performed on each sample before freezing and after thawing. Semen parameters and sperm DNA fragmentation were compared between these groups. Results: There was a significant decrease in sperm progressive motility, viability, and normal morphology after conventional freezing (32.78%, 79.58%, and 3.87% vs. 16%, 55.99%, and 2.55%, respectively). The sperm head, midpiece, and tail defect rate increased slightly after freezing. Furthermore, the DNA fragmentation index (DFI) was significantly higher after thawing than before freezing (19.21% prior to freezing vs. 22.23% after thawing). Significant increases in the DFI after cryopreservation were observed in samples with both normal and abnormal motility and morphology, as well as in those with normal viability. Conclusion: Conventional freezing seems to damage some sperm parameters, in particular causing a reduction in sperm DNA integrity.

Distribution of Brand Love on Customers’ Behavioral Intention: Cases of Five-star Hotels

Tri Minh CAO,Thanh Thi Chieu TRAN 한국유통과학회 2022 유통과학연구 Vol.20 No.4

Purpose: The study focuses on the distribution of brand love on customers behavioral intention at five-star hotels in Vietnam. Furthermore, the study also assesses the role of mediating variables and moderating variable involved in the research model. Research design, data and methodology This research surveys 458 customers using the services of five-star hotels in Vietnam through questionnaires on online platforms. Data cleaning and data analysis using SPSS 25.0 software combined with Smart-PLS 3.0 software were used in the research to evaluate the measurement model and structural model. Results: From the results of the structural model evaluation, it shows the positive distribution of brand love on customers’ behavioral intentions towards five-star hotels in Vietnam. The mediating roles of brand engagement, brand equity, customer motivation, and the participation of the moderating variable, customer expectations, are determined by this research model. Conclusions: Based on the study results, the distribution of brand love positively affects customers’ behavioral intention at five-star hotels in Vietnam, giving recommendations that have a positive impact on customer behavioral intention. In addition, the study shows the role of mediating variables as well as exploring the moderator s (customer expectations) in the distribution of relationships between customer motivation and customer behavioral intention.

Thinning and drilling laser-assisted hatching in thawed embryo transfer: A randomized controlled trial

Le, Minh Tam,Nguyen, Thi Tam An,Nguyen, Thi Thai Thanh,Nguyen, Van Trung,Le, Dinh Duong,Nguyen, Vu Quoc Huy,Cao, Ngoc Thanh,Aints, Alar,Salumets, Andres The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.3

Objective: In frozen and thawed embryos, the zona pellucida (ZP) can be damaged due to hardening. Laser-assisted hatching (LAH) of embryos can increase the pregnancy rate. This study compared thinning and drilling of the ZP before frozen embryo transfer (FET). Methods: Patients were randomly allocated into two groups for LAH using thinning or drilling on day 2 after thawing. Twenty-five percent of the ZP circumference and 50% of the ZP thickness was removed in the thinning group, and a hole $40{\mu}m$ in diameter was made in the drilling group. Results: A total of 171 in vitro fertilization/intracytoplasmic sperm injection FET cycles, including 85 cycles with drilling LAH and 86 cycles with thinning LAH, were carried out. The thinning group had a similar ${\beta}$-human chorionic gonadotropin-positive rate (38.4% vs. 29.4%), implantation rate (16.5% vs. 14.4%), clinical pregnancy rate (36.0% vs. 25.9%), miscarriage rate (5.8% vs. 2.4%), ongoing pregnancy rate (30.2% vs. 23.5%), and multiple pregnancy rate (7.0% vs. 10.6%) to the drilling LAH group. There were no significant differences in pregnancy outcomes between subgroups defined based on age (older or younger than 35 years) or ZP thickness (greater or less than $17{\mu}m$) according to the LAH method. Conclusion: The present study demonstrated that partial ZP thinning or drilling resulted in similar outcomes in implantation and pregnancy rates using thawed embryos, irrespective of women's age or ZP thickness.

Improving photocatalytic oxidation of semiconductor (TiO2, SnO2, ZnO)/CNTs for NOx removal

Hoang Phuong Nguyen,Thi Minh Cao,Tien-Thanh Nguyen,Viet Van Pham 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-

Traditional semiconductors, i.e., SnO2, ZnO, and TiO2 have a good photocatalytic activity but still manydisadvantages to applying in industry. In this study, these semiconductors are combined by commercialCNTs to form heterojunctions by a ball-milling route. The physical–chemical analyses include X-raydiffraction pattern (XRD), diffused reflectance spectra (UV–Vis DRS), Fourier transform infrared spectrum(FTIR), Mott-Schottky analysis, high-resolution transmission electron microscopy (HRTEM), and selectedarea electron diffraction (SAED) are run to characterize the as-prepared materials. The total photocatalyticNOx efficiency of SnO2/CNTs, ZnO/CNTs, and TiO2/CNTs composites generate green products, i.e.,NO3 – , HNO3, etc. with 10%, 10.1%, and 41.25% after 30 min under visible light illumination, respectively. We also found that ZnO/CNTs easily inactivated the photocatalytic ability and converted NO gas to a moretoxic product. Meanwhile, the highest selectivity of green products conversion belongs to SnO2/CNTsnanocomposite. Our findings will design and select an excellent photocatalytic oxidation system forNOx removal towards a flue gas treatment established.