http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Hue Thi My Van ),( Hyun Jung Woo ),( Hyung Min Jeong ),( Daulat Bikram Khadka ),( Su Hui Yang ),( Caho Zhao ),( Yi Feng Jin ),( Eung Seok Lee ),( Kwang Youl Lee ),( Young Joo Kwon ),( Won Jea Cho ) 전남대학교 약품개발연구소 2014 약품개발연구지 Vol.23 No.-
A series of 3-heteroarylisoquinolinamines were designed. synthesized and evaluated for cytotoxicity, topoisomerases (topos) inhibitory activities and cell cycle inhibition, Several of the 3heteroarylisoquinolines exhibited selective cytotoxicity against human ductal breast epithelial tumor (T47D) cells over non-cancerous human breast epithelial (MCF-10A) and human prostate cancer (DU14S) cells. Most of the derivatives showed greater cytotoxicity in human colorectal adenocarcinoma (HCT-1S) cells than camptothecin (CPT), etoposide and doxorubicin (DOX). Generally, 3-heteroarylisoquinolinamines displayed greater affinity for topo I than topo n. 3-Heteroarylisoquinolinamines with greater topo 1 inhibitory effect exhibited potent cytotoxicity. Piperazine-substituted derivative. Sb, with potent topo 1 and moderate topo n activities intercalated between DNA bases and interacted with topos through H-bonds at the DNA cleavage site of a docking model. Moreover. flowcytometry indicated that cytotoxic 3heteroarylisoquinolinamines led to accumulation of human cervical (HeLa) cancer cells in the different phases of the cell cycle before apoptosis. Taken together. 3-heteroarylisoquinolinamines possessed potent cytotoxicity with topos and cell cycle inhibitory activities. ⓒ 2014 Elsevier Masson SAS. All rights reserved.
( Hue Thi My Van ),( Hyunjung Woo ),( Hyung Min Jeong ),( Daulat Bikram Khadka ),( Su Hui Yang ),( Chao Zhao ),( Yifeng Jin ),( Eung-seok Lee ),( Kwang Youl Lee ),( Youngjoo Kwon ),( Won Jea Cho ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
A series of 3-heteroarylisoquinolinamines were designed, synthesized and evaluated for cytotoxicity, topoisomerases (topos) inhibitory activities and cell cycle inhibition. Several of the 3-heteroarylisoquinolines exhibited selective cytotoxicity against human ductal breast epithelial tumor (T47D) cells over non-cancerous human breast epithelial (MCF-10A) and human prostate cancer (DU145) cells. Most of the derivatives showed greater cytotoxicity in human colorectal adenocarcinoma (HCT-15) cells than camptothecin (CPT), etoposide and doxorubicin (DOX). Generally, 3-heteroarylisoquinolinamines displayed greater affinity for topo I than topo II. 3-Heteroarylisoquinolinamines with greater topo I inhibitory effect exhibited potent cytotoxicity. Piperazine-substituted derivative, 5b, with potent topo I and moderate topo II activities intercalated between DNA bases and interacted with topos through H-bonds at the DNA cleavage site of a docking model. Moreover, flow cytometry indicated that cytotoxic 3-heteroarylisoquinolinamines led to accumulation of human cervical (HeLa) cancer cells in the different phases of the cell cycle before apoptosis. Taken together, 3-heteroarylisoquinolinamines possessed potent cytotoxicity with topos and cell cycle inhibitory activities.ⓒ2014 Elsevier Masson SAS. aLL reserved.
( Daulat Bikram Khadka ),( Giap Huu Tran ),( Somin Shin ),( Hang Thi Minh Nguyen ),( Hue Thi Cao ),( Chao Zhao ),( Yifeng Jin ),( Hue Thi My Van ),( Minh Van Chau ),( Youngjoo Kwon ),( Thanh Nguyen Le 전남대학교 약품개발연구소 2015 약품개발연구지 Vol.24 No.-
A series of 2-arylquinazolinones with structural homology to known 3-arylisoquinolines were designed and synthesized in order to develop safe. effective, and selective cytotoxic agents targeting topoisomerases (topos). 2-Arylquinzolinones with various substitutions on the aromatic rings were obtained by thermal cyclodehydration/dehydrogenation on reacting anthranilamides and benzaldehydes. The compounds had superior topo l-inhibitory activities but were generally inactive against topo IIα, Among the 6-methyl-, 6-amino-, and 7-methylquinazolinones, 6-amino-substituted derivatives displayed potent cytotoxicity at submicromolar to nanomolar concentrations against human colorectal adenocarcinoma cells (HCT-15), human ductal breast epithelial tumor cells (T47D), and cervical cancer cells (HeLa). There was a good correlation between topo I inhibition and the cytotoxic effects of 6-aminoquinazolinones. Docking models demonstrated that topo I inhibition by these compounds is owing to intercalation and H-bond interactions with the DNA bases and amino acid residues at the enzymatic site.
Development of 3-aryl-1isoquinolinamines as potent antitumor agents based on CoMFA
( Su Hui Yang ),( Hue Thi My Van ),( Thanh Nguyen Le ),( Daulat Bikram Khadka ),( Suk Hee Cho ),( Kyung Tae Lee ),( Eung Seok Lee ),( Young Bok Lee ),( Chang Ho Ahn ),( Won Jea Cho ) 영남대학교 약품개발연구소 2011 영남대학교 약품개발연구소 연구업적집 Vol.21 No.-
Thanh Nguyen Le,Hue Thi My Van,Suh-Hee Lee,최현진,이광열,강복윤,조원제 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.1
The total synthesis of the natural phenolic benzo[c]phenanthridine alkaloid, oxyterihanine, was accomplished via substituted 3-arylisoquinoline intermediate. The key reaction was a coupling between the o-toluamide 4 and the benzonitrile 5.
Cho, Won-Jea,Le, Quynh Manh,Van, Hue Thi My,Lee, Kwang Youl,Kang, Bok Yun,Lee, Eung-Seok,Lee, Sang Kook,Kwon, Youngjoo WILEY-VCH Verlag 2007 Chem Inform Vol.38 No.43
<P>ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.</P>