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( Junko Tsuboki ),( Kiyomi Takaishi ),( Fumiko Ito ),( Ritsuo Honda ),( Hironori Tashiro ),( Hidetaka Katabuchi ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
Objective: In epithelial ovarian cancer (EOC), M2-polarized macrophage (Mø), a component of the cancer microenvironment in ascitic fluid as well as primary tumor, is thought to play an important role in cell- proliferation via paracrine activation of the STAT3 pathway. Onionin A (ONA), a natural compound purified from onions, biologically inhibits M2 polarization, and molecularly inactivates STAT3 signaling of Mø and tumor cells. Here we elucidated the indirect and direct anti-cancer effects of ONA via the STAT3 pathway. Methods: The indirect effects of ONA on EOC cells were analyzed under the co-culture system with human monocyte- derived Mø using BrdU ELISA assay. The direct effects of ONA alone and combinations with anti-cancer drugs (PTX, CBDCA, or CDDP) on proliferation and STAT3 activation of the human EOC cell lines (SKOV3, RMG1, or ES2) were evaluated using WST assay and western blot analysis. Results: M2Mø in the co-culture system enhanced proliferation of EOC cells, whereas ONA significantly reduced the enhancement of the cell-proliferation by inhibition of M2-polarization. In addition, ONA directly inhibited STAT3-activation and proliferation of EOC cells (P value < 0.01-0.05). Moreover, the suppressive effects against EOC cell proliferation were significantly increased by the combination of ONA with anti-cancer drugs (P value < 0.01-0.05). Conclusions: ONA exhibited direct anti-cancer effects in EOC as well as indirect effects by suppression of M2-polarization in co-culture system. It was suggested that the combination of ONA and anti-cancer drugs presents a new therapeutic strategy for treatment of EOC.
A Survey Study of the Physioanalysis in KCS Patients
Miyuchi Keiji,Yamaguchi Ken,Takaishi Ayako,Jin Ok Choi 한서대학교 보완대체의학연구소 2011 Research Journal of Complementary and Alternative Vol.- No.2
Our research is based on assessing the posture through testing. We examined the posture of the patient having the first visit at KCS center and after this had a certain period of treatments. We focused on the pelvic angle among the examined data. We analyzed the statistics of changes of the pelvic angle of patients. We proved that the pelvic angle was changes after treatment. This suggests that chiropractic care can be clinically prescribed for posture improvement of KCS patients. The posture is significantly affected with changes in the pelvic angle. The pelvic angle involves in the physiological curvature of the region of a lumbar. Although focus was placed on the pelvic angle, it is important that the human body maintains a healthy physiological curvature. The symptoms were improved by treatments and on the proper posture. After the analysis of the patient s posture, we treated patients according to the individual condition. The patient s balanced posture was improved along with their symptoms. It is Important that the original functions of human movement (normal range of motion) is in need of the ideal posture. If we cannot move a joint within the normal range for an extended period of time, the synovial fluid of the joint synovium becomes higher in viscosity. Increased friction from the movement can cause organic problems (for example deformation). In terms of prevention and quality of life, keeping the ideal posture is very important regardless of age or sex.
Velusamy, D.B.,Kim, R.H.,Takaishi, K.,Muto, T.,Hashizume, D.,Lee, S.,Uchiyama, M.,Aoyama, T.,Ribierre, J.C.,Park, C. Elsevier Science 2014 Organic electronics Vol.15 No.11
Polymer ferroelectric-gate field effect transistors (Fe-FETs) employing ferroelectric polymer thin films as gate insulators are highly attractive as a next-generation non-volatile memory. For minimizing gate leakage current of a device which arises from electrically defective ferroelectric polymer layer in particular at low operation voltage, the materials design of interlayers between the ferroelectric insulator and gate electrode is essential. Here, we introduce a new solution-processed interlayer of conductive reduced graphene oxides (rGOs) modified with a conjugated block copolymer, poly(styrene-block-paraphenylene) (PS-b-PPP). A FeFET with a solution-processed p-type oligomeric semiconducting channel and ferroelectric poly(vinylidene fluoride-co-trifluoroethylene) (PVDF-TrFE) insulator exhibited characteristic source-drain current hysteresis arising from ferroelectric polarization switching of a PVDF-TrFE insulator. Our PS-b-PPP modified rGOs (PMrGOs) with conductive moieties embedded in insulating polymer matrix not only significantly reduced the gate leakage current but also efficiently lowered operation voltage of the device. In consequence, the device showed large memory gate voltage window and high ON/OFF source-drain current ratio with excellent data retention and read/write cycle endurance. Furthermore, our PMrGOs interlayers were successfully employed to FeFETs fabricated on mechanically flexible substrates with promising non-volatile memory performance under repetitive bending deformation.
High-dose oral tegafur-uracil maintenance therapy in patients with uterine cervical cancer
Isao Sakaguchi,Takeshi Motohara,Fumitaka Saito,Kiyomi Takaishi,Yukitoshi Fukumatsu,Toshimitsu Tohya,Saburo Shibata,Hiroyuki Mimori,Hironori Tashiro,Hidetaka Katabuchi 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.3
Objective: The aim of this study was to determine the efficacy and toxicity of oral administration of tegafur-uracil (UFT) at a high dose, 600 mg/day, based on the tegafur dose, against uterine cervical cancer. Methods: This study consisted of a retrospective analysis. From April 1986 to March 1997, 309 patients with uterine cervical cancer were registered. Oral UFT was administered to 162 patients for maintenance therapy after an initial treatment (the UFT group). The other 147 patients were not treated with UFT (the control group). The survival rate was calculated for both groups and statistically analyzed using the log-rank test. Adverse events were compared between the UFT and control groups. Results: In the UFT group, 103 patients (63.6%) received UFT for ≥90 days. The drug dose was 600 mg/day for 137 patients (84.6%) and 300 to 400 mg/day for the remainder. The overall survival rate was significantly higher in the UFT group than in the control group (p<0.05). The prognosis was particularly favorable in stage III cases, in cases of squamous cell carcinoma, and in cases that were treated by radiotherapy. The most frequent side effects were nausea/vomiting (12.2%), appetite loss (10.1%), and leukopenia/neutropenia (5.8%). Conclusion: High-dose oral UFT maintenance treatment prolonged the disease-free survival and overall survival of patients with uterine cervical cancer, particularly of those with advanced disease.
( Yasuhiro Fujiwara ),( Masatsugu Okuyama ),( Yasuaki Nagami ),( Koichi Taira ),( Hirotaka Ishizu ),( Osamu Takaishi ),( Hiroshi Sato ),( Toshio Watanabe ) 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4
Background/Aims Belching is the act of expelling gas from the stomach or esophagus noisily through the oral cavity. Although it is a physiological phenomenon, belching may also be a symptom of upper gastrointestinal diseases such as reflux esophagitis and functional dyspepsia (FD). A detailed epidemiology of belching has not yet been reported. The aim of this study is to examine the prevalence and clinical characteristics of clinically significant belching (CSB) in adults. Methods We analyzed 1998 subjects who visited the hospital for annual health checkups. Belching was evaluated by a simple question “Do you burp a lot?” and scored as 0 (never), 1 (occasionally), 2 (sometimes), 3 (often), or 4 (always). Subjects with CSB were defined as having scores ≥ 3. We also collected the clinical parameters, endoscopic findings, and data according to the Athens Insomnia Scale, Rome IV questionnaire, and Hospital Anxiety and Depression Scale (HADS). Results Of the 1998 subjects, 121 (6.1%) had CSB. Subjects with CSB had FD more commonly than reflux esophagitis, but presence of heartburn was high (10.7% vs 3.1%). In addition, the HADS and Athens Insomnia Scale scores in subjects with CSB were significantly higher than those in subjects without CSB. Presence of heartburn (OR, 2.07; 95% CI, 1.05-4.09), presence of FD (OR, 2.12; 95% CI, 1.33-3.36), anxiety/depression (OR, 2.29; 95% CI 1.51-3.45), and sleep disturbances (OR, 1.73; 95% CI, 1.14-2.61) were significantly associated with CSB. Conclusion The detailed epidemiology of belching in the general adult population was clarified. (J Neurogastroenterol Motil 2021;27:581-587)
Kono Maori,Okuda Tomoaki,Ishihara Nami,Hagino Hiroyuki,Tani Yuto,Okochi Hiroshi,Tokoro Chiharu,Takaishi Masayuki,Ikeda Hidefumi,Ishihara Yasuhiro 한국독성학회 2023 Toxicological Research Vol.39 No.1
Fine particulate matter (PM2.5) exposure has a risk of inducing several health problems, especially in the respiratory tract. The skin is the largest organ of the human body and is therefore the primary target of PM2.5. In this study, we examined the effects of PM2.5 on the skin using a human 3-dimensional cultured epidermis model. PM2.5 was collected by cyclonic separation in Yokohama, Japan. Global analysis of 34 proteins released from the epidermis revealed that the chemokines, chemokine C-X-C motif ligand 1 (CXCL1) and interleukin 8 (IL-8), were significantly increased in response to PM2.5 exposure. These chemokines stimulated neutrophil chemotaxis in a C-X-C motif chemokine receptor 2-dependent manner. The oxidative stress and signal transducer and activator of transcription 3 pathways may be involved in the increased expression of CXCL1 and IL-8 in the human epidermis model. Interestingly, in the HaCaT human keratinocyte cell line, PM2.5 did not affect chemokine expression but did induce IL-6 expression, suggesting a different effect of PM2.5 between the epidermis model and HaCaT cells. Overall, PM2.5 could induce the epidermis to release chemokines, followed by neutrophil activation, which might cause an unregulated inflammatory reaction in the skin.
Exciton diffusion in near-infrared absorbing solution-processed organic thin films
Shin, H.-Y.,Woo, J. H.,Gwon, M. J.,Barthelemy, M.,Vomir, M.,Muto, T.,Takaishi, K.,Uchiyama, M.,Hashizume, D.,Aoyama, T.,Kim, D.-W.,Yoon, S.,Bigot, J.-Y.,Wu, J. W.,Ribierre, J. C. The Royal Society of Chemistry 2013 Physical chemistry chemical physics Vol.15 No.8
<P>We report on singlet–singlet annihilation and exciton diffusion in as-prepared p-type and annealed n-type thin films of the low-bandgap quinoidal quaterthiophene [QQT(CN)4] using ultrafast transient absorption measurements. The decay dynamics of exciton populations are well described by a one-dimensional diffusion-limited bimolecular recombination, indicating that the singlet excitons migrate preferentially along the stacking direction. Our results show that the exciton diffusion constants in QQT(CN)4 films do not vary significantly upon thermal annealing. Exciton diffusion lengths are measured to be as high as 4 and 5 nm in as-prepared and annealed QQT(CN)4 films, respectively. We also observe an influence of the excitation densities on the singlet exciton diffusion, which is attributed to phonon scattering. Because of the possibility of patterning p–n regions in QQT(CN)4 films by thermal nanolithography techniques, this study provides important insight not only into the photophysical properties of quinoidal oligothiophene derivatives but also for their future integration into high-performance p–n nanostructured near infrared light-sensing devices.</P> <P>Graphic Abstract</P><P>Exciton–exciton annihilation and exciton diffusion processes are investigated by femtosecond transient absorption in as-prepared p-type and annealed n-type thin films of the quinoidal quaterthiophene [QQT(CN)4]. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cp43705h'> </P>