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Hypoallergenic and Physicochemical Properties of the A2 β-Casein Fraction of Goat Milk
Tae-Hwan Jung,Hyo-Jeong Hwang,Sung-Seob Yun,Won-Jae Lee,Jin-Wook Kim,Ji-Yun Ahn,Woo-Min Jeon,Kyoung-Sik Han2.6* 한국축산식품학회 2017 한국축산식품학회지 Vol.37 No.6
Goat milk has a protein composition similar to that of breast milk and contains abundant nutrients, but its use in functional foods is rather limited in comparison to milk from other sources. The aim of this study was to prepare a goat A2 β-casein fraction with improved digestibility and hypoallergenic properties. We investigated the optimal conditions for the separation of A2 β-casein fraction from goat milk by pH adjustment to pH 4.4 and treating the casein suspension with calcium chloride (0.05 M for 1 h at 25°C). Selective reduction of β- lactoglobulin and αs-casein was confirmed using sodium dodecyl sulphate-polyacrylamide gel electrophoresis and reverse-phase high-performance liquid chromatography. The hypoallergenic property of A2 β-casein fraction was examined by measuring the release of histamine and tumor necrosis factor alpha from HMC-1 human mast cells exposed to different proteins, including A2 β-casein fraction. There was no significant difference in levels of both indicators between A2 β-casein treatment and the control (no protein treatment). The A2 β-casein fraction is abundant in essential amino acids, especially, branched-chain amino acids (leucine, valine, and isoleucine). The physicochemical properties of A2 β-casein fraction, including protein solubility and viscosity, are similar to those of bovine whole casein which is widely used as a protein source in various foods. Therefore, the goat A2 β-casein fraction may be useful as a food material with good digestibility and hypoallergenic properties for infants, the elderly, and people with metabolic disorders.
Assessment of In Vitro Assay System for Thyroid HormoneDisruptors Using Rat Pituitary GH3 Cells
Hee Jin Kim1,Hae Young Park1,Jeonga Kim1,Il Hyun Kang2,Tae Sung Kim2,Soon Young Han2,Tae Seok Kang2,Kui Lea Park2,Hyung Sik Kim1 한국독성학회 2006 Toxicological Research Vol.22 No.4
The development of in vitro assays has been recommended to screening and test-ing the potential endocrine disruptors (EDs). These assay systems focus only on identifying thethe thyroid hormone (TH) disruptors. The aim of this study was to evaluate a test system to detectTH disruptors using rat pituitary tumor GH3 cells. The test system is based on the TH-dependentincrease in growth rate. As expected, L-3,5,3-triiodothyronine (T3) markedly induced a morphologicalchange in GH 3 cells from flattened fibroblastic types to rounded or spindle-shaped types. T3 stimu-lated GH3 cell growth in a dose-dependent manner with the maximum growth-stimulating effect9 M. In addition, T3 increased the release of growth hor-mone and prolactin into the medium of the GH3 cells culture. Using this assay system, the TH-dis-rupting activities of bisphenol A (BPA) and its related compounds were examined. BPA,dimethylbisphenol A (DMBPA), and TCI-EP significantly enhanced the growth of GH3 cells in therange of 1 × 10-5M to 1 × 10-6M concentrations. In conclusion, this in vitro assay system might bestandardization before it can be used as a broad-based screening tool.
Chaetoglobosin A, an Inhibitor of Bleb Formation on K562 Cells Induced by Phorbol 12,13-Dibutyrate
KO, HACK-RYONG,KIM, BO YEON,AHN, SOON-CHEOL,OH, WON KEUN,KIM, JIN-HEE,LEE, HYUN SUN,KIM, HWAN-MOOK,HAN, SANG-BAE,MHEEN, TAE0ICK,AHN, JONG-SEOG 한국미생물 · 생명공학회 1998 Journal of microbiology and biotechnology Vol.8 No.6
Tae-Han Kim,So-Dam Lee,Sung-Eun Park 한국인간·식물·환경학회 2017 인간식물환경학회지 Vol.20 No.5
Recently, the air quality issue came to the fore to the occupants of indoor areas with the detection of a large amount of indoor air pollutants such as formaldehyde that causes headache and atopic dermatitis. In order to address this issue, the use of indoor air purifying plants is considered positively as an ecological improvement option. However, the objective performance verification on indoor air-conditioning air volume has not been sufficient. This study aims to verify possible linkage with a building’s air conditioning equipment in order to optimize indoor air-conditioning effects by vegetation bio-filters. To this end, 4 different types of air filter material and AHU (Air Handling Unit) system were linked under air conditions of total wind volume of 400, 600, 800, 1,000 CMH and pressure loss by material was monitored objectively. Finally, material-specific power consumption for system operation was calculated to review energy efficiency. As for pressure loss by material, in terms of total wind volume of 800±1.8 CMH, Pre filter was lowest at –11.69 mmAq and LMF-based vegetation mat was highest at –219.94 mmAq. Based on this, as for material-specific power consumption, the Pre filter, which has the lowest pressure loss, was expected to have power consumption 94.7% lower than the LMF-based vegetation mat.
Tae-Young Kim,Gi-Sung Han,Boo-Seong Kang,Kyung-Hoon Lee 대한건축학회 2020 Architectural research Vol.22 No.4
The purpose of this study is to establish a method for assessing a building’s risk against disaster, tentatively named the Korean integrated disaster evaluation simulator (K-IDES). Based on previous studies, FEMA’s risk management series and FEMA IRVS are selected as case studies for developing a frame work of K-IDES, through the comparative analysis of domestic building design guides, codes, and special acts related to disasters, in order to develop a risk assessment methodology for quantitative results. The assessment method consists of a classification system and calculating risk, and a simulation applying the developed checklist in K-IDES to similar types of high-rise buildings will be conducted to validate its accuracy. The final goal is to systemize an integrated risk management in a high-rise building against disasters for the purpose of recognizing vulnerable areas from the beginning of the design process and reinforcing it from potential threats after construction.
Sang Hyun Park,Sang Hwan Do,Hye Young Shin,Young Tae Jeon,Jung Won Hwang,Sung Hee Han 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.57 No.5
Background: This prospective, randomized, double-blind study was undertaken to compare prophylactic nicardipine infusion with esmolol infusion to determine their effects on the control of hemodynamic response during emergence from total intravenous anesthesia (TIVA) with propofol and remifentanil. Methods: One hundred and thirty two patients undergoing thyroidectomy were divided randomly into 3 groups. About 10 minutes before the end of surgery, propofol was stopped in all the patients and nicardipine group (n=44) received a continuous infusion of 2 μg/kg/min nicardipine during emergence from TIVA, esmolol group (n=44) received 250 μg/kg/min esmolol, and placebo group received 10-14 ml/hr of isotonic saline until 15 min after transfer to a postanesthesia care unit (PACU). Hemodynamic profiles were measured every minute throughout the study period. Results: MBP was significantly lower in the nicardipine group than in the esmolol group (P<0.05) from 10 min after PACU transfer until 10 min after study drug infusion stop. On the other hand, HR was significantly lower in the esmolol group than in the nicardipine group from 6 min after drug infusion. Conclusions: Nicardipine infusion attenuated blood pressure increases more effectively than esmolol infusion during emergence from TIVA. (Korean J Anesthesiol 2009;57:597∼603)