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Transmission ability of Zika virus with artificially infected Aedes albopictus in Korea
Yang Sung‐Chan,Lee Hee-Il,Kim Hyunwoo,Lee Wook‐Gyo 한국곤충학회 2021 Entomological Research Vol.51 No.8
Zika virus (ZIKV), a virus mainly occurring in South America, is now globally distributed. Understanding the pathogen transmission cycle in a vector is exceptionally important in developing disease control strategies. In this study, we performed ZIKV microinjection in Aedes albopictus (Skuese), to estimate its vertical and horizontal transmission ability. The virus infection rate was confirmed by real-time qPCR in the F1 generation derived from the ZIKV-injected Ae. albopictus. The minimum infection rate (MIR) of the F1 generation was highest when they were injected with the virus at 6–12 h (MIR: 16.1) and lowest at 12–24 h (MIR: 4.7) after feeding. In the developmental stage of the F1 progeny, MIR values were 1.0, 1.3, and 6.7 in each egg, larval, and adult stage, respectively, but ZIKV was not detected in the pupa stage. Virus transmission ability was not significantly different between the collection areas (Tongyeong and Jeju). Ae. albopictus demonstrated a high venereal transmission rate of ZIKV and was detected in males (6 pool/7 pool) and females (6 pool/7 pool), confirming that ZIKV can be transmitted from infected mosquitoes to uninfected mosquitoes via mating. This is the first study of the administration of a ZIKV microinjection to Ae. albopictus in Korea and suggests a possibility of a potential mechanism for the virus to survive during adverse conditions via vertical transmission.
Photolysis Properties of Merocyanine Dye LB Films by Various Time of UV Irradiation
Yang, Chang-Heon,Lee, Ji-Yoon,Sung, Gi-Chan,Kim, Gyong-Chol,Shin, Hoon-Kyu,Kwon, Young-Soo American Scientific Publishers 2011 Journal of Nanoscience and Nanotechnology Vol.11 No.2
<P>We fabricated the merocyanine dye LB films with arachidic acid (MD LB films). We compared absorption peak of before and after added Cd2+. The optical absorption peak of the MD LB films was shifted to 610 nm at 535 nm, when Cd2+ ions were added. We also investigated the optical absorption peak of the LB films by various time at 365 nm UV. We confirmed J-aggregation and photolysis properties. This is that studied the application possibility of the switching device and the nonvolatile memory.</P>
Isolation of novel bovine parainfluenza virus type 5 (bPIV5) and its incidence in Korean cattle
Yang, Dong-Kun,Nah, Jin-Ju,Kim, Ha-Hyun,Choi, Sung-Suk,Bae, You-Chan,Park, Jung-Won,Song, Jae-Young The Korean Society of Veterinary Science 2014 大韓獸醫學會誌 Vol.54 No.2
Four viruses showing cytopathic effects in MDBK cells were isolated from brains of cattle showing downer cattle syndrome in 2012. The isolates were confirmed to belong to the genus Rubulavirus of the subfamily Paramyxovirinae. Isolate QIA-B1201 had the ability to hemagglutinate red blood cells from several species of animals and was capable of adsorbing guinea pig erythrocytes on the surface of infected Vero cells. Nucleotide sequence analysis showed that two isolates (QIA-B1201 and QIA-B1204) had high similarity with other human and animal PIV5 isolates ranging from 98.1 to 99.8%. The highest sequence similarity of the two isolates corresponded to strain KNU-11 (99.8% at the nucleotide and amino acid level) isolated from suckling piglets in Korea in 2012. To evaluate the virulence of strain QIA-B1201, we inoculated bPIV5 into 5 week-old mice via both the intraperitoneal and intracranial route. Body weight was not significantly altered in mice inoculated with QIA-B1201. In this study, we isolated and characterized novel bPIV5s from brain samples showing downer cattle syndrome, but were not able to elucidate the pathogenicity of the bPIV5s in mice.
Basal cell carcinoma arising within seborrheic keratosis
( Chan-yang Lee ),( Ye-jin Lee ),( Hyung-jin Park ),( Hye-jin Ahn ),( Ji-youn Sung ),( Ki-heon Jeong ),( Min Kyung Shin ),( Mu-hyoung Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Seborrheic keratosis (SK) is one of the most common benign cutaneous tumors. However, it has been rarely reported that malignant tumors such as basal cell carcinoma (BCC), malignant melanoma and squamous cell carcinoma arising within SK. Seventy seven-year-old female presented with a brownish plaque on the left posterior thigh that had been present for more than 20 years. The ulcerative lesion has developed on the verrucous surfaced brownish plaque over the last few years. Skin biopsy performed two site of plaque including the ulcerated lesion and the peripheral margin. The ulcerated lesion revealed proliferation of basaloid cells palisading throughout the epidermis, clefting between the epithelium and stroma suggesting BCC and the peripheral margin showed epidermal hyperkeratosis, acanthosis, papilomatosis and pseudo-horn cyst suggesting SK. A total excised lesion showed histologic continuity from SK to BCC. Immunohistochemical analysis revealed extensive staining of CK19 and overexpression of p53 at the ulcerated lesion compared with the peripheral margin. These features suggest BCC arising within SK. We report a rare case of SK undergone malignant change to BCC.
Characterization of Subtilein, a Bacteriocin from Bacillus subtilis CAU131 (KCCM 10257)
( Sung Yong Park ),( Yong Jae Yang ),( Young Bae Kim ),( Jae Hoon Hong ),( Chan Lee ) 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.2
Bacillus subtilis CAU131 (KCCM 10257) isolated from a fermented shrimp product produces subtilein, tentatively named as a bacteriocin, which exhibited a bactericidal effect against closely related species such as Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 11778, and several other strains of Bacillus sp. The purification of the subtilein was achieved by applying a mono-Q anion exchange chromatography on FPLC and C18 reverse-phase chromatography on HPLC. After purification, specific activity of subtilein was increased about 3,000-fold compared with culture broth and its molecular mass was about 5,000 Da on SDS-PAGE. The antimicrobial activity of subtilein was well maintained at acidic and neutral pHs between 3 and 8. Subtilein was relatively heat stable, and its antimicrobial activity remained for 2 h at 80℃. However, the activity was reduced after heating at 100℃, and about 80% of the activity was found after 1h incubation at 100℃. The treatment of Bacillus subtilis ATCC 6633 with subtilein led to morphological changes in stationary-phase cells and most cells appeared to be lysed.
Yang, Hee-Man,Park, Chan Woo,Lim, Sujin,Park, Sung-Il,Chung, Bong Hyun,Kim, Jong-Duk Royal Society of Chemistry 2011 Chemical communications Vol.47 No.46
<P>Cross-linked magnetic nanoparticles were developed to improve the structural stability of amphiphilic polymer coated magnetic nanoparticles. These nanoparticles show strong potential for biomedical applications such as magnetic resonance imaging (MRI).</P> <P>Graphic Abstract</P><P>Biocompatible cross-linked magnetic nanoparticles loaded with fluorescence dye were prepared, and their biomedical applicability was evaluated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc16191a'> </P>
Pulmonary function and toxicities of proton versus photon for limited-stage small cell lung cancer
Sang Hoon Seo,Hongryull Pyo,Yong Chan Ahn,Dongryul Oh,Kyungmi Yang,Nalee Kim,Jong-Mu Sun,Sehhoon Park,Hyun Ae Jung,Se-Hoon Lee,Jin Seok Ahn,Myung-Ju Ahn,Jae Myoung Noh 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.4
Purpose: We aimed to compare the oncological outcomes and toxicities of definitive proton beam therapy (PBT) and photon beam therapy in patients with limited-stage small cell lung cancer (LS-SCLC). Materials and Methods: We retrospectively reviewed 262 patients with newly diagnosed LS-SCLC who underwent definitive PBT (n = 20; proton group) or photon beam therapy (n = 242; photon group) with concurrent chemotherapy between January 2016 and February 2021 and compared overall survival (OS), progression-free survival (PFS), dose-volume parameters, and toxicities between the groups. Results: The median follow-up duration was 24.5 months (range, 3.7 to 78.7). Baseline lung function was significantly worse and clinical target volume (CTV) was larger in the proton group (CTV: 296.6 vs. 215.3 mL; p = 0.080). The mean lung V10 was 37.7% ± 16.8% and 51.6% ± 24.5% in the proton and photon groups, respectively (p = 0.002). Two-year OS and PFS rates were 57.2% and 35.7% in the proton group and 65.3% and 40.8% in the photon group, respectively (p = 0.542 and 0.748, respectively). Grade ≥2 radiation pneumonitis and esophagitis occurred in 5 (25.0%) and 7 (35.0%) PBT-treated patients and 66 (27.3%) and 40 (16.5%) photon beam therapy-treated patients, respectively (p = 0.826 and 0.062, respectively). Conclusion: Although the proton group had poorer lung function and a larger CTV than that in the photon group, both groups exhibited comparable treatment outcomes and radiation-related toxicities in LS-SCLC. PBT may be a valuable therapeutic modality in patients with poor pulmonary function or extensive disease burden owing to its lung-sparing ability.
Design of In-situ Self-diagnosable Smart Controller for Integrated Algae Monitoring System
Sung Hwa Lee,Vinayagam Mariappan,Dong Chan Won,Jaekwon Shin,Seungyoun Yang 국제문화기술진흥원 2017 International Journal of Advanced Culture Technolo Vol.5 No.1
The rapid growth of algae occurs can induce the algae bloom when nutrients are supplied from anthropogenic sources such as fertilizer, animal waste or sewage in runoff the water currents or upwelling naturally. The algae blooms creates the human health problem in the environment as well as in the water resource managers including hypoxic dead zones and harmful toxins and pose challenges to water treatment systems. The algal blooms in the source water in water treatment systems affects the drinking water taste & odor while clogging or damaging filtration systems and putting a strain on the systems designed to remove algal toxins from the source water. This paper propose the emerging In-Situ self-diagnosable smart algae sensing device with wireless connectivity for smart remote monitoring and control. In this research, we developed the In-Site Algae diagnosable sensing device with wireless sensor network (WSN) connectivity with Optical Biological Sensor and environmental sensor to monitor the water treatment systems. The proposed system emulated in real-time on the water treatment plant and functional evaluation parameters are presented as part of the conceptual proof to the proposed research.