Metabolic Syndrome Is Associated with Delayed Heart Rate Recovery after Exercise

Jidong Sung,Yoon Ho Choi,박정배 대한의학회 2006 Journal of Korean medical science Vol.21 No.4

Heart rate (HR) recovery after exercise is a function of vagal reactivation, and its impairment is a predictor of overall mortality and adverse cardiovascular events. While metabolic syndrome is associated with sympathetic overactivity, little is known about the relationship between metabolic syndrome and HR recovery. A symptom-limited exercise stress test in healthy subjects (n=1,434) was used to evaluate HR recovery. Metabolic syndrome was defined according to the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP-III) criteria. Seventeen percent of subjects had ≥≥3 criteria for metabolic syndrome. HR recovery was lower in men than women and in smokers than nonsmokers. The subject with metabolic syndrome (vs. without) showed lower HR recovery (10.3 ±±11.6 vs. 13.6 ±±9.7 per minute) and higher resting HR (64.3 ±±10.3 vs. 61.6 ±±9.1 per minute). HR recovery correlated inversely to age (r=-0.25, p<0.0001), but not to resting HR or maximal oxygen uptake. Delayed HR recovery was associated with metabolic syndrome after an adjustment for age, sex, resting HR and smoking (p<0.01). Metabolic syn-drome is associated with impaired vagal reactivation. Adverse cardiovascular out-comes associated with metabolic syndrome may be mediated by the failure of vagal reactivation in addition to sympathetic overactivity.

Pathogenesis of Myocardial Cell Death and Effect of Cardiotrophin-1 in Coxsackieviral Myocarditis

Sung, Jidong,Jeon, Eun-Seok Yonsei cardiovascular center 2002 Korean journal of cardiovascular diseases Vol.3 No.1

The Long and Winding Road: To the Proper Understanding of High-density Lipoprotein

Jidong Sung 대한심장학회 2020 Korean Circulation Journal Vol.50 No.3

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Lipid and Ischemic Heart Disease Revisited: Mendelian Randomization Analysis

Jidong Sung 대한심장학회 2020 Korean Circulation Journal Vol.50 No.10

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Descriptive Study on the Korean Status of Percutaneous Coronary Intervention Using National Health Insurance Service-National Sample Cohort (NHIS-NSC) Database: Focused on Temporal Trend

Jidong Sung,Kyung Pyo Hong 대한심장학회 2019 Korean Circulation Journal Vol.49 No.12

Background and Objectives: Percutaneous coronary intervention (PCI) is an indispensable treatment modality in coronary artery disease. However, there is still inadequacy of comprehensive knowledge on the Korean status and trend of this important procedure using nation-wide and representative data. Methods: National Health Insurance Service-National Sample Cohort is a database containing demographic, health insurance reimbursement for patient management and health screening data of about one million Koreans for 12 years (2002–2013). Annual procedure rate for PCI was estimated by bootstrapping as per 100,000 person-years. Results: Among the whole cohort, total 12,186 PCI's were done during the study period. Mean age of subjects who underwent PCI was 57.6±11.2 years and male:female proportion was 68%:32%. Death from all cause occurred in 1,843 (15.1%), death from ischemic heart diseases in 662 (5.4%), death from all cardiovascular cause in 872 (7.2%) during the follow-up. The proportion of the primary PCI for acute myocardial infarction was estimated to be 24.0%. Estimated annual rate of PCI increased from median 29.1 (95% confidence interval [CI], 26.6–32.1) in 2002 to 107.7 (95% CI, 103.0–113.8) per 100,000 person-years in 2013. In this cohort, PCI was performed in total 180 hospitals, which annually increased from 59 in 2002 to 153 in 2013. Conclusions: PCI had increased in volume from 2002 to 2013. This descriptive data may be considered in policy making and planning further direction of management of coronary artery disease in Korea.

관상동맥질환과 Psycho - social Environment

성지동(Jidong Sung) 대한스트레스학회 2007 스트레스硏究 Vol.15 No.2

Impact of optimal glycemic control on the progression of coronary artery calcification in asymptomatic patients with diabetes

Won, Ki-Bum,Han, Donghee,Lee, Ji Hyun,Lee, Sang-Eun,Sung, Ji Min,Choi, Su-Yeon,Chun, Eun Ju,Park, Sung Hak,Han, Hae-Won,Sung, Jidong,Jung, Hae Ok,Chang, Hyuk-Jae Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.266 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited.</P> <P><B>Methods</B></P> <P>We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3.0 (2.0–4.4) years. The change in CAC was compared base on OGC status. OGC was defined as a follow-up hemoglobin A1C (HbA1C) of <7.0%, and CAC progression was defined by a square root (√) transformed difference between the baseline and follow-up CAC scores (Δ √transformed CAC) of ≥2.5.</P> <P><B>Results</B></P> <P>Despite no significant difference in the baseline CAC scores, the incidence of CAC progression was lower in the OGC group than in the non-OGC group (45.4% vs. 51.7%; <I>p</I> < 0.013). The two groups differed in the Δ √transformed (OGC, 3.8 ± 6.4; non-OGC, 4.7 ± 6.9; <I>p</I> = 0.016) and annualized Δ √transformed CAC (OGC, 1.1 ± 2.4; non-OGC, 1.4 ± 2.6; <I>p</I> = 0.010) scores. Subgroup analysis showed that OGC significantly reduced the risk of CAC progression in patients aged <65 years and in: smokers, and patients with a body mass index of <25 kg/m<SUP>2</SUP>, dyslipidemia, and baseline CAC scores between 1–100 and >400. In multivariate regression analysis, OGC was independently associated with a reduced risk of CAC progression (odds ratio, 0.745, 95% confidence interval, 0.601–0.924; <I>p</I> = 0.007).</P> <P><B>Conclusion</B></P> <P>OGC attenuated the progression of coronary artery calcification in asymptomatic patients with diabetes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In clinical practice, the significance of optimal glycemic control (OGC) is emphasized in patients with diabetes. </LI> <LI> Data on the impact of OGC on coronary artery calcification (CAC) progression in patients with diabetes has been limited. </LI> <LI> This study identified that OGC was independently associated with a reduced risk of CAC progression in asymptomatic patients with diabetes. </LI> </UL> </P>

Adiponectin is Associated with Impaired Fasting Glucose in the Non-Diabetic Population

Sang Yeun Kim,Sun Ju Lee,Hyoun Kyoung Park,Ji Eun Yun,Myoungsook Lee,Jidong Sung,Sun Ha Jee 한국역학회 2011 Epidemiology and Health Vol.33 No.-

OBJECTIVES: Adiponectin is strongly associated with diabetes in the Western population. However, whether adiponectin is independently associated with impaired fasting glucose (IFG) in the non-obese population is unknown. METHODS: The serum adiponectin, insulin resistance (IR), and waist circumference (WC) of 27,549 healthy Koreans were measured. Individuals were then classified into tertile groups by gender. IFG was defined as a fasting serum glucose of 100-125 mg/dL without diabetes. IR was calculated using the homeostasis model assessment of insulin resistance (HOMA-IR). The association of adiponectin and IFG was determined using logistic regression analysis. RESULTS: WC and adiponectin were associated with IFG in both men and women. However, the association of WC with IFG was attenuated in both men and women after adjustment for the HOMA-IR. Adiponectin was still associated with IFG after adjustment for and stratification by HOMA-IR in men and women. Strong combined associations of IR and adiponectin with IFG were observed in men and women. Multivariate adjusted odds ratios (ORs) (95% confidence interval [CI]) among those in the highest tertile of IR and the lowest tertile of adiponectin were 9.8 (7.96 to 12.07) for men and 24.1 (13.86 to 41.94) for women. CONCLUSION: These results suggest that adiponectin is strongly associated with IFG, and point to adiponectin as an additional diagnostic biomarker of IFG in the non-diabetic population.

정보 제공 피드백이 탐지 수행 증진에 미치는 효과: 가상 수화물 검사를 활용하여

임성준 ( Sung Jun Lim ),최지한 ( Jihan Choi ),이지동 ( Jidong Lee ),안지연 ( Ji Yeon Ahn ),문광수 ( Kwangsu Moon ) 한국안전학회(구 한국산업안전학회) 2019 한국안전학회지 Vol.34 No.1

The importance of aviation safety has been emphasized recently due to the development of aviation industry. Despite the efforts of each country and the improvement of screening equipment, screening tasks are still difficult and detection failures are frequent. The purpose of this study was to examine the effect of feedback on improving signal detection performance applying a Simulated Baggage Screening Program(SBSP) for improving aviation safety. SBSP consists of three parts: image combination, option setting and experiment. The experimental images were color-coded to reflect the items’ transmittance of the x-rays and could be combined as researchers’ need. In the option, the researcher could set up the information, incentive, and comments needed for training to be delivered on a number of tasks and times. Experiment was conducted using SBSP and participant’s performance information (hit, missed, false alarms, correct rejection, reaction time, etc.) was automatically calculated and stored. A total of 50 participants participated and each participant was randomly assigned to feedback and non-feedback group. Participants performed a total of 200 tasks and 20(10%) contained target object(gun and knife). The results showed that when the feedback was provided, the hit, correct rejection ratio and d′ were increased, however, the false alarms and miss decreased. However, there was no significant difference in response criteria(β). In addition, implications, limitations of this study and future research were discussed.

The association between metabolic syndrome and heart failure in middle-aged men and women : population-based study of 2 million individuals

김태은,김형수,Sung Jidong,김덕경,이명순,한성우,Kim Hyun Joong,김성해,유규형 한국역학회 2022 Epidemiology and Health Vol.44 No.-

OBJECTIVES: Although an association is known to exist between metabolic syndrome (MetS) and heart failure (HF) risk, large longitudinal studies are limited. We investigated metabolic status as a risk factor for HF in middle-aged men and women and considered sex differences in various risk factors for HF using nationwide real-world data. METHODS: Data obtained from the Korean National Health Insurance Service from 2009 to 2016 were analyzed. A total of 2,151,597 middle-aged subjects (between 50 and 59 years old) were enrolled. Subjects were divided into 3 groups (normal, pre‐ MetS, and MetS). Cox proportional hazard models were used to estimate the association between MetS and incident HF after adjusting for clinical risk factors. RESULTS: At baseline, MetS existed in 23.77% of men and 10.58% of women. Pre-MetS and MetS increased the risk of HF: the hazard ratios of pre-MetS for incident HF were 1.508 (95% confidence interval [CI], 1.287 to 1.767) in men and 1.395 (95% CI, 1.158 to 1.681) in women, and those of MetS were 1.711 (95% CI, 1.433 to 2.044) in men and 2.144 (95% CI, 1.674 to 2.747) in women. Current smoking, a low hemoglobin level, underweight (body mass index < 18.5 kg/m2 ), a high creatinine level, and acute myocardial infarction were also predictors of HF in both sexes. CONCLUSIONS: Pre-MetS and MetS were identified as risk factors for HF in middle-aged men and women. The effect of MetS on the occurrence of HF was stronger in women than in men. Pre-MetS was also a predictor of HF, but was associated with a lower risk than MetS.