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Park, Kanghui,Lee, Youngjeon,Park, Sookyoung,Lee, Seunghoon,Hong, Yunkyung,kil Lee, Sang–,Hong, Yonggeun Blackwell Publishing Ltd 2010 Journal of pineal research Vol.48 No.3
<P>Abstract: </P><P>Nitric oxide (NO) may aggravate neuronal damage after spinal cord injury (SCI). We hypothesized that NO produced by inducible nitric oxide synthase (iNOS) accelerates secondary damage to spinal tissue, which may be reversed by the neuroprotectant, melatonin. This study investigated the effects of combination therapy with melatonin (10 mg/kg) and exercise (10 m/min) on recovery from SCI caused by contusion. We examined locomotor recovery, iNOS gene expression, autophagic and apoptotic signaling, including Beclin-1, LC3, p53 and IKK&agr; protein expression and histological alterations in the ventral horn of the spinal cord. Melatonin in combination with exercise resulted in significantly increased hindlimb movement (<I>P </I><<I> </I>0.05), a reduced level of iNOS mRNA (<I>P </I><<I> </I>0.05) and more motor neurons in the ventral horn, versus control SCI and SCI plus exercise alone, with no effect on the other signaling molecules examined. This study shows that combined therapy with melatonin and exercise reduces the degree of secondary damage associated with SCI in rats and supports the possible use of melatonin in combination with exercise to reduce the side effects related to exercise-induced fatigue and impairment.</P>
New Prophylactic and Therapeutic Strategies for Spinal Cord Injury
Park, Sookyoung,Park, Kanghui,Lee, Youngjeon,Chang, Kyu-Tae,Hong, Yonggeun Institute of Lifestyle Medicine, Yonsei University 2013 Journal of lifestyle medicine Vol.3 No.1
<P>Melatonin production by the pineal gland in the vertebrate brain has attracted much scientific attention. Pineal melatonin is regulated by photoperiodicity, whereas circadian secretion of melatonin produced in the gastrointestinal tract is regulated by food intake. Thus, the circadian rhythm of pineal melatonin depends upon whether a species is diurnal or nocturnal. Spinal cord injury (SCI) involves damage to the spinal cord caused by trauma or disease that results in compromise or loss of body function. Melatonin is the most efficient and commonly used pharmacological antioxidant treatment for SCI. Melatonin is an indolamine secreted by the pineal gland during the dark phase of the circadian cycle. Neurorehabilitation is a complex medical process that focuses on improving function and repairing damaged connections in the brain and nervous system following injury. Physical activity associated with an active lifestyle reduces the risk of obesity, cardiovascular disease, type 2 diabetes, osteoporosis, and depression and protects against neurological conditions, including Parkinson’s disease, Alzheimer’s disease, and ischemic stroke. Physical activity has been shown to increase the gene expression of several brain neurotrophins (brain-derived neurotrophic factor [BDNF], nerve growth factor, and galanin) and the production of mitochondrial uncoupling protein 2, which promotes neuronal survival, differentiation, and growth. In summary, melatonin is a neural protectant, and when combined with therapeutic exercise, the hormone prevents the progression of secondary neuronal degeneration in SCI. The present review briefly describes the pathophysiological mechanisms underlying SCI, focusing on therapeutic targets and combined melatonin and exercise therapy, which can attenuate secondary injury mechanisms with minimal side effects.</P>
Therapeutic physical exercise in neural injury: friend or foe?
Park, Kanghui,Lee, Seunghoon,Hong, Yunkyung,Park, Sookyoung,Choi, Jeonghyun,Chang, Kyu-Tae,Kim, Joo-Heon,Hong, Yonggeun The Society of Physical Therapy Science 2015 JOURNAL OF PHYSICAL THERAPY SCIENCE Vol.27 No.12
<P>[Purpose] The intensity of therapeutic physical exercise is complex and sometimes controversial in patients with neural injuries. This review assessed whether therapeutic physical exercise is beneficial according to the intensity of the physical exercise. [Methods] The authors identified clinically or scientifically relevant articles from PubMed that met the inclusion criteria. [Results] Exercise training can improve body strength and lead to the physiological adaptation of skeletal muscles and the nervous system after neural injuries. Furthermore, neurophysiological and neuropathological studies show differences in the beneficial effects of forced therapeutic exercise in patients with severe or mild neural injuries. Forced exercise alters the distribution of muscle fiber types in patients with neural injuries. Based on several animal studies, forced exercise may promote functional recovery following cerebral ischemia via signaling molecules in ischemic brain regions. [Conclusions] This review describes several types of therapeutic forced exercise and the controversy regarding the therapeutic effects in experimental animals versus humans with neural injuries. This review also provides a therapeutic strategy for physical therapists that grades the intensity of forced exercise according to the level of neural injury.</P>
Sookyoung Park,Sang-Kil Lee,Jinyoung Won,Min-Hee Rho,Rae-Jun Park,Jin-Sang Kim,Yonggeun Hong 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.4
Caveolin is a signaling molecule in mammalian cells that might be involved in the pathogenesis and mechanism of cerebral ischemia. In this study, cerebral ischemia was induced by transient middle cerebral artery occlusion (MCAo)-reperfusion. This focal cerebral ischemia model is widely used and produces a typical neurological deficiency. This study investigated the changes in motor function and the expression of caveolins and inducible nitric oxide synthase (iNOS) in the brains of 12-week-old male Sprague-Dawley rats subjected to MCAo. The rats were evaluated 24, 48, and 72 hours after MCAo. Neurological and motor dysfunction were analyzed using the modified neurological severity score (mNSS), gait analysis, and the balance beam test. The expression of iNOS and caveolins was detected using on RT-PCR method. On assessing the behavior of MCAo rats, neurological deficiency, motor dysfunction, and impaired balance were detected. In addition, the expression of iNOS expression was increased, whereas that of caveolin-1 and -3 was decreased in MCAo-brain tissue. These results imply that iNOS and caveolins are strong causative factor of brain impairment at the molecular level after focal cerebral ischemia.
Differential expression of caveolins and myosin heavy chains in response to forced exercise in rats
Sookyoung Park,Yunkyung Hong,Youngjeon Lee,Jinyoung Won,Kyu-Tae Chang,Yonggeun Hong 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.1
Exercise training can improve strength and lead to adaptations in the skeletal muscle and nervous systems. Skeletal muscles can develop into two types: fast and slow, depending on the expression pattern of myosin heavy chain (MHC) isoforms. Previous studies reported that exercise altered the distribution of muscle fiber types. It is not currently known what changes in the expression of caveolins and types of muscle fiber occur in response to the intensity of exercise. This study determined the changes in expression of caveolins and MHC type after forced exercise in muscular and non-muscular tissues in rats. A control (Con) group to which forced exercise was not applied and an exercise (Ex) group to which forced exercise was applied. Forced exercise, using a treadmill, was introduced at a speed of 25 m/min for 30 min, 3 times/day (07:00, 15:00, 23:00). Homogenized tissues were applied to extract of total RNA for further gene analysis. The expression of caveolin-3 and MHC2a in the gastrocnemius muscle of female rats significantly increased in the Ex group compared with the Con group (P<0.05). Furthermore, in the gastrocnemius muscle of male rats, the expression of MHC2x was significantly different between the two groups (P<0.05). There was an increased expression in caveolin-3 and a slightly decreased expression in TGFβ-1 in muscular tissues implicating caveolin-3 influences the expression of MHC isoforms and TGFβ-1 expression. Eventually, it implicates that caveolin-3 has positive regulatory function in muscle atrophy induced by neural dysfunction with spinal cord injury or stroke.
젊은 남성에서 부하 적용이 어깨 벌림 동안 봉우리밑 공간 간격에 미치는 영향
박강희 ( Park Kanghui ),박한규 ( Park Hankyu ),박수경 ( Park Sookyoung ) 대한통합의학회 2020 대한통합의학회지 Vol.8 No.1
Purpose : This study was performed to comparison of distance change of subacromial space according to shoulder abduction angle in loaded and unloaded conditions. Methods : The subjects were 20 male college students, and the subacromial space was measured using an ultrasound diagnostic apparatus. The participants shoulder abduction was measured during each shoulder resting position and 45 ° abduction with loads of 1 ㎏, 2 ㎏, 3 ㎏. The collected data were analyzed by a paired t-test and repeated measure ANOVA with the SPSS (Ver. 22) program. Results : The subacromial space showed statistically significant decreased in 45 ° abduction than resting position (p<.001). All the subacromial space increased during the according to loads (1 ㎏, 2 ㎏, 3 ㎏) at the resting position but at 45 ° abduction showed statistically significant decreased as the load increases (p<.05). Also, subacromial space showed significant changes in the 2㎏, 3㎏ compared with the 0㎏ loads. Conclusion : These results identified that shoulder abduction angle and load were related to subacromial space. When resting position, subacromial space is larger at loads than unload. As the load and shoulder abduction angle increase, subacromial space is reduced compared to resting.