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Cortical Volumetric Correlates of Childhood Trauma, Anxiety, and Impulsivity in Bipolar Disorder
Song Hyehyun,Chon Myong-Wuk,Ryu Vin,Yu Rina,Lee Dong-Kyun,Lee Hyeongrae,Lee Wonhye,Lee Jung Hyun,Park Dong Yeon 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.7
Objective More recently, attention has turned to the linkage between childhood trauma and emotional dysregulation, but the evidence in bipolar disorder (BD) is limited. To determine neurobiological relationships between childhood trauma, current anxiety, and impulsivity, we investigated cortical volumetric correlates of these clinical factors in BD.Methods We studied 36 patients with DSM-5 BD and 29 healthy controls. Childhood trauma, coexisting anxiety, and impulsivity were evaluated with the Korean version-Childhood Trauma Questionnaire (CTQ), the Korean version-Beck Anxiety Inventory (BAI), and the Korean version-Barratt Impulsiveness Scale (BIS). Voxel-based morphometry (VBM) was used to assess gray matter volume (GMV) alterations on the brain magnetic resonance imaging (MRI). Partial correlation analyses were conducted to examine associations between the GMV and each scale in the BD group.Results Childhood trauma, anxiety, and impulsivity were interrelated in BD. BD patients revealed significant inverse correlations between the GMV in the right precentral gyrus and CTQ scores (r=-0.609, p<0.0003); between the GMV in the left middle frontal gyrus and BAI scores (r=-0.363, p=0.044). Moreover, patients showed similar tendency of negative correlations between the GMV in the right precentral gyrus and BIS scores; between the GMV in the left middle frontal gyrus and CTQ scores.Conclusion The present study provides evidence for a neural basis between childhood trauma and affect regulations in BD. The GMV alterations in multiple frontal lobe areas may represent neurobiological markers for anticipating the course of BD.
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Song, Xiaokai,Kim, Tae Kyung,Kim, Hyehyun,Kim, Dongwook,Jeong, Seok,Moon, Hoi Ri,Lah, Myoung Soo American Chemical Society 2012 Chemistry of materials Vol.24 No.15
<P>The transmetalation (the replacement of metal ions) of a family of highly porous isostructural metal–organic frameworks (MOFs), M<SUB>6</SUB>(BTB)<SUB>4</SUB>(BP)<SUB>3</SUB> (where M = Zn(II) (<B>1</B>), Co(II) (<B>2</B>), Cu(II) (<B>3</B>), and Ni(II) (<B>4</B>), BTB = 1,3,5-benzenetribenzoate, and BP = 4,4′-dipyridyl) with an <B>ith-d</B> net topology has been investigated. These compounds have different framework stabilities depending on the framework metal ions. The transmetalation and the reverse transmetalation reactions of the framework metal ions were observed between the MOFs, <B>1</B> and <B>2</B>, having a similar thermodynamic stability. While the transmetalation from thermodynamically less stable <B>1</B> and <B>2</B> to more stable <B>3</B> and <B>4</B> were achieved by soaking single crystals of <B>1</B> and <B>2</B> in a solution of <I>N,N</I>′-dimethylformamide (DMF) containing Cu(II) and Ni(II) ions, respectively, no reverse transmetalation was observed. By simply controlling the soaking time, not only could homogeneously transmetalated crystalline framework structures be prepared via the thermodynamically controlled complete replacement of the framework metal ions but also selectively transmetalated core–shell heterostructures were formed via kinetically controlled replacement that was mainly restricted to the external shell region of the crystal. The fully transmetalated MOFs showed significantly improved framework stabilities compared with the parent MOFs. A marked improvement in the framework stability was observed, even in the selectively transmetalated Co(II)/Cu(II)- and Co(II)/Ni(II)-core–shell heterostructures. Although the frameworks are partially transmetalated, the framework stability of not only the external shell region but also of the internal core region was significantly affected.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/cmatex/2012/cmatex.2012.24.issue-15/cm301605w/production/images/medium/cm-2012-01605w_0001.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/cm301605w'>ACS Electronic Supporting Info</A></P>
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EmoBridge: 장애학생과 필기 지원 인력 간의 소통 증진을 위한 협동 필기 프로그램 디자인
송형우(Hyungwoo Song),신민정(Minjeong Shin),주혜현(Hyehyun Chu),홍지인(Jiin Hong),이재찬(Jaechan Lee),은진수(Jinsu Eun),임하진(Hajin Lim) 한국HCI학회 2024 한국HCI학회 학술대회 Vol.2024 No.1
신체적, 정신적 장애로 인해 장애학생은 교육적 성취에 상당한 제약을 받고 있다. 따라서 많은 고등교육기관에서는 장애학생의 학습 지원을 위해 필기 지원인력 (Peer Notetaker) 프로그램을 운영하여 비장애 학생이 장애학생이 수강하는 수업의 필기를 대신 작성할 수 있게 하는 지원책을 마련하고 있다. 본 연구에서는 이러한 필기 지원인력 프로그램 이용 경험이 있는 장애학생과 지원인력 총 16 명을 대상으로 심층 인터뷰를 진행하여 이들이 경험하는 필기 상황 및 학습적, 관계적 측면에서의 문제점을 발견하였다. 이 같은 문제점들을 해결하는 방안으로서 장애학생과 지원인력이 필기를 실시간으로 공유하며 이모지로 소통할 수 있는 협동 필기 프로그램인 ‘EmoBridge’ 프로토타입을 개발 및 평가하였다. 본 연구는 필기 지원인력 프로그램에서 발생하는 다층적인 어려움에 대한 이해를 바탕으로, 협동 필기 프로그램의 디자인을 제시한데 그 의의가 있다.
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