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Song, Chanyoung,Noh, Young-Woock,Lim, Yong Taik Dove Medical Press 2016 International journal of nanomedicine Vol.11 No.-
<P>Effective induction of an antigen-specific cytotoxic T lymphocyte (CTL) immune response is one of the key goals of cancer immunotherapy. We report the design and fabrication of polyethylenimine (PEI)-coated polymer nanoparticles (NPs) as efficient antigen-delivery carriers that can induce antigen cross-presentation and a strong CTL response. After synthesis of poly(<SMALL>D</SMALL>,<SMALL>L</SMALL>-lactide-<I>co</I>-glycolide) (PLGA) NPs containing ovalbumin (OVA) by the double-emulsion solvent-evaporation method, cationic-charged PLGA NPs were generated by coating them with PEI. In a methyl tetrazolium salt assay, no discernible cytotoxic effect of PEI-coated PLGA (OVA) NPs was observed. The capacity and mechanism of PEI-coated PLGA (OVA) NPs for antigen delivery and cross-presentation on dendritic cells (DCs) were determined by fluorescence microscopy and flow cytometry. PEI-coated PLGA (OVA) NPs were internalized efficiently via phagocytosis or macropinocytosis in DCs and induced efficient cross-presentation of the antigen on MHC class I molecules via both endosome escape and a lysosomal processing mechanism. The DCs treated with PEI-coated PLGA (OVA) NPs induced a release of IL-2 cytokine from OVA-specific CD8-OVA1.3 T cells more efficiently than DCs treated with PLGA (OVA) NPs. Therefore, the PEI-coated PLGA (OVA) NPs can induce antigen cross-presentation and are expected to be used for induction of a strong CTL immune response and for efficient anticancer immunotherapy.</P>
Song, Chanyoung,Phuengkham, Hathaichanok,Kim, Sun-Young,Lee, Min Sang,Jeong, Ji Hoon,Shin, Sung Jae,Lim, Yong Taik Dove Medical Press 2017 International journal of nanomedicine Vol.12 No.-
<P>In this study, we suggest a designer vaccine adjuvant that can mimic the drainage of pathogens into lymph nodes and activate innate immune response in lymph nodes. By the amination of multivalent carboxyl groups in poly-(γ-glutamic acid) (γ-PGA) nanomicelles, the size was reduced for rapid entry into lymphatic vessels, and the immunologically inert nanomicelles were turned into potential activators of inflammasomes. Aminated γ-PGA nanomicelles (aPNMs) induced NLRP3 inflammasome activation and the subsequent release of proinflammatory IL-1β. The NLRP3-dependent inflammasome induction mechanism was confirmed through enzyme (cathepsin B and caspase-1) inhibitors and NLRP3 knockout mice model. After the aPNMs were combined with a clinically evaluated TLR3 agonist, polyinosinic–polycytidylic acid sodium salt (aPNM-IC), they triggered multiple arms of the innate immune response, including the secretion of pro-inflammatory cytokines by both inflammasomes and an inflammasome-independent pathway and the included type I interferons.</P>
Segmentation을 위한 저조도 데이터의 신경망 구조 탐색
박찬영(Chanyoung Park),송재원(Jaewon Song),김혜규(Hyegyu Kim) 한국정보기술학회 2022 Proceedings of KIIT Conference Vol.2022 No.12
‘자율주행시스템’ 구축에 image segmentation 기술은 핵심 요소이다. 그러나 기존 연구에서는 조도 조건이 좋은 상황(주간 이미지)에서의 segmentation 방법을 주로 다루고 있고, 조도 조건이 나쁜 상황(야간 이미지)에서의 segmentation 연구는 부족한 상황이다. 본 연구에서는 조도가 낮을 때의 segmentation 모델의 구조를 NAS(Neural Architecture Search) 알고리즘을 통해 찾았고, 주간 이미지를 이용하여 찾은 구조와의 비교를 진행했다. 기존 연구들과 비교했을 때 유의미한 성능을 내는 것을 확인하였다. Image segmentation technology is a key element for many applications, such as autonomous driving system. However, a lot of methods have been proposed, they mainly focus on daytime scenes, and segmentation studies with low illumination conditions (nighttime scenes) are insufficient. In this study, the structure of the segmentation model when illumination is low was found through a Neural Architecture Search (NAS) algorithm, and the structure found was compared using daytime images. Compared to previous studies, it was confirmed that it produced meaningful performance.
Proving the origin of magnetically inhomogeneity of FeRh film using polarized neutron reflectometry
Sehwan Song,Jiwoong Kim,Chang-woo Cho,Jisung Lee,Dooyong Lee,Doukyun Kim,Hyegyoung Kim,Haeyong Kang,Chul-Hong Park,Jun Kue Park,Jae Hyuck Jang,Noboru Miyata,Neeraj Kumar,Yeong-Ah Soh,Chanyoung Hwang,B 한국자기학회 2022 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2