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헛개나무 열매, 과병 및 종자의 항당뇨, 항산화 플라보노이드 함량 분석
이솔잎(Solip Lee),김현준(Hyun-Jun Kim),박영기(Youngki Park),류세환(Se Hwan Ryu),연상원(Sang Won Yeon),투르크아이만(Ayman Turk),이학현(Hak Hyun Lee),황방연(Bang Yeon Hwang),이미경(Mi Kyeong Lee) 한국생약학회 2023 생약학회지 Vol.54 No.4
Hovenia dulcis is a native plant of South Korea. The fruits of H. dulcis have been traditionally used for the treatment of hepatic disorders and metabolic diseases. The fruits of H. dulcis comprise of fruit stalks and seeds. In this study, the constituents and biological activity of fruit stalks and seeds of H. dulcis were compared. The seed extract showed excellent antioxidant and anti-diabetic activity as measured by DPPH radical scavenging and α-glucosidase inhibitory activity, respectively. In addition, the seeds contained high flavonoid content. However, the efficacy and flavonoid content of fruit stalks were quite low compared to seeds. Fractionation of seed extract using various chromatographic techniques resulted in the isolation of three compounds, which were identified as taxifolin (1), quercetin (2), and dihydrokaempferol (3). All three compounds showed antioxidant and anti-diabetic activity. Among them, compounds 1 and 2 were major compounds of seeds and proved to be contained as 8.3 and 1.3%, respectively, in the 50% EtOH seed extract. Therefore, the seeds of H. dulcis are suggested as a good source of antioxidant and anti-diabetic flavonoids.
조양희,Solip Lee,류세환,연상원,Ayman Turk, Bang,황방연,이미경 한국생약학회 2021 Natural Product Sciences Vol.27 No.4
Masclura tricuspidata, also called as Cudrania tricuspidata, is one of the most common Moraceae family plants in East Asia. Its trivial name follows mulberry due to the similar morphology. Investigation of the bioactive constituents of M. tricuspidata leaves yielded a new xanthone derivative along with twenty known compounds through various chromatographic techniques. A new compound was defined as mascluraxanthone (3), a prenylated xanthone glucoside on the basis of 1D and 2D NMR and MS data. Twenty known compounds were identified as four xanthone derivatives (1-2 and 4-5), two flavans (6-7), six flavanol derivatives (8-13), a flavonone (14) and seven flavonol derivatives (15-21). Among the isolated compounds, flavanol and flavonoid derivatives with 3′,4′-OH groups showed antioxidant and anti-tyrosinase activities. Conclusively, the leaves of M. tricuspidata are rich in aromatic compounds including xanthones and flavonoids. In addition, these constituents showed antioxidant and anti-tyrosinase potentials, which might be useful for oxidative stress related diseases.
Se Hwan Ryu,Ayman Turk,Sang Won Yeon,Solip Lee,Beom Seok Kim,Sung Min Ko,Bang Yeon Hwang,Mi Kyeong Lee 한국버섯학회 2023 버섯 Vol.27 No.1
Hericium erinaceus (lion’s mane mushroom) is an edible and medicinal mushroom that belongs to the family Hericiaceae. It has been traditionally used for the treatment of memory impairment and gastrointestinal diseases. We previously reported hericene A as an anti-diabetic constituent of H. erinaceus and investigated the effect of cultivation substrates on its content. As the continuation, the contents of five major compounds, including hericenes A-D, which exhibit α-glucosidase inhibitory activity together with ergosterol, were investigated according to the cultivation stage. H. erinaceus was cultured for 5 stages to induce fruiting bodies, and the contents of the compounds at each stage were quantified through HPLC analysis. Among the major compounds the content of hericene A was the highest, followed by hericene C and the content of hericenes B and D was relatively low. The contents of four hericene derivatives are the highest at stage 4 whereas the content of ergosterol was highest at stage 5. The highest α-glucosidase inhibitory activity of H. erinaceus was at stage 4, which correlates with the contents of hericene derivatives. Conclusively, H. erinaceus with better efficacy and high content of active constituents can be secured by the optimization of cultivation conditions.