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Final report of CCQM-K129 'Measurement of Mole Fractions of Cu, In, Ga and Se in Cu(In,Ga)Se2 Films
Kim, K J,Kim, A S,Jang, J S,Suh, J K,Wirth, T,Unger, W,Hodoroaba, V-D,Araujo, J R,Archanjo, B S,Galhardo, C E,Damasceno, J,Achete, C A,Wang, H,Wang, M,Bennett, J,Simon, D,Kurokawa, A,Terauchi, S,Fujim BUREAU INTERNATIONAL DES POIDS ET MESURES 2016 METROLOGIA -BERLIN- Vol.53 No.1
Noncoherent Detection of Orthogonal Modulation Combined with Alamouti Space-Time Coding
Simon, Marvin K.,Wang, Ji-Bing The Korea Institute of Information and Commucation 2003 Journal of communications and networks Vol.5 No.2
In this paper, we investigate the error probability performance of noncoherently detected orthogonal modulation combined with Alamouti space-time block coding. We find that there are two types of pair-wise error probabilities that characterize the performance. We employ methods that allow a direct evaluation of exact, closed-form expressions for these error probabilities. Theoretical as well as numerical results show that noncoherent orthogonal modulation combined with space-time block coding (STBC) achieves full spatial diversity. We derive an expression for approximate average bit error probability for-ary orthogonal signaling that allows one to show the tradeoff between increased rate and performance degradation.
Jaeil Chung,Kelly Wang,Alexander Podboy,Srinivas Gaddam,Simon K. Lo 대한소화기내시경학회 2022 Clinical Endoscopy Vol.55 No.1
Background/Aims: Endoscopic mucosal resection (EMR) is the primary treatment for duodenal adenomas; however, it is associatedwith a high risk of perforation and bleeding, especially with larger lesions. The goal of this study was to demonstrate the feasibilityand safety of endoscopic suturing (ES) for the closure of mucosal defects after duodenal EMR. Methods: Consecutive adult patients who underwent ES of large mucosal defects after EMR of large (>2 cm) duodenal adenomaswere retrospectively enrolled. The OverStitch ES system was employed for closing mucosal defects after EMR. Clinical outcomes andcomplications, including delayed bleeding and perforation, were documented. Results: During the study period, ES of mucosal defects was performed in seven patients in eight sessions (six for prophylaxisand two for the treatment of perforation). All ES sessions were technically successful. No early or delayed post-EMR bleeding wasrecorded. In addition, no clinically obvious duodenal stricture or recurrence was encountered on endoscopic follow-up evaluation,and no patients required subsequent surgical intervention. Conclusions: ES for the prevention and treatment of duodenal perforation after EMR is technically feasible, safe, and effective. ES should be considered an option for preventing or treating perforations associated with EMR of large duodenal adenomas.
James J. Lai,John J. Hill,Casey Y. Huang,Gino C. Lee,Karol W. Mai,Maggie Y. Shen,Simon K. Wang 전남대학교 의과학연구소 2024 전남의대학술지 Vol.60 No.1
Extracellular vesicles (EVs) function as potent mediators of intercellular communication for many in vivo processes, contributing to both health and disease related conditions. Given their biological origins and diverse functionality from correspondingly unique “cargo” compositions, both endogenous and modified EVs are garnering attention as promising therapeutic modalities and vehicles for targeted therapeutic delivery applications. Their diversity in composition, however, has revealed a significant need for more comprehensive analytical-based characterization methods, and manufacturing processes that are consistent and scalable. In this review, we explore the dynamic landscape of EV research and development efforts, ranging from novel isolation approaches, to their analytical assessment through novel characterization techniques, and to their production by industrial-scale manufacturing process considerations. Expanding the horizon of these topics to EVs for in-human applications, we underscore the need for stringent development and adherence to Good Manufacturing Practice (GMP) guidelines. Wherein, the intricate interplay of raw materials, production in bioreactors, and isolation practices, along with analytical assessments compliant with the Minimal Information for Studies of Extracellular Vesicles (MISEV) guidelines, in conjunction with reference standard materials, collectively pave the way for standardized and consistent GMP production processes.
Lai Nar Tung,Senchuan Song,Kin Tak Chan,Mei Yuk Choi,Ho Yu Lam,Chung Man Chan,Zhiyong Chen,Hector K. Wang,Hoi Ting Leung,Simon Law,Yanmin Huang,Huacan Song,Nikki P. Lee 대한암학회 2018 Cancer Research and Treatment Vol.50 No.4
Purpose Tumor xenograft model is an indispensable animal cancer model. In esophageal squamous cell carcinoma (ESCC) research, orthotopic tumor xenograft model establishes tumor xenograft in the animal esophagus, which allows the study of tumorigenesis in its native microenvironment. Materials and Methods In this study, we described two simple and reproducible methods to develop tumor xenograft at the cervical or the abdominal esophagus in nude mice by direct injection of ESCC cells in the esophageal wall. Results In comparing these two methods, the cervical one presented with more clinically relevant features, i.e., esophageal stricture, body weight loss and poor survival. In addition, the derived tumor xenografts accompanied a rapid growth rate and a high tendency to invade into the surrounding structures. This model was subsequently used to study the anti-tumor effect of curcumin, which is known for its potential therapeutic effects in various diseases including cancers, and its analogue SSC-5. SSC-5 was selected among the eight newly synthesized curcumin analogues based on its superior anti-tumor effect demonstrated in an MTT cell proliferation assay and its effects on apoptosis induction and cell cycle arrest in cultured ESCC cells. Treatment of orthotopic tumor-bearing mice with SSC-5 resulted in an inhibition in tumor growth and invasion. Conclusion Taken together, we have established a clinically relevant orthotopic tumor xenograft model that can serve as a preclinical tool for screening new anti-tumor compounds, e.g., SSC-5, in ESCC.